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Nathan Goodyear

ScienceDirect.com - The Journal of Steroid Biochemistry and Molecular Biology - Progest... - 0 views

www.sciencedirect.com/...S0960076009001216

progesterone progestins breast cancer receptors PR

shared by Nathan Goodyear on 15 May 12 - No Cached
  • Nathan Goodyear on 15 May 12
     
    this study states that progesterone promotes breast growth and has implications of breast cancer.  However, this study looked at progestins not progesterone.  Studies have shown a reduction of breast cancer risk with progesterone and an increase with progestins.  It would have been nice to have looked at "progesterone" metabolites.  This study shows the flaw that many have: the intermix progesterone and progestins as if they are one in the same and they are clearly not
Nathan Goodyear

Effects of progestin-only long-acting contraception on metabolic markers in obese women - 0 views

www.contraceptionjournal.org/...abstract

progestin contraception type II DM type II diabetes diabetes

shared by Nathan Goodyear on 08 Feb 13 - No Cached
  • Nathan Goodyear on 08 Feb 13
     
    Progestin is not a good synthetic progesterone anyways; but this study shows that progestin in obese women in the form of contraception, increases the risk of type II DM.
Nathan Goodyear

Apigenin Induces Apoptosis and Blocks Growth of Medroxyprogesterone Acetate-Dependent B... - 0 views

www.springerlink.com/...fulltext.pdf

apigenin breast cancer flavonoid bioflavonoid medroxyprogesterone acetate synthetic progestins progestins

shared by Nathan Goodyear on 22 May 12 - No Cached
  • Nathan Goodyear on 22 May 12
     
    Finally, something that lowers the risk associated with synthetic progestins. Progestins are progesterone pretenders that increase breast cancer. Apigenin, a component of bioflavonoid, was shown to inhibit growth and intact cause cell death.
Nathan Goodyear

Comparison of the efficacy of micronized... [Arch Gynecol Obstet. 2014] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...24488582

progesterone hormone hormones bioidentical progestin synthetic endometrial hyperplasia women

shared by Nathan Goodyear on 21 Feb 14 - No Cached
  • Nathan Goodyear on 21 Feb 14
     
    Study compared bioidentical progesterone (micronized progesterone) to a synthetic progestin in the inhibition of endometrial hyperplasia progression.  The study found that the synthetic progestin worked best, but they both inhibited progression of the endometrial hyperplasia when followed out to 3 months therapy.
Nathan Goodyear

Menopausal Hormone Therapy and Risk of Colorectal Cancer - 0 views

cebp.aacrjournals.org/...196.full

progesterone progestin estrogen breast cancer hormone hormones

shared by Nathan Goodyear on 19 Nov 13 - No Cached
  • Nathan Goodyear on 19 Nov 13
     
    This study looked at relative risk, but estrogen plus progestin reduces the risk of colorectal cancer.  Progestin is a poor sythetic progesterone analogue.  One wonders what additional benefit progesterone may add as studies have shown with regards to breast cancer.
Nathan Goodyear

ScienceDirect - The Journal of Steroid Biochemistry and Molecular Biology : Effects of ... - 0 views

www.sciencedirect.com/science

progestins HRT OCPs breast cancer

shared by Nathan Goodyear on 05 Nov 10 - No Cached
  • indicate that the use of t
  • e compounds at very high concentrations may be unfavourable, but do not support a role for them in directly stimulating
  • breast tumor proliferation at the low progestin concentration which are reached in the serum in oral contraceptive users
  • Nathan Goodyear on 05 Nov 10
     
    progestins in high dose increase risk of breast cancer
Nathan Goodyear

Medroxyprogesterone Acetate Induces Cell Proliferation through Up-Regulation ... - 0 views

endo.endojournals.org/...4917.long

medroxyprogesterone acetate progestin progestins breast cancer prover NF-kapppB

shared by Nathan Goodyear on 20 Nov 12 - No Cached
  • Nathan Goodyear on 20 Nov 12
     
    medroxyprogesterone acetate, synthetic progestin, shown to increase inflammation signaling in human breast cancer cells.  This is a proposed mechamism by which growth stimulation occurs with prover and breast cancer.  
Nathan Goodyear

Genomic agonism and phenotypic antagonism between estrogen and progesterone receptors i... - 0 views

advances.sciencemag.org/...e1501924.full

progesterone PR progesterone receptors progesterone receptor cancer breast cancer hormones

shared by Nathan Goodyear on 29 Jun 16 - No Cached
  • The presence and activity of PR significantly affect the prognostic value of ER.
  • The observed loss of PR protein expression in a subset of ER+/PR+ breast cancers, because of hypermethylation or deletion of the PR gene locus, results in the loss of ER prognostic value
  • These findings emphasize the clinical value of assessing both PR and ER expression in breast cancer samples
  • ...7 more annotations...
  • PR is an essential modulator of ER-regulated genes but also that it significantly contributes to the prognostic value of ER in ER+/PR+ breast cancers
  • PR-regulated genes have independent prognostic value, and the presence of PR correlates with favorable clinicopathological outcomes
  • this study demonstrates that progestin-activated PR redirects ER chromatin binding and functions as a genomic estrogen agonist and as a phenotypic estrogen antagonist in ER+/PR+ breast cancer cells and human tumors
  • Approximately 80% of ER+ breast cancers are also positive for PR,
  • In isolation, both hormones activate or inhibit cellular processes in similar directions, although the magnitude of these effects is less for progestin alone than for estrogen alone
  • PR-mediated antagonism of estrogenic phenotypes is well documented
  • joint activation of ER and PR antagonized ER-regulated oncogenic processes
  • Nathan Goodyear on 29 Jun 16
     
    WOW!!  study finds that progesterone through PR activity antagonizes ER protein expression by the cell.  This has huge implications in breast cancer and possible prostate cancer.  But then again, women don't need progesterone; only estrogen.  The presence of PR correlates with improved clinicopathological outcomes.  The authors do seem to get confused about progesterone and progestins.  They are not one in the same.
Nathan Goodyear

Progestin effects on growth in the human breast ca... [Biochem Biophys Res Commun. 1987... - 0 views

www.ncbi.nlm.nih.gov/...3593365

progestins breast cancer

shared by Nathan Goodyear on 04 Nov 10 - No Cached
  • Nathan Goodyear on 04 Nov 10
     
    Progestin effects on growth in the human breast cancer cell line T-47D--possible therapeutic implications.
Nathan Goodyear

Estrogenic Potential of Progestins in Oral Contraceptives to Stimulate Human Breast Can... - 0 views

cancerres.aacrjournals.org/...6539.full.pdf+html

progestins birth controls hormones oral contraceptives

shared by Nathan Goodyear on 04 Nov 10 - No Cached
  • Nathan Goodyear on 04 Nov 10
     
    Estrogenic Potential of Progestins in Oral Contraceptives to Stimulate Human Breast Cancer Cell Proliferation1
Nathan Goodyear

Progestins increase insulin receptor content and i... [Cancer Res. 1990] - PubMed result - 0 views

www.ncbi.nlm.nih.gov/...2253226

progestins breast cancer insulin

shared by Nathan Goodyear on 04 Nov 10 - No Cached
  • Nathan Goodyear on 04 Nov 10
     
    Progestins increase insulin receptor content and insulin stimulation of growth in human breast carcinoma cells.
Nathan Goodyear

Synthetic progestins induce proliferation of breas... [Mol Cell Endocrinol. 1994] - Pub... - 0 views

www.ncbi.nlm.nih.gov/...7926273

hormones bioidentical progesterone progestins

shared by Nathan Goodyear on 04 Nov 10 - No Cached
  • Nathan Goodyear on 04 Nov 10
     
    Estrogenic potential of progestins in oral contraceptives to stimulate human breast cancer cell proliferation.
Nathan Goodyear

Hormone replacement therapy containing progestins and given continuously increases brea... - 0 views

onlinelibrary.wiley.com/...abstract

hormones progesterone progestins breast cancer hormone bioidentical

shared by Nathan Goodyear on 18 Nov 10 - No Cached
  • Nathan Goodyear on 18 Nov 10
     
    Hormone replacement therapy containing progestins and given continuously increases breast carcinoma risk in Sweden
Nathan Goodyear

The estrogenic activity of synthetic progestins us... [Cancer. 1993] - PubMed result - 0 views

www.ncbi.nlm.nih.gov/...8431886

synthetic progestins breast cancer

shared by Nathan Goodyear on 12 Nov 10 - No Cached
  • Nathan Goodyear on 12 Nov 10
     
    The estrogenic activity of synthetic progestins used in oral contraceptives.
Nathan Goodyear

JAMA Network | JAMA | Estrogen Plus Progestin and the Incidence of Dementia a... - 0 views

jama.jamanetwork.com/article.aspx

estrogen dementia memory WHI HRT HT BHRT hormone therapy hormone hormones women MPA medroxyprogesterone acetate

shared by Nathan Goodyear on 06 Aug 13 - No Cached
  • Nathan Goodyear on 06 Aug 13
     
    Estrogen with progestin worsens cognitive decline in women >65.  Little can be taken from this study other than, medroxyprogesterone acetate is a bad drug and should not be given to women for any purpose, especially in those >65.  One wonders if bioidentical, physiologic hormone replacement would have the same effect?  I doubt it.  The likely negative impact of hormones on the brain in women >65 is due to the negative effects of MPA, the change in inflammatory cytokines, and the change in receptors.
Nathan Goodyear

Effects of tibolone and combined 17β-estradiol and norethisterone acetate on ... - 0 views

humrep.oxfordjournals.org/...2748.full

estradiol progestin hormone hormones HRT CRP women

shared by Nathan Goodyear on 17 Nov 13 - No Cached
  • Nathan Goodyear on 17 Nov 13
     
    Study finds that estradiol combined with synthetic progestin increased CRP.  No surprise.
Nathan Goodyear

Taylor & Francis Online :: Effects of Dietary Apigenin on Tumor Latency, Incidence and ... - 0 views

www.tandfonline.com/...01635581.2013.833637

breast cancer progestin apigenin medroxyprogesterone acetate

shared by Nathan Goodyear on 26 Nov 13 - No Cached
  • Nathan Goodyear on 26 Nov 13
     
    There is absolutely no reason for women to take medroxyprogesterone acetate.  Whether the author realizes it or not, he states a truth that progestin is a "trigger" in carcinogenesis of the breast.  This study was designed to look at high dose apigenin, which the study found increased risk.
Nathan Goodyear

Norgestrel and gestodene stimulate breast cancer cell growth through an oestrogen recep... - 0 views

www.ncbi.nlm.nih.gov/...PMC1968434

breast cancer HRT hormones hormone replacement progestins

shared by Nathan Goodyear on 05 Nov 10 - No Cached
  • Nathan Goodyear on 05 Nov 10
     
    synthetic progestins stimulate breast cancer
Nathan Goodyear

Breast cancer risk in relation to different types ... [Int J Cancer. 2005] - PubMed result - 0 views

www.ncbi.nlm.nih.gov/...15551359

progestins hormone hormones breast cancer risk

shared by Nathan Goodyear on 18 Nov 10 - No Cached
  • Nathan Goodyear on 18 Nov 10
     
    synthetic progestins increase breast cancer risk
Nathan Goodyear

Effect of Medroxyprogesterone Acetate on Endothelium-Dependent Vasodilation in Postmeno... - 0 views

circ.ahajournals.org/...1773

MPA synthetic medroxyprogesterone progestins

shared by Nathan Goodyear on 18 Nov 10 - No Cached
  • Nathan Goodyear on 18 Nov 10
     
    medroxyprogsterone acetate (synthetic progestin) increase vascular function in postmenopausal women
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