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Contents contributed and discussions participated by Nathan Goodyear

Nathan Goodyear

Dihydrotestosterone is a peripheral paracrine hormone. - PubMed - NCBI - 0 views

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    DHT is a paracrine hormone.  The most bioactive metabolite is 3-alpha-androstanediol.
Nathan Goodyear

Anemia in cancer - 0 views

  • Anemia is a frequent finding in cancer patients, occurring in >40% of cases
  • chemotherapy, the incidence of anemia may rise to 90%
  • Anemia exerts a negative influence on the quality of life
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  • Anemia has also been identified as an adverse prognostic factor
  • mild (10 g/dl—normal), moderate (8–10 g/dl), severe (6.5–8 g/dl) and life threatening (<6.5 g/dl or unstable patient) anemia
  • anemia in cancer patients is often multifactorial.
  • Cancer itself can directly cause or exacerbate anemia either by suppressing hematopoiesis through bone marrow infiltration or production of cytokines that lead to iron sequestration, or by reduced red blood cell production
  • in inflammatory anemia, iron deficiency should be defined by a low transferrin saturation of <20%, ferritin levels of <100 ng/ml and a low reticulocyte hemoglobin concentration of <32 pg
  • anemia to thrombocytosis, as commonly seen in cancer patients
  • TNF-α inhibits hemoglobin production
  • treatment itself may be a major cause of anemia
  • Other cytokines, such as interleukin-6 (IL-6), IL-1 and interferon-γ, have also been shown to inhibit erythroid precursors in vitro [9], albeit to a lesser extent
  • In inflammation, from whatever cause, IL-6 induces the liver to produce hepcidin. Hepcidin decreases iron absorption from the bowel and blocks iron utilization in the bone marrow
  • Numerous in vitro studies have illustrated the central role of TNF-α in the pathogenesis of anemia
  • nephrotoxic effects of particular cytotoxic agents such as platinum salts can also lead to the persistence of anemia through reduced Epo production by the kidney
  • Currently two options are at the disposal of the clinician for the treatment of anemia in cancer patients: transfusion of packed red blood cells and the use of erythropoiesis-stimulating agents (ESAs)
  • The goal of the treatment is to relieve the symptoms of anemia such as fatigue and dyspnea.
  • Transfusion of 1 unit of packed red blood cells has been estimated to result in an increase in the hemoglobin level of 1 g/dl in a normal-sized adult
  • a higher mortality rate in patients receiving ESA treatment
  • Recent concerns regarding the risk of thromboembolism in patients treated with ESA have been corroborated by the meta-analyses conducted by Tonnelli and Bennett
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    Great review of anemia in Cancer: 
    1)  blood loss
    2)  increased RBC loss
    3)   decreased RBC production

    Cancer infiltration of marrow can reduce hematopoiesis.  Inflammatory cytokines can reduce hematopoiesis.  Inflammatory cytokines can block Fe absorption.  Chemo and radiation can cause anemia--particularily platinum based therapies.
Nathan Goodyear

The relationship of pretreatment serum hemoglobin level to the survival of epithelial o... - 0 views

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    anemia associated with aggressive cancer and thus poor prognosis.
Nathan Goodyear

The importance of hemoglobin levels during radiotherapy for carcinoma of the cervix - G... - 0 views

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    Prognosis in cancer is reduced with anemia.  This study found a resolution with transfusion.
Nathan Goodyear

Anemia as an independent prognostic factor for survival in patients with cancer - Caro ... - 0 views

  • Anemia is common in cancer patients,1, 20 and it has been associated with lower survival
  • median survival was reduced by 20–43%
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    anemia is a poor prognostic biomarker in cancer.  But is it simply a biomarker of more advanced disease and thus merely the result of poor health?
Nathan Goodyear

Hormones.gr - 0 views

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    Nice review of the impact of exercise on cortisol and catecholeamines.
Nathan Goodyear

Non-Soy Legume Consumption Lowers Cholesterol Levels: A Meta-Analysis of Randomized Con... - 0 views

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    Legumes associated with lower cholesterol
Nathan Goodyear

Cruciferous Vegetables and Human Cancer Risk: Epidemiologic Evidence and Mechanistic Basis - 0 views

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    Cruciferous vegetables do appear to provide a means to attack Cancer risk.  In part through they are rich sources of DIM and I3C.
Nathan Goodyear

Edit Post ‹ Seasons Wellness | Seasons of Farragut - WordPress - 0 views

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    green, leafy vegetables decrease risk of diabetes.
Nathan Goodyear

Changes in Thymidine Kinase and α-Amylase Activity during Isoproterenol-stimu... - 0 views

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    salivary TK-1 increased in response to stimulated increased DNA synthesis in mouse model.
Nathan Goodyear

http://www.ccsenet.org/journal/index.php/cco/article/viewFile/26281/16499 - 0 views

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    another thumbs up for TK-1.  This finds serum and tumor TK-1 differentiate from normal, healthy tissue.
Nathan Goodyear

High-Intensity Intermittent Exercise and Fat Loss - 0 views

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    Nice review of the physiologic response to High-intensity intermittent exercise (HIIT).  HIIT is associated with increased catecholamines, cortisol, and HGH.
Nathan Goodyear

Estrogen and brain-derived neurotrophic factor (BDNF) in hippocampus: complexity of ste... - 0 views

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    Estrogen effects in the hippocampus with BDNF (surprise, surprise) appear to have different effects between the sexes.
Nathan Goodyear

What Happens to Your Brain on Sugar, Explained by Science - Mic - 0 views

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    This is your brain on drugs, sorry I meant sugar.
Nathan Goodyear

BMC Neuroscience | Full text | The effect of adolescent testosterone on hippocampal BDN... - 0 views

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    study finds that BDNF is more associated with cell proliferation and neurogenesis with normal circulating Testosterone levels.  
Nathan Goodyear

An inverse relationship between cortisol and BDNF levels in schizophrenia: data from hu... - 0 views

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    Elevated Cortisol found to have inverse association with BDNF.
Nathan Goodyear

JAMA Network | JAMA Pediatrics | Physical Activity and Performance at School:... - 0 views

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    literature review finds evidence that higher physical activity is associated with increased academic performance at school, though data is limited.
Nathan Goodyear

Dopamine-based reward circuitry responsivity, genetics, and overeating. - PubMed - NCBI - 0 views

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    low dopamine Rc associated appears to increase addiction to sugar and its positive effect on these same receptors (and another that positively interacts with dopamine Rc's) and results in overeating and weight problems.
Nathan Goodyear

High Testosterone in Women Linked with Insulin Resistance and CVD - 0 views

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    High Testosterone in women associated with increased insulin resistance.
Nathan Goodyear

Berberine Improves Insulin Sensitivity by Inhibiting Fat Store and Adjusting Adipokines... - 0 views

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    Berberine reduced BMI, improved insulin sensitivity, improved leptin sensitivity, and improved leptin:adiponectin ratio levels in people with metabolic syndrome after 3 months.
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