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Nathan Goodyear

Low free testosterone is associated wit... [Geriatr Gerontol Int. 2014] - PubMed - NCBI - 0 views

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    Low free Testosterone associated muscle loss in Japanese women.  This points to other studies that low T can cause problems in women--in this case muscle loss.  Like many things, Testosterone in women is likely a "U" shaped curve of function: low and high are bad with physiologic therapy good.
Nathan Goodyear

Longitudinal relationships of circul... [J Clin Endocrinol Metab. 2014] - PubMed - NCBI - 0 views

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    Declining Testosterone, calculated free Testosterone, Estradiol, and Estrone levels appear to be associated with muscle mass/strength decline in elderly men.  This points to a global decrease in HPA function rather than an individual, specific hormone deficiency.
Nathan Goodyear

The Effects of Supraphysiologic Doses of Testosterone on Muscle Size and Strength in No... - 0 views

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    Study finds that massive doping of Testosterone, 600 mg weekly, results in increase muscle mass and performance with strength training.  This dosing amounts to about 100 mg daily compared to the 5-10 mg of peak daily production of a young man.
Nathan Goodyear

Changes in fat and lean body mass during androgen-de... [Urology. 2004] - PubMed - NCBI - 0 views

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    Androgen deprivation therapy resulted in an 11% increase in fat mass and just under 4% decrease in lean muscle mass in men.  
Nathan Goodyear

Changes in body composition during a... [J Clin Endocrinol Metab. 2002] - PubMed - NCBI - 0 views

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    Androgen deprivation therapy was found to decrease lean muscle mass and increase abdominal adipose tissue, not visceral.  Significant change in body composition in men depleted of androgens in androgen deprivation therapy.
Nathan Goodyear

Predictive parameters of accelerated muscle loss in... [Am J Med. 2014] - PubMed - NCBI - 0 views

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    Study looked at muscle loss in older men and found that low activity, type II diabetes, low Total Testosterone and low free Testosterone, and increased PTH are associated with an increased muscle loss 
Nathan Goodyear

Is administrating branched-chain amino acid-enriched nutrition achieved symptom-free in... - 0 views

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    BCAA improve NH3 metabolism.  This is via muscle metabolism as reported in other studies.  This study highlighted the differences in BCAA supplementation.  One caveat is that high glutamine is the result from glutamate and this can increase hepatic encephalopathy.
Nathan Goodyear

Branched-chain amino acids and muscle ammoni... [Metab Brain Dis. 2013] - PubMed - NCBI - 0 views

  • BCAA metabolism may improve muscle net ammonia removal by supplying carbon skeletons for formation of alfa-ketoglutarate that combines with two ammonia molecules to become glutamine
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    Muscle becomes the primary mode of NH3 metabolism in liver cirrhosis.  The authors here propose that it is via an increase in muscle mass rather than specifically lowering NH3.  In fact, there is an early increase in NH3 production.
Nathan Goodyear

Diagnosis and treatment of late-onset hypogonadism: Systematic review and meta-analysis... - 0 views

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    Testosterone therapy is complex in hypogonadism.  Much of the marketing-based medicine of Low T today is in fact doping.  Increasing weight is clearly associated with a declining T level in men.  Testosterone therapy should be approach individually and therapies that use the one size fits all approach never work.  This is the case whether the use of synthetics or natural hormones are employed.  Testosterone has been shown to improve dysglycemia, MetS, reduce fat and increase muscle mass.  
Nathan Goodyear

JISSN | Full text | Creatine supplementation enhances muscle force recovery after eccen... - 0 views

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    Creatine supplementation shown to improve muscle recovery in injury.  The dosing included the standard loading dose at 0.3 g/kg of body weight divided in multiple doses.  Maintenance was at 0.1 g/kg of body weight.
Nathan Goodyear

Testosterone Improves the Regeneration of Old and Young Mouse Skeletal Muscle - 0 views

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    Testosterone increases muscle mass, strength and cell number.
Nathan Goodyear

Effect of Increasing Glutathione With Cysteine and Glycine Supplementation on Mitochond... - 0 views

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    Supporting glutathione levels with the precursors cysteine and glycine improved insulin receptor function, body fat, and muscle strength in HIV individuals.
Nathan Goodyear

The Role of Androgens and Estrogens on Healthy Aging and Longevity - 0 views

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    Customized hormone therapy benefits muscle and bone loss in men and women.  This is abstract only.
Nathan Goodyear

Effect of increasing glutathione with cysteine and glycine supplementation on mitochond... - 0 views

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    Abstract only available due to pre-release.  Cysteine and glycine supplementation feed the glutathione pathways.  In HIV men, this improved insulin sensitivity, body composition, and muscle strength.
Nathan Goodyear

Cambridge Journals Online - British Journal of Nutrition - Abstract - Post-exercise whe... - 0 views

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    Whey protein hydrolysate shown to be superior to amino acids in recovery phase of exercise.  
Nathan Goodyear

Testosterone Therapy Prevents Gain in Visceral Adipose Tissue and Loss of Skeletal Musc... - 0 views

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    Testosterone therapy slows visceral fat accumulation and increases muscle mass.
Nathan Goodyear

PLOS ONE: Overexpression of the Mitochondrial T3 Receptor Induces Skeletal Muscle Atrop... - 0 views

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    Overexpression of T3 receptors can contribute to muscle loss with aging.  
Nathan Goodyear

PLOS ONE: Overexpression of the Mitochondrial T3 Receptor p43 Induces a Shift in Skelet... - 0 views

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    T3 induces beneficial oxidative changes in muscles through its interaction with mitochondrial receptors.  PGC-1alpha and PPAR-gamma were involved in this process.  The important point here is that T3 is increasing oxidative function of muscle through interaction with mitochondria.
Nathan Goodyear

Dose-dependent effects of vitamin D on transdifferentiation of skeletal muscle cells to... - 0 views

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    Dose dependent vitamin D impact on fat.  Low vitamin D concentrations associated with fat adipogenesis.  Higher vitamin D concentrations inhibited adipogenesis.
Nathan Goodyear

Improving the Vitamin D Status of Vitamin D Deficient Adults Is Associated With Improve... - 0 views

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    vitamin D improves mitochondrial function through improved oxidative phosporylation.
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