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Nathan Goodyear

Acute Effects of Triiodothyronine (T3) Replacement Therapy in Patients with Chronic Hea... - 0 views

jcem.endojournals.org/...1351.long

T3 fT3 thyroid disease low T3 syndrome T3 syndrome cardiomyopathy CHF congestive heart failure

shared by Nathan Goodyear on 03 Jul 12 - No Cached
  • Nathan Goodyear on 03 Jul 12
     
    IV T3 was given to patients with chronic heart failure.  What the study found may surprise you: improved heart function (ventricular), improved BNP, decrease heart rate, no side effects.  T3 has been shown to be more predictive of cardiac death in those with cardiac disease, than elevated lipids or decreased ejection fraction.
Nathan Goodyear

Testosterone Supplementation in Heart Failure - 0 views

circheartfailure.ahajournals.org/...315.long

heart failure CHF cardiovascular disease low T low Testosterone low T male men hormone hormones congestive heart failure testosterone deficiency

shared by Nathan Goodyear on 15 Nov 13 - No Cached
  • Nathan Goodyear on 15 Nov 13
     
    Review of 4 studies found that Testosterone therapy improved exercise capacity in those patients with heart failure.
Nathan Goodyear

Will testosterone replacement therapy become a new treatment of chronic heart failure? ... - 0 views

www.ncbi.nlm.nih.gov/...PMC4842839

low Testosterone low T Testosterone CHF heart failure congestive heart failure male hormones hormones

shared by Nathan Goodyear on 16 May 16 - No Cached
  • TRT could improve significantly the exercise capacity of patients, compared with placebo
  • it could be seen that the effect of TRT on SBP and DBP was controversial
  • in men with congestive heart failure, testosterone reduced the Q-Td, whereas placebo had no effects
  • ...5 more annotations...
  • The MVC and PTmax were significantly improved in TRT patients but remained unchanged in the placebo group
  • handgrip strength improved significantly with testosterone treatment
  • According to EF assessed by echocardiography, no differences were observed between the patients who were prescribed testosterone and those who received placebo
  • There were no differences between the groups in circulating levels of NT pro-BNP, and inflammatory markers were unchanged, except for a decrease in TNF-α from baseline in the placebo group
  • Testosterone supplementation therapy appeared to be safe, and the subjects who accepted testosterone treatment did not appear any obvious adverse reactions.
  • Nathan Goodyear on 16 May 16
     
    Testosterone therapy in men with CHF found to increase exercise capacity, reduced the Q-T interval in men, improved muscle strength in men, and was found to be safe in meta-analysis.
Nathan Goodyear

Testosterone level and mortality in elderly men with systolic chronic heart failure - 0 views

www.ncbi.nlm.nih.gov/...PMC3739581

low T testosterone heart failure mortality congestive CHF men male hormone hormones hypogonadism

shared by Nathan Goodyear on 06 Apr 14 - No Cached
  • Nathan Goodyear on 06 Apr 14
     
    Good article.  Heart failure in men associated with lower Total Testosterone and estimated Free Testosterone. The severity of disease was associated with lower Testosterone levels.   I wish they would have measured free levels not estimated them.   Increased SHBG concentrations was associated increased CHF as well. This study found no association with mortality.
Nathan Goodyear

Effect of coenzyme Q10 supplementation on heart failure: a meta-analysis - 0 views

ajcn.nutrition.org/...268.abstract

CHF congestive heart failure CoQ10 heart failure

shared by Nathan Goodyear on 25 Jan 13 - No Cached
  • Nathan Goodyear on 25 Jan 13
     
    Meta-analysis shows that coQ10 "may" improve heart function in those with CHF.
Nathan Goodyear

Therapeutic effect of taurine in congestive heart failure: a double-blind crossover tri... - 0 views

www.ncbi.nlm.nih.gov/...3888464

Taurine CHF congestive heart failure heart heart health

shared by Nathan Goodyear on 22 Jun 16 - No Cached
  • Nathan Goodyear on 22 Jun 16
     
    Taurine an effective adjuvant in treatment of CHF.  Also shown to be safe.
Nathan Goodyear

Reverse T3 as a parameter of myocardial function impairment in heart failure. - 0 views

www.pubfacts.com/...n-impairment-in-heart-failure.

Thyroid hormone hormones reverse T3 rT3 free T3) CHF congestive heart failure CVD

shared by Nathan Goodyear on 24 Nov 14 - No Cached
  • Nathan Goodyear on 24 Nov 14
     
    reverse T3 and the free T3:rT3 can be used to assess prognosis of those with CHF.
Nathan Goodyear

Testosterone and pro-inflammatory cytokines in men with chronic heart failure - 0 views

www.endocrine-abstracts.org/...ea0003p250.htm

CHF congestive heart failure men male hormone hormones low T low t low Testosterone Testosterone IL-1beta TNF-alpha inflammation heart failure cardiovascular disease

shared by Nathan Goodyear on 13 Aug 14 - No Cached
  • Nathan Goodyear on 13 Aug 14
     
    Low bioavailable Testosterone associated with increased IL-1beta and TNF-alpha in men with CHF.
Nathan Goodyear

Thyroid Hormone Treatment to Mend a Broken Heart - 0 views

jcem.endojournals.org/...1172.full

free T3 fT3 heart cardiac MI myocardial infarction hypothyroidism hypothyroid CHF congestive heart failure hormone hormones thyroid

shared by Nathan Goodyear on 03 Jul 12 - No Cached
  • Nathan Goodyear on 03 Jul 12
     
    free T3 is critical in the heart healing post MI.  Hypothyroidism and CHF share many hemodynamic and cardiovascular similarities.
Nathan Goodyear

Role of dopamine in congestive heart failure: a contemporary appraisal. - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...12189316

dopamin CHF heart failure heart

shared by Nathan Goodyear on 01 Jun 17 - No Cached
  • Nathan Goodyear on 01 Jun 17
     
    dopamine has benefit in CHF.  Actually, use to be a therapy employed.
Nathan Goodyear

The role of dopamine receptors in the treatment of congestive heart failure. - PubMed -... - 0 views

www.ncbi.nlm.nih.gov/...2478806

dopamine CHF heart failure heart

shared by Nathan Goodyear on 01 Jun 17 - No Cached
  • Nathan Goodyear on 01 Jun 17
     
    Dopamine improves chronic CHF via its interactions with the dopamine receptors.
Nathan Goodyear

Safety and Hemodynamic Effects of Intravenous Triiodothyronine in Advanced Congestive H... - 0 views

www.ajconline.org/...abstract

CHF T3 hypothyroid hypothyroidism heart failure

shared by Nathan Goodyear on 31 Jan 12 - No Cached
  • Nathan Goodyear on 31 Jan 12
     
    Patients with CHF often have low T3 levels.  In this study, IV T3 was shown to be safe and well tolerated
Nathan Goodyear

The potential health benefits of taurine in cardiovascular disease - 0 views

www.ncbi.nlm.nih.gov/...PMC2586397

Taurine CHF congestive heart failure heart heart health cardiovascular CVD cardiovascular disease

shared by Nathan Goodyear on 22 Jun 16 - No Cached
  • Nathan Goodyear on 22 Jun 16
     
    Taurine safe and effect in CHF.
Nathan Goodyear

Testosterone: a natural tonic for the failing heart? - 0 views

qjmed.oxfordjournals.org/...689.full

CHF congestive heart failure testosterone heart men BHRT hormone hormones natural

shared by Nathan Goodyear on 20 Jun 12 - No Cached
  • Nathan Goodyear on 20 Jun 12
     
    This early in the evaluation: but testosterone therapy in those men with CHF is of considerable benefit.  This would improve the catabolic:anabolic state, reduce inflammation, improve strength/endurance and reduce CVD risk
Nathan Goodyear

Beneficial effects of testosterone therapy on... [Biomed Res Int. 2014] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...25110677

Low T testosterone low T low Testosterone CHF congestive heart failure exercise cardiovascular disease men male hormone hormones heart

shared by Nathan Goodyear on 13 Aug 14 - No Cached
  • Nathan Goodyear on 13 Aug 14
     
    Testosterone in men with CHF found to improve diastolic function and exercise distance versus placebo.  
Nathan Goodyear

Testosterone deficiency and cardiovascular mortality Morgentaler A, - Asian J Androl - 0 views

www.ajandrology.com/preprintarticle.asp

testosterone low t low Testosterone CVD cardiovascular mortality therapy

shared by Nathan Goodyear on 01 Dec 14 - No Cached
  • overall mortality and CV mortality were inversely associated with serum T concentrations.
  • men with low serum T, defined as < 8.7 nmol l−1 (250 ng dl−1 ), demonstrated significantly greater all-cause mortality than men with higher serum T (hazard ratio [HR]: 2.24; 95% CI: 1.41-3.57), as well as greater CV mortality
  • lower T levels were significantly associated with the presence of any CV disease
  • ...19 more annotations...
  • more than 30 years of studies suggesting that low levels of T represent an increased risk for CV and overall mortality,
  • lower serum T concentrations also are associated with CV disease, including incident coronary artery disease [17],[18],[19] and atherosclerosis,
  • the actual rate of adverse events was only half as great in the T group (123 events in 1223 men at risk = 10.1%) as in the untreated group (1587 events in 7486 men = 21.2%)
  • The study by Vigen et al. [7] has already undergone two published corrections,
  • 29 medical societies have called for retraction of the article, asserting "gross data mismanagement and contamination," that rendered the study "no longer credible
  • Mortality in T-treated men was reduced by approximately half in treated men compared with untreated men, at 10.3% versus 20.7%, respectively
  • The mortality rate for men who received TTh was 3.4 deaths per 100 person-years, and 5.7 deaths per 100 person-years in untreated men
  • HR of 0.61 (95%CI: 0.42-0.88; P = 0.008), indicating a significant reduction in mortality with TTh
  • men in the highest prognostic MI risk quartile, treatment with TTh was associated with reduced risk
  • tripling in T prescriptions in the US over the last decade
  • a majority of observational studies have found that low endogenous serum T levels are associated with increased mortality.
  • Men who received TTh were able to exercise significantly longer without ischemia compared with men who received placebo
  • In men with congestive heart failure, those who received T demonstrated greater walking distance and other functional endpoints compared with those who received placebo
  • TTh has been shown uniformly and repeatedly to improve several known CV risk factors, including reduced fat mass, body fat percent, and waist circumference, and increased lean mass
  • improved glycemic control
  • reductions in insulin resistance.
  • the evidence strongly points to improved CV status with normal serum T or treatment with TTh in men with TD
  • analysis of health insurance claims data that reported a 36% increased rate of nonfatal MI in the 90d following receipt of a T prescription compared with the 12 prior months.
  • Comparison with men who received a prescription for a phosphodiesterase type 5 inhibitor (PDE5i) revealed no increased rate of MI following the prescription
  • Nathan Goodyear on 01 Dec 14
     
    Great review by Morgentaler of Testosterone and CVD.  He highlights the significant flaws in the JAMA and the NEJM articles of Testosterone therapy risks.  Morgentaler highlights the significant evidence that points to low T and increased risk of CVD. On contention I have, is Morgantaler seems to flip aside the massive uptick of Testosterone use in the US as compared to other countries.  The evidence definitely points to Testosterone therapy as being safe in those with low T, but there is definitely a problem of significant Testosterone doping that is taking place as well.
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