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Nathan Goodyear

Autism and Clostridium Tetani - 0 views

www.ncbi.nlm.nih.gov/pubmed

ASD autism metabolic endotoxemia children inflammation dysbiosis gut flora microbiota

shared by Nathan Goodyear on 30 Jan 12 - No Cached
  • Nathan Goodyear on 30 Jan 12
     
    Dysbiosis is commonly found in children with ASD. Antibiotics disrupt the normal gut microbiota resulting in dysbiosis. This imbalance in gut bacteria is now known to cause systemic inflammatory states such as metabolic endotoxemia. There is no reason to think a similar link may be present between Gut inflammation and ASD
Nathan Goodyear

Diet-Induced Dysbiosis of the Intestinal Microbiota and the Effects on Immunity and Dis... - 0 views

www.ncbi.nlm.nih.gov/...PMC3448089

dysbiosis diet nutrition metabolic endotoxemia disease inflammation gut

shared by Nathan Goodyear on 27 Jul 14 - No Cached
  • The gut microbiota participates in the body’s metabolism by affecting energy balance, glucose metabolism, and low-grade inflammation associated with obesity and related metabolic disorders
  • Firmicutes and Bacteroidetes represent the two largest phyla in the human and mouse microbiota and a shift in the ratio of these phyla has been associated with many disease conditions, including obesity
  • In obese humans, there is decreased abundance of Bacteroidetes compared to lean individuals
  • ...21 more annotations...
  • weight loss in obese individuals results in an increase in the abundance of Bacteroidetes
  • there is conflicting evidence on the composition of the obese microbiota phenotype with regards to Bacteroidetes and Firmicutes ratios
  • Bifidobacteria spp. from the phyla Actinobacteria, has been shown to be depleted in both obese mice and human subjects
  • While it is not yet clear which specific microbes are inducing or preventing obesity, evidence suggests that the microbiota is a factor.
  • targeted manipulation of the microbiota results in divergent metabolic outcomes depending on the composition of the diet
  • The microbiota has been linked to insulin resistance or type 2 diabetes (T2D) via metabolic syndrome and indeed the microbiota of individuals with T2D is also characterized by an increased Bacteroidetes/Firmicutes ratio, as well as an increase in Bacillus and Lactobacillus spp
  • It was also observed that the ratio of Bacteriodes-Prevotella to C. coccoides-E. rectale positively correlated with glucose levels but did not correlate with body mass index [80]. This suggests that the microbiota may influence T2D in conjunction with or independently of obesity
  • In humans, high-fat Western-style diets fed to individuals over one month can induce a 71% increase in plasma levels of endotoxins, suggesting that endotoxemia may develop in individuals with GI barrier dyfunction connected to dysbiosis
  • LPS increases macrophage infiltration essential for systemic inflammation preceding insulin resistance, LPS alone does not impair glucose metabolism
  • early treatment of dysbiosis may slow down or prevent the epidemic of metabolic diseases and hence the corresponding lethal cardiovascular consequences
  • increased Firmicutes and decreased Bacteroidetes, which is the microbial profile found in lean phenotypes, along with an increase in Bifidobacteria spp. and Lactobacillus spp
  • mouse and rat models of T1D have been shown to have microbiota marked by decreased diversity and decreased Lactobacillus spp., as well as a decrease in the Firmicutes/Bacteroidetes ratio
  • microbial antigens through the innate immune system are involved in T1D progression
  • The microbiota appears to be essential in maintaining the Th17/Treg cell balance in intestinal tissues, mesenteric and pancreatic lymph nodes, and in developing insulitis, although progression to overt diabetes has not been shown to be controlled by the microbiota
  • There is evidence that dietary and microbial antigens independently influence T1D
  • Lactobacillus johnsonii N6.2 protects BB-rats from T1D by mediating intestinal barrier function and inflammation [101,102] and a combination probiotic VSL#3 has been shown to attenuate insulitis and diabetes in NOD mice
  • breast fed infants have higher levels of Bifidobacteria spp. while formula fed infants have higher levels of Bacteroides spp., as well as increased Clostridium coccoides and Lactobacillus spp
  • the composition of the gut microbiota strongly correlates with diet
  • In mice fed a diet high in fat, there are many key gut population changes, such as the absence of gut barrier-protecting Bifidobacteria spp
  • diet has a dominating role in shaping gut microbiota and changing key populations may transform healthy gut microbiota into a disease-inducing entity
  • “Western” diet, which is high in sugar and fat, causes dysbiosis which affects both host GI tract metabolism and immune homeostasis
  • Nathan Goodyear on 27 Jul 14
     
    Nice discussion of how diet, induces gut bacterial change, that leads to metabolic endotoxemia and disease.
Nathan Goodyear

Microbiota dysbiosis and barrier dysfunction in inflammatory bowel disease and colorect... - 0 views

www.ncbi.nlm.nih.gov/...PMC6234774

gut inflammation gut flora gut bacteria gut microbiota dysbiosis cancer gut microbiome colorectal cancer

shared by Nathan Goodyear on 10 Jan 21 - No Cached
  • Nathan Goodyear on 10 Jan 21
     
    Great discussion the the connection between gut dysbiosis, inflammation and cancer.
Nathan Goodyear

Diet, Microbiota and Immune System in Type 1 Diabetes Development and Evolution - 0 views

www.ncbi.nlm.nih.gov/...PMC4663589

diabetes type I diabetes dysbiosis gut gut flora gut microbiome gut microbiota

shared by Nathan Goodyear on 17 Oct 16 - No Cached
  • Nathan Goodyear on 17 Oct 16
     
    great review article on the relationship between gut dysbiosis and type I diabetes--particularly the bacteroidetes and Veillonella species; in contrast, Prevotella and Akkermansia special protects and maintains a healthy gut epithelium.
Nathan Goodyear

The Gut Microbiota and Type 1 Diabetes - 0 views

www.ncbi.nlm.nih.gov/...PMC4761565

diabetes type I diabetes gut gut flora gut health gut microbiome gut microbiota dysbiosis

shared by Nathan Goodyear on 17 Oct 16 - No Cached
  • A study by Bosi and colleagues suggested that the increased gut permeability preceded the clinical onset of T1D
  • gut permeability may be an important player in the development of T1D but, as yet, the findings in human studies have shown association but causation will be more difficult to prove.
  • Early childhood (≤ 3 month) introduction to cereals [10, 11] and cow's milk [48] were shown to promote beta cell autoimmunity
  • ...1 more annotation...
  • These findings suggest that prebiotics and probiotics could be potential therapeutic tools to improve gut integrity in various intestinal inflammatory and autoimmune diseases including T1D
  • Nathan Goodyear on 17 Oct 16
     
    another great review article of gut dysbiosis, altered gut permeability and type I diabetes.
Nathan Goodyear

Digestive Diseases and Sciences, Volume 57, Number 5 - SpringerLink - 0 views

www.springerlink.com/...5

IBS probiotics dysbiosis

shared by Nathan Goodyear on 31 May 12 - No Cached
  • Nathan Goodyear on 31 May 12
     
    study shows that IBS related to dysbiosis, imbalanced microbial population, in the small intestine.  But, as they always do, their thought of treatment is via the old paradigm.  How, about just restoring the bacterial balance with probiotics, which, themselves will kill the unwelcomed bacteria.
Nathan Goodyear

Involvement of gut microbiota in the developmen... [Gut Microbes. 2012] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...22572877

microbiota flora dysbiosis LPS lipopolysaccharides inflammation obesity IR insulin resistance type II DM

shared by Nathan Goodyear on 05 Sep 12 - No Cached
  • Nathan Goodyear on 05 Sep 12
     
    gut microbiota, and the imbalance of (dysbiosis) contributes to LPS and inflammation.  This results in obesity and type II DM.
Nathan Goodyear

short-term benefit from oral vancomycin treatment of regressive-onset autism - 0 views

www.ncbi.nlm.nih.gov/pubmed

autism ASD dysbiosis inflammation gut GI gastrointestinal children

shared by Nathan Goodyear on 30 Jan 12 - No Cached
  • Nathan Goodyear on 30 Jan 12
     
    disruption of gut bacteria balance, dysbiosis, proposed to play role in regression autism. This study treated these children with vancomycin. Short interval improvement was found. The take home from this study is the gut-brain connection in children with regression autism
Nathan Goodyear

Access : Nonalcoholic fatty liver disease: Microbiota in the pathogenesis of systemic a... - 0 views

www.nature.com/...nrendo.2012.25.html

fatty liver disease NAFLD non-alcoholic fatty liver inflammation dysbiosis metabolic

shared by Nathan Goodyear on 02 Aug 12 - No Cached
  • Nathan Goodyear on 02 Aug 12
     
    Fascinating read of how inflammation as a direct result of dysbiosis in the gut contributes to the progression of NALFD.
Nathan Goodyear

Interaction Between Obesity and the Gut Microbiota: Relevance in Nutrition - 0 views

www.uclouvain.be/...nteraction_between_obesity.pdf

GI gut inflammation dysbiosis obesity insulin resistance IR type II DM diabetes hypertension metabolic endotoxemia

shared by Nathan Goodyear on 08 Mar 12 - No Cached
  • Nathan Goodyear on 08 Mar 12
     
    Gut inflammation resultant from dysbiosis leads to inflammation, obesity, insulin resistance, type II DM, hypertension...
Nathan Goodyear

http://download.journals.elsevierhealth.com/pdfs/journals/0168-8278/PIIS016882781300887... - 0 views

download.journals.elsevierhealth.com/...PIIS0168827813008878.pdf

dysbiosis liver disease gut microbiota bacterial balance

shared by Nathan Goodyear on 10 Feb 14 - No Cached
  • Nathan Goodyear on 10 Feb 14
     
    gut bacterial balance plays role in progression of liver disease.  Dysbiosis worsens cirrhosis, liver failure...where as a health gut bacterial balance seems to slow progression
Nathan Goodyear

Gut Microbiota, Low-grade Inflammation, and Metabolic Syndrome. - ResearchGate - 0 views

www.researchgate.net/...mmation_and_Metabolic_Syndrome

gut inflammation metabolic syndrome microbiota dysbiosis

shared by Nathan Goodyear on 17 Feb 14 - No Cached
  • Nathan Goodyear on 17 Feb 14
     
    Gut dysbiosis can be the cause of chronic inflammation that results in metabolic syndrome.  This can be, in part, precipitated by delivery, breast feeding, and diet.
Nathan Goodyear

Microbial Cell Factories | Full text | Role of commensal and probiotic bacteria in huma... - 0 views

www.microbialcellfactories.com/...71

dysbiosis probiotic gut health

shared by Nathan Goodyear on 05 May 15 - No Cached
  • The most frequently found species are Gram-positive bacteria
  • Nathan Goodyear on 05 May 15
     
    good review of dysbiosis, commensal bacteria and gut health.
Nathan Goodyear

PLOS ONE: Microbial Dysbiosis in Colorectal Cancer (CRC) Patients - 0 views

journals.plos.org/...article

dybsiosis cancer colon cancer Bacteroidetes Prevotella IL-17

shared by Nathan Goodyear on 26 Feb 15 - No Cached
  • differences in the colon microbiota in individuals with colon cancer versus those with a normal colonoscopy
  • qPCR revealed significant elevation of the Bacteroides/Prevotella population in cancer patients that appeared to be linked with elevated IL17 producing cells in the mucosa of individuals with cancer.
  • Bacteroides genus populations and more specifically those of Bacteroides fragilis, have recently been shown to produce a metalloprotease in colon cancer patients, but not in controls [12] suggesting this species sub population might favor carcinogenesis
  • ...3 more annotations...
  • It is noteworthy that among the many mechanisms that may mediate associations between microbiota and human health [21]–[22], pro-inflammatory and immune cell activation in colon mucosa are of great importance in relation to malignancy
  • B. fragilis has been shown to induce mucosal regulatory T-cell responses in the intestine involving TH17 cell recruitment in experimental models
  • the elevations of Bacteroides in the stool and/or IL17 immunoreactive cells in the normal mucosa appear to be promising sensitive markers
  • Nathan Goodyear on 26 Feb 15
     
    A relationship between dysbiosis and colon cancer appears to be present.  Particularly an increase in Bacteroidetes and Prevotella species were found in those with colon cancer versus those without.  An inflammatory up regulation of IL-17 appears to be involved.  Whether this is a cause or effect is yet to be determined, but the presence of elevated Bacteroidetes species with increased IL17 could be used as sensitive biomarkers.
Nathan Goodyear

Pre-existing commensal dysbiosis is a host-intrinsic regulator of tissue inflammation a... - 0 views

cancerres.aacrjournals.org/...0008-5472.CAN-18-3464

tumor microbiome cancer

shared by Nathan Goodyear on 15 Aug 19 - No Cached
  • Nathan Goodyear on 15 Aug 19
     
    Study finds that gut dysbiosis provides inflammation that favors hormone positive breast cancer initiation and spread. Only abstract available here.
Nathan Goodyear

Microbiota disbiosis is associated with colorectal cancer - 0 views

www.ncbi.nlm.nih.gov/...PMC4313696

cancer colon cancer colorectal cancer dysbiosis gut bacteria

shared by Nathan Goodyear on 10 Sep 17 - No Cached
  • Nathan Goodyear on 10 Sep 17
     
    Study finds association between gut dysbiosis and colorectal cancer risk.
Nathan Goodyear

Monsanto Roundup: The Impacts of Glyphosate Herbicide on Human Health. Pathways to Mode... - 0 views

www.globalresearch.ca/...5342520

monsanto roundup glyphosate

shared by Nathan Goodyear on 12 Aug 13 - No Cached
  • Nathan Goodyear on 12 Aug 13
     
    Glyphosate inhibits CYP 450 enzymes.  The author states it well: "glyphosate enhances the damaging effects fo other food borne chemical residues and environnmental toxins.  Additionally, Glyphosate disrupts gut bacterial function in the human gut. This dysbiosis is well known to cause systemic disease, such as obesity, diabetes...
Nathan Goodyear

PLOS ONE: Microbial Dysbiosis Is Associated with Human Breast Cancer - 0 views

journals.plos.org/...article

cancer breast cancer dysbiosis bacteria microbiota gut flora

shared by Nathan Goodyear on 26 Feb 15 - No Cached
  • it is tempting to speculate that a decrease in bacterial load in a healthy individual may be a signal of heightened breast cancer risk
  • Nathan Goodyear on 26 Feb 15
     
    Study finds a decrease in gut bacterial load in women with breast cancer versus those without.  The authors propose that a decrease in bacterial load in healthy individuals might be a means to estimate breast cancer risk.  Could it all start in the gut?
Nathan Goodyear

Western Diet-Induced Dysbiosis in Farnesoid X Receptor Knockout Mice Causes Persistent ... - 0 views

ajp.amjpathol.org/...fulltext

dysbiosis inflammation diet nutrition gut flora gut bacteria

shared by Nathan Goodyear on 17 Jul 17 - No Cached
  • Nathan Goodyear on 17 Jul 17
     
    Western diet (high trans fats and sugar) linked to altered gut flora and resultant liver inflammation.  It would have been nice to have followed inflammatory biomarkers i.e. LPS.  This sounds just like metabolic syndrome.
Nathan Goodyear

Microbial dysbiosis and colon carcinogenesis: could colon cancer be considered a bacter... - 0 views

www.ncbi.nlm.nih.gov/...PMC3625019

dysbiosis colon cancer cancer gut bacteria

shared by Nathan Goodyear on 10 Sep 17 - No Cached
  • Nathan Goodyear on 10 Sep 17
     
    good discussion of the theory and relationship between gut symbiosis and colorectal cancer.
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