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Nathan Goodyear

HIF-1-mediated metabolic reprogramming reduces ROS levels and facilitates the metastati... - 0 views

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    HIF-1alpha and ROS relationship in cancer
Nathan Goodyear

The redox biology network in cancer pathophysiology and therapeutics - 0 views

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    Another nice review of the importance of redox in the tumor microenvironment
Nathan Goodyear

[Artesunate combined with vinorelbine plus cisplatin in treatment of advanced non-small... - 0 views

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    Artesunate augments cisplatin and navelbine.
Nathan Goodyear

http://ascopubs.org/doi/full/10.1200/JCO.2010.34.0026?url_ver=Z39.88-2003&rfr_id=ori%3A... - 0 views

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    CTC via cell search does not detect all CTCs; Not all people with cancer have CTCs; and not all CTCs lead to metastatic disease.
Nathan Goodyear

Clinical and biological significance of circulating tumor cells in cancer - 0 views

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    circulating tumor cells
Nathan Goodyear

An Oncolytic Virus Expressing a T-cell Engager Simultaneously Targets Cancer and Immuno... - 0 views

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    Oncolytic adenovirus kills cancer cell and activates Tcells.
Nathan Goodyear

https://onlinelibrary.wiley.com/doi/pdf/10.1111/bju.13554 - 0 views

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    Good brief review of the evidence of the psa flare
Nathan Goodyear

Prostate-specific antigen flare induced by cabazitaxel-based chemotherapy in patients w... - 0 views

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    Taxanes associated with PSA flare. The authors concluded that the flar within 12 weeks of therapy was not associated with any change in outcomes and could be ignored. The Taxanes as a whole group appears to be associated with this PSA flare pheonomenon.
Nathan Goodyear

Co-introduction of a steroid with docetaxel chemotherapy for metastatic castration-resi... - 0 views

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    Corticoidsteroid found to be associated with docetaxol associated PSA flare.
Nathan Goodyear

Prostate-specific antigen flare phenomenon with docetaxel-based chemotherapy in patient... - 0 views

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    PSA flare is associated with docetaxol chemotherapy in men undergoing treat for prostate cancer.
Nathan Goodyear

What do people fear about cancer? A systematic review and meta‐synthesis of c... - 0 views

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    Fear and cancer.
Nathan Goodyear

Testosterone and prostate cancer: an historical perspective on a modern myth. - 0 views

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    No evidence exists that Testosterone levels correlate with prostate cancer.
Nathan Goodyear

O2*− and H2O2-Mediated Disruption of Fe Metabolism Causes the Differential Su... - 0 views

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    Great read and synopsis of the interaction between vitamin C and the altered redox balance in cancer cells. The process involves Fe in part. Ascorbate increases H2O2 which increases the label Fe pool.
Nathan Goodyear

ScienceDirect - 0 views

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    Great review of the redox system in cancer cells. Everybody focus' on the ROS, but forget about the RNS from NO. The current marketing pushes NO for CVD.
Nathan Goodyear

Redox Regulation in Cancer Stem Cells - 0 views

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    Redox reactions in cancer stem cells
Nathan Goodyear

Antagonism of glycolysis and reductive carboxylation of glutamine potentiates activity ... - 0 views

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    Nice article out of the UK finds low glucose environment and glycolysis inhibitors improve oncolytic viral therapies.
Nathan Goodyear

https://www.nature.com/articles/6603740.pdf?origin=ppub - 0 views

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    Zometa (a bisphosophate) plus doxycycline reduce bone metastasis tumor burden on breast cancer model.
Nathan Goodyear

Vitamin C physiology: the known and the unknown andGoldilocks - 0 views

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    Great review of the metabolism of vitamin C.
Nathan Goodyear

Ascorbate in pharmacologic concentrations selectively generates ascorbate radical and h... - 0 views

  • Proposed mechanism
  • The data show that pharmacologic ascorbate concentrations produced Asc•− selectively in extracellular fluid compared with blood and that H2O2 formation occurred when Asc•− concentrations were >100 nM in extracellular fluid.
  • These data validate the hypothesis that ascorbate is a prodrug for selective delivery of reactive species to the extravascular space
  • ...22 more annotations...
  • pharmacologic ascorbate as a prooxidant drug for therapeutic use.
  • Recently we reported that pharmacologic ascorbic acid concentrations produced H2O2 concentrations of ≥25 μM, causing cancer cell death in vitro
  • We found that H2O2 concentrations generated in vivo were those that caused cancer cell death in vitro
  • When ascorbate was given parenterally, Asc•−, the product of a loss of one electron from ascorbate, was detected preferentially in extracellular fluid compared with blood
  • Asc•− generation in extracellular fluid depended on the ascorbate dose and the resulting concentrations
  • With i.v. administration of ascorbate, Asc•− concentrations were as much as 12-fold greater in extracellular fluid compared to blood and approached 250 nM
  • In blood, such Asc•− concentrations were never produced and were always <50 nM
  • These data are all consistent with the hypothesis that pharmacologic ascorbate concentrations in vivo serve as a prodrug for selective delivery of H2O2 to the extracellular space
  • After oral ingestion, control of intracellular and extracellular ascorbate concentrations is mediated by three mechanisms: intestinal absorption, tissue transport, and renal reabsorption
  • intestinal absorption, or bioavailability, declines at doses >200 mg
    • Nathan Goodyear
       
      significant limitation of gut absorption of vitamin C--at 200 mg po.
  • corresponding to plasma concentrations of ≈60 μM
    • Nathan Goodyear
       
      equates to 0.06 mM.  Max blood levels found with po AA dosing has been 0.22 mM
  • at approximately this concentration, the ascorbate tissue transporter SVCT2 approaches Vmax, and tissues appear to be saturated
    • Nathan Goodyear
       
      SVCT2 Rc in gut reach max binding.
  • also at ≈60 μM, renal reabsorption approaches saturation, and excess ascorbate is excreted in urine
  • Parenteral administration bypasses tight control
  • When tight control is bypassed, H2O2 forms in the extracellular space
  • in vivo validation of ascorbate as a prodrug for selective H2O2 formation
  • Temporarily bypassing tight control with parenteral administration of ascorbate allows H2O2 to form in discrete time periods only, decreasing likelihood of harm, and provides a pharmacologic basis for therapeutic use of i.v. ascorbate
  • H2O2 formation results in selective cytotoxicity
  • Tumor cells are killed with exposure to H2O2 for ≤30 min
  • In vitro, killing is mediated by H2O2 rather than Asc•−
  • In addition to cancer treatment, another potential therapeutic use is for treatment of infections. H2O2 concentrations of 25–50 μM are bacteriostatic
  • virally infected cells may also be candidates
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    follow up invivo study to previous study from 2005.  Here, the authors prove their hypothesis that ascorbate is a prodrug for delivery of H2O2.
Nathan Goodyear

Ascorbic acid: Chemistry, biology and the treatment of cancer - 0 views

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    Nice review of the effects of vitamin C as a reducer of metals in cancer. This plays a role in the effects of vitamin C in cancer.
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