decreased bifidobacterium gut flora results in increased absorption of LPS in high fat diets resulting in endotoxemia. This plays a significant role in diabetes
in addition to the type of diet being a modulator of microbiota composition, the timing of food intake plays a critical role in shaping intestinal microbial ecology.
the microbiota rhythms are influenced by the host clock and perform critical functions in the adaptation of metabolic processes to the diurnal fluctuations in the environment
Our study reveals that dysbiosis has a temporal dimension and that static microbiota comparisons might not be fully conclusive unless samples were taken in a controlled manner with respect to this important additional variable
This is a really nice study. Altered sleep-wake cycles result in altered food consumption which leads to altered gut microbiota diurnal oscillations. Gut microbiota have a normal diurnal oscillation. This altered gut flora then leads to increase insulin resistance, metabolic syndrome, diabetes...
a lack of microbiota results in a permanent ileal overproduction of corticosterone due to decreased expression of the D-box-binding E4BP4 repressor. This hypercorticosterolism generates systemic metabolic defects (hyperglycemia, insulin resistance, increased TG and FA)