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Nathan Goodyear

PLOS ONE: Probiotic Microbes Sustain Youthful Serum Testosterone Levels and Testicular ... - 0 views

journals.plos.org/...article

hormone hormones low T low Testosterone hypogonadism Testosterone probiotic L reuters probiotics Lactobacillus lactobacillus reuteri male aging

shared by Nathan Goodyear on 29 Apr 15 - No Cached
  • Studies in both humans and rodents, however, suggest that low testosterone is due to age-related lesions in testes rather than irregular luteinizing hormone metabolism
  • Various dietary factors and diet-induced obesity have been shown to increase the risk for late onset male hypogonadism and low testosterone production in both humans and mice
  • Testosterone deficiency and metabolic diseases such as obesity appear to inter-digitate in complex cause-and-effect relationships
  • ...28 more annotations...
  • dietary supplementation of aged mice with the probiotic bacterium Lactobacillus reuteri makes them appear to be younger than their matched untreated sibling mice
  • These results indicate that gut microbiota induce modulation of local gastrointestinal immunity resulting in systemic effects on the immune system which activate metabolic pathways that restore tissue homeostasis and overall health
  • all these studies we consistently observed that young and aged mice consuming purified L. reuteri organisms had particularly large testes and a dominant male behavior.
  • The testes of probiotic-fed aged mice were rescued from both seminiferous tubule atrophy and interstitial Leydig cell area reduction typical of the normal aging process. Preservation of testicular architecture despite advanced age or high-fat diet coincided with remarkably high levels of circulating testosterone. The beneficial effects of probiotic consumption were recapitulated by the depletion of the pro-inflammatory cytokine Il-17.
  • feeding of L. reuteri consistently increased the gonadal weights, consumption of a non-pathogenic strain of Escherichia coli (E. coli) K12 organisms did not affect testicular weight
  • mice with dietary L. reuteri supplements were rescued from diet-induced obesity and had normal body weight and lean physique
  • Despite the comparable numbers of ST profiles, we determined that testes from L. reuteri-treated mice had increased ST cross-sectioned profiles
  • the probiotic organism induced prominent Leydig cell accumulations in the interstitial tissue between the ST's
  • The probiotic-associated increase of interstitial Leydig cell areas was sustained with advancing age at 7 (CD vs CD+LR, P = 0.0025; CD+E.coli vs CD+LR, P = 0.0251) and 12 months
  • mice eating L. reuteri had profoundly increased levels of circulating testosterone regardless of the type of diet they consumed
  • previous studies we found that dietary probiotics counteract obesity [19] and age-related integumentary pathology [18] at least in part by down-regulating systemic pro-inflammatory IL-17A-dependent signaling
  • blocking pro-inflammatory Il-17 signaling entirely recapitulates the beneficial effects of probiotics
  • L. reuteri-associated prevention of age- and diet-related testicular atrophy correlates with increased numbers and size of Leydig cells
  • Lactobacillus reuteri we discovered that aging male animals had larger testes compared to their age-matched controls
  • xamined testes of probiotic microbe-fed mice and found that they had less testicular atrophy coinciding with higher levels of circulating testosterone compared to their age-matched controls
  • Similar testicular health benefits were produced using systemic depletion of the pro-inflammatory cytokine Il-17 alone, implicating a chronic inflammatory pathway in hypogonadism
  • One specific aspect of this paradigm is reciprocal activities of pro-inflammatory Th-17 and anti-inflammatory Treg cells
  • Feeding of L. reuteri organisms was previously shown to up-regulate IL-10 levels and reduce levels of IL-17 [19] serving to lower systemic inflammation
  • insufficient levels of IL-10 may increase the risk for autoimmunity, obesity, and other inflammatory disease syndromes
  • Westernized diets are also low in vitamin D, a nutrient that when present normally works together with IL-10 to protect against inflammatory disorders
  • Physiological feedback loops apparently exist between microbes, host hormones, and immunity
  • The hormone testosterone has been shown to act directly through androgen receptors on CD4+ cells to increase IL-10 expression
  • studies in both humans and rodents suggest that hypogonadism is due to age-related lesions in testes rather than irregular LH metabolism
  • We postulate that probiotic gut microbes function symbiotically with their mammalian hosts to impart immune homeostasis to maintain systemic and testicular health [34]–[35] despite suboptimal dietary conditions.
  • Dietary factors and diet-induced obesity were previously shown to increase risk for age-associated male hypogonadism, reduced spermatogenesis, and low testosterone production in both humans and mice [2]–[4], [8]–[11], [14]–[17], phenotypic features that in this study were inhibited by oral probiotic therapy absent milk sugars, extra protein, or vitamin D supplied in yogurt.
  • Similar beneficial effects of probiotic microbes on testosterone levels and sperm indices were reported in male mice that had been simultaneously supplemented with selenium
  • Testes histomorphometry and serum androgen concentration data were both suggestive of a probiotic-associated up-regulation of spermatogenesis in mice
  • the initial changes of testicular atrophy begin to occur in mice from the age of 6 moths onwards [7] and indicates that the trophic effect of L. reuteri on Leydig cells is a key event which precedes and prevents age-related changes in the testes of mice. This effect is reminiscent of earlier studies describing Leydig cell hyperplasia and/or hypertrophy in the mouse and the rat testis that were achievable by the administration of gonadotropins, including human chorionic gonadotropin, FSH and LH
  • Nathan Goodyear on 29 Apr 15
     
    Fascinating study on how the addition of Lactobacillus reuteri increased Testicular size, prevented testicular atrophy, increased serum Testosterone production and protected against diet-induced/obesity-induced hypogonadism.  This was a mouse model
fitspresso

LeanBiome™ (Official) | Get Save UpTo $540 Today Only! - 0 views

usleanbiome.com

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shared by fitspresso on 27 Sep 23 - No Cached
  • fitspresso on 27 Sep 23
     
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Nathan Goodyear

Probiotics for the treatment of a... [Ann Allergy Asthma Immunol. 2008] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...19119700

probiotics allergy asthma

shared by Nathan Goodyear on 19 Feb 13 - No Cached
  • Nathan Goodyear on 19 Feb 13
     
    A meta analysis of 12 randomized controlled trials found that 9 found improvement in allergies and asthma with probiotics.   A lot of studies have looked at probiotics and the prevention of allergies and asthma, but this meta analysis shows probiotics should be used as a part of therapy.
Nathan Goodyear

Probiotics and gut health: A special focus on liver diseases - 0 views

www.ncbi.nlm.nih.gov/...PMC2811790

probiotic probiotics liver cancer disease IBD IBS cirrhosis NAFLD gut health

shared by Nathan Goodyear on 05 Aug 14 - No Cached
  • Nathan Goodyear on 05 Aug 14
     
    Probiotics are not just for disease prevention, but also can be utilized as adjuncts for different liver disease states.  This review article highlights probiotics in IBD, IBS, surgery, NAFLD, cancer, and cirrhosis.
Nathan Goodyear

Oral spore-based probiotic supplementation was associated with reduced incidence of pos... - 0 views

www.wjgnet.com/...117.htm

probiotics spore probiotics LPS lipopolysaccharides IL-1beta inflammation gut gut bacteria gut flora gut health gut microbiome gut microbiota

shared by Nathan Goodyear on 05 Oct 17 - No Cached
  • Nathan Goodyear on 05 Oct 17
     
    Study finds spore probiotic for 30 days reduced LPS endotoxin by 42%, while the placebo group found a 36% increase.  As a result, and to no surprise, there was a significant drop in IL-beta.  Also, in the spore probiotic group, there was a 24% reduction in triglycerides.
Nathan Goodyear

Nutrients | Free Full-Text | Effect of Probiotics on Metabolic Outcomes in Pregnant Wom... - 0 views

www.mdpi.com/...htm

probiotics alternative medicine natural medicine natural therapies diabetes gestational diabetes

shared by Nathan Goodyear on 15 May 17 - No Cached
  • The gut microbial composition is altered during pregnancy
  • probiotic supplements may contribute to the maintenance of bacterial diversity and glucose homeostasis in individuals with metabolic disturbances
  • Assessment of four randomized controlled trials in this review involving 288 pregnant women with GDM found that a 6–8 week probiotic intervention did not improve FBG or LDL-cholesterol levels
  • ...5 more annotations...
  • probiotic supplementation in women with GDM was associated with significant reductions in insulin resistance
  • One proposed method is by the production of short chain fatty acids (SCFAs), generated as a by-product of bacterial fermentation of dietary fibers. SCFAs act as an energy source for intestinal cells and have been found to regulate the production of hormones effecting energy intake and expenditure such as leptin and grehlin
  • Another hypothesized mechanism of SCFA action includes reducing gastrointestinal permeability by upregulating transcription of tight junction proteins, enhancing production of Glucagon-like peptide-2 (GLP-2) which promotes crypt cell proliferation, and reducing inflammation in colonic epithelial cells by increasing PPAR-gamma activation
  • Maintenance of the integrity of the gut barrier minimizes the concentration of lipopolysaccharide (LPS) in circulation
  • LPS is a structural component of gram negative bacterial cell walls, which induces an immune-cell response upon absorption into the human bloodstream, stimulating proinflammatory cytokine production and the onset of insulin resistance and hyperglycemia
  • Nathan Goodyear on 15 May 17
     
    Review (4 studies) found that 6-8 weeks of probiotic therapy of pregnant women with gestational diabetes improved insulin resistance.
  • Open TeleShop on 17 May 17
     
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fnfdoc

Gut Health - Role Of Probiotics In Maintaining Gut Health - Health Blog - 0 views

fnfdoc.com/biotics-maintaining-gut-health

gut health blog Gut Health What Is Gut Health Gut Health Symptoms Unhealthy Gut Symptoms Healthy & Unhealthy Gut Gut Health Natural Sources Healthy Gut Gut Tract

shared by fnfdoc on 20 Jul 20 - No Cached
  • fnfdoc on 20 Jul 20
     
    We briefly described role of probiotics in maintaining gut health & how do probiotics work. What are natural sources & symptoms of unhealthy & healthy gut
Nathan Goodyear

Resolution of cryptosporidiosis with probiotic treatment - 0 views

pmj.bmj.com/...112.full.pdf

probiotic GI gastrointestinal probiotics

shared by Nathan Goodyear on 01 May 12 - No Cached
  • Nathan Goodyear on 01 May 12
     
    probiotic treatment has efficacy against active GI infection with cryptosporidium.
Nathan Goodyear

Probiotic Effects on Cold and Influenza-Like Symptom Incidence and Duration in Children - 0 views

pediatrics.aappublications.org/...e172.abstract

flu symptoms probiotics cold probiotic

shared by Nathan Goodyear on 25 Sep 11 - No Cached
  • Nathan Goodyear on 25 Sep 11
     
    probiotics shown to beneficial in cold and flu symptoms
Nathan Goodyear

Management of metabolic syndrome through probiotic and prebiotic interventions - 0 views

www.ncbi.nlm.nih.gov/...PMC3263193

probiotics probiotic metabolic syndrome metabolic syndrome

shared by Nathan Goodyear on 11 Sep 14 - No Cached
  • Nathan Goodyear on 11 Sep 14
     
    probiotic for metabolic syndrome.
Nathan Goodyear

Regulation of abdominal adiposity by probiot... [Eur J Clin Nutr. 2010] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...20216555

probiotic probiotics metabolism obesity

shared by Nathan Goodyear on 11 Sep 14 - No Cached
  • Nathan Goodyear on 11 Sep 14
     
    Probiotics for metabolic dysfunction.  In this case, the Lactobacillus gasser species.
Nathan Goodyear

The role of probiotic bacteria in cancer pre... [Microbes Infect. 2000] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...10884619

probiotic probiotics cancer colorectal Lactobacillus

shared by Nathan Goodyear on 05 Aug 14 - No Cached
  • Nathan Goodyear on 05 Aug 14
     
    The evidence of Lactobacillus probiotics to suppress colorectal cancer is limited to indirect evidence.
Nathan Goodyear

http://www.trjfas.org/pdf/issue_12_01/0121.pdf - 0 views

www.trjfas.org/...0121.pdf

probiotics

shared by Nathan Goodyear on 01 Apr 15 - No Cached
  • Nathan Goodyear on 01 Apr 15
     
    Non-medical study finds that probiotics can be used to eliminate pathogenic bacteria.  These probiotics release bactericidal and/or bacteriostatic chemicals that can eradicate/control pathogenic and opportunistic bacteria in aquaculture.  This same logic should be applied to the Gut as well.
Nathan Goodyear

JAMA Network | JAMA Pediatrics | Association of Early Exposure of Probiotics and Islet ... - 0 views

archpedi.jamanetwork.com/article.aspx

probiotics probiotic alternative medicine natural medicine diabetes complementary medicine

shared by Nathan Goodyear on 17 Dec 15 - No Cached
  • Nathan Goodyear on 17 Dec 15
     
    early probiotic supplementation decreased autoimmune Diabetes in children in study.
Nathan Goodyear

VSL#3 probiotic-mixture induces remission... [Am J Gastroenterol. 2005] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...15984978

probiotics ulcerative colitis VSL #3 IBD irritable bowel disease

shared by Nathan Goodyear on 14 Feb 13 - No Cached
  • Nathan Goodyear on 14 Feb 13
     
    high dose probiotic shown to provide significant benefit, even remission in those with mild/moderate ulcerative colitis.
Nathan Goodyear

AACI | Full text | The role of Probiotics in allergic diseases - 0 views

www.aacijournal.com/5

probiotics asthma allergic rhinitis allergies

shared by Nathan Goodyear on 20 Feb 13 - No Cached
  • Nathan Goodyear on 20 Feb 13
     
    studies of probiotics in the treatment of asthma and allergic rhinitis are mixed.  Studies do strongly suggest benefit in therapy for allergic rhinitis, but this study found no benefit with regards to asthma in its review of the literature.
Nathan Goodyear

Targeting gut microbiota in obesity: effects of prebiotics and probiotics. - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...21826100

leptin leptin resistance obesity probiotics metabolic syndrome gut gut flora gut microbiota

shared by Nathan Goodyear on 05 Jun 16 - No Cached
  • Nathan Goodyear on 05 Jun 16
     
    Only abstract available here.  Review finds probiotics can be used in the arsenal to treat obesity and metabolic syndrome.  The authors conclude that leptin sensitivity is one of the possible mechanisms.
Nathan Goodyear

Supplementation with Lactobac... [Cell Mol Biol (Noisy-le-grand). 1999] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...10541481

probiotics parasites parasitic infection probiotic

shared by Nathan Goodyear on 01 May 12 - No Cached
  • Nathan Goodyear on 01 May 12
     
    probiotics shown to be beneficial in intestinal parasitic infections.
Nathan Goodyear

JAMA Network | JAMA: The Journal of the American Medical Association | Probiotics for t... - 0 views

jama.jamanetwork.com/article.aspx

probiotics antibiotic induced diarrhea diearrhea antibiotic treatment prevention

shared by Nathan Goodyear on 15 May 12 - No Cached
  • Nathan Goodyear on 15 May 12
     
    probiotics shown to not only prevent antibiotic induced diarrhea; but to be effective as a treatment. 
Nathan Goodyear

Probiotics in the treatment of irritabl... [J Clin Gastroenterol. 2004] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...15220671

probiotics IBS irritable bowel syndrome Lactobacillus Bifidobacterium treatment

shared by Nathan Goodyear on 06 Mar 12 - No Cached
  • Nathan Goodyear on 06 Mar 12
     
    probiotics found to beneficial in those with IBS
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