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Contents contributed and discussions participated by Nathan Goodyear

Nathan Goodyear

JAMA Network | JAMA Internal Medicine | Trends in Androgen Prescribing in the United St... - 0 views

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    Startling statistic--25% of men started on Testosterone therapy have had not diagnostic evaluation of Testosterone levels.
Nathan Goodyear

Early Thimerosal Exposure and Neuropsychological Outcomes at 7 to 10 Years - NEJM - 0 views

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    Increasing mercury exposure associated with increasing tics in children.
Nathan Goodyear

Late-Onset Hypogonadism and Mortality in Aging Men: The Journal of Clinical Endocrinolo... - 0 views

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    severe hypogonadism was associated with a 5 fold increase risk of cardiovascular mortality and all cause mortality in men ages 40-79 in European study.
Nathan Goodyear

Thyroid Function Within the Normal Range and the Risk of Depression: A Population-Based... - 0 views

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    Elderly individuals with the lowest normal TSH values were found to be associated with increased depressive symptoms.  These patients were clearly not hyperthyroid.  This fits with other data that points to increased inflammation and reduced TSH levels.  Increased inflammation is associated with increased depression.
Nathan Goodyear

Subclinical Hypothyroidism, Weight Change, and Body Composition in the Elderly: The Car... - 0 views

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    Study found no significant effect of subclinical hypothyroidism on weight in the elderly.  However, higher free T4 levels were associated with lower baseline weight and weight loss in women. TSH and free T3 were not. associated.
Nathan Goodyear

Effects of Testosterone and Growth Hormone on the Structural and Mechanical Properties ... - 0 views

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    IN men with low Testosterone, Testosterone therapy improved trabecular bone, but not cortical bone.  Growth hormone provided no additional benefit.  This study looked at men with panhypopituitarism.
Nathan Goodyear

Journal of Endocrinological Investigation - 0 views

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    Study found that men who carry cell phones in their pants for > 4 hours have increased sperm fragmentation.  
Nathan Goodyear

Fatigue and serum testosterone in obstructive ... [Clin Respir J. 2014] - PubMed - NCBI - 0 views

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    Severe sleep apnea associated with lower Testosterone levels and fatigue.  The low level of Testosterone was the only factor predictive of fatigue and reduced activity in sleep apnea.  This was only found in severe sleep apnea, not mild cases.
Nathan Goodyear

Impact of Low Testosterone on Response to Treatment ... [Urology. 2014] - Pub... - 0 views

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    Here is where science and particularly conclusions fail the public.  The authors conclusions are that tadalifl improves ED and sexual function irrespective of Testosterone levels.  However, the results say something different.  The group with normal Testosterone responded better versus the low Testosterone group.  This difference didn't reach statistical significance though.  This lack of statistical significance does not exclude the fact that there indeed was a difference.  The authors conlcusions take no part in reporting the whole truth, just that which supports their hypothesis. The diagnosis of low T in this study was < 300 ng/dl
Nathan Goodyear

Serum Testosterone Levels and Mortality in M... [Am J Kidney Dis. 2014] - PubMed - NCBI - 0 views

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    Not clear in its association here, but lower Testosterone was associated with increased mortality in men with chronic kidney disease not on dialysis.  This was found in the 2nd lowest quintile only.  What the authors did find was that diabetes and increasing BMI are were associated with increasing incidence of low T.  This studies definition of low Testosterone was <350 ng/dl.  This differs from other definitions.
Nathan Goodyear

Testosterone, thrombophilia, throm... [Blood Coagul Fibrinolysis. 2014] - PubMed - NCBI - 0 views

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    This study's conclusion is to evaluate clotting factor i.e. factor V leiden, Factor VIII, and prothrombin prior to giving Testosterone.  This small study found increased clotting in some men on Testosterone. The problem here is the dosing of Testosterone in these men was 50-160 mg.  Physiologic dosing is 5-10 mg.  The problem is doping.  One wonders if physiologic dosing was undertaken if any of the men in this study would develop clotting problems, even though they had undiagnosed hypercoagulabitliy.
Nathan Goodyear

Cytotoxic Effects of Klebsiella oxytoca Strains Isolated from Patients with Antibiotic-... - 0 views

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    Colitis as a result of K. oxytoca
Nathan Goodyear

Neonatal abstinence syndrome and associated health care... [JAMA. 2012] - PubMed - NCBI - 0 views

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    Very disturbing trend.  Study finds that opioid addicted infants are on a dramatic risk in the US.  This study looked at Neionatal abstinence syndrome from 2000 to 2009.  This follows the significant increase in maternal opioid prescription use.  We physicians must do better.  Patients must demand better.  This study just focused on hospital costs directly associated with the Neonatal period.  No cost estimates are evaluated for long-term care.
Nathan Goodyear

Association between sex hormone-binding glob... [Sao Paulo Med J. 2014] - PubMed - NCBI - 0 views

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    low levels of SHBG associated with increasing incidence of metabolic syndrome in men ages 40-70.
Nathan Goodyear

Effect of different seasonal strength trai... [Hormones (Athens). 2014] - PubMed - NCBI - 0 views

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    Increased strength training associated with increased Total Testosterone and 3-alpha androstane idol  levels in trained athletes.  This was not found in free Testosterone levels.
Nathan Goodyear

Access : Prognostic and predictive value of plasma testosterone levels in patients rece... - 0 views

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    Higher base-line Testosterone levels associated with longer overall survival in men with prostate cancer.  The comparison was 32.7 months with higher T levels versus 22.4 months with lower T levels.  Anemia was also a poor prognostic variable.  Whether exogenous Testosterone therapy will change this is still unclear, but the authors suggest that this should play a role in whether to use salvage hormone therapy.
Nathan Goodyear

High-dose vitamin D supplementation and measur... [Fertil Steril. 2014] - PubMed - NCBI - 0 views

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    No significant statistical significance was found with vitamin D therapy and insulin sensitivity.  However, improved outcomes were found in 2 hour insulin and 2 hour glucose levels after a 75 gram OGTT.
Nathan Goodyear

Access : Vitamin D intake, blood 25(OH)D levels, and breast cancer risk or mortality: a... - 0 views

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    Meta-analysis finds that low vitamin D is more associated with mortality in women with breast cancer than increased incidence.
Nathan Goodyear

Testosterone, aging and s... [Curr Opin Endocrinol Diabetes Obes. 2014] - PubMed - NCBI - 0 views

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    Another review study.  Low Testosterone is associated with increased CVD in men.  However, some studies have suggested an increase in CVD with men using exogenous Testosterone therapy.  Is Testosterone the cause of CVD in men?  Likely, low T is a
Nathan Goodyear

Testosterone and cardiova... [Curr Opin Endocrinol Diabetes Obes. 2014] - PubMed - NCBI - 0 views

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    Review of recent articles suggest increased risk of cardiovascular disease in men. The issue at hand is the cause is not being treated and thus the Testosterone is fuel on the metabolic fire and the doping dose that most men receive.
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