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Computer Science Tuesday, April 25, 2023 Computer hardware Computer hardware is the physical components that make up a computer system. It includes everything from the central processing unit (CPU) to the monitor, keyboard, and mouse. Understanding the different types of hardware and how they work together is essential for anyone who works with computers. In this article, we will explore the various components of computer hardware, including internal and external components, and the peripherals that connect to them. We will also discuss the importance of hardware maintenance, the latest advancements in computer technology, and factors to consider when choosing the right hardware for your needs. Whether you are a computer technician, a gamer, or simply someone who uses a computer for everyday tasks, this article will help you better understand the world of computer hardware. Introduction to Computer Hardware Computer hardware refers to the physical components that make up a computer system. It includes everything from the processor and memory to input/output devices such as the keyboard and monitor. In this article, we will explore the different types of computer hardware and their functions. What is Computer Hardware Computer hardware refers to the physical components of a computer system. It includes all the components that can be touched, seen, and used to interact with a computer, such as the monitor, keyboard, and mouse. Hardware is different from computer software, which refers to the programs and applications that run on a computer system. History of Computer Hardware The history of computer hardware dates back to the 1820s when Charles Babbage, an English mathematician, and inventor, designed the first analytical engine, which was considered to be the first mechanical computer. With time, more complex electronic computers were developed, including the first Intel microprocessor in 1971. Since then, computer hardware has continued to evolve, becoming

Premature ovarian failure shown to be autoimmune.  This study from '97 describes the mechanism of the autoimmune ovarian failure.  Now, case studies are emerging of young women developing premature ovarian failure following the HPV vaccine.

Low estrogen levels in ovarian failure patients found to reduce flares in those with Lupus.  Estrogen can promote inflammation, especially high estrone levels.  It is easy to see how ovarian failure and a drop in estrogen could reduce inflammation and thus autoimmune flares.

CoQ10 in those with prior MIs, found to have reduced hospital readmission, less heart failure, and lower cardiovascular death.  Enough said.

Silver Line is one of the top hospital in Kochi, Kerala, India for Diabetic Kidney Care. Silver line provide expert surgeons for kidney transplantation, dialysis and treatment for kidney failure, diabetic kidney disease, diabetic kidney problems, chronic kidney disease and diagnosis the symptoms of kidney failure like fatigue, nausea and vomiting, heartburn, itchy skin.

Review of 4 studies found that Testosterone therapy improved exercise capacity in those patients with heart failure.

cancer and renal failure

great review of mitochondrial biogenesis, oxidative stress and heart failure.  

Testosterone therapy in men with CHF found to increase exercise capacity, reduced the Q-T interval in men, improved muscle strength in men, and was found to be safe in meta-analysis.

IV T3 was given to patients with chronic heart failure.  What the study found may surprise you: improved heart function (ventricular), improved BNP, decrease heart rate, no side effects.  T3 has been shown to be more predictive of cardiac death in those with cardiac disease, than elevated lipids or decreased ejection fraction.

Hypothyroidism is found to be associated with low T3, reduced heart contractility, and poor prognosis in heart failure

patients with heart failure and low vitamin C levels have higher inflammation as measured by hs-CRP and elevated risk of worse outcomes

subclinical hypothyroidism associated with increased risk of heart failure

increased risk of heart failure found in patients with TSH > 10.

study shows that testosterone therapy provides benefits in heart failure patients.

This article discusses the failure of androgen deprivation therapy and prostate cancer.  This failure is quite common.  The authors point to alpha-DHT as the primary mechanism through AR stimulation.  However, we know that DHT metabolites also stimulate estrogen receptors.

Good article.  Heart failure in men associated with lower Total Testosterone and estimated Free Testosterone. The severity of disease was associated with lower Testosterone levels.   I wish they would have measured free levels not estimated them.   Increased SHBG concentrations was associated increased CHF as well. This study found no association with mortality.

Only abstract available here, but low T is the result of primary (testicular failure) and/or secondary (HPA failure). 

T3 beneficial in those with acute heart failure

T3 improves cardiac output in those with heart failure