Skip to main content

Home/ Dr. Goodyear/ Group items tagged critically

Rss Feed Group items tagged

Filter: All | Bookmarks | Topics Simple Middle
Nathan Goodyear

The Beneficial Effects of Antioxidant Supplementation in Enteral Feeding in Critically ... - 0 views

www.anesthesia-analgesia.org/...857.long

IV intravenous vitamin C E critically ill sepsis antioxidant therapy treatment

shared by Nathan Goodyear on 29 Feb 12 - No Cached
  • Nathan Goodyear on 29 Feb 12
     
    IV vitamin C and vitamin E was found to lower the mortality rate in those with critical illness at the 28 day mark.  This study showed the safety and efficacy of IV vitamin C and vitamin E in those critically ill.
Nathan Goodyear

Reduced Activation and Increased Inactivation of Thyroid Hormone in Tissues of Critical... - 0 views

jcem.endojournals.org/...3202.full

TSH hypothyroid hypothyroidism T3 rT3 T4 thyroid hormone inflammation

shared by Nathan Goodyear on 07 Feb 12 - No Cached
  • Nathan Goodyear on 07 Feb 12
     
    critical illness is associated with low TSH, reduced T3, and increased rT3 production.  Inflammation is critically involved in this process.  This study from JCEM shows how unreliable TSH and T4 are.
Nathan Goodyear

Total vitamin C, ascorbic acid, and dehydroascorbic acid concentrations in plasma of cr... - 0 views

europepmc.org/...8615361

ascorbic acid vitamin C critical care critically ill

shared by Nathan Goodyear on 29 Jun 22 - No Cached
  • Nathan Goodyear on 29 Jun 22
     
    Vitamin levels decreased in critically ill.
Nathan Goodyear

Combining surgery and immunotherapy: turning an immunosuppressive effect into a therape... - 0 views

jitc.biomedcentral.com/...s40425-018-0398-7

surgery cancer immunotherapy immunosuppression metastasis

shared by Nathan Goodyear on 20 Feb 21 - No Cached
Amol kashikar liked it
  • Nathan Goodyear on 20 Feb 21
     
    The post-operative time period is critical to the long-term metastatic risk of cancer because surgery suppresses the immune system in this critical post-operative time period.
Nathan Goodyear

Hypovitaminosis C and vitamin C deficiency in critically ill patients despite recommend... - 0 views

www.ncbi.nlm.nih.gov/...PMC5725835

vitamin C deficiency hypovitaminosis C IV vitamin C septic shock critically ill hypovitaminosis ICU critical illness vitamin C critical care sepsis

shared by Nathan Goodyear on 14 Jul 22 - No Cached
  • Nathan Goodyear on 14 Jul 22
     
    Septic patients have lower vitamin C levels and respond less to typical dosing due to inflammaiton
Nathan Goodyear

Vitamin D Deficiency in Critically Ill Children - 0 views

pediatrics.aappublications.org/...421.abstract

vitamin D deficiency low children vitamins pediatrics vitamin d

shared by Nathan Goodyear on 18 Sep 12 - No Cached
  • Nathan Goodyear on 18 Sep 12
     
    vitamin D deficiency found highly prevalent in children with critical illness
Nathan Goodyear

The Association of Vitamin D Status With Pediatric Critical Illness - 0 views

pediatrics.aappublications.org/...429.abstract

vitamin D deficiency low children pediatrics vitamin d

shared by Nathan Goodyear on 18 Sep 12 - No Cached
  • Nathan Goodyear on 18 Sep 12
     
    Vitamin D deficiency found more prevalent in those children with critical illnesses; and with greater severity of illness.
Nathan Goodyear

Free T4, Free T3, and Reverse T3 in Critically III, Thermall... : The Journal of Trauma - 0 views

journals.lww.com/...everse_T3_in_Critically.1.aspx

free reverse T3 thyroid hypothyroid hypothyroidism

shared by Nathan Goodyear on 08 Mar 11 - No Cached
  • Significant suppression of serum concentrations of 3,5,3'-triiodothyronine (T3) and elevation of serum concentrations of 3,3',5'-triiodothyronine (rT3) were seen
  • Nathan Goodyear on 08 Mar 11
     
    low free T3: elevated reverse T3 in critically ill patients
Nathan Goodyear

Reduction of Resuscitation Fluid Volumes in Severely Burned Patients Using Ascorbic Aci... - 0 views

jamanetwork.com/...390538

IV vitamin C critical care vitamin C burns

shared by Nathan Goodyear on 31 Mar 20 - No Cached
  • Nathan Goodyear on 31 Mar 20
     
    IV vitamin C, high dose, found to benefit patients early in burn critical care.
Nathan Goodyear

Vitamin C revisited | Critical Care | Full Text - 0 views

ccforum.biomedcentral.com/...s13054-014-0460-x

IV vitamin C vitamin C sepsis stroke oxidative stress LPS

shared by Nathan Goodyear on 22 Aug 17 - No Cached
  • Nathan Goodyear on 22 Aug 17
     
    Great read on IV vitamin C in the critically ill.
Nathan Goodyear

Vitamin C may reduce the duration of mechanical ventilation in critically ill patients:... - 0 views

jintensivecare.biomedcentral.com/...s40560-020-0432-y

ventilation IV vitamin C vitamin C

shared by Nathan Goodyear on 11 Aug 20 - No Cached
  • Nathan Goodyear on 11 Aug 20
     
    Meta-analysis finds that vitamin C shortened ventilation time by 25% in critical ill.
Nathan Goodyear

Inflammation as a Link between Obesity and Metabolic Syndrome - 0 views

www.hindawi.com/...476380

inflammation obesity metabolic syndrome metabolic syndrome disease

shared by Nathan Goodyear on 14 Jan 13 - No Cached
  • Nathan Goodyear on 14 Jan 13
     
    inflammation shown to play a critical role in disease.  Here obesity causes inflammation, but obesity is the result of inflammation.  This then leads to metabolic syndrome, through which disease starts.
Smile Reef

Choosing a Pediatric Dentist in Las Vegas - 0 views

smilereef.com/...pediatric-dentist-in-las-vegas

special needs dentistry baby dentist childrens dentist las vegas oral sedation dentistry pediatric dentist las vegas kid dentist child dentist baby bottle tooth decay pediatric dental cavities in baby teeth dentist for kids

shared by Smile Reef on 20 May 13 - No Cached
  • Smile Reef on 20 May 13
     
    Finding the right doctor or dentist is critical. We have decided to help by listing some of the fabulous benefits you and your kids can find at Smile Reef Pediatric Dentist.
Nathan Goodyear

Maternal Immune Activation Alters Fetal Brain Development through Interleukin-6 - 0 views

www.jneurosci.org/...10695

flu vaccines vaccination influenza pregnancy IL-6 inflammation autism schizophrenia brain development

shared by Nathan Goodyear on 07 Nov 12 - No Cached
  • Nathan Goodyear on 07 Nov 12
     
    this study, though in mice, should strike fear in all parents.  This study found that the inflammatory biomarker IL-6 was critical in the development of autism and schizophrenia in the mice offspring.  Neuro development was altered by inflammation exposure during preganancy.  This was from a single injection of IL-6!  This in light of recent studies that show that the flu vaccine and other vaccines increase IL-6 production in pregnant mothers.  So, why did ACOG promote flu vaccines in pregnancy again?
Nathan Goodyear

Telomerase at the intersection of cancer and aging - 0 views

www.ncbi.nlm.nih.gov/...PMC3896987

telomere telomeres telomerase telomerase activator aging disease cancer

shared by Nathan Goodyear on 18 May 16 - No Cached
  • The anti-aging role of telomerase has been demonstrated to be largely mediated by its canonical role in elongating telomeres, which prevents the accumulation of critically short telomeres and loss of tissue homeostasis
  • Short telomeres, and subsequent DDR activation, could occur both in cancer and aging
  • increased abundance of short telomeres correlates with higher genomic instability and decreased longevity in various organisms, including mice, zebrafish, and yeast
  • ...15 more annotations...
  • mice deficient for telomerase or for telomere binding proteins are characterized by accelerated age-related defects
  • In humans, short telomeres are considered good indicators of an individual’s health status and correlate with both genetic and environmental factors
  • Although recent findings strongly support the idea that short telomeres drive several age-related diseases 38 we cannot exclude the possibility that in some situations short telomeres may be a consequence of the disease itself.
  • the current view is that telomerase deficiency may contribute to the early steps of cancer development by fueling chromosomal instability, while subsequent activation of telomerase may be necessary to allow tumor growth and tumor progression towards more malignant states
  • telomerase activation can be an early event in cancer, it is not necessary for cancer initiation
  • telomerase can stimulate tumor progression by ensuring maintenance of telomeres above a critically short length, thus preventing induction of cellular senescence or apoptosis
  • Almost all human cancers present activation of telomerase as a hallmark, most likely as a mechanism to allow unlimited cell proliferation of tumor cells
  • recent evidence demonstrated that short telomeres alone could lead to genomic instability and cancer
  • Getting rid of telomerase can also be problematic; the lack of telomerase could lead to increased chromosomal instability, which in turn could be at the basis for cancer initiation when tumor suppressor barriers are bypassed
  • telomerase activation is a potential therapeutic strategy for the treatment of age-related diseases
  • telomerase activation in adult or old mice by means of a gene therapy strategy was shown to be sufficient to improve metabolic fitness, neuromuscular capacity, and prevent bone loss, as well as significantly increase both median and maximum longevity, without increased cancer incidence
  • These studies suggest that telomerase expression could be considered a feasible approach to reverse tissue dysfunction and extend healthy lifespan without increasing cancer incidence
  • humans almost completely lose telomerase activity from somatic tissues in the adulthood
  • a change of paradigm seems to be occurring in telomerase biology, with a switch from viewing telomerase as fueling cancer to reversing aging
  • Telomerase expression in a background of high levels of tumor suppressors or in aged organisms seems to prevent its expected pro-cancer activity and yet it still functions as an anti-aging factor
  • Nathan Goodyear on 18 May 16
     
    Telomerase activity and longer telomere length is shown to correlated inversely with many chronic diseases of aging.  In contrast, telomerase activity is found to be involved in carcinogenesis.  Increased carcinogenic potential of telomerase activity has not borne out in studies.  In addition, increased CD8 cell activity as a result of telomerase activation will actually decrease carcinogenic potential via NK activation.
Nathan Goodyear

Leg vascular and skeletal muscle mitochondrial adaptations to aerobic high-intensity ex... - 0 views

www.ncbi.nlm.nih.gov/...28231611

exercise menopause post-menopause women hormones ER alpha muscle

shared by Nathan Goodyear on 28 Feb 17 - No Cached
  • Nathan Goodyear on 28 Feb 17
     
    The early post menopause phase is critical for women. This is the phase that requires intensify strategy for exercise. The ER alpha signaling is actually increased and the ability to build muscle is intensified if exercise, particularly resistance training, is employed.
1 - 20 of 138 Next › Last »
Showing 20▼ items per page