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Nathan Goodyear

Persistent epigenetic differences associated with prenatal exposure to famine in humans - 0 views

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    Epigenetic as a result of famine exposure prenatally.
Nathan Goodyear

Epigenetics: A New Bridge between Nutrition and Health - 0 views

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    7 year old study, though very much still relevant.  Nutrition effects epigenetics.
Nathan Goodyear

Chronic exposure to Low dose bacterial lipopolysaccharide inhibits leptin signaling in ... - 0 views

  • Obesity and models of obesity induced by ingestion of HF-diet in rodents are associated with chronically elevated circulating levels of LPS
  • chronic low-dose administration of LPS induces leptin-resistance in vagal afferent neurons and abolition of CCK-induced inhibition of food intake
  • HF fat feeding has been shown to enhance gastrointestinal permeability promoting the translocation of LPS to the circulation
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  • LPS leads to an increase in SOCS3 expression []. SOCS3 is a negative regulator of leptin signaling
  • We observed a significant increase in energy intake in the LPS-treated rats
  • the data provides a mechanism linking changes in gut microbiota induced by ingestion of HF diets to dysregulation of food intake and body weight
  • SOCS3 is an important mechanism by which leptin resistance develops in vagal afferent neurons and coincides with the onset of hyperphagia
  • Chronic low-dose LPS treatment induced TLR4 activation and MyD88 signaling in vagal afferent neurons, associated with increased SOCS3 expression and reduced leptin-signaling, characterized by the absence of leptin-induced pSTAT3.
  • We demonstrate that this chronic low dose LPS is sufficient to induce leptin–resistance in vagal afferent neurons, reduced sensitivity to the satiating effects of CCK, and loss of vagal afferent plasticity
  • it suggests that the increase in food intake and body weight we observed at week 6 in the LPS treated rats may be caused by LPS-induced leptin resistance.
  • chronic LPS treatment of mice for four weeks increased body weight
  • chronic LPS treatment of mice for four weeks increased subcutaneous fat
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    Very interesting study.  High fat diet in rats induced gut flora change that resulted in LPS which induced appetite through leptin resistance and reduced cholecystokinin signaling.
Nathan Goodyear

Effects of short-term high-fat overfeeding on genome-wide DNA methylation in the skelet... - 0 views

  • short-term HFO introduces DNA methylation changes on a genome-wide scale in human skeletal muscle
  • These changes were only partly reversed after 6–8 weeks
  • The induction of DNA methylation changes after 5 days of HFO supports the growing awareness of DNA methylation as a dynamic signal that is possibly relevant to short-term day-to-day metabolic adaptations, including acute exercise
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  • Diverging DNA methylation levels between elderly, but not young, genetically identical twins indicate that environmental exposures throughout life may permanently influence DNA methylation, suggesting some preservation of de novo DNA methylation in adults
  • our finding of a slow reversibility rate indicates the demethylation process may be somewhat impeded compared with the induction of methylation changes by diet, which could have implications for the preservation or build-up of CpG methylation over time
  • A slow reversibility of DNA methylation induced by carcinogenic agents has likewise been observed due to ingestion of high-fat diets in rodents
  • the relationship between DNA methylation and gene expression is not always straightforward
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    Study finds variability of methylation and some genetic expression alteration with high fat diet.  Restated, what you eat interacts with your DNA to alter genetic expression.  This has implications on initiation of therapy as well as response to therapy.
Nathan Goodyear

Ferritin Level Is Positively Associated with Chronic Kidney Disease in Korean Men, Base... - 0 views

  • The overloading of body iron plays a role as an oxidative stressor
  • active radicals can affect lipids, proteins, and deoxyribonucleic acid (DNA), resulting in tissue injury and dysfunction
  • Excess iron causes oxidative stress and induces inflammation, leading to renal disease progression
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  • Serum ferritin levels correlate with total body iron storage and systemic inflammation
  • The level of serum ferritin, an acute phase protein, is increased in an inflammatory environment
  • Previous studies have reported that elevated serum ferritin levels are associated with insulin resistance syndrome, hypertension, dyslipidemia, obesity, and metabolic syndrome as risk factors of CKD
  • elevated serum ferritin levels in hemodialysis patients predict higher mortality
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    great review and study: finds that elevated ferritin levels (> 200 ng/ml in men) was associated with increased chronic kidney disease in Korean study.
Nathan Goodyear

Epigenetic changes in blood leukocytes following an omega-3 fatty acid supplementation - 0 views

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    Epigenetic and really nutrigenomics: 6 week study of 3 gram omega 3 intake induced methylation changes.  Get that?  Only 6 weeks of omega 3 intake induces a change in genetic expression.
Nathan Goodyear

Omega-3 Fatty Acids and Inflammatory Processes - 0 views

  • marine n-3 PUFAs have also been shown to alter the production of inflammatory proteins including chemokines, cytokines, growth factors and matrix proteases
  • Two transcription factors that are likely to play a role in inflammation are nuclear factor κ B (NFκB) and PPAR-γ
  • NFκB is the principal transcription factor involved in upregulation of inflammatory cytokine, adhesion molecule and cyclooxygenase-2 genes
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  • PPAR-γ, is believed to act in an anti-inflammatory manner
  • PPAR-γ directly regulates inflammatory gene expression, it also interferes with the activation of NFκB creating an intriguing interaction between these two transcription factors
  • Both NFκB and PPAR-γ may be regulated by n-3 PUFAs.
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    great review of the anti-inflammatory effects of omega 3 DHA and EPA.  EPA inhibits COX and 5-LOX and their downstream prostaglandin and leukotrienes.  EPA/DHA inhibited endotoxin-stimulated IL-6, IL-8,TNF-alpha, and NFkappaB.
Nathan Goodyear

Fish Intake, Contaminants, and Human Health | Nutrition | JAMA | The JAMA Network - 0 views

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    Study finds that higher omega 3 intake over time associated with a reduction in blood clots, heart arrhythmias, lower triglycerides, lower heart rates and lower blood pressure.
Nathan Goodyear

Dietary selenium's protective effects against methylmercury toxicity. - PubMed - NCBI - 0 views

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    Selenium versus methyl mercury content of fish renders the argument of mercury content of fish as a concern, but in a few fish.
Nathan Goodyear

Making the Right Fish Choices: Fatty Acid Contents of 33 Different Fish Species. Plus: ... - 0 views

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    I don't normally post blog posts, however, this post has merits for the purpose of figure 1 and figure 2.   Figure 1 highlights the different omega 3:omega 6 of different fish and figure 2 highlights the different omega3;6 in wild versus farm raised fish.
Nathan Goodyear

Survey of n-3 and n-6 polyunsaturated fatty acids in fish and fish products - 0 views

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    Good read on the omega 3 versus omega 6 content of different fish.
Nathan Goodyear

A Ketogenic Diet Extends Longevity and Healthspan in Adult Mice: Cell Metabolism - 0 views

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    study of mice finds that high fat diet changes genetic expression, epigenetics, to increase lifespan of mice by 13%.
Nathan Goodyear

Reduction in the Incidence of Type 2 Diabetes With the Mediterranean Diet - 0 views

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    Mediterranean diet + EVOO or + nuts reduced diabetes risk those in high risk by 52%.  This was a 4 year f/u study.  A reduction of circulating inflammatory biomarkers was also noted.  Insulin resistance was noted to be improved as early as 3 months, but weight was not changed statistically throughout this study
Nathan Goodyear

Mediterranean diet supplemented with nuts reduces waist circumference and shifts lipopr... - 0 views

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    Mediterranean diet with added mixed nuts reduced atherogenic lipoprotein profile: decreased LDL particle number, increased LDL particle size...Even reduced waist circumference.
Nathan Goodyear

Western Diet-Induced Dysbiosis in Farnesoid X Receptor Knockout Mice Causes Persistent ... - 0 views

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    Western diet (high trans fats and sugar) linked to altered gut flora and resultant liver inflammation.  It would have been nice to have followed inflammatory biomarkers i.e. LPS.  This sounds just like metabolic syndrome.
Nathan Goodyear

Immunonutrition in Surgical Patients: Ingenta Connect - 0 views

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    Malnutrition is associated with increased surgical risk and poor outcomes. The authors support IV preoperative nutrition at least 10 days prior to surgery and for 7 days post surgery.  This therapy reduced inflammation and oxidative stress.
Nathan Goodyear

A guide to perioperative nutrition - ScienceDirect - 0 views

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    Nutritional supplementation pre/post operative will reduce bruising, swelling, inflammation, promote wound healing, augment immune system, reduce surgical induced oxidation.
Nathan Goodyear

Preoperative parenteral nutrition of malnourished surgical patients. - PubMed - NCBI - 0 views

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    malnutrition is associated with increased surgical complication and mortality risk; IV decreased complications and mortality
Nathan Goodyear

Understanding the Role of Nutrition and Wound HealingNutrition in Clinical Practice - J... - 0 views

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    Malnutrition linked to poor wound healing, decreased wound tensile strength, and increased infection rates.
Nathan Goodyear

Malnutrition and Clinical Outcomes: The Case for Medical Nutrition Therapy - ScienceDirect - 0 views

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    40-55% of adults hospitalized found to be malnourished or at risk for malnutrition with a whopping 12% severely malnourished.
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