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Nathan Goodyear

A Review of the Mechanism of Injury and Treatment Approaches for Illness Resulting from... - 0 views

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    great review on the science and treatment of mold and mycotoxins.
Nathan Goodyear

Role of certain trace minerals in oxidative stress, inflammation, CD4/CD8 lymphocyte ra... - 0 views

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    Asthma associated with low selenium, low zinc, high copper, low glutathione peroxidase, glutathione reductase, and catalase activity; in contrast, increased hs-CRP, and TBARS was  noted.  Interesting that FEV1 and FVC positively correlated with Se levels.
Nathan Goodyear

Glutathione Redox Regulates Airway Hyperresponsiveness and Airway Inflammation in Mice ... - 0 views

  • γ-GCE reduced levels of IL-4, IL-5, IL-10, and the chemokines eotaxin and RANTES (regulated on activation, normal T cell expressed and secreted) in bronchoalveolar lavage fluid, whereas it enhanced the production of IL-12 and IFN-γ.
  • γ-GCE suppressed eosinophils infiltration
  • γ-GCE directly inhibited chemokine-induced eosinophil chemotaxis
  • ...10 more annotations...
  • these findings suggest that changing glutathione redox balance, increase in GSH level, and the GSH/GSSG ratio by γ-GCE, ameliorate bronchial asthma by altering the Th1/Th2 imbalance through IL-12 production from APC and suppressing chemokine production and eosinophil migration itself.
  • Bronchial asthma is a typical helper T cell type 2 (Th2) disease
  • Through the release of Th2 cytokines, such as IL-4, IL-5, and IL-13, orchestrate the recruitment and activation of the primary effector cells of the allergic response: the mast cells and the eosinophils
  • Glutathione is the most abundant nonprotein sulfhydryl compound in almost all cells. This tripeptide plays a significant role in many biological processes. It also constitutes the first line of the cellular defense mechanism against oxidative injury along with SOD, ascorbate, vitamin E, and catalase, and is the major intracellular redox buffer in ubiquitous cell types
  • We have shown that glutathione redox status, namely the balance between intracellular reduced (GSH) and oxidized (GSSG) glutathione, in murine antigen-presenting cells (APC) plays a central role in determining which of the reductive and oxidative APC predominate during immune status, and the balance between reductive and oxidative APC regulates Th1/Th2 balance through production of IL-12
  • we have also shown that exposure of human alveolar macrophages to the Th1 cytokine IFN-γ or the Th2 cytokine IL-4 either increases or decreases the GSH/GSSG ratio, respectively, which regulates Th1/Th2 balance through IL-12 production
  • the ability to generate a Th1 or Th2 type response has turned out to depend not only on T cells but also on the intracellular glutathione redox status of APC
  • Th1 cytokine IFN-γ and Th2 cytokine IL-4 increases and decreases the GSH/GSSG ratio, respectively, and that this ratio influences LPS-induced IL-12 production from alveolar macrophages
  • the ability to generate a Th1 or Th2 response is dependent on glutathione redox status of APC
  • administration of γ-GCE elevates GSH level and GSH/GSSG ratio in the lung, and ameliorates AHR and eosinophilic airway inflammation by altering the Th1/Th2 balance and suppressing chemokine production and eosinophil migration in a mouse asthma model
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    glutathione redox reaction plays an important role in the ability to balance Th1 and Th2 and thus disease potential i.e. asthma as this study example.  
Nathan Goodyear

Glutathione prevents the early asthmatic reaction and airway hyperresponsiveness in gui... - 0 views

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    animal model finds that glutathione depletion increases hyperactivity of bronchioles.  Early exposure to glutathione ethyl ester, a precursor to glutathione, blunted the airway hyperactivity.
Nathan Goodyear

Nebulized Glutathione Induces Bronchoconstriction in Patients with Mild Asthma (ATS Jou... - 0 views

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    Study finds that nebulizer glutathione in mild asthma induces bronchoconstriction.  This despite the knowledge that glutathione peroxidase activity is known to be depressed in those with asthma.  The severity of the asthma of the individuals included in this study might explain the finding.
Nathan Goodyear

Testosterone regulation of homocysteine metabolism modulates redox status in human pros... - 0 views

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    in disease prostate, Testosterone down regulates transulfuration pathway and glutathione production.
Nathan Goodyear

Optimal Serum Selenium Concentrations Are Associated with Lower Depressive Symptoms and... - 0 views

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    Optimal Selenium levels associated with lower incidence of depressive moods--link to optimal glutathione pathways?  
Nathan Goodyear

Deficient Glutathione in the Pathophysiology of Mycotoxin-Related Illness - 0 views

  • Decreased function of the enzymes of glutathione production results in a microenvironment depleted of glutathione on a chronic basis
  • In humans, deficiency of glutathione can lead to chronic conditions [97], including chronic asthma
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    Mycotoxins deplete glutathione production and this depletion of glutathione is a portion go the toxicity/ill effects related to mycotoxins.  This article also points to evidence that glutathione can actually be employed in the treatment of mycotoxin related conditions/illnesses.
Nathan Goodyear

Glutathione supplementation improves macrophage functions in HIV. - PubMed - NCBI - 0 views

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    reduced glutathione, via increased oxidative stress, levels lost in HIV.  NAC and liposomal Glutathione increased innate immune function--macrophages.
Nathan Goodyear

The critical role of glutathione in maintenance of the mitochondrial genome. - Research... - 0 views

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    Only abstract available.  Loss of glutathione leads to loss in mitochondrial DNA.
Nathan Goodyear

Unveiling the Mechanisms for Decreased Glutathione in Individuals with HIV Infection - 0 views

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    men with HIV have GSH depleted macrophages.  GSH is the reduced, ready to act form of Glutathione.  In contrast, the macrophages were high in the oxidized form of Glutathione--GSSG.  In HIV, the high inflammation increased oxidative stress, likely overwhelmed Nrf2 activation and resulted in decreased GSH synthase transcription and thus decreased Glutathione production balance.
Nathan Goodyear

The critical role of glutathione in maintenance of the mitochondria... - PubMed - NCBI - 0 views

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    Abstract only available in this link--loss of glutathione results in decreased mitochondria.  This has significant disease implications.
Nathan Goodyear

http://www.iasj.net/iasj?func=fulltext&aId=1538 - 0 views

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    serum and salivary oxidative stress biomarkers used to follow children with autism in Iraq.
Nathan Goodyear

Internet Scientific Publications - 0 views

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    Study of Iraqi population at elevated risk of stroke found that both serum and salivary levels of malondialdehyde, glutathione, superoxide dismutase, and uric acid proved useful as potential biomarkers of risk assessment.
Nathan Goodyear

Lead-induced dysregulation of superoxide dismuta... [Environ Res. 2005] - PubMed - NCBI - 0 views

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    Pb induces dysfunction of SOD, CAT, and GPX.
Nathan Goodyear

Low mercury concentrations cause oxidative stress and endothelial dysfunction in conduc... - 0 views

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    Hg induces vascular ROS through depletion of glutathione.  This study found that low dose, chronic Hg exposure induced ROS that resulted in vascular dysfunction i.e. hypertension.
Nathan Goodyear

Peripheral oxidative stress in relapsing-remitting multiple sclerosis - 0 views

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    Relapsing remitting MS patients found to have in increased 8OHdG, reduced glutathione, reduced glutathione to oxidized glutathione ratio, super oxidized disumutase, glutathione reductase, and global oxidative stress.  In contrast, decreased total antioxidant capacity, oxidized glutathione, glutathione perioxidase, and glutathione transferase were found in relapsing remitting MS patients.
Nathan Goodyear

MR spectroscopic imaging of glutathione in the white and gray matter at 7 T with an app... - 0 views

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    Interesting study on glutathione.  The study looked at glutathione levels in the brain using MR.  The authors found lower glutathione levels in the Grey matter versus normal controls and lower glutathione levels in white matter lesions.
Nathan Goodyear

ERYTHROCYTE GLUTATHIONE PEROXIDASE DEFICIENCY IN MULTIPLE SCLEROSIS - Shukla - 2009 - A... - 0 views

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    Reduced glutathione peroxidase in the erythrocytes of MS patients.
Nathan Goodyear

A Randomized Controlled Pilot Trial of Oral N-Acetylcysteine in Children with Autism - 0 views

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    900 mg of NAC over short 4 week course provided significant improvement in behavior of children with autism.  No pre treatment evaluation was performed.  One wonders if therapeutic therapy was actually undertaken if the results would have been better.  NAC is a precursor to Glutathione production and detoxification compromise is common place in autism.
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