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Different progesterone metabolites shown to have different tumor effects.  Implications are that, just as estrogen metabolism effects cancer risk, so does progesterone metabolism.

phosphocreatine helps to maintains muscular performance.  This appears to be an early benefit.  The question is does this help in prolonged performance requirements.

testosterone therapy does not increase prostate cancer.

The majority of people with PTHP after TBI remain undiagnosed.  The current thought, is that 25% of those with TBI have at least one pituitary hormone deficiency.  It does not have to be total pituitary failure.  Deficiencies can be isolated.

post-traumatic hypopituitarism is found in 40% of those with TBI.  The severity does correlate with the increased likelihood of developing PTHP.  Isolated deficiencies have been found in PTHP.

allopregnanolone increases human neural stem cells. Not only does allopregnanolone reduce inflammation, it plays a role in neurogenesis and thus recovery.

A very small study, but vitamin C shown to reduce fatigue, perception of fatigue and reduced heart rate.  This has implications in improving athletic performance.  The question, what does high dose vitamin C due for fatigue, heart rate, and athletic performance.

diagnostic accuracy again proven for salivary cortisol. So why does BCBS consider this experimental?  Maybe they just don't read research.

Is breast cancer a product of the environment?  Not totally, but the environment does play a role and the IOM discuss the current knowledge on the environment and breast cancer

good look of how the the gut health, or lack there of, can influence energy homeostasis and contribute to obesity.  This article points to the presence of LPS playing a role in metabolic endotoxemia.  It does discuss the importance of the microbiota and their possible role in the low-grade systemic inflammation condition that is obesity.

How does inflammation cause insulin resistance?  This in-depth paper helps to explain the current understanding.   More and more obesity is part of a growing inflammatory epidemic.

red wine does appear to have health benefits over white wine through aromatase inhibition.  Aromatase inhibition reduces estrogen levels.  So, if the breast cancer risk is associated with elevated estrogen, then this would logically reduce the risk.  The exact amount is unknown, but aromatase inhibition is a treatment of those with breast CA.

Oral vitamin C shown to reduce fast blood glucose, post meal blood glucose, and HgbA1C.  This study was down with metformin.  Vitamin C was used with metformin in those with type II DM.  This supports the use of vitamin C in blood sugar control.  Vitamin C does not increase blood glucose levels.

It is no surprise that hyperglycemia is associated with increased hospital stay and post operative infection.  I have seen this in my former population.  Especially in prolapse and incontinence surgeries (which I no longer perform).  However, what is interesting is that 1/3 of the non-diabetics are hyperglycemic.  The preparation of the individual has just as much to do with the successful outcome of the surgery as does the surgery itself.

Great review on dehydroepiandrosterone (DHEA): what it is, what it does, and the literature behind our current understanding.

The women's health initiative dietary modification trial of almost 50,000 women found no association between a low fat diet and a reduction of colorectal cancer.  Translation: a low fat diet does not lower the risk of colorectal cancer.

Rats that were sensitized to cocaine, preferred artificial sweeteners over that of cocaine. Think about that for a moment.  Does that redefine addiction?

LPS and minimal oxidized LDL have synergistic effects on inflammatory signaling.  Together the two promote inflammatory signaling from macrophages at much lower levels than either one alone.  They do this through macrophage NF-KappaB and AP-1 pathways.  And this resultant inflammation promotes atherosclerosis.  Where does all this start?  our diet and our gut.

nice review of natural therapies for scleroderma.  Life extensions always does a great job of supporting natural therapies with science.

Nice review of the mixed data on Testosterone and Prostate disease. It is clear that Testosterone does not precipitate prostate cancer.  The intraprostatic hormone milieu likely is different than that present in the serum.  No surprise there.  5alpha reductase decreases prostate volume, PSA, and low-grade prostate cancer, but actually increases aggressive prostate cancer. Supraphysiologic doping in young men associated with no increase in prostate disease. PSA no longer to be followed in men < 55.  Mortality rate not changed.  PSA change of 1.4 ng/ml is appropriate for additional prostate evaluation.  Testosterone therapy on average increased 0.5 ng/ml. Still, no mention of aromatase activity in this article.  Why is it that hormone sensitive disease in men is only with regards to androgens and women estrogen.