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Nathan Goodyear

Frontiers | Can Reverse T3 Assay Be Employed to Guide T4 vs. T4/T3 Therapy in Hypothyro... - 0 views

www.frontiersin.org/...full

cancer thyroid hormones reverse T3 thyroid metabolism rT3

shared by Nathan Goodyear on 30 Jan 21 - No Cached
  • Nathan Goodyear on 30 Jan 21
     
    This study claims no viable benefit for the follow of rT3 in patients on T4/T3 treatment; yet, rT3 increases cancer cell proliferation by up to 80%?!?! Inflammation increases rT3!?!? Context, context, context.
Nathan Goodyear

Thyroid Replacement Therapy and Heart Failure - 0 views

circ.ahajournals.org/...385.full

thyroid T3 hormone hormones cardiovascular disease heart health failure CHF MI myocardial infarction heart attack heart disease

shared by Nathan Goodyear on 24 Sep 14 - No Cached
  • A good biomarker of intracardiac TH signaling would be helpful but has not been identified. In the absence of such a marker, a rational, cautious therapeutic approach might be to restore and maintain over time biochemical euthyroidism as documented by normal circulating levels of TSH, FT4, and FT3.
  • a low-T3 state resulting from altered peripheral TH metabolism secondary to caloric restriction is associated with impaired cardiac contractility
  • Low-T3 syndrome is the central finding and defines the illness in a variety of acute and chronic severe nonthyroidal illnesses with cardiac origin, including MI, HF, and surgically treated cardiac disease.1 Low circulating levels of T3 in the absence of primary thyroid hypofunction have been found in 20% to 30% of patients with dilated cardiomyopathy.
  • ...1 more annotation...
  • FT3 levels were inversely correlated to coronary artery disease
  • Nathan Goodyear on 24 Sep 14
     
    Great review of the current understanding of thyroid hormone metabolism in cardiac tissue.  Low T3 and increased rT3 (via increased D3 activity) is CLEARLY associated with poor cardiac performance and post MI and CHF is associated with poor outcomes.  T3 is critical in cardiac remodeling and recovery post MI.  T3 is actually a vasodilatory in the coronary arteries.   Why a endocrinologist would call rT3 useless only points to their ignorance of the literature.
Nathan Goodyear

Reduced activation and increased ina... [J Clin Endocrinol Metab. 2003] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...12843166

inflammation illness thyroid hypothyroid hypothyroidism TSH free T3 rT3 T3:rT3 ratio

shared by Nathan Goodyear on 02 Feb 12 - No Cached
  • These observed changes, in correlation with a low T(3)/rT(3) ratio, may represent tissue-specific ways to reduce thyroid hormone bioactivity during cellular hypoxia and contribute to the low T(3) syndrome of severe illness.
  • Nathan Goodyear on 02 Feb 12
     
    inflammation and critical illness associated with low TSH, low T3, elevated rT3 and low T3:rT3 ratio.
Nathan Goodyear

Adverse effects of reverse triiodothyronine on cellular metabolism as assessed by 1H an... - 0 views

www.researchgate.net/...by_1H_and_31P_NMR_spectroscopy

rT3 reverse T3 3 3' 5'-Triiodothyronine T3 thyroid hormone hormones receptor metabolism

shared by Nathan Goodyear on 12 Feb 15 - No Cached
  • Nathan Goodyear on 12 Feb 15
     
    Only abstract available here.  In vitro study finds that rT3 decreased the metabolic effect of T3.  This gives the impression that rT3 has an antagonist effect to T3 on the receptor.
Nathan Goodyear

Reverse T3 as a parameter of myocardial function impairment in heart failure. - 0 views

www.pubfacts.com/...n-impairment-in-heart-failure.

Thyroid hormone hormones reverse T3 rT3 free T3) CHF congestive heart failure CVD

shared by Nathan Goodyear on 24 Nov 14 - No Cached
  • Nathan Goodyear on 24 Nov 14
     
    reverse T3 and the free T3:rT3 can be used to assess prognosis of those with CHF.
Nathan Goodyear

Type 1 5'-deiodinase activity is inhibited by oxidative stress and restored by alpha-li... - 0 views

www.ncbi.nlm.nih.gov/...26947333

thyroid T3 oxidative stress alpha lipoic acid deiodinase rT3 reverse T3 thyroid metabolites thyroid metabolism hormones

shared by Nathan Goodyear on 28 Sep 16 - No Cached
  • Nathan Goodyear on 28 Sep 16
     
    oxidative stress decreased type 1 deiodinase activity and thus T4 to T3 conversion, resulting in increased rT3 production.  Of interesting note, Alpha lipoic acid increased type I deiodinase activity and T4 to T3 conversion.
Nathan Goodyear

Reverse T3 as a parameter of myocardial functi... [Int J Cardiol. 2010] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...19428128

thyroid hormone hormones reverse T3 fT3_rT3 rT3 heart failure CHF cardiovascular disease.

shared by Nathan Goodyear on 16 Aug 14 - No Cached
  • Nathan Goodyear on 16 Aug 14
     
    Another study regarding reverse T3 that many Endocrinologists need to read.  In this study, the authors find that significantly higher reverse T3 levels were associated with myocardial function impairment (MFI) class IV.  This MFI class IV was also found associated with a decreased fT3/rT3.
Nathan Goodyear

Specific 3,3′,5′-Triiodothyronine (Reverse T3) Binding Sites on Rat Liver Pla... - 0 views

informahealthcare.com/...10799898309041848

reverse T3 rT3 3 3' 5'-Triiodothyronine thyroid hormone hormones receptor

shared by Nathan Goodyear on 12 Feb 15 - No Cached
  • Nathan Goodyear on 12 Feb 15
     
    rat model finds T4 and rT3 receptors at plasma membrane.  T3 was found to bind with lower affinity than rT3 and T4 at the same receptor binding site.
Nathan Goodyear

Cellular and Molecular Basis of Deiodinase-Regulated Thyroid Hormone Signaling - 0 views

www.ncbi.nlm.nih.gov/...PMC2647704

thyroid hormone T3 T4 rT3 deiodinase selenium hormones

shared by Nathan Goodyear on 10 Nov 14 - No Cached
  • Nathan Goodyear on 10 Nov 14
     
    Anything and everything one would want to know regarding thyroid hormone signaling.  Doctors, especially endocrinologists, need to read this.  T4 is not or is ever inside target cells.  The enzymes, deiodinase types 1, 2, and 3, are what control the thyroid hormone at the cellular levels.  Deiodinase-2 is what generates T3 in the cytosol of the cell.  In contrast, deiodinase-3 is what generates rT3 which is inactive.  High Fat diet increases deiodinase-3.
Nathan Goodyear

Effect of metoclopramide--a dopaminergic blocker a... [Acta Endocrinol (Copenh). 1985] ... - 0 views

www.ncbi.nlm.nih.gov/...4002999

cortisol T4 T3 rT3

shared by Nathan Goodyear on 14 Mar 11 - No Cached
  • High levels of cortisol may be responsible for the altered TT4 peripheral metabolism to TT3 and rT3 in these patients.
  • Nathan Goodyear on 14 Mar 11
     
    elevated cortisol blocks T4 to T3 conversion and increases rT3 production
Nathan Goodyear

Thyroid Hormone Concentrations, Disease, Physical Function, and Mortality in Elderly Me... - 0 views

jcem.endojournals.org/...6403

hormone thyroid concentrations rT3 reverse T3 hypothyroid hypothyroidism

shared by Nathan Goodyear on 08 Mar 11 - No Cached
  • High serum rT3 may result from a decreased peripheral metabolism of thyroid hormones due to the aging process itself and/or disease and may reflect a catabolic state.
  • Nathan Goodyear on 08 Mar 11
     
    elevated serum rT3 indicates tissue hypothyroidism; very different than rT3 in the pituitary, where high concentrations accumulate
Nathan Goodyear

Free T4, Free T3, and Reverse T3 in Critically III, Thermall... : The Journal of Trauma - 0 views

journals.lww.com/...everse_T3_in_Critically.1.aspx

free reverse T3 thyroid hypothyroid hypothyroidism

shared by Nathan Goodyear on 08 Mar 11 - No Cached
  • Significant suppression of serum concentrations of 3,5,3'-triiodothyronine (T3) and elevation of serum concentrations of 3,3',5'-triiodothyronine (rT3) were seen
  • Nathan Goodyear on 08 Mar 11
     
    low free T3: elevated reverse T3 in critically ill patients
Nathan Goodyear

Reduced Activation and Increased Inactivation of Thyroid Hormone in Tissues of Critical... - 0 views

jcem.endojournals.org/...3202.full

TSH hypothyroid hypothyroidism T3 rT3 T4 thyroid hormone inflammation

shared by Nathan Goodyear on 07 Feb 12 - No Cached
  • Nathan Goodyear on 07 Feb 12
     
    critical illness is associated with low TSH, reduced T3, and increased rT3 production.  Inflammation is critically involved in this process.  This study from JCEM shows how unreliable TSH and T4 are.
Nathan Goodyear

Direct effects of thyroid hormones on rat coronary... [Thyroid. 1998] - PubMed result - 0 views

www.ncbi.nlm.nih.gov/...9709915

T3 vasodilation rT3

shared by Nathan Goodyear on 01 Feb 11 - No Cached
  • Our results also suggest that thyroid hormones may play a role in preventing myocardial ischemia by inducing coronary artery vasodilation.
  • Nathan Goodyear on 01 Feb 11
     
    T3 increases vasodilation of arteries and improves cardiac blood flow in rat model; rT3 does not
Nathan Goodyear

Relationship of thyroid hormone levels and cardiov... [Endocrine. 2014] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...23546612

thyroid hormone hormones rT3 reverse T3 cardiovascular disease diabetes

shared by Nathan Goodyear on 16 Aug 14 - No Cached
  • Nathan Goodyear on 16 Aug 14
     
    Patients with type II Diabetes and h/o of CVE  have higher rT3 in study.  The Endocrinologist that said reverse T3 is completely irrelevant needs to read more studies and stop listening to opinion.
Nathan Goodyear

The Role of Thyroid Hormones in Hepatocyte Proliferation and Liver Cancer - 0 views

www.ncbi.nlm.nih.gov/...PMC6730500

oxidative stress deiodinase T3 T4 thyroid hormones rT3 HIF-1alpha

shared by Nathan Goodyear on 30 Jan 21 - No Cached
  • Nathan Goodyear on 30 Jan 21
     
    Oxidative stress/inflammation via HIF-1alpha increase D3 which increases rT3 to increase proliferation in cancer; in contrast, there is a decrease in D1 and D2 to decrease T3 and T4. The question is the systemic versus the TME.
Nathan Goodyear

Minireview: Cracking the Metabolic Code for Thyroid Hormone Signaling - 0 views

www.ncbi.nlm.nih.gov/...PMC3159779

thyroid hormone hormones reverse T3 free T3 rT3 T4 metabolism

shared by Nathan Goodyear on 16 Aug 14 - No Cached
  • Nathan Goodyear on 16 Aug 14
     
    Here is a great review of thyroid hormone metabolism published in the very relevant journal Endocrinology.  The review describes the peripheral metabolism of the pro hormone T4 and the peripheral metabolism to free T3 and/or reverse T3 and the associated metabolic implications.  Why don't more endocrinologists read?This is an animal study.
Nathan Goodyear

Action of Reverse T3 on Cancer Cells: Endocrine Research: Vol 44, No 4 - 0 views

www.tandfonline.com/...07435800.2019.1600536

cancer rT3 reverse T3

shared by Nathan Goodyear on 30 Jan 21 - No Cached
  • Nathan Goodyear on 30 Jan 21
     
    In vitro study finds that rT3 increases cancer proliferation by 50-80%. Wow!
Nathan Goodyear

IL-6 promotes nonthyroidal illness syndrome by blocking thyroxine activation while prom... - 0 views

europepmc.org/3083773

rT3 reverse T3 T3 thyroid deiodinase-3 inflammation IL-6 thyroid hormones T4

shared by Nathan Goodyear on 04 Feb 21 - No Cached
  • Nathan Goodyear on 04 Feb 21
     
    IL-6 decreases deiodinase type I and 2; but increases type 3. The result is an increase in rT3 and in cancer-growth.
Nathan Goodyear

Nonthyroidal Illness Syndrome and Thyroid Hormone Actions at Integrin αvβ3 | ... - 0 views

academic.oup.com/...4834034

thyroid hormones rT3 T4 T3 reverse T3 cancer

shared by Nathan Goodyear on 04 Feb 21 - No Cached
  • Nathan Goodyear on 04 Feb 21
     
    RT3 favors cancer growth.
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