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Nathan Goodyear

Lifestyle changes in women with polycystic ovary syndrome. - PubMed - NCBI - 0 views

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    Cochran review of 6 studies of only 164 women found lifestyle interventions improved body composition, mostly fat loss, decreased the hyperandrogen status and improved insulin resistance in women with PCOS.
Nathan Goodyear

Dietary composition in the treatment of polycystic ovary syndrome: a systematic review ... - 0 views

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    Weight loss is the best positive effect for women with PCOS.  Higher fat and protein, with a lower carb diet benefited women with PCOS.  A low Glycemic index plan benefited women with PCOS.  
Nathan Goodyear

Neuroendocrine androgen action is a key extraovarian mediator in the development of pol... - 0 views

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    Androgen receptors in the brain may be key in metabolic effects found in PCOS
Nathan Goodyear

Intravenously administered vitamin C as cancer therapy: three cases - 0 views

  • peak plasma concentrations obtained intravenously are estimated to reach 14 000 μmol/L, and concentrations above 2000 μmol/L may persist for several hours
  • Emerging in vitro data show that extracellular ascorbic acid selectively kills some cancer but no normal cells by generating hydrogen peroxide
  • Death is mediated exclusively by extracellular ascorbate, at pharmacologic concentrations that can be achieved only by intravenous administration
  • ...6 more annotations...
  • Vitamin C may serve as a pro-drug for hydrogen peroxide delivery to extravascular tissues, but without the presence of hydrogen peroxide in blood
  • not all cancer cells were killed by ascorbic acid in vitro
  • Intravascular hemolysis was reported after massive vitamin C administration in people with glucose-6-phosphate dehydrogenase deficiency
  • Administration of high-dose vitamin C to patients with systemic iron overload may increase iron absorption and represents a contraindication
  • Ascorbic acid is metabolized to oxalate, and 2 cases of acute oxalate nephropathy were reported in patients with pre-existing renal insufficiency given massive intravenous doses of vitamin C
  • Rare cases of acute tumour hemorrhage and necrosis were reported in patients with advanced cancer within a few days of starting high-dose intravenous vitamin C therapy, although this was not independently verified by pathologic review
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    IV vitamin C associated with prolonged survival in 3 patients with different cancers.  Peak serum levels reached 14,000 micromol/L, which levels above the 1,000 micro mol/L (cancer cell cytotoxic threshold) were maintained for hours
Nathan Goodyear

Smoldering multiple myeloma | Blood Journal - 0 views

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    nice review of smoldering myeloma.
Nathan Goodyear

Striatal H3K27 Acetylation Linked to Glutamatergic Gene Dysregulation in Human Heroin A... - 0 views

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    Heroin use, and yes prescription opiate use, alters glutamate pathways.  Opiates change the brain.  
Nathan Goodyear

Effects of a Skin Neuropeptide (Substance P) on Cutaneous Microflora - 0 views

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    substance P from skin flora, i.e. bacillus cereus, implicated in skin disease like psoriasis, acne, rosacea...
Nathan Goodyear

The role of microorganisms in psoriasis. - PubMed - NCBI - 0 views

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    gut bacteria implicated in psoriasis
Nathan Goodyear

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2607638/pdf/jnma00404-0073.pdf - 0 views

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    gut bacteria implicated in psoriasis.
Nathan Goodyear

Bile Acid Metabolism and Signaling - 0 views

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    good review of bile acid metabolism
Nathan Goodyear

Resistance Training for Glycemic Control, Muscular Strength, and Lean Body Mass in Old ... - 0 views

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    8 weeks of resistance training in patients with sarcopenia and diabetes found to improve glycemic control
Nathan Goodyear

Effects of chronic celecoxib on testicular function in normal and lipopolysaccharide-tr... - 0 views

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    Animal study from '09 found that COX2 inhibitor blunted LPS decrease in testes weight, decrease in testicular interstitial fluid, and serum Testosterone.  The point here is that LPS, in this animal model, decreased gonadal weight and Testosterone production and the anti inflammatory, COX2, blunted that effect.
Nathan Goodyear

O2⋅− and H2O2-Mediated Disruption of Fe Metabolism Causes the Differential Su... - 0 views

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    IV vitamin C shown to have selective cytotoxicity, no surprise, on lung cancer and glioblastoma cells via H2O2, while at the same time safe to other cells.  
Nathan Goodyear

Selenium and L-carnitine reduce oxidative stress in the heart of rat induced by 2.45-GH... - 0 views

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    animal study finds high dose Carnitine plus selenium protects against oxidative stress of the heart.
Nathan Goodyear

Coenzyme Q10 supplementation reduces oxidative stress and increases antioxidant enzyme ... - 0 views

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    CoQ10 supplementation of 150 mg in individuals with CAD found to have increased catalase activity, increased SOD activity, an increased MDA levels.  This reduced oxidative stress, TC, and LDL levels.
Nathan Goodyear

Effect of selenium and Q10 on the cardiac biomarker NT-proBNP: Scandinavian Cardiovascu... - 0 views

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    4 year study finds that 200 mg CoQ10 and 200 mg Se reduced NT-proBNP and cardiovascular mortality.  
Nathan Goodyear

Bacterial Lipopolysaccharide-Induced Inflammation Compromises Testicular Function at Mu... - 0 views

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    animal study finds LPS, lipopolysaccharides, decreases Testosterone production at the level of the leydig cells in the testes.
Nathan Goodyear

Metabolic endotoxaemia related inflammation is associated with hypogonadism in overweig... - 0 views

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    Study finds that inflammation that is the result of obesity in men (IL-6) negatively effects the leading cell and Sertoli cells in men.  Testosterone levels in these men correlated significantly with lipopolysaccharide binding protein.  This points to a negative correlation b/t LPS metabolic endotoxemia and low Testosterone.  Could Testosterone merely be the result of an unhealthy diet and gut?
Nathan Goodyear

Substituting whole grains for refined grains in a 6-wk randomized trial has a modest ef... - 0 views

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    small study finds diet rich in whole grains compared to refined grains improves gut bacteria balance and immune system.  Maybe the key to optimal gut health is the diet?
Nathan Goodyear

Steam cooking significantly improves in vitro bile acid binding of collard greens, kale... - 0 views

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    steamed veggies aid acid function.
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