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Nathan Goodyear

Effect of Testosterone Replacement Therapy on Cognitive Performance and Depression in M... - 0 views

www.ncbi.nlm.nih.gov/...PMC5209560

low T Low testosterone Testosterone male hormones Testosterone therapy depression brain cognition ED erectile dysfunction

shared by Nathan Goodyear on 09 Jan 17 - No Cached
  • Azad et al [15] used single photon emission computed tomography and showed that, after 3~5 weeks of TRT, cerebral perfusion was increased in the midbrain and the superior frontal gyrus in seven men with hypogonadism
  • After 12~14 weeks, increased perfusion was still observed in the midbrain as well as in the midcingulate gyrus
  • TDS patients who received TRT showed significant improvement in cognitive function only if mild cognitive impairment was present at baseline
  • ...4 more annotations...
  • Cherrier et al [17] evaluated a sample of 32 subjects, which included 17 men with mild cognitive impairment and 15 with Alzheimer's disease. At the 6-week follow-up, patients who received TRT showed significantly better scores regarding spatial memory, constructional abilities, and verbal memory compared to those noted in the placebo group. Taken together, these results suggest that TRT has a beneficial effect on cognitive function
  • TRT improved mood and well-being, and reduced fatigue and irritability in hypogonadal men
  • The study by Pope et al [20] involved men with depression refractory to standard anti-depressants, and found that TRT lowered the Hamilton Depression score,
  • depression tends to increase as testosterone levels decrease [21], it is highly likely that TRT improved symptoms of depression by increasing testosterone levels.
  • Nathan Goodyear on 09 Jan 17
     
    men with Testosterone <300 ng/dl with levels after 8 months of therapy achieving +680 ng/dl.
Nathan Goodyear

Nutrients | Free Full-Text | Vitamin C Status Correlates with Markers of Metabolic and ... - 0 views

www.mdpi.com/...htm

vitamin C health cognition

shared by Nathan Goodyear on 28 Feb 18 - No Cached
  • vitamin C deficiency is the fourth most prevalent nutrient deficiency reported in the United States
  • Hypovitaminosis C (defined as a plasma concentration ≤23 µmol/L)
  • The CHALICE (Canterbury Health, Ageing and Lifecourse) study is a unique New Zealand study comprising a comprehensive database of determinants of health
  • ...17 more annotations...
  • The CHALICE cohort of 404 individuals aged 50 years had an average vitamin C intake of ~110 mg/day, which should provide adequate plasma concentrations [14]. Despite this, a significant proportion of the participants had inadequate plasma vitamin C status
  • inadequate plasma vitamin C concentrations (i.e., &lt;50 µmol/L)
  • adequate plasma levels (i.e., &gt;50 µmol/L)
  • Higher plasma vitamin C status was associated with lower weight, BMI and waist circumference
  • plasma vitamin C was negatively associated with blood triglycerides, HbA1c and insulin, and positively associated with HDL levels.
  • No correlation was found between plasma vitamin C and the two indicators of heart health; blood pressure and cardiovascular risk score.
  • 2.4% of 50-year-olds were deficient in vitamin C (i.e., &lt;11 µmol/L)
  • hypovitaminosis C (i.e., &lt;23 µmol/L)
  • A high proportion (63%) of our participants had inadequate plasma vitamin C concentrations (i.e., &lt;50 µmol/L)
  • The association of low vitamin C with obesity in this study replicates results in the literature [35,40,41,42,43,44], and it is apparent that individuals with higher weight require higher intakes of vitamin C to reach adequate vitamin C status
  • higher plasma vitamin C status is associated with lower circulating levels of blood triglycerides, insulin and HbA1c
  • A role for vitamin C in the prevention or management of diabetes and/or metabolic syndrome has been suggested
  • In this study, we also demonstrate lower levels of mild cognitive impairment in those with high vitamin C status
  • The odds of mild cognitive impairment were twice as high for those below 23 μmol/L plasma vitamin C concentration.
  • Vitamin C is present at very high concentrations in the brain
  • animal models have shown that the brain is the last organ to be depleted of the vitamin during prolonged deficiency
  • A recent animal study has shown that moderate vitamin C deficiency may play a role in accelerating amyloid plaque accumulation in Alzheimer’s disease
  • Nathan Goodyear on 28 Feb 18
     
    New study: vitamin C levels correlate with cognitive and metabolic health. What is your vitamin C level? Despite the adequate levels of vitamin C intake, a large % of the individuals had inadequate vitamin C levels which points to a demand issue.  Higher oxidative stress, chronic inflammation... would drive demand for vitamin C higher. Lower vitamin C levels were associated with more metabolic disease, ie. DM, and more cognitive decline.
Nathan Goodyear

Frontiers | Adherence to a Mediterranean-Style Diet and Effects on Cognition in Adults:... - 0 views

journal.frontiersin.org/...full

nutrition diet mediterranean diet brain alzheimer's disease Alzheimers memory

shared by Nathan Goodyear on 26 Sep 16 - No Cached
  • adherence to a MedDiet pattern is associated with less cognitive decline, dementia, or AD
  • higher adherence to a MedDiet was related to either slowing the rate of cognitive decline, minimizing the conversion to AD or improving the cognitive function
  • The more specific cognitive domains that improved with MedDietS were memory, delayed recognition, executive function, long-term working memory, and visual constructs
  • Nathan Goodyear on 26 Sep 16
     
    Mediterranean diet found to improve cognition and slow progression and/or risk of Alzheimer's disease.
Nathan Goodyear

Meta-analysis of double blind randomized controlled clinical trials of acetyl-L-carniti... - 0 views

www.crd.york.ac.uk/...ShowRecord.asp

Acetyl-L-carnitine acetyl Carnitine cognition cognitive decline brain alzheimer disease

shared by Nathan Goodyear on 04 Nov 13 - No Cached
  • Nathan Goodyear on 04 Nov 13
     
    Meta-analysis of 21 studies on acetyl Carnitine finds improvement with mild cognitive impairment and/or prevention of cognitive deterioration.
Nathan Goodyear

Testosterone Treatment of Men With Mild Cognitive Impairment and Lo... - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...25392187

low T low Testosterone low T Testosterone cognition cognitive decline men male hormone hormones memory hypogonadism

shared by Nathan Goodyear on 24 Nov 14 - No Cached
  • Nathan Goodyear on 24 Nov 14
     
    small study finds limited improvement in cognition in men with low T and mild Cognitive impairment.  Little application from this study.
Nathan Goodyear

Sex hormones and cognitive decline ... [Psychoneuroendocrinology. 2009] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...18845400

men estrogen estradiol estrone dementia cognitive decline low T low testosterone hormones hormone

shared by Nathan Goodyear on 30 Apr 13 - No Cached
  • Nathan Goodyear on 30 Apr 13
     
    increased estradiol and estrone levels in men associated with cognitive decline.  This was distinct from age, CVD, and APOE genotype.  This points to a clear association between increased aromatase activity and inflammation that contributes to cognitive decline in men.
Nathan Goodyear

JAMA Network | Archives of Neurology | Effects of Growth Hormone-Releasing Hormone on C... - 0 views

archneur.jamanetwork.com/article.aspx

GHRH cognitive function executive aging hormone hormones

shared by Nathan Goodyear on 07 Sep 12 - No Cached
  • Nathan Goodyear on 07 Sep 12
     
    GHRH, for 20 weeks shown to subjectively and objectively improve cognitive function in adults.  
Nathan Goodyear

Lifelong Estrogen Exposure and Memory in Older Postmenopausal Women - Journal of Alzhei... - 0 views

iospress.metapress.com/...q781740m46771311

estrogen alzheimer dementia postmenopause women hormone hormones memory

shared by Nathan Goodyear on 10 Sep 13 - No Cached
  • Nathan Goodyear on 10 Sep 13
     
    Study finds suggestion of cognitive protection by enduring estrogen exposure.  Interesting, that estrogen seems to protect against cognitive decline in women, yet increases cognitive decline in men.
Nathan Goodyear

Oxidative Stress, Testosterone, and Cognition among Caucasian and Mexican-American Men ... - 0 views

iospress.metapress.com/...t1717503235m8667

Testosterone alzheimer memory disease stress oxidative oxidative stress men male hormone hormones cognition

shared by Nathan Goodyear on 03 Mar 14 - No Cached
  • Nathan Goodyear on 03 Mar 14
     
    Interesting study. This study points out the differences between individuals and groups i.e. Mexian-Americans and Caucasians in this study.  Men with low oxidative stress, Testosterone was associated with no cognitive dysfunction.  In contrast, with high oxidative stress, Testosterone therapy was associated with cognitive impairment in caucasians only.
Nathan Goodyear

Lower-But-Normal Serum TSH level Is Associated With the Development or Progression of C... - 0 views

press.endocrine.org/...jc.2013-3385

TSH cognition dementia elderly aging brain hormone hormones functional hypothyroidism

shared by Nathan Goodyear on 03 Mar 14 - No Cached
  • Nathan Goodyear on 03 Mar 14
     
    This study points to an association between a low-normal TSH and cognitive decline in the elderly.  An association is not causative, but functional hypothyroidism does result in cognitive impairment, so the association would logically fit.  The results of this study do as well.
Nathan Goodyear

Cognitive dysfunction in postmenopausal breast cancer patients on aromatase inhibitors,... - 0 views

informahealthcare.com/...era.11.112

breast cancer cognitive decline dysfunction women estradiol aromatase

shared by Nathan Goodyear on 10 Mar 14 - No Cached
  • Nathan Goodyear on 10 Mar 14
     
    Just the abstract here.  Declining estradiol production found to be associated with increased cognitive dysfunction or cognitive decline in those using aromatase inhibitor therapy.  Aromatase inhibition therapy is used to block Testosterone to Estradiol production in women with ER+ breast cancer.
Nathan Goodyear

Increased risk of cognitive impairment or dementia in women who underwent oophorectomy ... - 0 views

www.neurology.org/...1074

dementia cognitive decline menopause Estrogen women HRT HT BHRT hormone hormones

shared by Nathan Goodyear on 06 Aug 13 - No Cached
  • Nathan Goodyear on 06 Aug 13
     
    Untold risk of early ovary removal appears to be cognitive decline and increased risk of dementia.  The earlier the age of removal, the more the increased risk of cognitive decline.  
Nathan Goodyear

Hormonal changes and their impact on cognition and... [Maturitas. 2014] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...24953176

cognition brain low T Testosterone low t men male hormone hormones

shared by Nathan Goodyear on 24 Jun 14 - No Cached
  • Nathan Goodyear on 24 Jun 14
     
    low T appears to be associated with cognitive decline in men.  If low T is present on testing, then therapy is appropriate to improve cognition.
Nathan Goodyear

Stuck at the bench: Potential natural neuroprotective compounds for concussion - 0 views

www.ncbi.nlm.nih.gov/...PMC3205506

concussions concussion natural therapies brain curcumin omega 3 resveratrol green tea EGCG EPA DHA vitamin E vitamin c vitamin D

shared by Nathan Goodyear on 20 Feb 16 - No Cached
  • Long-chain polyunsaturated fatty acids, including eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), are highly enriched in neuronal synaptosomal plasma membranes and vesicles
  • The predominant CNS polyunsaturated fatty acid is DHA
  • effective supplementation and/or increased ingestion of dietary sources rich in EPA and DHA, such as cold-water fish species and fish oil, may help improve a multitude of neuronal functions, including long-term potentiation and cognition.
  • ...45 more annotations...
  • multiple preclinical studies have suggested that DHA and/or EPA supplementation may have potential benefit through a multitude of diverse, but complementary mechanisms
  • pre-injury dietary supplementation with fish oil effectively reduces post-traumatic elevations in protein oxidation
  • The benefits of pre-traumatic DHA supplementation have not only been independently confirmed,[150] but DHA supplementation has been shown to significantly reduce the number of swollen, disconnected and injured axons when administered following traumatic brain injury.
  • DHA has provided neuroprotection in experimental models of both focal and diffuse traumatic brain injury
  • potential mechanisms of neuroprotection, in addition to DHA and EPA's well-established anti-oxidant and anti-inflammatory properties
  • Despite abundant laboratory evidence supporting its neuroprotective effects in experimental models, the role of dietary DHA and/or EPA supplementation in human neurological diseases remains uncertain
  • Several population-based, observational studies have suggested that increased dietary fish and/or omega-3 polyunsaturated fatty acid consumption may reduce risk for ischemic stroke in several populations
  • Randomized control trials have also demonstrated significant reductions in ischemic stroke recurrence,[217] relative risk for ischemic stroke,[2] and reduced incidence of both symptomatic vasospasm and mortality following subarachnoid hemorrhage
  • Clinical trials in Alzheimer's disease have also been largely ineffective
  • The clinical evidence thus far appears equivocal
  • curcumin has gained much attention from Western researchers for its potential therapeutic benefits in large part due to its potent anti-oxidant[128,194,236] and anti-inflammatory properties
  • Curcumin is highly lipophilic and crosses the blood-brain barrier enabling it to exert a multitude of different established neuroprotective effects
  • in the context of TBI, a series of preclinical studies have suggested that pre-traumatic and post-traumatic curcumin supplementation may bolster the brain's resilience to injury and serve as a valuable therapeutic option
  • Curcumin may confer significant neuroprotection because of its ability to act on multiple deleterious post-traumatic, molecular cascades
  • studies demonstrated that both pre- and post-traumatic curcumin administration resulted in a significant reduction of neuroinflammation via inhibition of the pro-inflammatory molecules interleukin 1β and nuclear factor kappa B (NFκB)
  • no human studies have been conducted with respect to the effects of curcumin administration on the treatment of TBI, subarachnoid or intracranial hemorrhage, epilepsy or stroke
  • studies have demonstrated that resveratrol treatment reduces brain edema and lesion volume, as well as improves neurobehavioral functional performance following TBI
  • green tea consumption or supplementation with its derivatives may bolster cognitive function acutely and may slow cognitive decline
  • At least one population based study, though, did demonstrate that increased green tea consumption was associated with a reduced risk for Parkinson's disease independent of total caffeine intake
  • a randomized, placebo-controlled trial demonstrated that administration of green tea extract and L-theanine, over 16 weeks of treatment, improved indices of memory and brain theta wave activity on electroencephalography, suggesting greater cognitive alertness
  • Other animal studies have also demonstrated that theanine, another important component of green tea extract, exerts a multitude of neuroprotective benefits in experimental models of ischemic stroke,[63,97] Alzheimer's disease,[109] and Parkinson's disease
  • Theanine, like EGCG, contains multiple mechanisms of neuroprotective action including protection from excitotoxic injury[97] and inhibition of inflammation
  • potent anti-oxidant EGCG which is capable of crossing the blood-nerve and blood-brain barrier,
  • Epigallocatechin-3-gallate also displays neuroprotective properties
  • More recent research has suggested that vitamin D supplementation and the prevention of vitamin D deficiency may serve valuable roles in the treatment of TBI and may represents an important and necessary neuroprotective adjuvant for post-TBI progesterone therapy
  • Progesterone is one of the few agents to demonstrate significant reductions in mortality following TBI in human patients in preliminary trials
  • in vitro and in vivo studies have suggested that vitamin D supplementation with progesterone administration may significantly enhance neuroprotection
  • Vitamin D deficiency may increase inflammatory damage and behavioral impairment following experimental injury and attenuate the protective effects of post-traumatic progesterone treatment.[37]
  • emerging evidence has suggested that daily intravenous administration of vitamin E following TBI significantly decreases mortality and improves patient outcomes
  • high dose vitamin C administration following injury stabilized or reduced peri-lesional edema and infarction in the majority of patients receiving post-injury treatment
  • it has been speculated that combined vitamin C and E therapy may potentiate CNS anti-oxidation and act synergistically with regards to neuroprotection
  • one prospective human study has found that combined intake of vitamin C and E displays significant treatment interaction and reduces the risk of stroke
  • Pycnogenol has demonstrated the ability to slow or reduce the pathological processes associated with Alzheimer's disease
  • Pcynogenol administration, in a clinical study of elderly patients, led to improved cognition and reductions in markers of lipid peroxidase
  • One other point of consideration is that in neurodegenerative disease states like Alzheimer's disease and Parkinson's disease, where there are high levels of reactive oxygen species generation, vitamin E can tend to become oxidized itself. For maximal effectiveness and to maintain its anti-oxidant capacity, vitamin E must be given in conjunction with other anti-oxidants like vitamin C or flavonoids
  • These various factors might account for the null effects of alpha-tocopherol supplementation in patients with MCI and Alzheimer's disease
  • preliminary results obtained in a pediatric population have suggested that post-traumatic oral creatine administration (0.4 g/kg) given within four hours of traumatic brain injury and then daily thereafter, may improve both acute and long-term outcomes
  • Acutely, post-traumatic creatine administration seemed to reduce duration of post-traumatic amnesia, length of time spent in the intensive care unit, and duration of intubation
  • At three and six months post-injury, subjects in the creatine treatment group demonstrated improvement on indices of self care, communication abilities, locomotion, sociability, personality or behavior and cognitive function when compared to untreated controls
  • patients in the creatine-treatment group were less likely to experience headaches, dizziness and fatigue over six months of follow-up
  • CNS creatine is derived from both its local biosynthesis from the essential amino acids methionine, glycine and arginine
  • Studies of patients with CNS creatine deficiency and/or murine models with genetic ablation of creatine kinase have consistently demonstrated significant neurological impairment in the absence of proper creatine, phosphocreatine, or creatine kinase function; thus highlighting its functional importance
  • chronic dosing may partially reverse neurological impairments in human CNS creatine deficiency syndromes
  • Several studies have suggested that creatine supplementation may also reduce oxidative DNA damage and brain glutamate levels in Huntington disease patients
  • Another study highlighted that creatine supplementation marginally improved indices of mood and reduced the need for increased dopaminergic therapy in patients with Parkinson's disease
  • Nathan Goodyear on 20 Feb 16
     
    great review of natural therapies in the treatment of concussions
Nathan Goodyear

Mediterranean Diet, Cognitive Function, and Dementia: A Systematic Review of the Evidence - 0 views

advances.nutrition.org/...889.abstract

mediterranean diet nutrition brain health cognition dementia diet

shared by Nathan Goodyear on 21 May 17 - No Cached
  • Nathan Goodyear on 21 May 17
     
    review finds Mediterranean diet associated with improved cognitive function and possible delay in cognitive decline.
fitspresso

https://www.sightcare-co.com/ - 0 views

www.sightcare-co.com

sight care sightcare group training nearsightedness food for eyesight carey codd vitasight vision how to cure bad eye tips fix improve your red light eyes diet improvement skincare malaysia costos de medicare indonesia singapore eyecare

shared by fitspresso on 27 Sep 23 - No Cached
  • fitspresso on 27 Sep 23
     
    Sight Care | Official Site sightcare-co.com · by Sight Care Sight Care Only $49/Bottle Limited Time Offer! Sight Care Special Deal + Special 67% Discount Save $600 + 180 Days Money Back Guarantee #1.The Sight Care vision supplement is a dietary supplement for helping you improve your vision and brain health. Sight Care eye supplements are formulated to provide a synergistic blend of vitamins, minerals, antioxidants, and other bioactive compounds that are essential for maintaining healthy vision Regular Price: 147/per bottle Only for: $49/per bottle What Is Sight Care? This powerful vision support supplement is made with a unique blend of natural ingredients and plant extracts that work together synergistically to deliver numerous benefits for your brain and eye health. With Sight Care, you can expect to experience increased energy levels, improved eyesight, and an overall revitalized sense of well-being. Taking care of your vision health is not just about seeing clearly; it's also about maintaining your overall brain health. As we age, our vision deteriorates, and our eyes and brain can experience a decline in function, but there are steps you can take to support your visual and cognitive health. Regular eye exams are crucial for detecting and treating vision problems early on, and making healthy choices such as eating a nutritious diet and exercising regularly can also help. However, with busy schedules, it can be difficult to find the time to devote to a healthy lifestyle. This is where the Sight Care supplement comes in. It's designed to support both vision and brain health with its blend of natural ingredients that have been shown to promote healthy vision and cognitive function You must not compromise your eye health for momentary exhilaration. If you are glued to digital screens day and night, you must take measures to prevent eye diseases like age-related macular degeneration. The SightCare vision supplement has been made using 100% natura
Nathan Goodyear

Association Between Serum 25(OH) Vitamin D and the Risk of Cognitive Decline in Older W... - 0 views

biomedgerontology.oxfordjournals.org/...1092.abstract

vitamin D cognitive decline cognitive decline memory women vitamin

shared by Nathan Goodyear on 12 Feb 13 - No Cached
  • Nathan Goodyear on 12 Feb 13
     
    Just an association, but low vitamin  D levels found to be associated with decreased cognitive function in older women.  Found in women with levels < 20.
Nathan Goodyear

Huperzine A for Alzheimer's disease. [Cochrane Database Syst Rev. 2008] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...18425924

alzheimer disease Alzheimer's disease Alzheimer's Huperzine-A memory cognition

shared by Nathan Goodyear on 03 Oct 12 - No Cached
  • Nathan Goodyear on 03 Oct 12
     
    Review of 6 trials on 454 patients found Huperzine A improved cognition and executive function with no serious adverse events in patients with Alzheimer's disease.  Yet, their conclusion is, "...inadequate evidence to make any recommendation..."   Does it improve executive cognitive function?   Yes.  Does in have serious side effects?  No.  And we are waiting on...?
Nathan Goodyear

A prospective study of diurnal cortisol and cognitive function in community-dwelling el... - 0 views

www.ncbi.nlm.nih.gov/...PMC2894868

cognitive decline cognition saliva salivary cortisol urinary elderly stress hormone hormones

shared by Nathan Goodyear on 20 Feb 12 - No Cached
  • Nathan Goodyear on 20 Feb 12
     
    High salivary cortisol and decrease metabolism of cortisol (urinary) is associated with increased cognitive decline in the elderly.
Nathan Goodyear

JAMA Network | Archives of Neurology | Insulin Resistance in Cognitive ImpairmentThe In... - 0 views

archneur.jamanetwork.com/article.aspx

IR insulin resistance brain neurodegenerative disorders Alzheimer's disease obesity neurology dementia

shared by Nathan Goodyear on 11 Jun 12 - No Cached
  • Nathan Goodyear on 11 Jun 12
     
    insulin resistance shown to play a role in cognitive impairment.  Rising Insulin resistance is not just associated with obesity, but also brain dysfunction similar to that in strokes.  This indicates a vascular component in the cognitive function.  The same rise in obesity will likely result in a rise in neurodegenerative disorders.
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