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It does appear that medicine is moving in the direction of a non-linear approach to disease.  This brief review discusses the early analysis of the relationship of psychiatric conditions, inflammation, and cardiovascular disease.

this study looked at salivary testosterone to serum testosterone and found poor correlation.  One major problem with this study is the significantly smaller amount (10 fold) of testosterone in women than men in healthy individuals.  This study took place in postmenopausal women, which would have significantly lower levels than healthy women.  They also don't discuss the pitfalls of equilibrium dialysis of serum free testosterone.  Another major flaw is the mere logic of looking at serum for tissue activity.   What is the correlation between serum levels and tissue activity.  There is tremendous assumptions being undertaken that serum levels of testosterone whether total or free translate to genomic or non-genomic signaling.  I also wonder if newer techniques using Mass Spec can better detect the typically pico levels of testosterone in women's saliva?  This study does nothing to dissuade the use of salivary testing.

only abstract available here. Mouse model finds possible explanation for low Testosterone and diabetes link.  Actually, the link is between the metabolite DHT and the AR. The activity of AR from DHT binding induces beta cell insulin secretion in the presence of glucose.  This is dependent on glucagon-like peptide 1 receptor activation also, which AR activation by DHT does in fact do.

flu vaccine does not prevent asthma exacerbations in those with asthma.

A revisit of the saturation model of Testosterone therapy and prostate cancer.  Review finds Testosterone therapy does not "appear to promote prostate cancer growth".  The saturation model is the thought around the AR.  At low concentrations, there is a greater sensitivity of Testosterone to AR binding at very low T levels; but above those very low T levels, prostate cancer becomes insensitive to the Testosterone.

new study concludes that hormone therapy does not improve skin aging.  Though I would like to see hormone levels evaluated to assure physiologic hormone levels were obtained to conclude this lack of relationship.

men with Testosterone <300 ng/dl with levels after 8 months of therapy achieving +680 ng/dl.

Chemo brain.  Does it exist?  Large study finds significant cognitive decline in follow up at 6 months in breast cancer patients treated with chemo compared to control group.

high prevalence of thyroid antibodies, TPO, in women with PCOS.  This does not prove cause and effect, merely an association.  Both are inflammation driven.

multivitamins associated with a decreased risk of major CVD events in 20 prospective study.  This is likely a component of a healthy lifestyle, but still shows that MVA use does have positive effects over all long duration.

new study finds that men >65 with low libido and Testosterone levels < 275 increase sexual function with Testosterone therapy.  Only libido was improved; no benefit to erectile function was noted--note that is likely due to depleted NO.  Given time that should improve with he increase in NO synthase and thus NO.  I have a fault with on elf the comments on this study: they point out that increased free Testosterone and estradiol levels were associated with improved sexual activity.  This lacks an understanding of the physiology.  In men with low T > 65, the majority are dealing with inflammation and excess weight; all of which increase aromatase activity and thus estradiol activity.  This does not indicate that an increase in estradiol activity is associated with improved libido in men.  How can elevated estrogen levels lead to low T and then increase levels are associated with improved libido?  This is merely a reflection of the body's dysfunctional physiology.  This observation of increased estradiol by no means shows cause and effect.  Scientists need to due a better job in vetting what they write!

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Who wouldn't love to look young and beautiful? Minor signs of ageing can make us panic because such signs start appearing one after the other making you look older and less pretty as would look without them. Wrinkles and lines appear because your skin loses its elasticity and volume over time. We know that ageing is an inevitable process but we wish to delay it and look youthful for more and more time.

Eyebrow hair loss is rare. However, this does not make it less disturbing for the people who experience it. There are many factors, which can contribute to the eyebrow hair loss. Over-plucking, medication, eczema, alopecia areata, and lupus are some common triggers of eyebrow hair loss

sex hormones play a role in the gout.  It appears that testosterone therapy increases uric acid levels and estradiol decreases uric acid levels.  Though, I question this based on the use of serum levels and thus inadequate assessment of aromatase activity.  Aromatase activity does not occur in the serum, it occurs in the tissue, thus saliva would be the best tool.

Discusses normal testosterone rhythm and then what sleep disruption does to disrupt this rhythm.

progesterone inactivates NK cells through depolarization.  Estrogen does not.  This has merit as one of the mechanisms behind the hormone/immunity role in infertility.

smoking reduces serum testosterone in rats.  The real question is what does it do to the salivary levels (tissue) and the metabolism of testosterone.

This is a recent review of the literature regarding estrogen metabolism. It has been proposed that 2:16 OH estrone ratio is predictive of breast, prostate cancer. This study does not find that association