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Nathan Goodyear

Is dehydroepiandrosterone a hormone? - 0 views

joe.endocrinology-journals.org/...169.full.pdf

DHEA dehydroepiandrosterone hormone hormones

shared by Nathan Goodyear on 20 Feb 12 - No Cached
  • Nathan Goodyear on 20 Feb 12
     
    Great review on dehydroepiandrosterone (DHEA): what it is, what it does, and the literature behind our current understanding.
Nathan Goodyear

Concentrations of total and free dehydroepiandrosterone in plasma and dehydroepiandrost... - 0 views

www.clinchem.org/...2042

dehydroepiandrosterone saliva testing salivary adrenal function secretion

shared by Nathan Goodyear on 20 Jan 11 - No Cached
  • Nathan Goodyear on 20 Jan 11
     
    Conclusion: "the concentration of DHEA in saliva is a reliable index of adrenal DHEA secretion..."
Nathan Goodyear

Dehydroepiandrosterone and Analogs Inhibit DNA Binding of AP-1 and Airway Smooth Muscle... - 0 views

jpet.aspetjournals.org/...876.long

DHEA inflammation dehydroepiandrosterone

shared by Nathan Goodyear on 30 Jul 13 - No Cached
  • Nathan Goodyear on 30 Jul 13
     
    DHEA beneficial at the biochemistry level in asthma.  DHEA inhibits the activation of transcription factor activator protein-1.
Nathan Goodyear

Administration of Dehydroepiandrosterone Suppresses Experimental Allergic Encephalomyel... - 0 views

www.jimmunol.org/...7094.long

MS multiple Sclerosis DHEA dehydroepiandrosterone inflammation TNF-alpha IFN-gamma

shared by Nathan Goodyear on 30 Jul 13 - No Cached
  • Nathan Goodyear on 30 Jul 13
     
    DHEA found to decrease IFN-gamma, IL-12, and TNF-alpha through inhibition of NF-kappaB in animal model of MS.
Nathan Goodyear

Dehydroepiandrosterone, its metab... [J Steroid Biochem Mol Biol. 2014] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...24846830

DHEA metabolites metabolism hormone hormones dehydroepiandrosterone

shared by Nathan Goodyear on 24 Jun 14 - No Cached
  • Nathan Goodyear on 24 Jun 14
     
    abstract only, but the article is a good review of DHEA metabolism
Nathan Goodyear

Low Dehydroepiandrosterone Sulfate is Associated With Increased Risk of Ischemic Stroke... - 0 views

stroke.ahajournals.org/...1784.full

DHEA DHEAS DHEA-S dehydroepiandrosterone stroke women female hormone hormones cardiovascular disease

shared by Nathan Goodyear on 22 Jul 14 - No Cached
  • Nathan Goodyear on 22 Jul 14
     
    Lower DHEAS, not below normal, levels associated with increased risk of ischemic stroke in women when compared to higher DHEAS levels.
Nathan Goodyear

Dehydroepiandrosterone and its sulfate predict the 5-year risk of coronary heart diseas... - 0 views

www.ncbi.nlm.nih.gov/...25443702

heart disease DHEA dehydroepiandrosterone hormone hormones DHEAS DHEA-S men male CHD

shared by Nathan Goodyear on 23 Apr 15 - No Cached
  • Nathan Goodyear on 23 Apr 15
     
    low DHEA and DHEA-S associated with increased risk of Coronary Heart Disease in elderly men.
Nathan Goodyear

Dehydroepiandrosterone (DHEA) rather than testoste... [Int J Sports Med. 2000] - PubMed... - 0 views

www.ncbi.nlm.nih.gov/...10683093

dhea dehydroepiandrosterone testing saliva salivary

shared by Nathan Goodyear on 22 Nov 10 - No Cached
  • Nathan Goodyear on 22 Nov 10
     
    Saliva and DHEA testing
Nathan Goodyear

Dehydroepiandrosterone in systemic lupus erythemat... [Arthritis Rheum. 1995] - PubMed ... - 0 views

www.ncbi.nlm.nih.gov/...8849355

dehydroepiandrosterone SLE Lupus

shared by Nathan Goodyear on 05 Jan 11 - No Cached
  • Nathan Goodyear on 05 Jan 11
     
    DHEA aids in SLE treatment for mild/moderat SLE
Nathan Goodyear

An open study of dehydroepiandrosterone in systemi... [Arthritis Rheum. 1994] - PubMed ... - 0 views

www.ncbi.nlm.nih.gov/...7945493

dehydroepiandrosterone Lupus SLE

shared by Nathan Goodyear on 05 Jan 11 - No Cached
  • Nathan Goodyear on 05 Jan 11
     
    DHEA improves SLE symptom score and reduces Corticosteroid requirments
Nathan Goodyear

Dehydroepiandrosterone suppresses interleukin 10 synthesis in women with systemic lupus... - 0 views

www.ncbi.nlm.nih.gov/...PMC1754850

dehydroepiandrosterone interleukin Lupus

shared by Nathan Goodyear on 05 Jan 11 - No Cached
  • Nathan Goodyear on 05 Jan 11
     
    DHEA lowers Lupus Flares in CHinese women
Nathan Goodyear

Assessing cortisol and dehydroepiandrosterone (DHEA) in saliva: effects of collection m... - 0 views

jop.sagepub.com/...643.abstract

saliva cortisol DHEA

shared by Nathan Goodyear on 18 Jan 11 - No Cached
  • Assessing cortisol and dehydroepiandrosterone (DHEA) in saliva:
  • Nathan Goodyear on 18 Jan 11
     
    assessing cortisol and DHEA in saliva
Nathan Goodyear

Dehydroepiandrosterone for women in the peri- or postmenopausal phase. - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...25609024

DHEA women female hormone hormones dehydroepiandrosterone

shared by Nathan Goodyear on 06 Feb 15 - No Cached
  • Nathan Goodyear on 06 Feb 15
     
    Supporting evidence for DHEA improvement for women is mixed and minimal.  Full article is not available so the question as whether a need was indicated based on testing is not available.  Side effects were seen with DHEA--primarily acne.  
Nathan Goodyear

Inhibition of 1,2-dimethylhydrazine-induced colon tumorigenesis in Balb/c mice by dehyd... - 0 views

carcin.oxfordjournals.org/...57.abstract

colon cancer tumor DHEA dehydroepiandrosterone hormone hormones

shared by Nathan Goodyear on 19 Nov 14 - No Cached
  • Nathan Goodyear on 19 Nov 14
     
    Only abstract available here.  DHEA, in mouse model, finds reduced malignant lesions in colon.
Nathan Goodyear

Differential Effects of Dehydroepiandrosterone and Testosterone in Prostate and Colon C... - 0 views

press.endocrine.org/...en.2012-2249

testosterone prostate colon colon cancer cancer NGF nerve growth factor dhea dehydroepiandrosterone

shared by Nathan Goodyear on 19 Nov 14 - No Cached
  • Several studies indicate that DHEA may enhance cancer-promoting activities in several prostate cancer cell lines acting as agonist or antagonist for the intracellular AR
  • the estrogenic metabolites of DHEA, 5a-androstane-3b, 17b-diol (3b-Adiol) and E2 bind to estrogen receptors but not to AR
  • no specific receptor has been identified for DHEA
  • ...16 more annotations...
  • Different members of neurotrophins are expressed during cancer progression, suggesting their involvement in cell proliferation, anoikis protection, and malignancy
  • Regulation of the apoptotic machinery in prostate and colon cancer cells by testosterone occurs rapidly and is initiated at the plasma membrane level through specific membrane-binding sites not involving the classical cytoplasmic AR
  • testosterone exerts potent regulatory effects on prostate and colon cancer cell apoptosis
  • Testosterone increased cell death in a dose-dependent manner
  • testosterone antagonizes the prosurvival effects of DHEA in neuronal cells, blocking its binding to NGF receptors
  • treatment of cells with DHEA exerted a strong antiapoptotic effect,
  • Androgens hold a central role in prostate and colon cancer biology
  • elevated levels of DHEA or its sulfate ester DHEA-sulfate in young adults are associated to low incidence of androgen-dependent tumors
  • DHEA may play a protective role in young prostate
  • The decline of DHEA with aging may contribute to prostate cancer progression associated with advanced age
  • DHEA is an effective antiapoptotic factor, reversing the serum deprivation-induced apoptosis in prostate cancer cells (DU145 and LNCaP cell lines) as well as in colon cancer cells
  • NGF appears to exert similar antiapoptotic actions in both prostate and color cancer cells
  • exposure of prostate DU145 and colon Caco2 cancer cells to testosterone totally blocked the protective effects of both DHEA and NGF. These findings suggest that testosterone acts as an antagonist of DHEA and NGF
  • These findings support the hypothesis that testosterone may inhibit cancer cell growth by antagonizing the proliferative, antiapoptotic effects of endogenous factors, such as DHEA or NGF, in the case of prostate and colon cancer cells
  • intratumor hormonal microenvironment may play a critical role in tumor progression.
  • The paracrine interactions of androgens with locally produced NGF may define tumor cell fate
  • Nathan Goodyear on 19 Nov 14
     
    Full article of previously posted abstract.  Cancers are unique.  Not all cancers are alike.  Whether they are tissue specific or not, cancers are unique.  This article describes the uniqueness of DHEA and Testosterone cancer, with particular attention to colon.
Nathan Goodyear

Neurobiological and Neuropsychiatric Effects of Dehydroepiandrosterone (DHEA) and DHEA ... - 0 views

www.ncbi.nlm.nih.gov/...PMC2725024

DHEA DHEA-S neurology neuropsychiatry

shared by Nathan Goodyear on 11 Dec 12 - No Cached
  • Nathan Goodyear on 11 Dec 12
     
    Everything you wanted to know about DHEA, DHEA-S in general and as they relate to neuropsychiatry.
Nathan Goodyear

Dehydroepiandrosterone in systemic lupus erythematosus - 0 views

www.ncbi.nlm.nih.gov/...PMC2701249

DHEA hormone hormones autoimmune disease autoimmune Lupus SLE

shared by Nathan Goodyear on 02 Jun 13 - No Cached
  • Nathan Goodyear on 02 Jun 13
     
    DHEA therapy has provided benefit in autoimmune disease.  IN this study they review the previous articles and physiology behind DHEA's proposed benefit in autoimmune disease.
Nathan Goodyear

Dehydroepiandrosterone (DHEA)--a precursor steroid... [J Sex Med. 2011] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...22032408

DHEA inflammation hormone hormones

shared by Nathan Goodyear on 02 Jun 13 - No Cached
  • Nathan Goodyear on 02 Jun 13
     
    DHEA reduces inflammation, improves insulin function, and provides improved cognitive function.
Nathan Goodyear

Dehydroepiandrosterone in the treatment of erectile... [Urol Res. 2001] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...11585284

DHEA ED low libido

shared by Nathan Goodyear on 12 Jun 13 - No Cached
  • Nathan Goodyear on 12 Jun 13
     
    DHEA may be beneficial in those with ED + hypertension and those with organic ED cause.  "Organic" causes like diabetes and neurological problems DHEA provided no benefit.
Nathan Goodyear

Dehydroepiandrosterone in the treatment of erectile ... [Urology. 1999] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...10096389

DHEA ED low libido

shared by Nathan Goodyear on 12 Jun 13 - No Cached
  • Nathan Goodyear on 12 Jun 13
     
    small study finds 50 mg of DHEA improves symptoms of ED.  Small study, so hard to take a lot from this, but DHEA is an androgen, so logically it makes sense.  
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