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Nathan Goodyear

Preclinical Serum 25-Hydroxyvitamin D Levels and Risk of Type 1 Diabetes in a Cohort of... - 0 views

aje.oxfordjournals.org/...aje.kws243.short

vitamin D type I DM diabetes DM

shared by Nathan Goodyear on 08 Feb 13 - No Cached
  • Nathan Goodyear on 08 Feb 13
     
    Increased type I DM in white military personal with low vitamin D.  The lower the vitamin D, the higher the risk.
Nathan Goodyear

Association of vitamin D deficiency with incidence of type 2 diabetes in high-risk Asia... - 0 views

ajcn.nutrition.org/...524.abstract

vitamin D type II DM diabetes vitamin D deficiency

shared by Nathan Goodyear on 07 Mar 13 - No Cached
  • Nathan Goodyear on 07 Mar 13
     
    vitamin D deficiency associated with increased type II DM.  This was found to be associated independently from other variables.
Nathan Goodyear

Effects of progestin-only long-acting contraception on metabolic markers in obese women - 0 views

www.contraceptionjournal.org/...abstract

progestin contraception type II DM type II diabetes diabetes

shared by Nathan Goodyear on 08 Feb 13 - No Cached
  • Nathan Goodyear on 08 Feb 13
     
    Progestin is not a good synthetic progesterone anyways; but this study shows that progestin in obese women in the form of contraception, increases the risk of type II DM.
Nathan Goodyear

A blunted cortisol awakening response and hippocampal atrophy in type 2 diabetes mellitus - 0 views

www.ncbi.nlm.nih.gov/...PMC2774914

PTSD type II DM diabetes cortisol saliva salivary hormone hormones testing test evaluation hippocampus memory

shared by Nathan Goodyear on 20 Feb 12 - No Cached
  • Nathan Goodyear on 20 Feb 12
     
    Individuals with type II DM, found to have blunted morning cortisol and decreased hippocampal volume.  The hippocampus is the focus of memory.  This is similar to what is found in PTSD.
Nathan Goodyear

Access : Type 2 diabetes as an inflammatory disease : Nature Reviews Immunology - 0 views

www.nature.com/...nri2925.html

inflammation diabetes type II DM

shared by Nathan Goodyear on 20 Mar 12 - No Cached
  • Nathan Goodyear on 20 Mar 12
     
    Inflammation plays critical role in the development of type II DM
Nathan Goodyear

JCI - Chronic inflammation in fat plays a crucial role in the development of obesity-re... - 0 views

www.jci.org/19451

inflammation obesity overweight WAT adipose tissue fat insulin resistance type II diabetes DM

shared by Nathan Goodyear on 20 Mar 12 - No Cached
  • Nathan Goodyear on 20 Mar 12
     
    how inflammation contributes to obesity.  Nice discussion of the inflammatory signaling that leads to obesity.  This occurs predominately in white adipose tissue WAT.  This leads to insulin resistance and type II DM.
Nathan Goodyear

Zinc and diabetes--clinical links and molecul... [J Nutr Biochem. 2009] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...19442898

Zinc Zn diabetes DM glucose

shared by Nathan Goodyear on 31 Aug 12 - No Cached
  • Zinc supplementation of animals and humans has been shown to ameliorate glycemic control in type 1 and 2 diabetes, the two major forms of diabetes mellitus, but the underlying molecular mechanisms have only slowly been elucidated. Zinc seems to exert insulin-like effects by supporting the signal transduction of insulin and by reducing the production of cytokines, which lead to beta-cell death during the inflammatory process in the pancreas in the course of the disease
  • Nathan Goodyear on 31 Aug 12
     
    Zn show to help in glycemic control in both type I and II diabetics.  It appears to do this through inflammation reduction and thus improved insulin/Receptor signal transduction.   Also of note, antibodies against Zn transporter have been found in type I DM.
Nathan Goodyear

Involvement of gut microbiota in the developmen... [Gut Microbes. 2012] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...22572877

microbiota flora dysbiosis LPS lipopolysaccharides inflammation obesity IR insulin resistance type II DM

shared by Nathan Goodyear on 05 Sep 12 - No Cached
  • Nathan Goodyear on 05 Sep 12
     
    gut microbiota, and the imbalance of (dysbiosis) contributes to LPS and inflammation.  This results in obesity and type II DM.
Nathan Goodyear

The effect of leg hyperthermia using far in... [Acta Med Okayama. 2010] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...20424670

IR sauna DM diabetes TYpe II oxidative stress

shared by Nathan Goodyear on 14 Nov 11 - No Cached
  • Nathan Goodyear on 14 Nov 11
     
    IR sauna over short 2 week study shown to improve oxidative stress in patients with type 2 DM
Nathan Goodyear

Low Vitamin D Level is Linked to Greater Chance of Risk Factors for Type 2 Diabetes - 0 views

www.endo-society.org/...actors-for-Type-2-Diabetes.cfm

vitamin D metabolic syndrome DM type II Diabetes heart disease CVD vitamin d

shared by Nathan Goodyear on 30 Jul 12 - No Cached
  • Nathan Goodyear on 30 Jul 12
     
    low vitamin D linked to increased risk of metabolic syndrome, type II DM, and heart disease.
Nathan Goodyear

Supplementation of Vitamin C Reduces Blood Glucose and Improves Glycosylated Hemoglobin... - 0 views

www.ncbi.nlm.nih.gov/...PMC3254006

vitamin C C type II DM diabetes glucose vitamins

shared by Nathan Goodyear on 31 Jul 12 - No Cached
  • Nathan Goodyear on 31 Jul 12
     
    Oral vitamin C shown to reduce fast blood glucose, post meal blood glucose, and HgbA1C.  This study was down with metformin.  Vitamin C was used with metformin in those with type II DM.  This supports the use of vitamin C in blood sugar control.  Vitamin C does not increase blood glucose levels.
Nathan Goodyear

The worldwide epidemiology of type 2 diabetes mellitus[mdash]present and future perspec... - 0 views

www.nature.com/...nrendo.2011.183.html

type II DM diabetes epidemiology

shared by Nathan Goodyear on 02 Aug 12 - No Cached
  • Nathan Goodyear on 02 Aug 12
     
    nice article on the epidemiology of type II DM.  Included in the discussion is the point that HgbA1C is now used as the choice for diagnosis: >6.5.
Nathan Goodyear

alpha-Lipoic acid treatment decreases serum lactate and pyruvate concentrations and imp... - 0 views

care.diabetesjournals.org/...280.abstract

alpha-lipoic-acid alpha lipoic acid type II DM diabetes lactic lactate pyruvate ALA

shared by Nathan Goodyear on 02 Aug 12 - No Cached
  • Nathan Goodyear on 02 Aug 12
     
    alpha lipoic acid improves glucose control in individuals with type II DM.  This study showed decreased lactic acid and pyruvate levels with alpha lipoic acid therapy.  Therapy in this study consisted of ALA of 600 mg twice daily.
Nathan Goodyear

Oxidative Stress and Stress-Activated Signaling Pathways: A Unifying Hypothesis of Type... - 0 views

edrv.endojournals.org/...599.long

free radicals oxidative stress damage inflammation type II DM alpha lipoic acid alpha-lipoic-acid diabetes

shared by Nathan Goodyear on 02 Aug 12 - No Cached
  • In patients with diabetes, LA levels are reduced (48, 74, 103). LA has long been used for the treatment of diabetic neuropathy in Germany
  • evidence indicates that it increases insulin sensitivity in patients with type 2 diabetes
  • LA has been shown to 1) quench free radicals, 2) prevent singlet oxygen-induced DNA damage, 3) exhibit chelating activity, 4) reduce lipid peroxidation, 5) increase intracellular glutathione levels, and 6) prevent glycation of serum albumin (73, 74). LA is able to reduce oxidative stress-mediated NF-κB activation in vitro (74, 108, 109) and in patients with type 2 diabetes
  • ...2 more annotations...
  • Activation of NF-κB can also be blocked by several other thiol-containing antioxidants including N-acetyl-l-cysteine (NAC)
  • Other clinically available antioxidants reported to have antiinflammatory, antioncogenic, and/or antiatherogenic properties that have been shown to block the activation of NF-κB include resveratrol (115, 116), (-)-epicatechin-3-gallate (117), pycnogenol (118), silymarin (119), and curcumin (120)
  • Nathan Goodyear on 02 Aug 12
     
    Great read!  If you want to see how free radicals and oxidative stress contribute to inflammation and disease (DM in this case), read this article.
Nathan Goodyear

Interaction Between Obesity and the Gut Microbiota: Relevance in Nutrition - 0 views

www.uclouvain.be/...nteraction_between_obesity.pdf

GI gut inflammation dysbiosis obesity insulin resistance IR type II DM diabetes hypertension metabolic endotoxemia

shared by Nathan Goodyear on 08 Mar 12 - No Cached
  • Nathan Goodyear on 08 Mar 12
     
    Gut inflammation resultant from dysbiosis leads to inflammation, obesity, insulin resistance, type II DM, hypertension...
Nathan Goodyear

Emerging epidemic of type 2 diabetes in youth. - 0 views

care.diabetesjournals.org/...345.abstract

Diabetes DM Type II children pediatrics

shared by Nathan Goodyear on 24 Aug 11 - No Cached
  • Nathan Goodyear on 24 Aug 11
     
    children with type II DM has risen from 5% to 45%
Nathan Goodyear

Metabolic Effects of Fructose and the Worldwide Increase in Obesity - 0 views

physrev.physiology.org/...23.abstract

HCFS fructose IR insulin resistance obesity DM diabetes type II HTN high blood pressure

shared by Nathan Goodyear on 25 Oct 11 - No Cached
  • Nathan Goodyear on 25 Oct 11
     
    high fructose intake results in insulin resistance, obesity, type II DM, and high blood pressure
Nathan Goodyear

Testosterone Replacement in Hypogonadal Men With Type 2 Diabetes and/or Metabolic Syndr... - 0 views

care.diabetesjournals.org/...dc10-1233

low T low testosterone testosterone men male hormone hormones hypogonadal men DM type II DM type II diabetes insulin resistance LDL total cholesterol LpA ED erectile dysfunction metabolic syndrome

shared by Nathan Goodyear on 17 Jul 12 - No Cached
  • Nathan Goodyear on 17 Jul 12
     
    testosterone therapy in men with low Testosterone shown to improve insulin resistance, lower cholesterol and LDL, lower LpA, and improve ED.
Nathan Goodyear

Changes in Gut Microbiota Control Metabolic Endotoxemia-Induced Inflammation in High-Fa... - 0 views

diabetes.diabetesjournals.org/...1470.full

metabolic metabolic endotoxemia obesity overweight LPS inflammation flora diet

shared by Nathan Goodyear on 29 Feb 12 - No Cached
  • Nathan Goodyear on 29 Feb 12
     
    2008 article from diabetes.  This article supports metabolic endotoxemia arising out of the gut.  High fat diet intake results in disrupted gut flora, resulting in increrased LPS release, resulting in inflammation, leads to leaky gut, systemic endotoxemia, inflammation, and thus metabolic dysfunction: see obesity, DM..
Nathan Goodyear

JAMA Network | Archives of Internal Medicine | Statin Use and Risk of Diabetes Mellitus... - 0 views

archinte.jamanetwork.com/article.aspx

type II DM Diabetes DM statins statin therapy cholesterol

shared by Nathan Goodyear on 21 Jun 12 - No Cached
  • Nathan Goodyear on 21 Jun 12
     
    women using statin therapy to lower cholesterol have increased type II Diabetes.  Variables were accounted for and this existed across all classes of statins.
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