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Nathan Goodyear

Hyperbaric oxygen therapy promotes neurogenesis: where do we stand? - 0 views

  • Numerous in vivo and in vitro studies confirm that HBOT induces neurogenesis
  • HIF-1α is the principal mediator of cellular hypoxia adaptations
  • activated by hypoxia, HIF-1α causes the transcription of its regulated downstream genes, including erythropoietin (EPO) and VEGF which are known to promote neurogenesis
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  • The safety of HBOT was also evaluated and it was pointed out that, if given at proper paradigms, like 1.5 ATA for 60 minutes, HBOT will not cause oxygen toxicity
  • Rockswold et al., on the other hand, found that HBOT might be potentially beneficial for severe TBI patients
  • McDonagh et al., concluded that there was insufficient evidence to establish the effectiveness of HBOT in the treatment of TBI
  • The first multicenter, randomized, double-blind, controlled trial in 2009 found that 40-hour HBOT of 24% oxygen at 1.3 ATM produced significant improvement in children's overall functioning, receptive language, social interaction, eye contact, and sensory/cognitive awareness compared to those received slightly pressurized room air
  • Another study in 2010 on 16 autism patients, adopting a similar treatment paradigm, showed no effect on a wide array of behavioral evaluations
  • To date, there is little evidence that HBOT causes malignant growth or metastasis. A history of malignancy should therefore not be considered as a contraindication for HBOT
  • HBOT enhances the production of reactive oxygen species (ROS) and causes oxidative stress in body tissues
  • Excessive accumulation of oxidative stress may contribute to neurodegenerative processes and cell death in the brain, as seen in diseases like Alzheimer's disease (AD) and Parkinson's disease (PD)
  • Hormesis
  • process that results in a functional improvement of cellular stress resistance, survival, and longevity in response to sub-lethal levels of stress
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    great review of hbot, brain injury, neuroplasticity and neurogenesis.
Nathan Goodyear

Hyperbaric oxygen therapy for traumatic brain injury - 0 views

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    great review article on the positive effects of hbot in TBI
Nathan Goodyear

Interleukin-10 mediates the neuroprotection of hyperbaric oxygen therapy against trauma... - 0 views

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    abstract of animal study finds that hyperbaric therapy provides neuroprotection via increase in IL-10; improved blood-brain barrier, improved tight junctions were about of the benefit found.
Nathan Goodyear

Hyperbaric Oxygen Therapy Can Improve Post Concussion Syndrome Years after Mild Traumat... - 0 views

  • The changes in SPECT images after treatment indicate that HBOT led to reactivation of neuronal activity in stunned areas that seemed normal under CT and MRI imaging. While SPECT imaging has a limited spatial resolution (compared, for example, to fMRI), the changes in activity were sufficiently robust to be clearly detected by the SPECT images.
  • HBOT might initiate a cellular and vascular repair mechanism and improve cerebral vascular flow
  • HBOT induces regeneration of axonal white matter , , , , has positive effect upon the myelinization and maturation of injured neural fibers , and can stimulate axonal growth and increase the ability of neurons to function and communicate with each other
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  • HBOT was found to have a role in initiation and/or facilitation of angiogenesis and cell proliferation processes needed for axonal regeneration .
  • The observed reactivation of neuronal activity in the stunned areas found here, along with similar results in post-stroke patients
  • At the cellular level, HBOT can improve cellular metabolism, reduce apoptosis, alleviate oxidative stress and increase levels of neurotrophins and nitric oxide through enhancement of mitochondrial function (in both neurons and glial cells)
  • HBOT may promote the neurogenesis of endogenous neural stem cells
  • With regard to secondary injury mechanisms in mTBI, HBOT can initiate vascular repair mechanism and improve cerebral vascular flow , , , , promote blood brain barrier integrity and reduce inflammatory reactions as well as brain edema
  • It might be possible that HBOT enables the metabolic change simply by supplying the missing energy/oxygen needed for those regeneration processes.
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    Hbot therapy, according to study, induces neuroplasticity and improves brain function in post concussion syndrome and those with mTBI.  The important point about this study was that the study was done years after the injury; what if the therapy was employed immediately after...
Nathan Goodyear

High School Football and Risk of Neurodegeneration: A Community-Based Study - Mayo Clin... - 0 views

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    Study finds increased TBI in high school football players, but not an increase in neurodegenerative disease.
Nathan Goodyear

Fasting is neuroprotective following traumatic brain injury - Davis - 2008 - Journal of... - 0 views

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    short term fasting and ketosis provides neuroprotection and preserves mitochondria in animal TBI study.  This study found preventative effects of the ketones.
Nathan Goodyear

http://www.jlr.org/content/early/2014/04/10/jlr.R046706.full.pdf - 0 views

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    Ketones for TBI?
Nathan Goodyear

DIET, KETONES AND NEUROTRAUMA - 0 views

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    ketones to heal TBI?
Nathan Goodyear

Ketogenic Diet Prevents Alterations in Brain Metabolism in Young but not Adult Rats aft... - 0 views

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    ketones promote cerebral metabolic recovery after TBI.  Younger brains switch to ketone metabolism more readily compared to older brains.  Only abstract available here.
Nathan Goodyear

Ketogenic Diet - Nutrition and Traumatic Brain Injury - NCBI Bookshelf - 0 views

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    good review of the impact of ketones on TBI.  The authors conclude that precursors to ketones may be the right approach to treatment.  This would be MCT's and ketones.
Nathan Goodyear

Vitamin E Protects Against Oxidative Damage and Learning Disability After Mild Traumati... - 0 views

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    Animal study: vitamin E protects against mild TBI
Nathan Goodyear

https://www.cns.org/sites/default/files/clinical_neuro/Chapter18_0.pdf - 0 views

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    Human study: High dose IV vitamin C and IM vitamin E shown to improve outcome.
Nathan Goodyear

Time-level relationship for lipid peroxidation and the protective effect of alpha-tocop... - 0 views

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    Animal study: vitamin E (alpha tocopherol only therapy) protected against lipid oxidation in mild and severe TBI.
Nathan Goodyear

Vitamin E reduces amyloidosis and improves cognitive function in Tg2576 mice following ... - 0 views

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    animal model: vitamin E reduced brain lipid oxidation post TBI.
Nathan Goodyear

Targeting Dopamine in Acute Traumatic Brain Injury - 0 views

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    great read on the current understanding of dopamine in TBI--essentially an excitotoxic story.
Nathan Goodyear

Depletion of Brain Docosahexaenoic Acid Impairs Recovery from Traumatic Brain Injury - 0 views

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    DHA plays important role in TBI risk and recovery.
Nathan Goodyear

Diminished brain resilience syndrome: A modern day neurological pathology of increased ... - 0 views

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    concussions
Nathan Goodyear

Hypopituitarism after traumatic brain injury. - PubMed - NCBI - 0 views

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    TBI results in isolated or complete pituitary failure (PTHP) in up to 40% of those with TBI.  
Nathan Goodyear

High Prevalence of Chronic Pituitary and Target-Organ Hormone Abnormalities after Blast... - 0 views

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    The prevalence of post traumatic hypopituitarism post TBI sits at around 35%.  
Nathan Goodyear

Prevalence of chronic hypopituitarism after blast concussion -- Wilkinson et al. 27 (1)... - 1 views

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    One of the first studies to look at PCS found that 42% of soldiers produced abnormally low hormone production following TBI one year after the injury.  This study highlights the potential pituitary dysfunction that can result from TBI.
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