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Contents contributed and discussions participated by Nathan Goodyear

Nathan Goodyear

Calcium plus vitamin D supplementation influences biomarkers of inflammation and oxidat... - 0 views

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    Vitamin D plus calcium found to reduce inflammation and oxidative stress in women with PCOS.  CRP and MDA were decreased.  Notice dosing.
Nathan Goodyear

Subclinical Hypothyroidism and the Risk of Stroke Events and Fatal Stroke: An Individua... - 0 views

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    TSH positively associated with increase stroke in those adults less than 65.
Nathan Goodyear

Gut-brain link grabs neuroscientists : Nature News & Comment - 0 views

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    Gut-brain connection via gut microbiome starts to move mainstream.
Nathan Goodyear

Relationships between diet-related changes in the gut microbiome and cognitive flexibility - 0 views

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    High dietary sugar intake alters gut bacteria (increased Clostridia sp. and decrease Bacteroidetes sp).  This resulted in decreased memory learning and memory in rat study.  
Nathan Goodyear

Chronic Inflammation and Cytokines in the Tumor Microenvironment - 0 views

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    Acute inflammation is a response to an alteration induced by a pathogen or a physical or chemical insult, which functions to eliminate the source of the damage and restore homeostasis to the affected tissue. However, chronic inflammation triggers cellular events that can promote malignant transformation of cells and carcinogenesis. Several inflammatory mediators, such as TNF-α, IL-6, TGF-β, and IL-10, have been shown to participate in both the initiation and progression of cancer. In this review, we explore the role of these cytokines in important events of carcinogenesis, such as their capacity to generate reactive oxygen and nitrogen species, their potential mutagenic effect, and their involvement in mechanisms for epithelial mesenchymal transition, angiogenesis, and metastasis. Finally, we will provide an in-depth analysis of the participation of these cytokines in two types of cancer attributable to chronic inflammatory disease: colitis-associated colorectal cancer and cholangiocarcinoma.
Nathan Goodyear

Individual diet has sex-dependent effects on vertebrate gut microbiota : Nature Communi... - 0 views

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    Sex difference of gut flora has different metabolic effects from the same diet.  Could it all begin in the get?  Are gut flora sexist?  Of course not, but this study highlights the sex difference of the gut flora and the gender different effects.
Nathan Goodyear

Gender Bias in Autoimmunity Is Influenced by Microbiota - 0 views

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    autoimmune disease sexual preference appears to have Gut origins.
Nathan Goodyear

Association between serum total testosterone and Body Mass Index in middle aged healthy... - 0 views

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    Study finds low total Testosterone significantly associated with increased BMI in university employees. The definition of low T in this study was 280 ng/dl.
Nathan Goodyear

5B.06: ASSOCIATION OF PLASMA TESTOSTERONE WITH CENTRAL HAEMODYNAMICS IN HYPERTENSIVE ME... - 0 views

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    low total Testosterone is associated with increased central blood pressure elevation.  Less association was found with peripheral blood pressure.
Nathan Goodyear

Estrogens and Their Genotoxic Metabolites Are Increased in Obese Prepubertal Girls: The... - 0 views

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    Obesity in young girls increases Estradiol production compared to thin young girls.  Obesity increased  the Estrogen metabolite 16lpha-OH-E1  and this positively correlated with IL-6. 
Nathan Goodyear

Low testosterone level is an independent risk factor for high-grade prostate cancer det... - 0 views

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    low Testosterone is associated with increased risk of high grade prostate cancer at time of biopsy compared to normal Testosterone.
Nathan Goodyear

Thieme E-Journals - International Journal of Sports Medicine / Abstract - 0 views

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    Ultra endurance athletic events associated with significant increase in systemic inflammation due to damaged gut.
Nathan Goodyear

A dose-response study of consuming high-fructose corn syrup-sweetened beverages on lipi... - 0 views

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    HFCS increase biomarkers of cardiovascular disease.
Nathan Goodyear

Testosterone regulation of homocysteine metabolism modulates redox status in human pros... - 0 views

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    in disease prostate, Testosterone down regulates transulfuration pathway and glutathione production.
Nathan Goodyear

Salivary Testosterone and a Trinucleotide (CAG) Length Polymorphism in the Androgen Rec... - 0 views

  • Testosterone correlated inversely with participant age (r = −0.39, p = 0.012) and positively with number of CAG repeats
  • transactivation potential of the AR appears to decline in graded relation to an increasing number of CAG repeats, which are distributed over a normative range of 11–37 and, in Caucasian populations, commonly average 21–22 repeats
  • When activated by androgens, ARs translocate to the cell nucleus, where they exert transcriptional control of androgen-dependent genes by binding to androgen response elements within gene regulatory sequences
  • ...10 more annotations...
  • some evidence suggests a high number of CAG repeats may be associated with cognitive aging
  • androgens (like other steroid hormones) promote or repress the expression of genes specifying an array of cellular proteins
  • diurnal variation in testosterone levels
  • salivary testosterone correlated negatively with participant age and positively with CAG length variation in the AR gene
  • CAG repeat number varied inversely with reactivity of the ventral amygdala to facial expressions of negative affect
  • higher salivary testosterone was likewise associated with a greater number of AR CAG repeats
  • relative androgen insensitivity in ARs with a larger number of CAG repeats
  • Because circulating testosterone is regulated via negative feedback through the hypothalamic-pituitary-gonadal axis, diminished androgen sensitivity at higher CAG repeat lengths may reduce feedback suppression of luteinizing hormone (LH). LH would then be maintained at higher levels, in turn promoting higher testosterone production
  • Testosterone up-regulates AVP expression in the amygdala
  • Oxytocin exerts an inhibitory influence on AVP expression in the central amygdala, and the synthesis of oxytocin is mediated by estrogen and estrogen receptors
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    Study used saliva to measure Testosterone levels in men.  Testosterone levels were inversely associated with age, but positively associated with CAG repeat sequences in the AR.
Nathan Goodyear

Validation of Blood Spot Sampling for Gonadotropins and Ovarian Hormone Levels in Repro... - 0 views

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    blood spot Estradiol, Progesterone, LH, and FSH levels shown to be comparable to plasma levels.
Nathan Goodyear

Percutaneous progesterone delivery via cream or gel application in postmenopausal women... - 0 views

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    Topical hormones best evaluated via saliva and/or blood spot. Urine and particularly serum does not increase with dosing.  That does not mean the topical hormone therapy is ineffective, just that serum and urine are not optimal to follow topical therapy.  When looking at endogenous hormones without any therapies: serum, saliva, urine, and blood spot are equivalent.
Nathan Goodyear

Effects of endurance exercise on free testosterone concentration and the binding affini... - 0 views

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    exercise increases Testosterone production via catecholamine mechanism.  Free Testosterone increases independent from SHBG affinity.
Nathan Goodyear

Neuropsychopharmacology - Testosterone Suppression of CRH-Stimulated Cortisol in Men - 0 views

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    Testosterone inhibits CRH and thus cortisol.
Nathan Goodyear

Testosterone Suppression of CRH-stimulated Cortisol in Men - 0 views

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    Testosterone inhibits CRH and thus cortisol production in men.  This has implications in men with low T and low Cortisol.
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