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Nathan Goodyear

High School Football and Risk of Neurodegeneration: A Community-Based Study - Mayo Clin... - 0 views

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    Study finds increased TBI in high school football players, but not an increase in neurodegenerative disease.
Nathan Goodyear

Fasting is neuroprotective following traumatic brain injury - Davis - 2008 - Journal of... - 0 views

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    short term fasting and ketosis provides neuroprotection and preserves mitochondria in animal TBI study.  This study found preventative effects of the ketones.
Nathan Goodyear

http://www.jlr.org/content/early/2014/04/10/jlr.R046706.full.pdf - 0 views

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    Ketones for TBI?
Nathan Goodyear

DIET, KETONES AND NEUROTRAUMA - 0 views

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    ketones to heal TBI?
Nathan Goodyear

Ketogenic Diet Prevents Alterations in Brain Metabolism in Young but not Adult Rats aft... - 0 views

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    ketones promote cerebral metabolic recovery after TBI.  Younger brains switch to ketone metabolism more readily compared to older brains.  Only abstract available here.
Nathan Goodyear

Ketogenic Diet - Nutrition and Traumatic Brain Injury - NCBI Bookshelf - 0 views

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    good review of the impact of ketones on TBI.  The authors conclude that precursors to ketones may be the right approach to treatment.  This would be MCT's and ketones.
Nathan Goodyear

Vitamin E Protects Against Oxidative Damage and Learning Disability After Mild Traumati... - 0 views

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    Animal study: vitamin E protects against mild TBI
Nathan Goodyear

https://www.cns.org/sites/default/files/clinical_neuro/Chapter18_0.pdf - 0 views

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    Human study: High dose IV vitamin C and IM vitamin E shown to improve outcome.
Nathan Goodyear

Time-level relationship for lipid peroxidation and the protective effect of alpha-tocop... - 0 views

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    Animal study: vitamin E (alpha tocopherol only therapy) protected against lipid oxidation in mild and severe TBI.
Nathan Goodyear

Vitamin E reduces amyloidosis and improves cognitive function in Tg2576 mice following ... - 0 views

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    animal model: vitamin E reduced brain lipid oxidation post TBI.
Nathan Goodyear

Targeting Dopamine in Acute Traumatic Brain Injury - 0 views

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    great read on the current understanding of dopamine in TBI--essentially an excitotoxic story.
Nathan Goodyear

Depletion of Brain Docosahexaenoic Acid Impairs Recovery from Traumatic Brain Injury - 0 views

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    DHA plays important role in TBI risk and recovery.
Nathan Goodyear

Diminished brain resilience syndrome: A modern day neurological pathology of increased ... - 0 views

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    concussions
Nathan Goodyear

Hypopituitarism after traumatic brain injury. - PubMed - NCBI - 0 views

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    TBI results in isolated or complete pituitary failure (PTHP) in up to 40% of those with TBI.  
Nathan Goodyear

High Prevalence of Chronic Pituitary and Target-Organ Hormone Abnormalities after Blast... - 0 views

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    The prevalence of post traumatic hypopituitarism post TBI sits at around 35%.  
Nathan Goodyear

Prevalence of chronic hypopituitarism after blast concussion -- Wilkinson et al. 27 (1)... - 1 views

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    One of the first studies to look at PCS found that 42% of soldiers produced abnormally low hormone production following TBI one year after the injury.  This study highlights the potential pituitary dysfunction that can result from TBI.
Nathan Goodyear

Concussions' Lingering Effects Linked to Hormone Deficiency - Scientific American - 0 views

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    Scientific American article from 2013 highlights the link between head trauma and pituitary dysfunction.  
Nathan Goodyear

Dietary Strategy to Repair Plasma Membrane After Brain Trauma - 0 views

  • concussive brain injury is a major cause of neuropsychological disability in spite of no obvious neuronal death
  • TBI elicits oxidative damage to plasma membrane phospholipids
  • DHA is the most abundant polyunsaturated fatty acid (PUFA) in the brain, where the DHA-containing phospholipids contribute to plasma membrane biogenesis and receptor signaling
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  • curcumin has potent anti-inflammatory and antioxidant activities that can function to reduce oxidative damage and cognitive deficits associated with neurological disorders
  • Curcumin provided in the diet before TBI can reduce oxidative damage and counteract TBI-related cognitive dysfunction
  • Our previous study indicated that n-3 fatty acids supplemented in the diet counteracted learning disability after TBI
  • curcumin contributes to enhance the effects of DHA on TBI by promoting phosphorylation of the BDNF receptor TrkB in the hippocampus
  • previous evidence indicates that curcumin10 and DHA5 counteract TBI-related learning disability by involving BDNF
  • Our findings indicate that curcumin counteracted the TBI-related reduction in n-3 DPA.
  • curcumin may promote the conversion of n-3 DPA to DHA
  • the combination of both nutrients has been reported to produce anti-inflammatory action
  • the enhanced actions of curcumin and DHA in reducing cholesterol levels could be interpreted as preservation of levels of phospholipids in the plasma membrane
  • curcumin and DHA may contribute to reduce inflammation associated with the action of cholesterol in the pathology of TBI.
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    Curcumin and DHA shown to protect against TBI through a reduction in inflammation and maintenance of brain phospholipid membranes.  BDNF is increases also.
Nathan Goodyear

Omega-3 Fats Critical to Brain Health After Traumatic Injury and Surgery - 0 views

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    Just the press release, but DHA and EPA found to improve nerve cell survival, reduce neuroinflammation and decrease oxidative stress via "resolvins"
Nathan Goodyear

Dietary Supplementation With the Omega-3 Fatty Acid Docosahe... : Neurosurgery - 0 views

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    Animal study finds pre-emptive DHA at 40 mg/kg reduced injury response during medically induced TBI.  Not only can DHA be used with TBI, but this study suggests it can be used in a prevention mode.
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