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Nathan Goodyear

Deficient Glutathione in the Pathophysiology of Mycotoxin-Related Illness - 0 views

  • Decreased function of the enzymes of glutathione production results in a microenvironment depleted of glutathione on a chronic basis
  • In humans, deficiency of glutathione can lead to chronic conditions [97], including chronic asthma
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    Mycotoxins deplete glutathione production and this depletion of glutathione is a portion go the toxicity/ill effects related to mycotoxins.  This article also points to evidence that glutathione can actually be employed in the treatment of mycotoxin related conditions/illnesses.
Nathan Goodyear

Glutathione supplementation improves macrophage functions in HIV. - PubMed - NCBI - 0 views

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    reduced glutathione, via increased oxidative stress, levels lost in HIV.  NAC and liposomal Glutathione increased innate immune function--macrophages.
Nathan Goodyear

The critical role of glutathione in maintenance of the mitochondrial genome. - Research... - 0 views

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    Only abstract available.  Loss of glutathione leads to loss in mitochondrial DNA.
Nathan Goodyear

Unveiling the Mechanisms for Decreased Glutathione in Individuals with HIV Infection - 0 views

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    men with HIV have GSH depleted macrophages.  GSH is the reduced, ready to act form of Glutathione.  In contrast, the macrophages were high in the oxidized form of Glutathione--GSSG.  In HIV, the high inflammation increased oxidative stress, likely overwhelmed Nrf2 activation and resulted in decreased GSH synthase transcription and thus decreased Glutathione production balance.
Nathan Goodyear

The critical role of glutathione in maintenance of the mitochondria... - PubMed - NCBI - 0 views

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    Abstract only available in this link--loss of glutathione results in decreased mitochondria.  This has significant disease implications.
Nathan Goodyear

http://www.iasj.net/iasj?func=fulltext&aId=1538 - 0 views

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    serum and salivary oxidative stress biomarkers used to follow children with autism in Iraq.
Nathan Goodyear

Internet Scientific Publications - 0 views

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    Study of Iraqi population at elevated risk of stroke found that both serum and salivary levels of malondialdehyde, glutathione, superoxide dismutase, and uric acid proved useful as potential biomarkers of risk assessment.
Nathan Goodyear

Lead-induced dysregulation of superoxide dismuta... [Environ Res. 2005] - PubMed - NCBI - 0 views

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    Pb induces dysfunction of SOD, CAT, and GPX.
Nathan Goodyear

Low mercury concentrations cause oxidative stress and endothelial dysfunction in conduc... - 0 views

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    Hg induces vascular ROS through depletion of glutathione.  This study found that low dose, chronic Hg exposure induced ROS that resulted in vascular dysfunction i.e. hypertension.
Nathan Goodyear

Peripheral oxidative stress in relapsing-remitting multiple sclerosis - 0 views

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    Relapsing remitting MS patients found to have in increased 8OHdG, reduced glutathione, reduced glutathione to oxidized glutathione ratio, super oxidized disumutase, glutathione reductase, and global oxidative stress.  In contrast, decreased total antioxidant capacity, oxidized glutathione, glutathione perioxidase, and glutathione transferase were found in relapsing remitting MS patients.
Nathan Goodyear

MR spectroscopic imaging of glutathione in the white and gray matter at 7 T with an app... - 0 views

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    Interesting study on glutathione.  The study looked at glutathione levels in the brain using MR.  The authors found lower glutathione levels in the Grey matter versus normal controls and lower glutathione levels in white matter lesions.
Nathan Goodyear

ERYTHROCYTE GLUTATHIONE PEROXIDASE DEFICIENCY IN MULTIPLE SCLEROSIS - Shukla - 2009 - A... - 0 views

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    Reduced glutathione peroxidase in the erythrocytes of MS patients.
Nathan Goodyear

A Randomized Controlled Pilot Trial of Oral N-Acetylcysteine in Children with Autism - 0 views

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    900 mg of NAC over short 4 week course provided significant improvement in behavior of children with autism.  No pre treatment evaluation was performed.  One wonders if therapeutic therapy was actually undertaken if the results would have been better.  NAC is a precursor to Glutathione production and detoxification compromise is common place in autism.
Nathan Goodyear

Effect of Increasing Glutathione With Cysteine and Glycine Supplementation on Mitochond... - 0 views

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    Supporting glutathione levels with the precursors cysteine and glycine improved insulin receptor function, body fat, and muscle strength in HIV individuals.
Nathan Goodyear

Aluminum induced immunoexcitotoxicity in neurodevelopmental and neurodegenerative disor... - 0 views

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    Great review of the scientific evidence of Aluminum in microglial activation and immunoexcitotoxicity and neurodegeneration of the brain.
Nathan Goodyear

Biomarkers of Adverse Response to Mercury: Histopathology versus Thioredoxin Reductase ... - 0 views

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    Mercury and changes in detoxification biomarkers.
Nathan Goodyear

World J Gastroenterol - 0 views

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    IV antioxidant mixture of vitamin C, glutathione, glycyrrhiza, and B-complex reduces liver enzymes.  Arm taking only oral shows no decline in liver enzymes.
Nathan Goodyear

Effect of glutathione on the cadmium chelation of EDTA in a patient with cadmium intoxi... - 0 views

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    EDTA and glutathione for chelation of Cadmium
Nathan Goodyear

Roundup Disrupted Male Reproductive Func... [Free Radic Biol Med. 2013] - PubMed - NCBI - 0 views

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    Glyphosate, component of Roundup is well known to be an endocrine disruptor.  This rat study describes the mechanism  of disruption of the Sertoli cells resulting in male infertility.  In addition to the disruption of spermatogenesis, Glyphosate was shown to deplete glutathione levels compromising detoxification.  If that is not enough, oxidative damage marker TBARS was elevated.  
Nathan Goodyear

Potentiation of Melphalan Cytotoxicity in Human Ovarian Cancer Cell Lines by Glutathion... - 0 views

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    glutathione levels inversely associated with drug resistance in the treatment of ovarian cancer.
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