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Nathan Goodyear

Differential Effects of Dehydroepiandrosterone and Testosterone in Prostate and Colon C... - 0 views

press.endocrine.org/...en.2012-2249

testosterone prostate colon colon cancer cancer NGF nerve growth factor dhea dehydroepiandrosterone

shared by Nathan Goodyear on 19 Nov 14 - No Cached
  • Several studies indicate that DHEA may enhance cancer-promoting activities in several prostate cancer cell lines acting as agonist or antagonist for the intracellular AR
  • the estrogenic metabolites of DHEA, 5a-androstane-3b, 17b-diol (3b-Adiol) and E2 bind to estrogen receptors but not to AR
  • no specific receptor has been identified for DHEA
  • ...16 more annotations...
  • Different members of neurotrophins are expressed during cancer progression, suggesting their involvement in cell proliferation, anoikis protection, and malignancy
  • Regulation of the apoptotic machinery in prostate and colon cancer cells by testosterone occurs rapidly and is initiated at the plasma membrane level through specific membrane-binding sites not involving the classical cytoplasmic AR
  • testosterone exerts potent regulatory effects on prostate and colon cancer cell apoptosis
  • Testosterone increased cell death in a dose-dependent manner
  • testosterone antagonizes the prosurvival effects of DHEA in neuronal cells, blocking its binding to NGF receptors
  • treatment of cells with DHEA exerted a strong antiapoptotic effect,
  • Androgens hold a central role in prostate and colon cancer biology
  • elevated levels of DHEA or its sulfate ester DHEA-sulfate in young adults are associated to low incidence of androgen-dependent tumors
  • DHEA may play a protective role in young prostate
  • The decline of DHEA with aging may contribute to prostate cancer progression associated with advanced age
  • DHEA is an effective antiapoptotic factor, reversing the serum deprivation-induced apoptosis in prostate cancer cells (DU145 and LNCaP cell lines) as well as in colon cancer cells
  • NGF appears to exert similar antiapoptotic actions in both prostate and color cancer cells
  • exposure of prostate DU145 and colon Caco2 cancer cells to testosterone totally blocked the protective effects of both DHEA and NGF. These findings suggest that testosterone acts as an antagonist of DHEA and NGF
  • These findings support the hypothesis that testosterone may inhibit cancer cell growth by antagonizing the proliferative, antiapoptotic effects of endogenous factors, such as DHEA or NGF, in the case of prostate and colon cancer cells
  • intratumor hormonal microenvironment may play a critical role in tumor progression.
  • The paracrine interactions of androgens with locally produced NGF may define tumor cell fate
  • Nathan Goodyear on 19 Nov 14
     
    Full article of previously posted abstract.  Cancers are unique.  Not all cancers are alike.  Whether they are tissue specific or not, cancers are unique.  This article describes the uniqueness of DHEA and Testosterone cancer, with particular attention to colon.
Nathan Goodyear

Dehydroepiandrosterone (DHEA)-A Precursor Steroid or an Active Hormone in Human Physiol... - 0 views

onlinelibrary.wiley.com/...abstract

DHEA DHEA-S steroid hormone physiology hormones

shared by Nathan Goodyear on 20 Feb 12 - No Cached
  • no significant adverse or negative side effects of DHEA were reported in clinical studies of men and women.
  • Nathan Goodyear on 20 Feb 12
     
    review of the clinical studies of DHEA and DHEA-S find no negative side-effects: only positive effects.  Overdosage of DHEA, which is common in women, obviously can result in side effects, though.
Nathan Goodyear

Neurobiological and Neuropsychiatric Effects of Dehydroepiandrosterone (DHEA) and DHEA ... - 0 views

www.ncbi.nlm.nih.gov/...PMC2725024

DHEA DHEA-S neurology neuropsychiatry

shared by Nathan Goodyear on 11 Dec 12 - No Cached
  • Nathan Goodyear on 11 Dec 12
     
    Everything you wanted to know about DHEA, DHEA-S in general and as they relate to neuropsychiatry.
Nathan Goodyear

Dehydroepiandrosterone (DHEA) replacement decreases insulin resistance and lowers infla... - 0 views

www.ncbi.nlm.nih.gov/...PMC3156603

DHEA inflammation TNF-alpha IL-6 insulin resistance triglycerides aging

shared by Nathan Goodyear on 09 May 16 - No Cached
  • Nathan Goodyear on 09 May 16
     
    DHEA declines with age.  DHEA therapy, 50 mg daily, was found to reduce TNF-alpha and IL-6.  DHEA also lowered triglycerides.
Nathan Goodyear

Steroid sulfatase gene variation and DHEA r... [Physiol Genomics. 2004] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...15152080

exercise resistance training DHEA DHEA-S DHEAS hormone hormones

shared by Nathan Goodyear on 03 Aug 14 - No Cached
  • Nathan Goodyear on 03 Aug 14
     
    Short 10 week course of resistance exercise associated with an increase in DHEA and DHEAS in both men and women.
Nathan Goodyear

Effect of DHEA-sulfate on adiponectin gene expression in adipose tissue from different ... - 0 views

www.eje.org/...593.full

DHEA-S DHEAS adiponectin adipose tissue adipocytes fat cells insulin resistance obesity

shared by Nathan Goodyear on 17 Mar 12 - No Cached
  • Nathan Goodyear on 17 Mar 12
     
    DHEA-S shown to increase genetic expression of adiponectin in human adipose tissue.  This has enormous implications on the link between DHEA and insulin resistance induce obesity. This is a peripheral tissue problem, not a central problem.
Nathan Goodyear

ScienceDirect.com - Journal of Chromatography B - Simultaneous determination of salivar... - 0 views

www.sciencedirect.com/...S1570023208008131

LC-MS liquid chromatography mass mass spectroscopy saliva salivary hormone hormones testosterone DHEA

shared by Nathan Goodyear on 14 Aug 12 - No Cached
  • Nathan Goodyear on 14 Aug 12
     
    LC-MS for salivary testosterone and DHEA validated.  Also, T and DHEA were shown to have specific diurnal rhythms.  Changes in levels were also followed after DHEA therapy.
Nathan Goodyear

Low Dehydroepiandrosterone Sulfate is Associated With Increased Risk of Ischemic Stroke... - 0 views

stroke.ahajournals.org/...1784.full

DHEA DHEAS DHEA-S dehydroepiandrosterone stroke women female hormone hormones cardiovascular disease

shared by Nathan Goodyear on 22 Jul 14 - No Cached
  • Nathan Goodyear on 22 Jul 14
     
    Lower DHEAS, not below normal, levels associated with increased risk of ischemic stroke in women when compared to higher DHEAS levels.
Nathan Goodyear

Dehydroepiandrosterone and its sulfate predict the 5-year risk of coronary heart diseas... - 0 views

www.ncbi.nlm.nih.gov/...25443702

heart disease DHEA dehydroepiandrosterone hormone hormones DHEAS DHEA-S men male CHD

shared by Nathan Goodyear on 23 Apr 15 - No Cached
  • Nathan Goodyear on 23 Apr 15
     
    low DHEA and DHEA-S associated with increased risk of Coronary Heart Disease in elderly men.
Nathan Goodyear

http://cancerres.aacrjournals.org/content/51/5/1366.full.pdf - 0 views

cancerres.aacrjournals.org/...1366.full.pdf

bladder cancer bladder cancer DHEA DHEAS DHEA-S

shared by Nathan Goodyear on 05 Jan 15 - No Cached
  • Nathan Goodyear on 05 Jan 15
     
    low DHEA and DHEAS is associated with increased risk of bladder cancer in both sexes.  
Nathan Goodyear

Web of Knowledge [v.5.3] - Web of Science - 0 views

cel.webofknowledge.com/full_record.do

DHEA DHEA-S adipose tissue obesity overweight fat

shared by Nathan Goodyear on 20 Mar 12 - No Cached
  • Nathan Goodyear on 20 Mar 12
     
    human study: revealed a decrease in saturated fatty acids, omega-6 in those supplemented with DHEA-S.  DHEA-S was found to improve the metabolic profile of adipose tissue
Nathan Goodyear

The Benefits and Harms of Systemic Dehydroepiandrosterone (DHEA) in Postmenopausal Wome... - 0 views

press.endocrine.org/...jc.2014-2261

DHEA women hormone hormones

shared by Nathan Goodyear on 07 Oct 14 - No Cached
  • Nathan Goodyear on 07 Oct 14
     
    Review of the data points to poor quality of evidence dealing with DHEA in post-menopausal women with normal adrenal function.  Yet if DHEA is low, which is >95% produced by adrenals in women, then how can the adrenal function be "normal".   The meta-analysis found no improvement in libido and/or sexual function, and no improvement in lipids, glucose, weight... was noted.  Essentially not positive or negative effects were noted.  Abstract only available here, so dosage is a question.
Nathan Goodyear

The adipose tissue metabolism: role of testosterone and dehydroepiandrosterone. - PubMe... - 0 views

www.ncbi.nlm.nih.gov/...10997611

Testosterone DHEA lipoprotein lipase adipose tissue hormones

shared by Nathan Goodyear on 17 Jun 15 - No Cached
  • T inhibits lipid uptake and lipoprotein-lipase (LDL) activity in adipocytes, and stimulates lipolysis
  • T inhibits differentiation of adipocyte precursor cells
  • DHEA stimulates resting metabolic rate (RMR) and lipid oxidation, and enhances glucose disposal, by increasing the expression of GLUT-1 and GLUT-4 on fat cell plasma membrane
  • ...2 more annotations...
  • The insulin-like effect of DHEA would be associated to a decrease of plasma insulin concentrations and, thus, to an increase of the molar ratio between lipolytic hormones and insulin
  • the fat-reducing effect of both T and DHEA seems to be more evident at the level of visceral adipose tissue
  • Nathan Goodyear on 17 Jun 15
     
    Testosterone inhibits lipid uptake into adipocytes.  Testosterone inhibits lipoprotein lipase.  Testosterone stimulated lipolysis.  Testosterone inhibits adipocyte differentiation of proginator cells. DHEAs effects are through different mechanisms.   Both have a preference for activity with visceral adipose tissue.
Nathan Goodyear

The association between serum dehydroepiandrosterone sulfate (DHEA-... - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...25692973

DHEA DHEA-S DHEAS BMD osteoporosis men male hormone hormones

shared by Nathan Goodyear on 02 Mar 15 - No Cached
  • Nathan Goodyear on 02 Mar 15
     
    Only abstract available here, but lower DHEA-S (still in reference normal range) associated with lower bone mineral density and increased osteoporosis risk.
Nathan Goodyear

Exercise training-induced triglyceride lowering negatively correlates with DHEA levels ... - 0 views

www.nature.com/...0801637a.html

exercise DHEA Triglycerides hormone hormones

shared by Nathan Goodyear on 03 Aug 14 - No Cached
  • Nathan Goodyear on 03 Aug 14
     
    aerobic exercise over 8 weeks increased DHEA modestly.  An inverse relationship between DHEA and Triglycerides was seen.
Nathan Goodyear

Blood dehydroepiandrosterone sulphate (DHEAS) levels in pemphigoid/pemphigus and psoria... - 0 views

www.researchgate.net/...phigoidpemphigus_and_psoriasis

DHEA DHEAS dehydroepiandrostenedione hormones autoimmune disease autoimmune lupus psoriasis

shared by Nathan Goodyear on 03 Dec 15 - No Cached
  • Nathan Goodyear on 03 Dec 15
     
    low DHEA found in individuals with autoimmune disease.  The authors conclude that this may contribute to the cause of the disease(s)
Nathan Goodyear

Effect of acute DHEA administration on free testosterone in middle-aged and young men f... - 0 views

www.ncbi.nlm.nih.gov/...23417481

HIIT high intensity intermittent training high intensity training exercise free Testosterone DHEA hormones Testosterone

shared by Nathan Goodyear on 02 Oct 17 - No Cached
  • Nathan Goodyear on 02 Oct 17
     
    Decline in free Testosterone, especially in physically unfit men, blunted by oral 50 mg DHEA night before exercise.  Total Testosterone and DHEA remained significantly low up to 24 hours post HIIT.
Nathan Goodyear

Effects of transdermal application of DHEA on the levels of steroids, gonadotropins and... - 0 views

www.ncbi.nlm.nih.gov/...11252535

DHEA LH hormones DHEA-S Testosterone estradiol androstenedione

shared by Nathan Goodyear on 02 Oct 17 - No Cached
  • Nathan Goodyear on 02 Oct 17
     
    topical DHEA found to significantly decrease LH.
Nathan Goodyear

Simultaneous d... [J Chromatogr B Analyt Technol Biomed Life Sci. 2009] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...19010090

saliva salivary hormone hormones testing testosterone DHEA LC-MS_MS salivary hormone salivary hormones low T low testosterone liquid chromatography mass spectroscopy

shared by Nathan Goodyear on 02 Mar 13 - No Cached
  • Nathan Goodyear on 02 Mar 13
     
    salivary testosterone and DHEA evaluation by LC-MS/MS validated and shown to be applicable in the diagnosis and therapy in those men with low testosterone and DHEA.
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