Skip to main content

Home/ Dr. Goodyear/ Group items tagged HPA

Rss Feed Group items tagged

Filter: All | Bookmarks | Topics Simple Middle
Nathan Goodyear

The Androgen 5α-Dihydrotestosterone and Its Metabolite 5α-Androstan-3β, 17β-D... - 0 views

www.jneurosci.org/...1448.full

DHT 3 beta androstanediol androgens Hypothalamus HPA hormones stress

shared by Nathan Goodyear on 15 Jul 15 - No Cached
  • Sex steroid hormones are primarily responsible for sex difference in adult HPA function; androgens inhibit whereas estrogens enhance HPA axis activation after a stressor
  • the PVN contains relatively high levels of AR (Bingaman et al., 1994; Zhou et al., 1994) and ERβ (Alves et al., 1998; Hrabovszky et al., 1998; Somponpun and Sladek, 2003) but is essentially devoid of ERα
  • the nonaromatizable androgen DHT and the nonselective ER ligand E2 influence HPA reactivity by acting on neurons within or surrounding the PVN
  • ...9 more annotations...
  • inhibitory action of DHT is detectable at both the level of hormone secretion as well as PVN c-fos mRNA expression
  • the inhibition can be mimicked by the DHT metabolite 3β-diol and by the subtype selective ERβ agonist DPN
  • E2 acts to enhance HPA reactivity
  • the ability of the ER antagonist tamoxifen, but not the AR antagonist flutamide, to block the inhibitory actions of DHT, speaks to the intracellular mechanism by which this inhibitory signal might be transduced.
    • Nathan Goodyear
      Nathan Goodyear on 15 Jul 15
       
      that is because the interaction with the DHT metabolite is not with the AR, but with the ER-beta.
  • the DHT metabolite 3β-diol and the ERβ-subtype-selective agonist DPN suppressed ACTH, corticosterone, and c-fos mRNA responses to restraint stress in a manner similar to DHT
  • metabolism of DHT to 3β-diol and subsequent binding to ERβ can be inhibitory to HPA reactivity, and this is one possible mechanism for the action of DHT.
  • Our data also suggest that E2 enhances the reactivity of the HPA axis to stress by acting on or near neurons of the PVN
  • the actions of E2 appear to be through an ERα-dependent mechanism
  • these studies suggest that ERβ, within the male hypothalamus, acts to inhibit the HPA axis and that the inhibitory effects of DHT may be, at least in part, via its intracellular conversion to 3β-diol and subsequent binding to ERβ
  • Nathan Goodyear on 15 Jul 15
     
    DHT metabolites: particularly 3beta-androstanediol inhibit HPA axis through ER-beta.
Nathan Goodyear

Age-associated changes in hypothalamic-pituitary-testicular function in middle-aged and... - 0 views

www.eje-online.org/...445.abstract

HPA HPA axis testosterone overweight obesity men male hormone hormones low T low testosterone

shared by Nathan Goodyear on 05 Mar 13 - No Cached
  • Nathan Goodyear on 05 Mar 13
     
    weight gain and obesity are associated with a dysfunctional HPA axis and low testosterone in men.  Reduction in weight will restore HPA axis function.
Nathan Goodyear

Inflammation and cortisol response in coronary artery disease: Annals of Medicine: Vol ... - 0 views

www.tandfonline.com/...07853890802508934

HPA axis HPA inflammation hormones stress cortisol CAD coronary artery disease

shared by Nathan Goodyear on 12 Oct 16 - No Cached
  • Nathan Goodyear on 12 Oct 16
     
    Inflammation disrupts HPA axis.  This is no surprise as we Know that inflammation can disrupt Testosterone in men and progesterone production in women.  This study suggests that this HPA axis disruption contributes to CAD.
Nathan Goodyear

Acupuncture blocks cold stress-induced increases in the hypothalamus-pituitary-adrenal ... - 0 views

joe.endocrinology-journals.org/...95

acupuncture stress HPA sympathetic nervous system

shared by Nathan Goodyear on 28 May 13 - No Cached
  • Nathan Goodyear on 28 May 13
     
    acupuncture decreases HPA sympathetic drive.  Acupuncture calms the HPA axis and relieves stress.  Granted this is in a rat model.
Nathan Goodyear

Acute Glucocorticoid Deficiency and Diabetes Insipidus Are Common After Acute Traumatic... - 0 views

jcem.endojournals.org/...3229.abstract

traumatic brain injury brain injury HPA cortisol

shared by Nathan Goodyear on 21 Aug 13 - No Cached
  • Nathan Goodyear on 21 Aug 13
     
    High rate (78%) of those post TBI have low cortisol levels due to damaged HPA axis.  Low cortisol levels post TBI are associated with an increase mortality rate and increased long-term HPA disruption.
Nathan Goodyear

Idiopathic hypogonadotropic hypogonadism in a ... [Fertil Steril. 1997] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...9093212

clomid HPA hypothalmus pituitary low T Testosterone male men hormone hormones endurance exercise athlete

shared by Nathan Goodyear on 24 Jul 14 - No Cached
  • Nathan Goodyear on 24 Jul 14
     
    Case study finds clomid restores HPA function and normalizes Testosterone production in HPA suppressed endurance athlete.
Nathan Goodyear

Utility of Salivary Cortisol Measurements in Cushing's Syndrome and Adrenal Insufficiency - 1 views

jcem.endojournals.org/...3647.abstract

saliva salivary cortisol hormone hormones test testing evaluation adrenal HPA axis BHRT

shared by Nathan Goodyear on 28 Nov 11 - No Cached
  • It is expected that the use of the measurement of salivary cortisol will become routine in the evaluation of patients with disorders of the HPA axis.
  • Nathan Goodyear on 28 Nov 11
     
    Salivary cortisol testing shown to have sensitivity and specificity that exceeds 90%.  Final Quote: "salivary cortisol will become routine in the evaluation of patients with disorders of the HPA axis
Nathan Goodyear

Gonadal status and outcome of bariatric surgery in obese men - Aarts - 2013 - Clinical ... - 0 views

onlinelibrary.wiley.com/...full

low T Testosterone overweight obese bariatric surgery men male hormone hormones free testosterone

shared by Nathan Goodyear on 04 Feb 14 - No Cached
  • Nathan Goodyear on 04 Feb 14
     
    Small study of 13 men found that weight loss following bariatric surgery resulted in improved HPA function in 10/13.  Three men had resistant HPA dysfunction.  Free Testosterone was followed.
Nathan Goodyear

Caloric Restriction Increases Serum Testoster... [Horm Metab Res. 2013] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...24198220

low T Testosterone calorie restriction calorie restriction obesity aromatase men male hormone hormones

shared by Nathan Goodyear on 19 Feb 14 - No Cached
  • Nathan Goodyear on 19 Feb 14
     
    Calorie restriction increases serum Testosterone levels in obese men.  This fits with other research that weight reduction in obese men can resolve low T.  The obvious proposed mechanisms are a reduction in aromatase activity due to a loss of adiposity, a decrease in inflammatory cytokine production thus negatively effecting the HPA, improved HPA signaling and thus improved Testicular production of Testosterone.
Nathan Goodyear

Leptin inhibition of the hypothalamic-pituitary-adrenal axis in response to stress. - P... - 0 views

www.ncbi.nlm.nih.gov/...9275075

leptin CRH HPA axis HPA hormone hormones

shared by Nathan Goodyear on 17 Jun 15 - No Cached
  • Nathan Goodyear on 17 Jun 15
     
    Leptin inhibits CRH, thus decreasing the HPA axis.
Nathan Goodyear

Sex differences in the adult HPA axis and affectiv... [Brain Res. 2014] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...24857958

bisphenol A Bisphenol-A BPA xenoestrogen HPA hypothalamic-pituitary-adrenal EDR endocrine disrupter brain hormone hormones

shared by Nathan Goodyear on 27 May 14 - No Cached
  • Nathan Goodyear on 27 May 14
     
    Animal study finds that Bisphenol A exposure in utero has profound different effects in male offspring versus female offspring.  In the male offspring there appears to be an up regulation of the HPA axis.  The opposite appears true in the female off spring.  Additionally, the receptors are effected differently as well.
Nathan Goodyear

Complete reversal of adult-onset isolated hypo... [Fertil Steril. 2006] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...17070201

clomid hypogonadism low T TEstosteorne men male hormone hormones

shared by Nathan Goodyear on 24 Jul 14 - No Cached
  • Nathan Goodyear on 24 Jul 14
     
    study finds restoration of HPA in men with low T.  This was performed via clomid therapy at 25 to 50 mg daily for 4 months.  Increase in pulsatile LH, increase in serum Testosterone levels, and increase in sexual function was found.  Clomid restores HPA function that is suppressed from estrogen inhibition.  In this case, clomid is function as an estrogen antagonist.
Nathan Goodyear

The hypothalamic-pituitary-adrenal axis and sex hormones in chronic stress and obesity:... - 0 views

www.ncbi.nlm.nih.gov/...PMC3464358

obesity overweight stress HPA hormones

shared by Nathan Goodyear on 19 Feb 13 - No Cached
  • Nathan Goodyear on 19 Feb 13
     
    Very nice article on the thoughts currently involving stress, overactivity of the HPA axis and obesity.
Nathan Goodyear

The effect of common genetic variati... [J Clin Endocrinol Metab. 2012] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...22112815

saliva salivary hormone hormones depression 11-betaHSD1 HPA SNPs

shared by Nathan Goodyear on 10 Oct 12 - No Cached
  • Nathan Goodyear on 10 Oct 12
     
    hyperactive HPA axis associated with depression. This is becoming evident in the literature.  This study looked at SNPS in the etiology of elevated cortisol and/or androstenedione.  They followed the results with saliva and found that 3 SNPS were associated with increased 11Beta-HSD1 activity and associated increased depression.
Nathan Goodyear

Obesity and Gender influence cortisol secretion and metabolism in man - 0 views

jcem.endojournals.org/...1806.full.pdf

obesity obese overweight cortisol cortisone HPA

shared by Nathan Goodyear on 24 Apr 12 - No Cached
  • Nathan Goodyear on 24 Apr 12
     
    This study reveals the degree of metabolism dysfunction in obesity. This study suggests that cortisol metabolism is increased in obesity, which results in increased HPA activity resulting in increased peripheral cortisol production. The question to be asked: is serum, salivary, and urinary cortisol results revealing the same function of cortisol. The answer is no.
Nathan Goodyear

Aromatase Inhibition in the Human Male Reveals a Hypothalamic Site of Estrogen Feedback - 0 views

jcem.endojournals.org/...3027.long

estrogen estradiol estrone testosterone low T HPA hypothalamus pituitary male

shared by Nathan Goodyear on 25 Apr 12 - No Cached
  • Nathan Goodyear on 25 Apr 12
     
    estrogen shown to have two sites of negative feedback in men. First in the hypothalamus and second in the pituitary.  In many men, aromatase inhibition can restore the HPA by eliminating the negative feedback of estrogen on the hypothalamus and the pituitary.
Nathan Goodyear

Hypothalamic-pituitary-adrenal stress axis function and the relationship with chronic w... - 0 views

www.ncbi.nlm.nih.gov/...PMC1257426

stress HPA adrenal adrenals cortisol saliva salivary pain

shared by Nathan Goodyear on 01 May 12 - No Cached
  • Nathan Goodyear on 01 May 12
     
    Those with chronic pain shown to have HPA dysfunction.  Elevated cortisol was found via saliva evaluation.  This with pain had the higher cortisol levels.
Nathan Goodyear

Salivary cortisol patterns in vital exhaustion. [J Psychosom Res. 2000] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...11164057

saliva salivary cortisol fatigue vital exhaustion HPA hormone hormones

shared by Nathan Goodyear on 02 May 12 - No Cached
  • Nathan Goodyear on 02 May 12
     
    "vital exhaustion" associated with suppressed HPA activity and low cortisol.
Nathan Goodyear

Decreased cortisol awakening respon... [Psychoneuroendocrinology. 2005] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...15808926

stress ELE early life stressor cortisol saliva salivary hormones hormone HPA

shared by Nathan Goodyear on 30 Apr 12 - No Cached
  • Nathan Goodyear on 30 Apr 12
     
    early life stressors shown to reduce morning cortisol on salivary testing.  This indicates an altered HPA axis.
Nathan Goodyear

Diagnosis of secondary adrenal insufficiency in patients with hypothalamic-pituitary di... - 0 views

www.eje-online.org/...9.full

saliva salivary cortisol hormone hormones HPA

shared by Nathan Goodyear on 22 Aug 12 - No Cached
  • Nathan Goodyear on 22 Aug 12
     
    European journal of endocrinology article compared serum to salivary cortisol and found them to be equal, but due to ease of collection, salivary cortisol to be preferable.  This article was using cortisol to assess HPA axis dysfunction.
1 - 20 of 84 Next › Last »
Showing 20▼ items per page