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Nathan Goodyear

Human gut microbiota in obesity and after gastric bypass - 0 views

dl-web.dropbox.com/...PNAS-2009-Zhang-0812600106.pdf

obesity weight loss inflammation metabolic endotoxemia bariatric surgery gastric bypass probiotics firmicutes gut flora microbiota

shared by Nathan Goodyear on 26 Jan 12 - No Cached
  • Nathan Goodyear on 26 Jan 12
     
    It is proposed that the balance of bacteria in the gut play a critical role in energy utilization and obesity. This study showed that bypass surgery altered the gut bacteria to favor weight loss: decrease in firmicutes species. But, do we really need gastric bypass to do that? Of course not. Probiotics will do the same.
indiacardiacsurg

Totally Endoscopic Arterial Bypass Surgery (TECAB) Method Used by Dr. Naresh Trehan - 0 views

www.briefingwire.com/...ethod-used-by-dr-naresh-trehan

Dr. Naresh Trehan Dr.Trehan Cardiac Surgeon in Medanta Gurgaon Delhi Medanta Gurgaon Delhi

shared by indiacardiacsurg on 22 Feb 22 - No Cached
  • indiacardiacsurg on 22 Feb 22
     
    Dr. Naresh Trehan is the best in India offering specialized endoscopic surgery. Dr. Naresh Trehan accomplished the TECAB surgeries-a single bypass and a double bypass-through 4 keyholes (fingertip-size) incisions less than one centimeter long.
Nathan Goodyear

Gut microbiota after gastric bypass in human obesity: increased richness and associatio... - 0 views

ajcn.nutrition.org/...16.abstract

gastric bypass obesity gut microbiota microbiota inflammation WAT white adipose tissue dysbiosis gut

shared by Nathan Goodyear on 26 Jun 13 - No Cached
  • Nathan Goodyear on 26 Jun 13
     
    Not that I am proposing gastric bypass for weight loss.  IN my mind that is like a lobotomy for headache.  But, this study shows the link between gut bacteria and obesity.  This study documented an increase in the expression of certain bacteria types in the gut.   This was associated with increase in white adipose tissue gene expression.  Linking directly the gut and fat.
Nathan Goodyear

Variation in the 4q25 Chromosomal Locus Predicts Atrial Fibrillation After Coronary Art... - 0 views

circgenetics.ahajournals.org/...499.full

SNP AF atrial fibrillation coronary artery bypass cardiovascular disease 4q25

shared by Nathan Goodyear on 12 Sep 12 - No Cached
  • Nathan Goodyear on 12 Sep 12
     
    SNP in 4q25 associated with increased Atrial fibrillation post coronary artery bypass.
Nathan Goodyear

Gastric Bypass Surgery for Morbid Obesity Leads to an Increase in Bone Turnover and a D... - 0 views

jcem.endojournals.org/...1061

bypass gastric obesity surgery side effects bone loss

shared by Nathan Goodyear on 21 Mar 11 - No Cached
  • Nathan Goodyear on 21 Mar 11
     
    Gastric Bypass leads to bone loss; through malabsorption
Nathan Goodyear

Obesity Surgery, Volume 14, Number 2 - SpringerLink - 0 views

www.springerlink.com/...825740k3r2735308

Vitamin B B vitamins vitamin gastric bypass neuropathy peripheral neuropathy Bariatric surgery obesity

shared by Nathan Goodyear on 26 Jun 12 - No Cached
  • Nathan Goodyear on 26 Jun 12
     
    B vitamin deficiency following gastric bypass resulting in neuropathy.
Nathan Goodyear

Copper deficiency after gastric surgery: a reason ... [Am J Med Sci. 2009] - PubMed result - 0 views

www.ncbi.nlm.nih.gov/...19365170

deficiency copper gastric bypass

shared by Nathan Goodyear on 25 Jan 11 - No Cached
  • Nathan Goodyear on 25 Jan 11
     
    Copper deficiency present in gastric bypass patients: results in physiologic dysfunction in neurotransmitter synthesis
Nathan Goodyear

Impact of gastric bypass operation on survival: A population-based analysis - 0 views

www.journalacs.org/...abstract

gastric bypass impact weight loss obesity

shared by Nathan Goodyear on 11 May 11 - No Cached
  • Thirty-day mortality after gastric bypass is higher than previously reported and closely linked to surgeon inexperience
  • Nathan Goodyear on 11 May 11
     
    Understand: surgery is surgery.  The death rate from weight loss surgeries is higher than reported as this large study shows.  Another thought: what are the long-term health implications.  I can tell you from the clients that I see, it is not good
Nathan Goodyear

Ascorbate in pharmacologic concentrations selectively generates ascorbate radical and h... - 0 views

www.ncbi.nlm.nih.gov/...PMC1885574

vitamin C ascorbic acid Cancer

shared by Nathan Goodyear on 05 Mar 18 - No Cached
  • Proposed mechanism
  • The data show that pharmacologic ascorbate concentrations produced Asc•− selectively in extracellular fluid compared with blood and that H2O2 formation occurred when Asc•− concentrations were >100 nM in extracellular fluid.
  • These data validate the hypothesis that ascorbate is a prodrug for selective delivery of reactive species to the extravascular space
  • ...22 more annotations...
  • pharmacologic ascorbate as a prooxidant drug for therapeutic use.
  • Recently we reported that pharmacologic ascorbic acid concentrations produced H2O2 concentrations of ≥25 μM, causing cancer cell death in vitro
  • We found that H2O2 concentrations generated in vivo were those that caused cancer cell death in vitro
  • When ascorbate was given parenterally, Asc•−, the product of a loss of one electron from ascorbate, was detected preferentially in extracellular fluid compared with blood
  • Asc•− generation in extracellular fluid depended on the ascorbate dose and the resulting concentrations
  • With i.v. administration of ascorbate, Asc•− concentrations were as much as 12-fold greater in extracellular fluid compared to blood and approached 250 nM
  • In blood, such Asc•− concentrations were never produced and were always <50 nM
  • These data are all consistent with the hypothesis that pharmacologic ascorbate concentrations in vivo serve as a prodrug for selective delivery of H2O2 to the extracellular space
  • After oral ingestion, control of intracellular and extracellular ascorbate concentrations is mediated by three mechanisms: intestinal absorption, tissue transport, and renal reabsorption
  • intestinal absorption, or bioavailability, declines at doses >200 mg
    • Nathan Goodyear
      Nathan Goodyear on 05 Mar 18
       
      significant limitation of gut absorption of vitamin C--at 200 mg po.
  • corresponding to plasma concentrations of ≈60 μM
    • Nathan Goodyear
      Nathan Goodyear on 05 Mar 18
       
      equates to 0.06 mM.  Max blood levels found with po AA dosing has been 0.22 mM
  • at approximately this concentration, the ascorbate tissue transporter SVCT2 approaches Vmax, and tissues appear to be saturated
    • Nathan Goodyear
      Nathan Goodyear on 05 Mar 18
       
      SVCT2 Rc in gut reach max binding.
  • also at ≈60 μM, renal reabsorption approaches saturation, and excess ascorbate is excreted in urine
  • Parenteral administration bypasses tight control
  • When tight control is bypassed, H2O2 forms in the extracellular space
  • in vivo validation of ascorbate as a prodrug for selective H2O2 formation
  • Temporarily bypassing tight control with parenteral administration of ascorbate allows H2O2 to form in discrete time periods only, decreasing likelihood of harm, and provides a pharmacologic basis for therapeutic use of i.v. ascorbate
  • H2O2 formation results in selective cytotoxicity
  • Tumor cells are killed with exposure to H2O2 for ≤30 min
  • In vitro, killing is mediated by H2O2 rather than Asc•−
  • In addition to cancer treatment, another potential therapeutic use is for treatment of infections. H2O2 concentrations of 25–50 μM are bacteriostatic
  • virally infected cells may also be candidates
  • Nathan Goodyear on 05 Mar 18
     
    follow up invivo study to previous study from 2005.  Here, the authors prove their hypothesis that ascorbate is a prodrug for delivery of H2O2.
Nathan Goodyear

British Journal of Cancer - Role of glucose and ketone bodies in the metabolic control ... - 0 views

www.nature.com/...6601269a.html

glucose ketones cancer ketogenic diet ketogenic diet nutrition brain

shared by Nathan Goodyear on 03 Jul 13 - No Cached
  • Nathan Goodyear on 03 Jul 13
     
    Use of ketones to bypass the use of cancer cells of glucose as fuel.  This, selects out healthy cells and their adaptive metabolism versus the unadaptable metabolism of cancer cells.  
Nathan Goodyear

Nutrition & Metabolism | Full text | Targeting energy metabolism in brain cancer: revie... - 0 views

www.nutritionandmetabolism.com/...30

nutrition ketogenic diet ketogenic diet brain cancer

shared by Nathan Goodyear on 03 Jul 13 - Cached
  • Nathan Goodyear on 03 Jul 13
     
    Good review of the normal brain metabolism and then the benefits of the ketogenic diet to bypass glucose as the source of energy in states of cancer.
Nathan Goodyear

Intermediary metabolism of fructose. - 0 views

ajcn.nutrition.org/...754S.full.pdf+html

fructose metabolism

shared by Nathan Goodyear on 19 Sep 13 - No Cached
  • Nathan Goodyear on 19 Sep 13
     
    Good review on the metabolism of fructose.  Fructose is able to bypass the key regulatory step in glycolysis and promote Triglyceride synthesis without any negative feedback.
Nathan Goodyear

Fructose: A Key Factor in the Development of Metabolic Syndrome and Hypertension - 0 views

www.ncbi.nlm.nih.gov/...PMC3677638

fructose phosphofructokinase MetS metabolic syndrome metabolic syndrome insulin resistance ATP mitochondria uric acid

shared by Nathan Goodyear on 01 Oct 13 - No Cached
  • Nathan Goodyear on 01 Oct 13
     
    Fructose intake increases MetS and hypertension.  The high fructose intake upregulates phosphofructokinase which increases triglyceride production, bypassing central regulation.  This results in ATP depletion with reduced capacity to recover.  Thus attempts by the cells to increase ATP through AMP deaminase results in uric acid production.
Nathan Goodyear

Free triiodothyronine: a novel predictor of postoperative atrial fibrillation -- Cerill... - 0 views

ejcts.ctsnetjournals.org/...487

triiodothyronine free T3 atrial fibrillation CABG cardiovascular disease

shared by Nathan Goodyear on 01 Feb 11 - No Cached
  • Nathan Goodyear on 01 Feb 11
     
    Conclusions: Low basal fT3 concentration can reliably predict the occurrence of postoperative Atrial Fibrillation in Coronary-bypass patients
Nathan Goodyear

Plasma Ghrelin Levels after Diet-Induced Weight Loss or Gastric Bypass Surgery - NEJM - 0 views

www.nejm.org/...NEJMoa012908

diet weight loss overweight weight-loss surgery ghrelin bypass

shared by Nathan Goodyear on 26 Oct 11 - No Cached
  • Nathan Goodyear on 26 Oct 11
     
    "diets" and weight-loss surgery effect ghrelin diferently
Nathan Goodyear

Inhibition of tumor angiogenesis as a strategy to circumvent acquired resista... - 0 views

onlinelibrary.wiley.com/...bies.950130106

chemotherapy angiogenesis

shared by Nathan Goodyear on 25 Sep 20 - No Cached
  • Nathan Goodyear on 25 Sep 20
     
    Even with cancer chemoresistance to chemo, the move to inhibit angiogenesis i.e. via lower dose, allows a bypass of the resistance to another means of action.
indian-health

Top 12 Cardiologists in Bangalore Leaders in the Treatment of Coronary Artery Disease - 0 views

www.briefingwire.com/...ent-of-coronary-artery-disease

best cardiologist in bangalore top 10 cardiologist in bangalore Top 12 Cardiologists in Bangalore top cardiologist in bangalore best heart hospital in bangalore cardiologist bangalore best heart specialist in bangalore heart specialist bangalore

shared by indian-health on 02 Mar 22 - No Cached
  • indian-health on 02 Mar 22
     
    Best cardiac surgery hospitals Bangalore recently received the coveted three-star rating from the Society of Thoracic Surgeons (STS) for its patient care and outcomes in isolated coronary artery bypass grafting (CABG) procedures.
indiacardiacsurg

High apoplexy Reduction with No-Touch Beating Heart Bypass Surgery - 0 views

www.briefingwire.com/...h-beating-heart-bypass-surgery

Dr. Naresh Trehan heart specialist India Best Cardiac Surgeon in Medanta Gurgaon Delhi Medanta Gurgaon Delhi

shared by indiacardiacsurg on 07 Feb 22 - No Cached
  • indiacardiacsurg on 07 Feb 22
     
    The no-touch beating heart technique completed "without aortic manipulation, at the same time as achieved best by a minority of surgeons, has an essential place within the risk patient undergoing CABG," commented Dr. Naresh Trehan heart specialist India. Email id: - nareshtrehan@indiacardiacsurgerysite.com Call: - +91-9370586696
indiacardiacsurg

Best CABG Surgeons in India - 0 views

youtube.com/...Jy00SGdBRzM

CABG surgeons in India Top CABG surgeons of India Best CABG surgeons India Top 10 CABG surgeons of India India's Best CABG surgeons

shared by indiacardiacsurg on 29 Mar 25 - No Cached
  • indiacardiacsurg on 29 Mar 25
     
    India is home to world-renowned cardiac surgeons specializing in Coronary Artery Bypass Grafting (CABG). Experts like
indiacardiacsurg

Which heart conditions can be treated with minimally invasive surgery? - 0 views

youtube.com/...6vU0KjJeJQM

Heart Surgery in Low Cost Best hospitals for minimally invasive cardiac india Affordable Top surgeons of

shared by indiacardiacsurg on 01 Mar 25 - No Cached
  • indiacardiacsurg on 01 Mar 25
     
    Minimally invasive heart surgery treats conditions like Mitral and Aortic Valve issues, Atrial seal defect (ASD), certain Coronary Artery Bypass cases, and tricuspid valve Repair. With smaller cuts and faster recovery, it's the future of heart care.
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