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Contents contributed and discussions participated by Nathan Goodyear

Nathan Goodyear

Long-Term Testosterone Treatment in Elderly Men wi... [J Sex Med. 2014] - PubMed - NCBI - 0 views

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    Testosterone therapy, undecanoate in this study, found to improve body weight, decrease waist circumference, BMI, lower Total Cholesterol, lower triglycerides, decrease fasting glucose, decrease HgbA1c, decrease blood pressure and increase HDL in men >59.  
Nathan Goodyear

Chronic Inflammation in Benign Prostate Tissue Is Associated with High-Grade Prostate C... - 0 views

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    Chronic prostattis in men associated with prostate cancer.  Even more concerning, is the increase in high Gleasons score prostate cancer.  This is no surprise as inflammation will increase aromatase activity in the prostate which will increase estrogen production which has been shown to be carcinogenic.
Nathan Goodyear

Triptolide inhibits colon-rectal cancer cells ... [Phytomedicine. 2012] - PubMed - NCBI - 0 views

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    Triptolide, active component of chinese herb thunder god vine, found to inhibit growth of cool-rectal cancer cells.
Nathan Goodyear

Triptolide inhibits ovarian cancer cell invasion by repression of matrix metalloprotein... - 0 views

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    Triptolide, a component of thunder god vine (Tripterygium wilfordii) found to counter ovarian cancer through decreased matrix metalloproteinase 7 and 19 as well as increasing E-cadherin. This effect reduces invasion and spread of cancer.
Nathan Goodyear

PLOS ONE: Triptolide Inhibits the Proliferation of Prostate Cancer Cells and Down-Regul... - 0 views

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    Thunder god vine, Tripterygium wilfordii, found to inhibit tumor growth.  This study specifically looked at prostate cancer cell lines.
Nathan Goodyear

Comparison of Tripterygium wilfordii Hook F with methotrexate in the treatment of activ... - 0 views

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    Thunder god vine found to equal the effects of methotrexate in the treatment of rheumatoid arthritis joint pain.
Nathan Goodyear

Performance of Massachusetts Male Aging Study (MM... [Aging Male. 2014] - PubMed - NCBI - 0 views

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    This study tried to see if questionnaires could replaced free Testosterone test to diagnosis hypogonadism.  The answer of course is no.  One needs both to properly assess a individual.
Nathan Goodyear

The relationship between ... [Curr Opin Endocrinol Diabetes Obes. 2014] - PubMed - NCBI - 0 views

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    Obstructive Sleep apnea (OSA)  is associated with low Testosterone levels in men.  This study found that Testosterone therapy not only did not improve OSA, but actually worsened OSA.
Nathan Goodyear

Laparoscopic sleeve gastrectomy im... [Chirurgia (Bucur). 2014 Mar-Apr] - PubMed - NCBI - 0 views

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    Weight loss has been shown to improve Testosterone levels in men.  This study finds that sleeve gastrectomy improves Testosterone.  This is a indirect effect.  
Nathan Goodyear

Sex steroids and cardiovascular disease - 0 views

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    Previously posted article.  The journal changed the URL
Nathan Goodyear

JAMA Network | JAMA Internal Medicine | Trends in Androgen Prescribing in the United St... - 0 views

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    Startling statistic--25% of men started on Testosterone therapy have had not diagnostic evaluation of Testosterone levels.
Nathan Goodyear

Early Thimerosal Exposure and Neuropsychological Outcomes at 7 to 10 Years - NEJM - 0 views

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    Increasing mercury exposure associated with increasing tics in children.
Nathan Goodyear

Late-Onset Hypogonadism and Mortality in Aging Men: The Journal of Clinical Endocrinolo... - 0 views

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    severe hypogonadism was associated with a 5 fold increase risk of cardiovascular mortality and all cause mortality in men ages 40-79 in European study.
Nathan Goodyear

Thyroid Function Within the Normal Range and the Risk of Depression: A Population-Based... - 0 views

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    Elderly individuals with the lowest normal TSH values were found to be associated with increased depressive symptoms.  These patients were clearly not hyperthyroid.  This fits with other data that points to increased inflammation and reduced TSH levels.  Increased inflammation is associated with increased depression.
Nathan Goodyear

Subclinical Hypothyroidism, Weight Change, and Body Composition in the Elderly: The Car... - 0 views

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    Study found no significant effect of subclinical hypothyroidism on weight in the elderly.  However, higher free T4 levels were associated with lower baseline weight and weight loss in women. TSH and free T3 were not. associated.
Nathan Goodyear

Effects of Testosterone and Growth Hormone on the Structural and Mechanical Properties ... - 0 views

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    IN men with low Testosterone, Testosterone therapy improved trabecular bone, but not cortical bone.  Growth hormone provided no additional benefit.  This study looked at men with panhypopituitarism.
Nathan Goodyear

Journal of Endocrinological Investigation - 0 views

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    Study found that men who carry cell phones in their pants for > 4 hours have increased sperm fragmentation.  
Nathan Goodyear

Fatigue and serum testosterone in obstructive ... [Clin Respir J. 2014] - PubMed - NCBI - 0 views

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    Severe sleep apnea associated with lower Testosterone levels and fatigue.  The low level of Testosterone was the only factor predictive of fatigue and reduced activity in sleep apnea.  This was only found in severe sleep apnea, not mild cases.
Nathan Goodyear

Impact of Low Testosterone on Response to Treatment ... [Urology. 2014] - Pub... - 0 views

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    Here is where science and particularly conclusions fail the public.  The authors conclusions are that tadalifl improves ED and sexual function irrespective of Testosterone levels.  However, the results say something different.  The group with normal Testosterone responded better versus the low Testosterone group.  This difference didn't reach statistical significance though.  This lack of statistical significance does not exclude the fact that there indeed was a difference.  The authors conlcusions take no part in reporting the whole truth, just that which supports their hypothesis. The diagnosis of low T in this study was < 300 ng/dl
Nathan Goodyear

Serum Testosterone Levels and Mortality in M... [Am J Kidney Dis. 2014] - PubMed - NCBI - 0 views

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    Not clear in its association here, but lower Testosterone was associated with increased mortality in men with chronic kidney disease not on dialysis.  This was found in the 2nd lowest quintile only.  What the authors did find was that diabetes and increasing BMI are were associated with increasing incidence of low T.  This studies definition of low Testosterone was <350 ng/dl.  This differs from other definitions.
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