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Nathan Goodyear

Obesity - Inducible Toll-like Receptor and NF-[kappa]B Regulatory Pathway Expression in... - 0 views

  • TLRs are functionally inducible and associated with downstream NF-B activation and proinflammatory cytokine production.
  • TLRs represent a family of receptors that are critical to the innate immune response against foreign pathogens and microorganisms
  • LPS has been shown to induce proinflammatory chemokine gene expression in differentiated human adipocytes through TLR and NF-B action
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  • Stimulation of TLRs initiates intracellular signaling cascades resulting in downstream NF-B and mitogen-activated protein kinase activation and production of proinflammatory chemokines associated with mechanisms of metabolic dysfunction and cardiovascular disease progression.
  • Elevated fatty acids levels associated with obesity activate TLR4 signaling in fat cells and macrophages, and induce insulin resistance in murine models
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    TLR, especially TLR-4, is directly involved in NF-KappaB activation and release of inflammatory cytokines
Nathan Goodyear

Pregnancy-Specific Down-Regulation of NF-κB Expression in T Cells in Humans I... - 0 views

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    this article discusses how progesterone protects the developing pregnancy.  Progesterone down regulates NF-kappaB and thus downregulates Th1 activity.
Nathan Goodyear

Alpha-lipoic acid inhibits TNF-alpha-induced NF-kapp... [FASEB J. 2001] - PubMed - NCBI - 0 views

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    alpha lipoic acid inhibits NF-kappa B activation by inhibiting TNF-alpha
Nathan Goodyear

Peroxisome proliferator-activated receptors in inflammation control - 0 views

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    PPARs are key regulators in inflammation control. PPARs are nuclear transcription factors that decrease NF-KappaB transcription.
Nathan Goodyear

New roles for estrogens in rheumatoid arthritis. - PubMed - NCBI - 0 views

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    Estradiol appears to be pro-inflammatory in the synovial fluids of men/women with RA.  This appears to be mediated through NF-KappaB.
Nathan Goodyear

Inhibitory Effect of Progesterone on Inflammatory Factors after Experimental Traumatic ... - 0 views

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    Now, this is in a rat TBI model; but progesterone was shown to reduce the inflammatory response post TBI. Particularily, through NF-kappa B inhibition.
Nathan Goodyear

Progesterone treatment inhibits the inflammatory a... [Brain Res. 2005] - PubMed - NCBI - 0 views

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    progesterone shown to decrease NF-KappaB and other inflammatory signaling after TBI in rat model. Part of the role of progesterone is as an anti-inflammatory.
Nathan Goodyear

IKK-[beta] links inflammation to obesity-induced insulin resistance - Nature Medicine - 0 views

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    inflammation plays critical role in insulin resistance and the associated inflammatory conditions.  IKK-Beta and NF-KappaB are heavily involved in local and systemic inflammatory signaling.
Nathan Goodyear

Dietary vitamin D deficiency in rats from middle to old age leads to elevated tyrosine ... - 0 views

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    Low dietary vitamin D intake associated with increased oxidative stress, NF-KappaB transcription and damage to brain in animal model.
Nathan Goodyear

Google Image Result for http://web.rcai.riken.jp/en/labo/signaling/images/R3_3116065229... - 0 views

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    Great diagram of how the innate and acquired arms of the immune system stimulate NF-kappaB and result in inflammation
Nathan Goodyear

Toll-like receptor 4 as a predictor of clinical outcomes of estrogen receptor-negative ... - 0 views

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    TLR4 promotes tumor progression, aggression, and resistance in ER-
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