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Nathan Goodyear

Glucocorticoids and 11beta-hydroxysteroid... [Minerva Endocrinol. 2007] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...17912154

cortisol 11-betaHSD1 obesity metabolic syndrome

shared by Nathan Goodyear on 14 Mar 12 - No Cached
  • Nathan Goodyear on 14 Mar 12
     
    Dysregulation of 11-betaHSD1 plays significant role in metabolic syndrome.  Decreased 11-betaHSD activity is found in the liver and increased 11-betaHSD1  is found in peripheral fat.  Take home: 11-betaHSD1 activity and cortisol metabolism differs in different tissue
Nathan Goodyear

Tissue-Specific Dysregulation of Cortisol Metabolism in Human Obesity - 0 views

jcem.endojournals.org/...1418.short

11-betaHSD cortisone cortisol men obesity overweight fat adipose tissue adiposity

shared by Nathan Goodyear on 13 Mar 12 - No Cached
  • Nathan Goodyear on 13 Mar 12
     
    dysregulated cortisol metabolism plays a role in obesity.  This study looked at obese men.  Decreased liver 11-betaHSD1 activity was found in the liver, with decreased cortisone to cortisol conversion.  Additionally, increase cortisol metabolites were found.  However, there was found to be an increase in 11-betaHSD1 activity in the adipose tissue increasing the cortisone to cortisol conversion indicating an increase in peripheral cortisol production.
Nathan Goodyear

11beta-hydroxysteroid dehydrogenase type 1 an... [Front Horm Res. 2008] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...18230901

11-betaHSD1 fat adipose tissue adipoxytes liver metabolic syndrome insulin resistance dyslipidemia hypertension fatty

shared by Nathan Goodyear on 14 Mar 12 - No Cached
  • Adipose-selective 11beta -HSD1 transgenic mice exhibited elevated intra-adipose and portal, but not systemic corticosterone levels, abdominal obesity, hyperglycaemia, insulin resistance, dyslipidaemia and hypertension
  • transgenic overexpression of 11beta -HSD1 in liver yielded an attenuated metabolic syndrome with mild insulin resistance, dyslipidaemia, hypertension and fatty liver, but not obesity or glucose intolerance
  • Nathan Goodyear on 14 Mar 12
     
    11-betaHSD1 expression and effect is site specific.
Nathan Goodyear

Microglia express functional 11 beta-hydroxysteroid deh... [Glia. 2010] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...20544861

11-betaHSD 11-betaHSD1 microglia brain cortisol hormone hormones

shared by Nathan Goodyear on 05 Jun 14 - No Cached
  • Nathan Goodyear on 05 Jun 14
     
    microglia in the brain express 11 beta-hydroxysteroid dehydrogenase type 1 only.  This consistent with the brain as a whole.
Nathan Goodyear

Dietary Macronutrient Content Alters Cortisol Metabolism Independently of Body Weight C... - 0 views

jcem.endojournals.org/...4480.long

cortisol 11-betaHSD1 low carb diet low carb carbohydrates metabolism macronutrients

shared by Nathan Goodyear on 07 Oct 13 - No Cached
  • Nathan Goodyear on 07 Oct 13
     
    Extra-adrenal cortisol production is increased by 11-Beta-HSD1 via low Carb diet.  This is counter to that seen in mice studies.  The fat content of the diet could explain this.  This study looked at men.
Nathan Goodyear

Liver X Receptors Downregulate 11β-Hydroxysteroid Dehydrogenase Type 1 Expres... - 0 views

diabetes.diabetesjournals.org/...2426.long

11-betaHSD 11-betaHSD1 cortisol hormone hormones liver fat adipose tissue adipose tissue

shared by Nathan Goodyear on 05 Jun 14 - No Cached
  • Nathan Goodyear on 05 Jun 14
     
    11beta-HSD type 1 is predominantly expressed in liver and adipose tissue.
Nathan Goodyear

Immunohistochemical localization of ... [J Clin Endocrinol Metab. 1998] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...9543163

11-betaHSD 11-betaHSD1 cortisol hormone hormones ovary liver fat adipose tissue adrenal glands

shared by Nathan Goodyear on 05 Jun 14 - No Cached
  • Nathan Goodyear on 05 Jun 14
     
    11beta-HSD type I is highly expressed in liver, adrenal glands, ovaries, and adipose tissue in human immunohistochemical analysis.
Nathan Goodyear

11Beta hydroxysteroid dehydrogenase ty... [Clin Endocrinol (Oxf). 2006] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...17121533

11-betaHSD 11-betaHSD1 muscle hormone hormones

shared by Nathan Goodyear on 05 Jun 14 - No Cached
  • Nathan Goodyear on 05 Jun 14
     
    11beta-HSD type I dominantly expressed in muscle.
Nathan Goodyear

The effect of common genetic variati... [J Clin Endocrinol Metab. 2012] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...22112815

saliva salivary hormone hormones depression 11-betaHSD1 HPA SNPs

shared by Nathan Goodyear on 10 Oct 12 - No Cached
  • Nathan Goodyear on 10 Oct 12
     
    hyperactive HPA axis associated with depression. This is becoming evident in the literature.  This study looked at SNPS in the etiology of elevated cortisol and/or androstenedione.  They followed the results with saliva and found that 3 SNPS were associated with increased 11Beta-HSD1 activity and associated increased depression.
Nathan Goodyear

Effects of Peroxisome Proliferator-Activated Receptor-α and -γ Agonists on 11... - 0 views

jcem.endojournals.org/...1848.long

11-betaHSD1 PPAR agonist PPAR-alpha PPAR-gamma PPARs cortisol

shared by Nathan Goodyear on 08 Oct 13 - No Cached
  • Nathan Goodyear on 08 Oct 13
     
    PPAR alpha and/or PPAR gamma does not down regulate 11Beta-HSD1.
Nathan Goodyear

Increased whole-body and sustained liver cortisol r... [Diabetes. 2011] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...21266326

11-betaHSD1 adipose tissue obesity diabetes cortisol

shared by Nathan Goodyear on 08 Oct 13 - No Cached
  • Nathan Goodyear on 08 Oct 13
     
    Adipose 11Beta-HSD1 activity is increased in obese individuals with type II DM.  
Nathan Goodyear

Cambridge Journals Online - Proceedings of the Nutrition Society - Fulltext -... - 0 views

journals.cambridge.org/...displayFulltext

11-betaHSD1 metabolism obesity energy cortisol nutrition

shared by Nathan Goodyear on 08 Oct 13 - No Cached
  • Nathan Goodyear on 08 Oct 13
     
    Peripheral 11Beta-HSD1 plays critical role in fat metabolism and energy utilization.  Good discussion on the role that extra-adrenal 11Beta-HSD1 plays in metabolism
Nathan Goodyear

Resveratrol inhibits 11β-hydroxysteroid dehydrogenase type 1 activity in rat ... - 0 views

joe.endocrinology-journals.org/...X1.extract

Resveratrol 11-betaHSD1 hormone hormones

shared by Nathan Goodyear on 09 Dec 13 - No Cached
  • Nathan Goodyear on 09 Dec 13
     
    Resveratrol shown to inhibit 11beta-hydroxysteroid dehydrogenase I in rat study.
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