Group items tagged

T3 in the post MI individual decreases the MI infarct size and the progression to heart failure. What is really  interesting about this study is that the T3 induced mitochondrial biogenesis and activity which is a great thing in recovery of MI and also in disease i.e. cancer.  However, it appears to increase HIF-1alpha and angiogenesis which is stimulated by retrograde signaling.  There is a muddied picture here.  Because T3 stimulates oxidative phosphorylation and mitochondria biogenesis which is favorable for health.  However, in this study of rats, it induced HIF-1alpha and angiogenesis in post MI, which is favorable to recovery, yet this is unfavorable for cancer.    Yet oxidative phosphorylation is favorable to cancer prevention/elimination and MI recovery.

Testosterone therapy in men with low T found to reduce all cause mortality, stroke and MI.

Testosterone therapy in older men found to provide no increase in MI risk.  In fact, those men with high MI risk, Testosterone provided protection against MI.

Testosterone therapy in men with low T to restore physiologic Testosterone levels found to reduce mortality, MI, and stroke risk.

Wow, thyroid hormones play a significant role in cardiac remodeling post MI.  Thyroid hormones, "promotes tissue growth and differentiation and favorably remodels cardiac cell while increases cellular survival..."  How many people post-MI are having their thyroid evaluated, let alone correctly evaluated?

Great review of the current understanding of thyroid hormone metabolism in cardiac tissue.  Low T3 and increased rT3 (via increased D3 activity) is CLEARLY associated with poor cardiac performance and post MI and CHF is associated with poor outcomes.  T3 is critical in cardiac remodeling and recovery post MI.  T3 is actually a vasodilatory in the coronary arteries.   Why a endocrinologist would call rT3 useless only points to their ignorance of the literature.

Estradiol shown to increase EPC activity post MI in female MI rat model

This study appears to fly in the face of the recent studies on the dangers of Testosterone therapy in those with comorbidities.  This study was a retrospective cohort.  The study found that men in the highest risk for MI, had a reduced MI risk with Testosterone therapy.  Men in the lower risk quartiles had no such benefit.  Of note, the frequency of injections suggests inadequate dosing i.e. 4.4 in first year and 8.2 in follow up.  Most injection regimens will require at least monthly injections, though Testosterone pellets were used.  Of special note, no mention of level testing of Testosterone prior to study and/or during study and follow up.

Low T3 post MI is associated with increased CHF, morbidity and mortality.  Article discusses thyroid hormones and cardiac function/remodeling post infarct.  The article also lays the ground work for a new study of T3 in patients post MI to be followed for 6 months.

homocysteine associated with MI risk

New cohort study finds increased risk of Testosterone in men > 65 and those : these are based in marketing-based medicine not evidence based medicine.

Mi enfermedad renal se ha mantenido en la etapa 2 durante 8 años,pero la ultima prueba de sangre maestra mi sangre nitrogeno de urea es de 42 mg / dl y el nivel de creatinina en suero es de 4,2 mg / dl.

Mi enfermedad renal se ha mantenido en la etapa 2 durante 8 años,pero la ultima prueba de sangre maestra mi sangre nitrogeno de urea es de 42 mg / dl y el nivel de creatinina en suero es de 4,2 mg / dl.

Mi nivel de creatinina baja desde 8.6 a 5.4 después de la diálisis, significa eso mi enfermedad va bien? Diálisis como uno de los tratamiento común de insuficiencia renal, puede disminuir el alto nivel de creatinina mediante la descarga de las toxinas adicionales de la sangre.

Soy un paciente de insuficiencia renal ,y recientemente mi GFR baja en 8 rápidamente ,mi nivel de creatinina aumenta a 13.Por cierto,yo todavía tengo buena producción de orina. Soy un paciente de insuficiencia renal ,y recientemente mi GFR baja en 8 rápidamente ,mi nivel de creatinina aumenta a 13.Por cierto,yo todavía tengo buena producción de orina.

CoQ10 in those with prior MIs, found to have reduced hospital readmission, less heart failure, and lower cardiovascular death.  Enough said.

This study looked at those with previous MIs.  This study found a reduction in recurrent events in those receiving EDTA chelation versus placebo.  The authors of this study looked at the Hazard ratio, which was reduced in every end point that this study was designed to evaluate.

Vitamin D (25 OH) below 34 ng/ml associated with double risk of MI.

free T3 is critical in the heart healing post MI.  Hypothyroidism and CHF share many hemodynamic and cardiovascular similarities.

NORVIT trial showed that vitamin B12, B6, and folic acid reduced homocysteine levels by 27%, however it did not lower MI, stroke,or mortality rate.  ONe variable to consider is the polypharmacy of the study group ie.  they were taking statins, beta blockers, diuretics, coumadin... so was the lack of change in mortality the result of polypharmacy?  And was the polypharmacy blocking the increased CVD risks associated with elevated homocysteine that would have been treatable with vitamin B12, B6, and folic acid.

High Estradiol is reproducible finding in men with Diabetes.  Link to MI not able to be determined.