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Nathan Goodyear

Progesterone neuroprotection in trauma... [Front Neuroendocrinol. 2009] - PubMed - NCBI - 0 views

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    Progesterone has a neuroprotective and promyelinating effects in the nervous system.  Progesterone increases BDNF.  Progesterone increases proliferation and differentiation of oligodendrocyte progenitor cells which will increase myelin production.
Nathan Goodyear

Therapeutic effects of progesterone and its metabolites in traumatic brain injury may i... - 0 views

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    Progesterone and its metabolite allopregnanolone show promise in protecting the brain in TBI.
Nathan Goodyear

Acta Pharmacologica Sinica - The neuroprotective effects of progesterone on traumatic b... - 0 views

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    Good discussion and review of progesterone's role as neuroprotective in TBI.
Nathan Goodyear

The Role of Progesterone in Traumatic Brain Injury : The Journal of Head Trauma Rehabil... - 0 views

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    Progesterone useful in inflammation reduction in Traumatic Brain Injuries.  This applies to both sexes.
Nathan Goodyear

Dietary Curcumin Supplementation Counteracts Reduction in Levels of Molecules Involved ... - 0 views

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    TBI leaves the mitochondria of the brain compromised.  The result is a compromise in the ability to produce energy leaving the brain limited in its ability to heal and or handle additional insults.  This animal study found curcumin able to provide preservation of the energy pathways post TBI.  This has implications on any neuro-insult, not just TBI
Nathan Goodyear

Dietary curcumin counteracts the outcome of traum... [Exp Neurol. 2006] - PubMed - NCBI - 0 views

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    curcumin functions to reduce inflammation and free radicals.  Curcumin also increases BDNF post TBI, which will improve synaptic plasticity, cognition, and memory.  
Nathan Goodyear

A pyrazole curcumin derivative restores membrane homeostasis disrupted after brain trauma - 0 views

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    TBI associated with increased  4-Hydroxynonenal.  This is associated with increased lipid per oxidation.  Curcumin protects against this lipid peroxidation per this study.
Nathan Goodyear

Use of Zinc as a Treatment for Tr... [Neurorehabil Neural Repair. 2012] - PubMed - NCBI - 0 views

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    Another study showing benefit of Zn in TBI
Nathan Goodyear

Improving treatments and outcomes: an emerging role... [Nutr Rev. 2012] - PubMed - NCBI - 0 views

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    Zinc emerging as a tool in the treatment/recovery of TBI
Nathan Goodyear

The Neurosteroid Allopregnanolone Promotes Proliferation of Rodent and Human Neural Pro... - 0 views

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    allopregnanolone increases human neural stem cells. Not only does allopregnanolone reduce inflammation, it plays a role in neurogenesis and thus recovery.
Nathan Goodyear

Progesterone and allopregnanolone reduce inflamma... [Exp Neurol. 2004] - PubMed - NCBI - 0 views

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    progesterone and allopregnanolone shown to reduce IL-1beta and TNF-alpha in TBI rat model.
Nathan Goodyear

Progesterone treatment inhibits the inflammatory a... [Brain Res. 2005] - PubMed - NCBI - 0 views

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    progesterone shown to decrease NF-KappaB and other inflammatory signaling after TBI in rat model. Part of the role of progesterone is as an anti-inflammatory.
Nathan Goodyear

Neuroendocrine disorders after... [J Neurol Neurosurg Psychiatry. 2008] - PubMed - NCBI - 0 views

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    The majority of people with PTHP after TBI remain undiagnosed.  The current thought, is that 25% of those with TBI have at least one pituitary hormone deficiency.  It does not have to be total pituitary failure.  Deficiencies can be isolated.
Nathan Goodyear

Hypopituitarism after traumatic brain injury - 0 views

  • PTHP is observed in about 40% of patients with a history of TBI
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    post-traumatic hypopituitarism is found in 40% of those with TBI.  The severity does correlate with the increased likelihood of developing PTHP.  Isolated deficiencies have been found in PTHP.
Nathan Goodyear

Inhibitory Effect of Progesterone on Inflammatory Factors after Experimental Traumatic ... - 0 views

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    Now, this is in a rat TBI model; but progesterone was shown to reduce the inflammatory response post TBI. Particularily, through NF-kappa B inhibition.
Nathan Goodyear

The epidemiology of sports-related tra... [J Head Trauma Rehabil. 1998] - PubMed - NCBI - 0 views

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    analysis of sports related TBI
Nathan Goodyear

Chronic Traumatic Encephalopathy in Athletes: Progressive Tauopathy following Repetitiv... - 0 views

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    discussion of chronic traumatic encephalopathy.  Good discussion of the neuropathological findings in 3 athletes.
Nathan Goodyear

Chronic Traumatic Encephalopathy: Chronic Degenerative Disease - 0 views

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    Good discussion on chronic traumatic encephalopathy. CTE is a condition found in the military and sports related head trauma. This is usually the result of low, repetitive impact injuries to the brain. Though, genetic susceptibility is discussed as well.
Nathan Goodyear

Mild Traumatic Brain Injury in UK Military Personnel Returni... : The Journal of Head T... - 0 views

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    Prevalence of mild Traumatic Brain Injury was found to be 9.5% in returning US soldiers.  This was associated with PTSD and Etoh abuse.
Nathan Goodyear

Concussive Brain Injury Enhances Fear Learning and Excitatory Processes in the Amygdala - 0 views

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    Link between TBI and PTSD.
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