Group items tagged

I look forward to the published results of this study as this abstract references the WHI as the "same entry" criteria.  I imagine the HRT would be the same too, but will wait to see.  There is a serious problem with proper reporting of synthetic estrogens as bioidentical estrogens and synthetic progestins as bioidentical progesterone;  Also, what is the dosage. Most individuals are massively overdosed.  This study was said to be a "landmark".  Could just be don't use synthetic hormones: which is what the WHI said.

Study compared bioidentical progesterone (micronized progesterone) to a synthetic progestin in the inhibition of endometrial hyperplasia progression.  The study found that the synthetic progestin worked best, but they both inhibited progression of the endometrial hyperplasia when followed out to 3 months therapy.

Yale study finds estrogen therapy in improves health in women ages 50-59.  The problems with hormone therapy is synthetics and overdosing.  The problem with the WHI was they used medroxy progesterone acetate--a synthetic progestin.   That is not progesterone.  This study estimated that 91,000 + died due to the uneducated view that estrogen HRT is dangerous.  What is dangerous is leaving the HRT and BHRT recommendations to those with conflicts of interest and a lack of knowledge of the science.

study finds that HRT given as women transition through menopause has benefiical effect in people with Alzheimer's.  However, when given years later, after menopause, no benefit is found.  In fact, rates increased.  Several flaws with this study.  First, they used synthetic hormones, particularily progestins.  Second, there seems to be no thought that the interpretation of the signal  has changed.  For example, we know that when men have low T, their estrogen receptor status changes from ER beta to ER alpha, which is more proinflammatory.  Third, use bioidentical hormones and compare these to synthetic hormones.

Older study finds weak synthetic androgen improves weight loss in obese postmenopausal women.  This study compared nandrolone decanoate to spironolactone--an androgen receptor antagonist.  No change in glucose or insulin was seen.  Hard to draw a strong conclusion from this study due to the comparison of a synthetic androgen versus an anti-androgen.  This comparison could have exaggerated the benefit of androgen in these women.

The estrogenic activity of synthetic progestins used in oral contraceptives.

Finally, something that lowers the risk associated with synthetic progestins. Progestins are progesterone pretenders that increase breast cancer. Apigenin, a component of bioflavonoid, was shown to inhibit growth and intact cause cell death.

this study revealed increased breast cancer risk in women on "estrogen" and "testosterone" therapy.  Now, several problems here: first, are these synthetic hormone or bioidentical.  Second, the dosages appear, in what is written, to be supra physiologic.  Third, giving supra physiologic estradiol and testosterone will obviously create imbalances and growth potential.  Fourth, how were the women evaluated prior to starting hormone therapy and then were they remonitered (unlikely), fifth, were hormone metabolites evaluated (too, also unlikely).  This study has serious flaws and very little can be extrapolated other than: don't take supra physiologic hormone levels without appropriate evaluation.  Enough said

medroxyprogsterone acetate (synthetic progestin) increase vascular function in postmenopausal women

synthetic progestins promote estrogen alpha Receptor activity: increased growth potential

synthetic progestin (MPA) off sets beneficial estrogen heart benefits

bioidentical progesterone lowers breast cancer risk; synthetic progestins increase breast cancer risk

synthetic nutrients less effective against cancer, than natural nutrients

Not especially new, but IV vitamin C + daily doxycycline found to kill cancer stem cells.

Plant microRNA found to exist in human serum from gut absorption to then alter genetic expression in in-vitro and in vivo studies.

medroxyprogesterone acetate, synthetic progestin, shown to increase inflammation signaling in human breast cancer cells.  This is a proposed mechamism by which growth stimulation occurs with prover and breast cancer.  

natural PPAR agonists.  Maybe provide some of the anti-inflammatory improved lipid metabolism without the side effects found in their synthetic counterpart avandia

Synthetic analogue of DHEA metabolite, HE3286, analyzed as treatment in Parkinson.s disease.

Progestin is not a good synthetic progesterone anyways; but this study shows that progestin in obese women in the form of contraception, increases the risk of type II DM.