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Nathan Goodyear

Leptin signaling and cancer chemoresistance: Perspectives - 0 views

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    Leptin and cancer
Nathan Goodyear

How I treat Langerhans cell histiocytosis | Blood Journal - 0 views

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    Langerhans cell histiocytosis
Nathan Goodyear

Human cytomegalovirus in high grade serous ovarian cancer possible implications for pat... - 0 views

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    CMV plays role in ovarian cancer. EBV, HPV have shown to play role in other cancers. The likely mechanism is via genetic incorporation of viral genome into the cancer genome.
Nathan Goodyear

The Endocannabinoid System and Sex Steroid Hormone-Dependent Cancers - 0 views

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    Endocannabinoids and cancer.
Nathan Goodyear

BPS Publications - 0 views

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    CBD and prostate cancer
Nathan Goodyear

In Vitro Anticancer Activity of Plant-Derived Cannabidiol on Prostate Cancer Cell Lines - 0 views

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    High CBD downregulates prostate CBD1, CBD2, chemosensitizes CSCs, suppressed cancer cell formation, down regulated IL-6 and IL-8, decreased PSA, and VEGF.
Nathan Goodyear

The role of cannabinoids in prostate cancer: Basic science perspective and potential cl... - 0 views

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    THC and prostate cancer
Nathan Goodyear

Evaluation of abnormal liver function tests | Postgraduate Medical Journal - 0 views

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    Nice review on liver function tests.
Nathan Goodyear

Thus, these opinions are not based on all the relevant research that is available and a... - 0 views

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    CD 57 cells infiltrating solid tumor microenvironment yields positive prognosis. Inverse relationship for Mets.
Nathan Goodyear

Regulation of nausea and vomiting by cannabinoids and the endocannabinoid system - 0 views

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    Great read on the use of CBD, THC in nausea/vomiting. Data in humans is lacking and most of the data is related to prescription drugs.
Nathan Goodyear

SVCT1 and SVCT2: key proteins for vitamin C uptake. - PubMed - NCBI - 0 views

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    Good review of sodium ascorbate co-transporters SVCT.
Nathan Goodyear

Exploring the basic science of prolapse meshes - 0 views

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    Mesh implantation, here in the vaginal area, increases both M1 and M2 maturation migration. M1 increases pro-inflammatory signaling and processes and M2 promotes remodeling/healing... Both increase, but M1 increases more than M2 proportionally. M2 can increase the bridge scaring that can occur as well as the potential for immune suppression and autoimmune/cancer implications
Nathan Goodyear

The Role of Macrophage Polarization in Infectious and Inflammatory Diseases - 0 views

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    Good read/discussion on the maturation process of M1, M2 and their interaction with the Th1 and Th2 signaling in infections and inflammation: think autoimmune disease, chronic disease, and cancer.
Nathan Goodyear

American Journal of Obstetrics & Gynecology Home Page - 0 views

  • M1 macrophages are characterized by the secretion of reactive oxygen species and proinflammatory cytokines and chemokines and can be identified via the cell surface marker CD86
  • M2 macrophages secrete growth factors and antiinflammatory immune modulators and can be identified by the cell surface marker CD206
  • an overzealous M2 response can also lead to excess tissue deposition and fibrosis
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  • Studies of similar meshes that are used in hernia repair have demonstrated that all polypropylene meshes induce a prolonged inflammatory response at the site of implantation
  • the long-term presence of activated inflammatory cells, such as macrophages at the mesh tissue interface, can impact negatively the ability of the mesh to function as intended.
  • All M1 proinflammatory and M2 proremodeling cytokines and chemokines were increased in mesh explants as compared with nonmesh tissue (Table 3Table 3), which indicated a robust, active, and ongoing host response to polypropylene long after implantation
  • Comparison of the ratio of the M2 proremodeling cytokines (IL-10+IL-4) with the M1 proinflammatory cytokines (TNF-α+IL-12p70) revealed a decrease in mesh explants as compared with controls (P = .003), which indicated a shift towards a proinflammatory profile.
  • Mesh explants contained a higher number of total cells/×200 field when compared with controls (682.46 ± 142.61 cells vs 441.63 ± 126.13 cells; P < .001) and a lower ratio of M2:M1 macrophages (0.260 ± 0.161 cells vs 1.772 ± 1.919; P = .001), which supported an ongoing proinflammatory response.
  • the host response was proportional to the amount of material in contact with the host
  • A persistent foreign body response was observed in mesh-tissue complexes that were excised from women who required surgical excision of mesh months to years after mesh implantation
  • The host response was characterized by a predominance of macrophages with an increase in both proinflammatory and proremodeling cytokines/chemokines along with increased tissue degradation, as evidenced by increased MMP-2 and -9
  • Mesh-tissue complexes removed for mesh exposure had increased pro–MMP-9 that indicated a proinflammatory and tissue destruction–type response
  • The presence of macrophages, elevated cytokines, chemokines, and MMPs in tissue-mesh complexes that were excised from patients with exposure or pain suggests that polypropylene mesh elicits an ongoing host inflammatory response
  • In the presence of a permanent foreign body, the implant is surrounded with a fibrotic capsule because it cannot be degraded
  • For hernia meshes, if the fibers are too close (<1 mm), the fibrotic response to neighboring fibers overlaps, or “bridges,” and results in “bridging fibrosis” or encapsulation of the mesh
  • Gynemesh PS has a highly unstable geometry when loaded that resulted in pore collapse and increasing stiffness of the product
  • mesh shrinkage (50-70%) has been described to occur after transvaginal insertion of prolapse meshes
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    Mesh and the abnormal immune response.
Nathan Goodyear

Chemotherapy Enhances Metastasis Formation via VEGFR-1-Expressing Endothelial Cells | C... - 0 views

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    Chemotherapy again found to increase metastasis in vitro and in vivo studies through the VEGF-1 expression
Nathan Goodyear

Specific chemotherapeutic agents induce metastatic behaviour through stromal- and tumou... - 0 views

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    paclitaxel and carboplatin accelerated lung metastasis in tumour-bearing mice.
Nathan Goodyear

Paclitaxel therapy promotes breast cancer metastasis in a TLR4-dependent manner - 0 views

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    Taxol can promote tumor metastasis through TLR4 mechanism.
Nathan Goodyear

Neoadjuvant chemotherapy induces breast cancer metastasis through a TMEM-mediated mecha... - 0 views

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    Study looked at tumor microenvironment of metastasis structures (TMEMs) involved in metastasis. It has also been shown that taxane-based chemotherapies promote tumor regrowth by inducing angiogenesis. In this study, the tumor growth was slowed with taxanes chemotherapies, but it increased TMEMs and thus metastatic potential.
Nathan Goodyear

Blocking IL1β Pathway Following Paclitaxel Chemotherapy Slightly Inhibits Pri... - 0 views

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    IL1β levels are elevated in response to paclitaxel chemotherapy which is pro-metastatic.
Nathan Goodyear

The HK2 Dependent "Warburg Effect" and Mitochondrial Oxidative Phosphorylation in Cance... - 0 views

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    biochemistry strikes again: hexokinase 2 shown to be key step in cancer proliferation, energy metabolism and mortality. 3BP shown to be a potent glycolytic inhibitor and in animal studies shown to have significant mortality effects on cancer. Also, great review of cancer cell metabolism i.e Warburg effect, Crabtree effect, LDH, PD, PDK...
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