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Nathan Goodyear

Access : Type 2 diabetes as an inflammatory disease : Nature Reviews Immunology - 0 views

www.nature.com/...nri2925.html

inflammation diabetes type II DM

shared by Nathan Goodyear on 20 Mar 12 - No Cached
  • Nathan Goodyear on 20 Mar 12
     
    Inflammation plays critical role in the development of type II DM
Nathan Goodyear

Thyroid Hormone Treatment to Mend a Broken Heart - 0 views

jcem.endojournals.org/...1172.full

free T3 fT3 heart cardiac MI myocardial infarction hypothyroidism hypothyroid CHF congestive heart failure hormone hormones thyroid

shared by Nathan Goodyear on 03 Jul 12 - No Cached
  • Nathan Goodyear on 03 Jul 12
     
    free T3 is critical in the heart healing post MI.  Hypothyroidism and CHF share many hemodynamic and cardiovascular similarities.
Nathan Goodyear

NF-κB and cancer: how intimate is this relationship - 0 views

www.ncbi.nlm.nih.gov/...PMC3148942

cancer inflammation NF-KappaB

shared by Nathan Goodyear on 22 Jan 12 - No Cached
  • Nathan Goodyear on 22 Jan 12
     
    NF-KappaB plays a critical role in the development of cancer. NF-kappaB is a transcription factor that promotes inflammation.  This reveals the important relationship between inflammation and cancer.
Nathan Goodyear

IKK-[beta] links inflammation to obesity-induced insulin resistance - Nature Medicine - 0 views

www.nature.com/...nm1185.html

inflammation insulin resistance IKK-Beta NF-kapppB

shared by Nathan Goodyear on 21 Dec 11 - No Cached
  • Nathan Goodyear on 21 Dec 11
     
    inflammation plays critical role in insulin resistance and the associated inflammatory conditions.  IKK-Beta and NF-KappaB are heavily involved in local and systemic inflammatory signaling.
Nathan Goodyear

PPARs, Obesity, and Inflammation - 0 views

www.ncbi.nlm.nih.gov/...PMC1783744

PPARs PPAR obesity overweight weight-loss lipid metabolism

shared by Nathan Goodyear on 05 Jan 12 - No Cached
  • Nathan Goodyear on 05 Jan 12
     
    PPARs and how they regulate lipid metabolism.  PPARs play a critical role in obesity and inflammation
Nathan Goodyear

Human gut microbiota in obesity and after gastric bypass - 0 views

dl-web.dropbox.com/...PNAS-2009-Zhang-0812600106.pdf

obesity weight loss inflammation metabolic endotoxemia bariatric surgery gastric bypass probiotics firmicutes gut flora microbiota

shared by Nathan Goodyear on 26 Jan 12 - No Cached
  • Nathan Goodyear on 26 Jan 12
     
    It is proposed that the balance of bacteria in the gut play a critical role in energy utilization and obesity. This study showed that bypass surgery altered the gut bacteria to favor weight loss: decrease in firmicutes species. But, do we really need gastric bypass to do that? Of course not. Probiotics will do the same.
Nathan Goodyear

Colonic CD8 and gamma delta T-cell infiltration with epithelial damage in children with autism. - 0 views

www.ncbi.nlm.nih.gov/...11241044

ASD autism inflammation children Lymphoid nodular hyperplasia LNH regressive

shared by Nathan Goodyear on 30 Jan 12 - No Cached
  • Nathan Goodyear on 30 Jan 12
     
    Study shows that gastrointestinal epithelial dysfunction is found in autism. This would play a critical role in systemic inflammation and would contribute to ASD symptoms through the gut-brain connection.
Nathan Goodyear

Reduced activation and increased ina... [J Clin Endocrinol Metab. 2003] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...12843166

inflammation illness thyroid hypothyroid hypothyroidism TSH free T3 rT3 T3:rT3 ratio

shared by Nathan Goodyear on 02 Feb 12 - No Cached
  • These observed changes, in correlation with a low T(3)/rT(3) ratio, may represent tissue-specific ways to reduce thyroid hormone bioactivity during cellular hypoxia and contribute to the low T(3) syndrome of severe illness.
  • Nathan Goodyear on 02 Feb 12
     
    inflammation and critical illness associated with low TSH, low T3, elevated rT3 and low T3:rT3 ratio.
Nathan Goodyear

Depletion of plasma antioxidants in surgical intensive care unit patients requiring parenteral feeding: effects of parenteral nutrition with or without alanyl-glutamine dipeptide supplementation - 0 views

www.nutritionjrnl.com/...abstract

antioxidant antioxidants vitamin C glutathione E Zinc nutrition

shared by Nathan Goodyear on 29 Feb 12 - No Cached
  • Nathan Goodyear on 29 Feb 12
     
    Critically ill patients found to be depleted in glutathione, vitamin C, Zinc, and too a lesser extent: vitamin E.  The obvious treatment would be to replace those identified deficiencies
Nathan Goodyear

http://eu-acme.org/europeanurology/upload_articles/Bonkhoff.pdf - 0 views

eu-acme.org/...Bonkhoff.pdf

estrogen estradiol ER receptors ER alpha ER beta prostate cancer male men hormone hormones

shared by Nathan Goodyear on 20 Jan 14 - No Cached
  • Nathan Goodyear on 20 Jan 14
     
    Estrogen plays a critical role in the initiation of carcinogenesis of prostate cancer through the ER alpha/beta expression.  As the authors state in their conclusion, "...ER alpha signaling potentiates the carcinogenic effects of androgens on the prostatic epithelium."
Nathan Goodyear

Cambridge Journals Online - Proceedings of the Nutrition Society - Fulltext - Extra-adrenal regeneration of glucocorticoids by 11β-hydroxysteroid dehydrogenase type 1: physiological regulator and pharmacological target for energy partitioning - 0 views

journals.cambridge.org/...displayFulltext

11-betaHSD1 metabolism obesity energy cortisol nutrition

shared by Nathan Goodyear on 08 Oct 13 - No Cached
  • Nathan Goodyear on 08 Oct 13
     
    Peripheral 11Beta-HSD1 plays critical role in fat metabolism and energy utilization.  Good discussion on the role that extra-adrenal 11Beta-HSD1 plays in metabolism
Nathan Goodyear

A meta-analysis of the association bet... [Cancer Causes Control. 2013] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/pubmed

abortion breast cancer

shared by Nathan Goodyear on 03 Dec 13 - No Cached
  • Nathan Goodyear on 03 Dec 13
     
    Study was undertaken in China due to alarming increase in breast cancer in Chinese women. This meta-analysis of 36 articles found a 44% increase in breast cancer with one abortion.  This increased to 76% at 2 and 89% at 3 abortions respectively.   This study is very important and previous criticisms of prior studies linking abortion to breast cancer has been reporting bias.  In China, due to the one child policy, abortion is a way of life and there is no cultural shame involved.
Nathan Goodyear

Scopus - Document details - 0 views

www.scopus.com/...display.url

cancer immune system NK cells NK natural killer cells innate

shared by Nathan Goodyear on 15 Jun 14 - No Cached
  • Nathan Goodyear on 15 Jun 14
     
    Stress decreases the innate immune response.  This is critical in the battle against cancer.  Specifically, low NK activity is found in stress individuals with cancer.
Nathan Goodyear

http://www.researchgate.net/profile/Costanzo_Moretti/publication/12777565_Leptin_and_androgens_in_male_obesity_evidence_for_leptin_contribution_to_reduced_androgen_levels/links/02bfe50e5334207a93000000.pdf - 0 views

www.researchgate.net/...02bfe50e5334207a93000000.pdf

leptin low T low Testosterone obese men male hormone hormones obesity

shared by Nathan Goodyear on 17 Jun 15 - No Cached
  • Nathan Goodyear on 17 Jun 15
     
    Normal leptin levels are critical to puberty; but in obese men, increased leptin is associated with gonadal decrease in Testosterone.  It appears to occur through a decrease in 17-OH progesterone to Testosterone: suggesting an inhibitory activity in the conversion of 17-OH progesterone to Testosterone in obese men.
Nathan Goodyear

Omega-3 Fats Critical to Brain Health After Traumatic Injury and Surgery - 0 views

www.issfal.org/...r-traumatic-injury-and-surgery

omega 3 omega-3 DHA EPA TBI memory cognition inflammation traumatic brain injury brain injury brain

shared by Nathan Goodyear on 31 Aug 15 - No Cached
  • Nathan Goodyear on 31 Aug 15
     
    Just the press release, but DHA and EPA found to improve nerve cell survival, reduce neuroinflammation and decrease oxidative stress via "resolvins"
Nathan Goodyear

Thyroid hormone and "cardiac metamorphosis": poten... [Pharmacol Ther. 2008] - PubMed result - 0 views

www.ncbi.nlm.nih.gov/...18455802

thyroid hormone heart cardiac

shared by Nathan Goodyear on 02 Feb 11 - No Cached
  • Nathan Goodyear on 02 Feb 11
     
    thyroid hormone plays important role in heart failure and heart repair; thyroid balance critical
Nathan Goodyear

The intestine and its microflora are partners for the protection of the host: report on the Danone Symposium "The Intelligent Intestine," held in Paris, June 14, 2002 - 0 views

www.ajcn.org/...675.abstract

microflora probiotics probiotic gut bacteria immune system health intesting

shared by Nathan Goodyear on 07 Sep 11 - No Cached
  • The intestine is the primary immune organ of the body represented by the gut-associated lymphoid tissue through innate and acquired immunity
  • Nathan Goodyear on 07 Sep 11
     
    The balance of our gut bacteria are critical to the health of our immune system and thus the health of the whole body
Nathan Goodyear

Transkingdom Control of Microbiota Diurnal Oscillations Promotes Metabolic Homeostasis: Cell - 0 views

www.cell.com/...S0092-8674(14)01236-7

gut microbiota microflora flora shiftwork jet lag metabolic syndrome insulin resistance diabetes

shared by Nathan Goodyear on 20 Oct 14 - No Cached
  • in addition to the type of diet being a modulator of microbiota composition, the timing of food intake plays a critical role in shaping intestinal microbial ecology.
  • the microbiota rhythms are influenced by the host clock and perform critical functions in the adaptation of metabolic processes to the diurnal fluctuations in the environment
  • Our study reveals that dysbiosis has a temporal dimension and that static microbiota comparisons might not be fully conclusive unless samples were taken in a controlled manner with respect to this important additional variable
  • ...1 more annotation...
  • our taxonomic analysis indicates that microbiota oscillations are following rhythmic food intake
  • Nathan Goodyear on 20 Oct 14
     
    This is a really nice study.  Altered sleep-wake cycles result in altered food consumption which leads to altered gut microbiota diurnal oscillations.  Gut microbiota have a normal diurnal oscillation.  This altered gut flora then leads to increase insulin resistance, metabolic syndrome, diabetes...
Nathan Goodyear

Thyroid Replacement Therapy and Heart Failure - 0 views

circ.ahajournals.org/...385.full

thyroid T3 hormone hormones cardiovascular disease heart health failure CHF MI myocardial infarction heart attack heart disease

shared by Nathan Goodyear on 24 Sep 14 - No Cached
  • A good biomarker of intracardiac TH signaling would be helpful but has not been identified. In the absence of such a marker, a rational, cautious therapeutic approach might be to restore and maintain over time biochemical euthyroidism as documented by normal circulating levels of TSH, FT4, and FT3.
  • a low-T3 state resulting from altered peripheral TH metabolism secondary to caloric restriction is associated with impaired cardiac contractility
  • Low-T3 syndrome is the central finding and defines the illness in a variety of acute and chronic severe nonthyroidal illnesses with cardiac origin, including MI, HF, and surgically treated cardiac disease.1 Low circulating levels of T3 in the absence of primary thyroid hypofunction have been found in 20% to 30% of patients with dilated cardiomyopathy.
  • ...1 more annotation...
  • FT3 levels were inversely correlated to coronary artery disease
  • Nathan Goodyear on 24 Sep 14
     
    Great review of the current understanding of thyroid hormone metabolism in cardiac tissue.  Low T3 and increased rT3 (via increased D3 activity) is CLEARLY associated with poor cardiac performance and post MI and CHF is associated with poor outcomes.  T3 is critical in cardiac remodeling and recovery post MI.  T3 is actually a vasodilatory in the coronary arteries.   Why a endocrinologist would call rT3 useless only points to their ignorance of the literature.
Nathan Goodyear

The Diuretic Effect in Human Subjects of an Extract of Taraxacum officinale Folium over a Single Day - 0 views

www.ncbi.nlm.nih.gov/...PMC3155102

Dandelion diuretic natural herbs

shared by Nathan Goodyear on 07 Jan 15 - No Cached
  • Nathan Goodyear on 07 Jan 15
     
    Dandelion root has historically shown benefit as diuretic.  Study finds support for tincture, though this is a small pilot.  Dosing is critical.
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