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Home/ Seasons Wellness/ Contents contributed and discussions participated by Nathan Goodyear

Contents contributed and discussions participated by Nathan Goodyear

Nathan Goodyear

http://www.cyanotech.com/pdfs/bioastin/batl43.pdf - 0 views

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    study finds that 12 mg of astaxanthin lowered CRP in 8 week study
Nathan Goodyear

Astaxanthin decreased oxidative stress and inflammation and enhanced immune response in... - 0 views

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    astaxanthin reduced oxidative stress biomarker and inflammation in human study.
Nathan Goodyear

http://www.altmedrev.com/publications/16/4/355.pdf - 0 views

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    astaxanthin reduces oxidative stress and inflammation.
Nathan Goodyear

Systemic lupus erythematosus: sex hormones in male patients. - PubMed - NCBI - 0 views

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    more men with lupus have low Testosterone compared to controls in small study.
Nathan Goodyear

Profile of sex hormones in male patients with systemic lupus erythematosus. - PubMed - ... - 0 views

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    low Testosterone trends in some men with Lupus.  The authors conclude it may be causative in some men and not in others.
Nathan Goodyear

Sex hormones in male patients with systemic lupus erythematosus: a comparison with othe... - 0 views

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    low Testosterone found in men with Lupus; the authors conclude is is more associative with chronic disease.
Nathan Goodyear

http://onlinelibrary.wiley.com/store/10.1002/art.11105/asset/11105_ftp.pdf;jsessionid=4... - 0 views

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    good review of sex hormones and LUPUS; whether it is causative or not, sex hormones trends exist in LUPUS i.e. low DHEA in both sexes, low progesterone in women, and low Testosterone in women>men.
Nathan Goodyear

Exercise increases mitochondrial glutamate oxidation in the mouse cerebral cortex - App... - 0 views

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    exercise found to reduce glutamate excitotoxicity in mouse study.
Nathan Goodyear

Acute severe hypothyroidism is not associated with hyponatremia even with increased wat... - 0 views

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    study finds severe hypothyroidism that is abrupt is not associated with low sodium.
Nathan Goodyear

Hyponatremia and the Thyroid: Causality or Association? - 0 views

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    hypothyroidism and hyponatremia is a rare finding; more commonly associated with severe hypothyroidism.  Co-exisitng medical complications need to be considered.
Nathan Goodyear

JAMA Network | JAMA Oncology | Preventable Incidence and Mortality of Carcinoma Associa... - 0 views

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    Health lifestyle interventions reduce the incidence and mortality from cancer.
Nathan Goodyear

JAMA Network | JAMA Oncology | The Preventability of Cancer:  Stacking the Deck - 0 views

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    Lifestyle interventions to prevent cancer
Nathan Goodyear

IJMS | Free Full-Text | Defective Homocysteine Metabolism: Potential Implications for S... - 0 views

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    very nice review of homocysteine pathways.
Nathan Goodyear

Telomerase at the intersection of cancer and aging - 0 views

  • The anti-aging role of telomerase has been demonstrated to be largely mediated by its canonical role in elongating telomeres, which prevents the accumulation of critically short telomeres and loss of tissue homeostasis
  • Short telomeres, and subsequent DDR activation, could occur both in cancer and aging
  • increased abundance of short telomeres correlates with higher genomic instability and decreased longevity in various organisms, including mice, zebrafish, and yeast
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  • mice deficient for telomerase or for telomere binding proteins are characterized by accelerated age-related defects
  • In humans, short telomeres are considered good indicators of an individual’s health status and correlate with both genetic and environmental factors
  • Although recent findings strongly support the idea that short telomeres drive several age-related diseases we cannot exclude the possibility that in some situations short telomeres may be a consequence of the disease itself.
  • the current view is that telomerase deficiency may contribute to the early steps of cancer development by fueling chromosomal instability, while subsequent activation of telomerase may be necessary to allow tumor growth and tumor progression towards more malignant states
  • telomerase activation can be an early event in cancer, it is not necessary for cancer initiation
  • telomerase can stimulate tumor progression by ensuring maintenance of telomeres above a critically short length, thus preventing induction of cellular senescence or apoptosis
  • Almost all human cancers present activation of telomerase as a hallmark, most likely as a mechanism to allow unlimited cell proliferation of tumor cells
  • recent evidence demonstrated that short telomeres alone could lead to genomic instability and cancer
  • Getting rid of telomerase can also be problematic; the lack of telomerase could lead to increased chromosomal instability, which in turn could be at the basis for cancer initiation when tumor suppressor barriers are bypassed
  • telomerase activation is a potential therapeutic strategy for the treatment of age-related diseases
  • telomerase activation in adult or old mice by means of a gene therapy strategy was shown to be sufficient to improve metabolic fitness, neuromuscular capacity, and prevent bone loss, as well as significantly increase both median and maximum longevity, without increased cancer incidence
  • These studies suggest that telomerase expression could be considered a feasible approach to reverse tissue dysfunction and extend healthy lifespan without increasing cancer incidence
  • humans almost completely lose telomerase activity from somatic tissues in the adulthood
  • a change of paradigm seems to be occurring in telomerase biology, with a switch from viewing telomerase as fueling cancer to reversing aging
  • Telomerase expression in a background of high levels of tumor suppressors or in aged organisms seems to prevent its expected pro-cancer activity and yet it still functions as an anti-aging factor
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    Telomerase activity and longer telomere length is shown to correlated inversely with many chronic diseases of aging.  In contrast, telomerase activity is found to be involved in carcinogenesis.  Increased carcinogenic potential of telomerase activity has not borne out in studies.  In addition, increased CD8 cell activity as a result of telomerase activation will actually decrease carcinogenic potential via NK activation.
Nathan Goodyear

Automated Assay of Telomere Length Measurement and Informatics for 100,000 Subjects in ... - 0 views

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    epidemiological study finds that telomere length inversely correlated with longevity, especially in those > 75.  The sex differences was significant beyond the age of 50, with women having longer telomere lengths.
Nathan Goodyear

Telomerase reactivation reverses tissue degeneration in aged telomerase deficient mice - 0 views

  • age-progressive loss of telomere function in mice has been shown to provoke widespread p53 activation resulting in activation of cellular checkpoints of apoptosis, impaired proliferation and senescence, compromised tissue stem cell and progenitor function, marked tissue atrophy and physiological impairment in many organ systems
  • Despite chromosomal instability, the brief course of telomerase reactivation was not sufficient to promote carcinogenesis (data not shown), a finding consistent with a role for telomerase in promoting progression of established neoplasms
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    another mouse study that found that increasing telomerase activity in shortened telomere mice improved tissue regeneration.
Nathan Goodyear

Extranuclear Actions of the Androgen Receptor Enhance Glucose-Stimulated Insulin Secret... - 0 views

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    only abstract available here. Mouse model finds possible explanation for low Testosterone and diabetes link.  Actually, the link is between the metabolite DHT and the AR. The activity of AR from DHT binding induces beta cell insulin secretion in the presence of glucose.  This is dependent on glucagon-like peptide 1 receptor activation also, which AR activation by DHT does in fact do.
Nathan Goodyear

JCI - Hotspot autoimmune T cell receptor binding underlies pathogen and insulin peptide... - 0 views

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    Type I diabetes can be caused by Tcell autoimmunity against beta cells induced by gut flora and MCH/TCR cross reactivity.
Nathan Goodyear

Delayed Neuroendocrine Sexual Maturation in Female Rats After a Very Low Dose of Bisphe... - 0 views

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    low dose of BPA in rat model finds delayed sexual maturation.
Nathan Goodyear

Subcutaneous Testosterone: An Effective Delivery Mechanism for Masculinizing Young Tran... - 0 views

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    This post is only on the concept of subcutaneous Testosterone as an effective alternative to IM.
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