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Nathan Goodyear

Significance of serum ferritin as a prognostic factor in advanced hepatobiliary cancer ... - 0 views

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    Ferritin is increased as a byproduct of the inflammation, which studies suggest, are the result of TAMs. Some ferritin is also likely the result of release from cell death. L-ferritin is the most prevalent in cancer. Elevated ferritin is associated with a poor prognosis in many cancers. It also correlates with CRP, WBC in this study. 1 mg/ml of serum ferritin correlates to 8mg of stored Fe.
Nathan Goodyear

mTOR Signaling in Growth, Metabolism, and Disease - 0 views

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    Great read on MTOR signaling and its impact of tumorigenesis.
Nathan Goodyear

Alkaline phosphatase isoenzyme activities in rheumatoid arthritis: hepatobiliary enzyme... - 0 views

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    ALP fractionation isoenzyme study can provide deeper understanding of disease involvement.
Nathan Goodyear

Acidic extracellular microenvironment and cancer - 0 views

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    Cancer thrives in an acidic micro environment, which also limits penetration of the immune system and other therapies often used in the treatment of cancer.
Nathan Goodyear

IJMS | Free Full-Text | mTOR Signaling in Cancer and mTOR Inhibitors in Solid Tumor Tar... - 0 views

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    Incredible review on mTOR and carcinogenesis and promotion of cancer proliferation
Nathan Goodyear

Amino acid management in cancer - 0 views

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    Serine, glycine, glutamine, glutamate, asparagine upregulated in cancer. Most glutamine is converted to glutamate to drive alpha-ketoglutarate production to drive energy production. It also upregulates mTOR signaling.
Nathan Goodyear

Protein Restriction, Epigenetic Diet, Intermittent Fasting as New Approaches for Preven... - 0 views

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    Calorie restriction and protein restriction inhibit IGF-1, insulin, AkT, PI3K, and mTOR. In addition, those with protein intake >20%, compared to 10%, was associated with a 4 fold increase in cancer death risk and a 75% increase in overall mortality. Protein restriction inhibits tumor growth, associated with a 30-70% reduction in IGF-1, reduced the accumulation of oxidized proteins. The restriction of tryptophan alone reduced inflammation.
Nathan Goodyear

Modulating the therapeutic response of tumours to dietary serine and glycine starvation... - 1 views

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    cell culture study finds that restriction of serine and glycine inhibit cancer proliferation
Nathan Goodyear

Branched-chain amino acid metabolism in cancer - 0 views

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    Branched-chain amino acids play role in cancer. Sugar is not the only player and glutamine is not the only amino acid involved.
Nathan Goodyear

Partial Thromboplastin Time - StatPearls - NCBI Bookshelf - 0 views

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    Good review of the PTT test
Nathan Goodyear

Influence of complications following immediate breast reconstruction on breast cancer r... - 0 views

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    Wound complications and infection increase breast cancer recurrence by 4.6 and 6.15 times respectively.
Nathan Goodyear

Intravenous Mistletoe Treatment in Integrative Cancer Care: A Qualitative Study Explori... - 0 views

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    Review on IV mistletoe
Nathan Goodyear

Hepatic safety of antibiotics used in primary care - 0 views

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    Nice review of antibiotics and their impact on the liver
Nathan Goodyear

A phase I study of niclosamide in combination with enzalutamide in men with castration-... - 0 views

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    Study finds no help with CRPC with niclosamide due to limited tolerability of dosing > 1500 mg
Nathan Goodyear

https://pdfs.semanticscholar.org/3f03/58787b2bfb3f9614df62f3c545e689fbccd4.pdf?_ga=2.15... - 0 views

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    Picibanil augments Dendritic cell activation and signaling.
Nathan Goodyear

Quercetin Suppresses Drug-Resistant Spheres via the p38 MAPK-Hsp27 Apoptotic Pathway in... - 0 views

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    Quercetin found to inhibit HSP27 expression
Nathan Goodyear

http://cancerres.aacrjournals.org/content/canres/54/18/4952.full.pdf - 0 views

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    Quercetin found to inhibit HSP70 intracellular aggregation thus increasing the effects of 42C hyperthermia induced apoptosis.
Nathan Goodyear

Quercetin and tamoxifen sensitize human melanoma cells to hyperthermia. - PubMed - NCBI - 1 views

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    Quercetin and tamoxifen were shown to reduce HSP27 expression when used in conjunction with severe hyperthermia (42.5 C)
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