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Nathan Goodyear

Toll-like receptor signaling links dietary fatty acids to the metabolic syndrome - 0 views

www.ncbi.nlm.nih.gov/...PMC3099529

TLR toll-like receptors toll-like receptors fatty acids fat metabolic syndrome obesity overweight inflammation dietary

shared by Nathan Goodyear on 08 Oct 12 - No Cached
  • Activation of the innate immune system controls macronutrient metabolism
  • the innate immune response is the first line of defense against invading pathogens, wherein highly conserved pathogen-associated molecular patterns (PAMPs) are recognized by cognate pattern recognition receptors (PRRs
  • many studies have supported the idea that cytokine signaling directly promotes insulin resistance
  • ...10 more annotations...
  • innate immune system may be causally linked to obesity
  • adipose tissue contains a substantial population of macrophages, and macrophage-driven adipose inflammation contributes significantly to the pathogenesis of obesity
  • Collectively, activation of the innate immune system is strongly associated with ASCVD, insulin resistance, and obesity, and recent evidence suggests that much of this association can be traced to a unique family of PRRs known as TLRs
  • TLRs are a family of type I transmembrane receptors, currently thought to comprise at least 13 members in mammals, that specifically recognize a variety of microbial PAMPs and trigger host cellular responses
  • Free SFAs have indeed been demonstrated to elicit TLR4-dependent and TLR2-dependent responses in several cell types.
  • Endogenous SFAs released from adipocytes activate cocultured macrophages via TLR4 [18], indicating the potential for cellular crosstalk in adipose tissue. Collectively, there is a growing body of evidence that SFAs promote, whereas long chain PUFA antagonize, TLR4-dependent and TLR2-dependent signaling in multiple cell models
  • In an elegant study, Shi et al. [16] demonstrated that SFAs activate TLR4-dependent signaling in both macrophages and adipocytes, and mice lacking TLR4 are protected against insulin resistance driven by intravenous lipid infusion
  • In addition to effects in macrophages and adipocytes, SFAs can activate TLR4 in the hypothalamus, which triggers a central inflammatory response that results in resistance to anorexigenic signals
  • endogenous SFAs can indeed promote innate immunity and inflammatory disease
  • This finding strongly supports the work of Hwang and coworkers [19–22] demonstrating that ω-3 PUFAs can effectively counteract SFA-induced TLR4 activation in cultured macrophages and dendritic cells.
  • Nathan Goodyear on 08 Oct 12
     
    high dietary fatty acids linked to metabolic syndrome through TLR.
Nathan Goodyear

The role of melatonin in the cells of the innate immunity: a review - Calvo - 2013 - Jo... - 0 views

onlinelibrary.wiley.com/...jpi.12075

melatonin innate immunity NK-kappaB NK cells innate immune system T cells

shared by Nathan Goodyear on 17 Nov 21 - No Cached
  • Nathan Goodyear on 17 Nov 21
     
    Melatonin is a powerful stimulant to the innate immune system.
Nathan Goodyear

Lipopolysaccharide activates an innate immune system response in human adipose tissue i... - 0 views

ajpendo.physiology.org/...E740.long

LPS lipopolysaccharides diabetes type II diabetes metabolic endotoxemia inflammation innate immune system immune system obesity human

shared by Nathan Goodyear on 15 Jan 13 - No Cached
  • Nathan Goodyear on 15 Jan 13
     
    Lipopolysaccharide induces innate immune system activation resulting in type II diabetes and obesity.
Nathan Goodyear

Obesity, innate immunity and gut inflammation : Current Opinion in Gastroenterology - 0 views

journals.lww.com/...y_and_gut_inflammation.13.aspx

obesity immunity gut inflammation innate immune system

shared by Nathan Goodyear on 21 Dec 11 - No Cached
  • Nathan Goodyear on 21 Dec 11
     
    gut inflammation contributes to obesity through the innate immune pathways.
Nathan Goodyear

Innate Immune Pathway Links Obesity to Insulin Resistance - 0 views

circres.ahajournals.org/...1531.full

insulin resistance FFA obesity innate immune system TLR4 NF-kappaB inflammation cytokines inflammatory

shared by Nathan Goodyear on 21 Dec 11 - No Cached
  • Nathan Goodyear on 21 Dec 11
     
    insulin resistance leads to excess FFA, obesity and activation of the innate immune signaling.  This uses TLR4  and stimulates NF-KappaB transcription.  The result is inflammation and associated inflammatory disease conditions.
Nathan Goodyear

Dysregulated Innate Immune Responses in Young Children with Autism Spectrum Disorders: ... - 0 views

mercola.fileburst.com/...europsych%20--%20Jyonouchi.pdf

autism ASD LPS inflammation innate immune system gut gastrointestinal

shared by Nathan Goodyear on 29 Jan 12 - No Cached
  • Nathan Goodyear on 29 Jan 12
     
    Dysfunctions of the innate immune system, in the gastrointestinal system, in children with autism found. LPS found to be involved. Again, revealing a gut-brain connection in autism.
Nathan Goodyear

iNOS (NOS2) at a Glance - 0 views

jcs.biologists.org/...2865.full.pdf

LPS iNOS NOS2 inflammation innate immune system NO

shared by Nathan Goodyear on 11 Dec 12 - No Cached
  • Nathan Goodyear on 11 Dec 12
     
    good review of the role of iNOS and NO in the innate immune system and inflammatory cascade.
Nathan Goodyear

Principles of innate and adaptive immunity - Immunobiology - NCBI Bookshelf - 0 views

www.ncbi.nlm.nih.gov/...NBK27090

immune system immune system innate immunity adaptive immunity humoral innate adaptive immunity

shared by Nathan Goodyear on 15 Jan 13 - No Cached
  • Nathan Goodyear on 15 Jan 13
     
    good basic review of the immune system.
Nathan Goodyear

Scopus - Document details - 0 views

www.scopus.com/...display.url

cancer immune system NK cells NK natural killer cells innate

shared by Nathan Goodyear on 15 Jun 14 - No Cached
  • Nathan Goodyear on 15 Jun 14
     
    Stress decreases the innate immune response.  This is critical in the battle against cancer.  Specifically, low NK activity is found in stress individuals with cancer.
Nathan Goodyear

Divergence of gut permeability and mucosal immune gene expression in two glut... - 0 views

fulltextreports.com/...disease-and-gluten-sensitivity

Gluten sensitivity

shared by Nathan Goodyear on 03 May 11 - No Cached
  • GS as a condition associated with prevalent gluten-induced activation of innate, rather than adaptive, immune responses in the absence of detectable changes in mucosal barrier function.
  • Nathan Goodyear on 03 May 11
     
    Gluten sensitivity a result of the innate immunity
Nathan Goodyear

Differential pathways regulating innate and adaptive antitumor immune respons... - 0 views

www.ncbi.nlm.nih.gov/...PMC3128477

beta-glucan immune system cancer cells

shared by Nathan Goodyear on 22 May 14 - No Cached
  • Nathan Goodyear on 22 May 14
     
    beta glucans stimulate both innate and adaptive immune system to attack tumor cells.
Nathan Goodyear

Pathway Central: LDL Oxidation in Atherogenesis - 0 views

www.sabiosciences.com/pathway.php

LDL cholesterol oxidized LDL plaque inflammation CVD cardiovascular disease

shared by Nathan Goodyear on 21 May 13 - No Cached
  • Nathan Goodyear on 21 May 13
     
    Great diagram.  This diagram shows the current knowledge of how plaque is formed in arteries.  The major point here is the oxidation of LDL and the activation of the innate immune system and resultant inflammatory signaling.  In the vast majority of cases, the inflammation is driving this process, not the LDL.
Nathan Goodyear

Non-Celiac Gluten Sensitivity | Molina-Infante | OmniaScience Monographs - 0 views

www.omniascience.com/...261

non-celiac gluten sensitivity NCGS gluten

shared by Nathan Goodyear on 17 Oct 16 - No Cached
  • Nathan Goodyear on 17 Oct 16
     
    Only abstract available here.  Non-celiac gluten sensitivity review.  NCGS is an innate immune response rather than a humoral or autoimmune response.
Nathan Goodyear

Toll-Like Receptor-4 Mediates Vascular Inflammation and Insulin Resistance in Diet-Indu... - 0 views

circres.ahajournals.org/...1589.short

inflammation insulin resistance obesity FFA saturated fat TLR4 NF-kappaB IKK-Beta

shared by Nathan Goodyear on 21 Dec 11 - No Cached
  • Nathan Goodyear on 21 Dec 11
     
    high saturated fat intake (excess FFA) shown to contribute to obesity through TLR4 receptors.  TLR4 receptors are mediators in the innate immunity.   The result will be both IKK-Beta and NF-KappaB.
Nathan Goodyear

Histochemistry and Cell Biology, Volume 127, Number 2 - SpringerLink - 0 views

www.springerlink.com/...yj35n4j531j67211

TLR TLR-4 toll-like receptors inflammtion obesity LPS lipopolysaccharides

shared by Nathan Goodyear on 19 Jan 12 - No Cached
  • Nathan Goodyear on 19 Jan 12
     
    Abstract only, but this study shows that the innate immunity plays a role in the development of obesity through the TLR.  LPS was shown to stimulate the inflammatory cascade through the TLRs
Nathan Goodyear

Bacterial lipopolysaccharide both renders resistant mice susceptible to mercury-induced... - 0 views

www.ncbi.nlm.nih.gov/...PMC1809427

autism lipopolysaccharide LPS mercury Hg autoimmune disease inflammation

shared by Nathan Goodyear on 22 Jul 13 - No Cached
  • Nathan Goodyear on 22 Jul 13
     
    Lipopolysaccharide, LPS, released from gram negative bacteria exacerbates the innate immune system response to mercury.  This study found increased IgG1 and IgE levels increased in response to Hg with the presence of LPS.   This study looked at the autoimmune impact of LPS in autism.
Nathan Goodyear

Toll-like receptors in innate immunity - 0 views

intimm.oxfordjournals.org/...1.full

Toll-like receptors Toll-like receptors TLRs innate immune system immunity

shared by Nathan Goodyear on 15 Jun 14 - No Cached
  • Nathan Goodyear on 15 Jun 14
     
    Great review of Toll-like receptors.
Nathan Goodyear

Google Image Result for http://web.rcai.riken.jp/en/labo/signaling/images/R3_3116065229... - 0 views

www.google.com/imgres

NF-kapppB inflammation

shared by Nathan Goodyear on 25 Mar 11 - No Cached
  • Nathan Goodyear on 25 Mar 11
     
    Great diagram of how the innate and acquired arms of the immune system stimulate NF-kappaB and result in inflammation
Nathan Goodyear

Orally Administered Particular β-Glucan Modulates Tumor-capturing Dendritic C... - 0 views

www.ncbi.nlm.nih.gov/...PMC2970627

cancer cells beta-glucan

shared by Nathan Goodyear on 22 May 14 - No Cached
  • Nathan Goodyear on 22 May 14
     
    Beta glucans have both an innate and adaptive effect to enhance the environment in/and around tumor.  Beta glucans stimulate the immune system signaling to attack tumors.
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