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Nathan Goodyear

Testosterone Replacement in Hypogonadal Men With Type 2 Diabetes and/or Metabolic Syndr... - 0 views

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    Testosterone therapy in men with low Testosterone was found to improve insulin sensitivity, total cholesterol levels, LDL, Lpa, and sexual performance in men with low T, type II diabetes and/or metabolic syndrome.  There is suggestion that muscle composition was improved as well.
Nathan Goodyear

Hormonal and lifestyle determinants of appendicular skeletal muscle mass in men: the MI... - 0 views

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    muscle loss, sarcopenia is a significant marker of poor health in men.  This study of 845 men age 45-85 finds that low Testosterone, low vitamin D, low physical activity, smoking, and thin body build are associated with sarcopenia in men.
Nathan Goodyear

Predictors of skeletal muscle mass in elderly men and women - 0 views

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    Study of men and women finds that low free Testosterone, physical activity, and IGF1 is associated with muscle mass in men; no such relationship between sex hormone and muscle mass in women was found.
Nathan Goodyear

Relationship between Low Free Testosterone Levels and Loss of Muscle Mass : Scientific ... - 0 views

  • Our data confirm that a low FT level is a significant predictor of a risk for loss of appendicular muscle
  • Total lean mass is associated with bioavailable T in postmenopausal women
  • Further studies are needed to determine the role of androgens in preserving muscle mass in women
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  • Approximately 1% to 2% of T in the blood exists as FT
  • appendicular muscle loss was significantly associated with low levels of FT
  • These results suggest that a threshold level of FT exists for muscle loss, rather than a dose-response relationship
  • In the previous cross-sectional and longitudinal studies of French and American men, no dose-response relationships were reported between T and muscle mass
  • A minimal serum level of FT may be needed to preserve muscle mass in men, regardless of race/ethnicity.
  • Our result is in line with previous studies that reported a relationship between low FT and low muscle mass in men
  • T stimulates protein synthesis and inhibits protein degradation in muscle cells
  • T also increases satellite cell replication and activation in older men
  • In this study, no significant association between TT levels and muscle loss were observed
  • Although a progressive decrease in TT levels with ageing is observed in middle-aged and elderly American men16, 17, the TT levels do not change during ageing in Japanese men
  • FT levels may be a good marker for the loss of muscle mas
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    study of Japanese men finds that low free Testosterone was a predictor of decrease in muscle mass.
Nathan Goodyear

Testosterone and weight loss: the evidence - 0 views

    • Nathan Goodyear
       
      What a ridiculous statement!
  • Testosterone therapy increases LBM, reduces fat mass and produces sustained and significant weight loss, reduction in waist circumference and BMI
Nathan Goodyear

http://www.centromedicoathenas.com.br/Content/Uploads/Info/158.pdf - 0 views

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    to be read.
Nathan Goodyear

Exercise-Associated Muscle Cramps - 0 views

  • athletes who develop EAMC often ingest similar amounts of fluid during exercise as do their noncramping counterparts
  • Oral fluid ingestion may be ineffective, and intravenous fluid may provide a faster delivery for athletes suffering from acute EAMC
  • It is interesting that stretching the affected muscle almost immediately relieves EAMC
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  • Stretching, the primary treatment for acute EAMC
  • National Athletic Trainers’ Association recommends that athletes prone to muscle cramping add 0.3 to 0.7 g/L of salt to their drinks to stave off muscle cramps
  • Others have recommended adding higher amounts of sodium (about 3.0 to 6.0 g/L) to sports drinks based on the frequency of EAMC
  • intravenous infusion of fluids removes this delay, and it has been used to aid athletes who develop acute EAMC
  • maintaining hydration and adequate electrolyte levels is a good prevention strategy for individuals susceptible to EAMC
  • Fluid volumes of 1.8 L per hour have been well tolerated by tennis athletes who are susceptible to EAMC
  • Monitoring an athlete’s body weight is an easy method of ensuring adequate fluid replacement and individualizes each athlete’s fluid needs
  • the National Athletic Trainers’ Association and the American College of Sports Medicine recommend a volume of fluid that allows for less than a 2% body weight reduction
  • Endurance training may also serve as an effective means of preventing EAMC by expanding plasma volume and the extracellular fluid compartment15 and delaying neuromuscular fatigue
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    Exercise associated muscle cramps or EAMC is not worked out.  The theories include dehydration, mineral/electrolyte deficiencies, and neuromuscular activity.
Nathan Goodyear

Resistance exercise training improves heart rate variability and mu... - PubMed - NCBI - 0 views

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    High repetition, low weight is associated with improved Heart rate variability, muscle strength and endurance in non-healthy-CAD patients.
Nathan Goodyear

Weekly Versus Monthly Testosterone Administration on Fast and Slow ... - PubMed - NCBI - 0 views

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    Weekly Testosterone injections increase type 1 slow muscle fibers more than type II fast twitch muscle fibers compared to monthly injections.  The study looked at older men with sarcopenia and low T.
Nathan Goodyear

Muscle Strength, Body Composition, and Physical Activity in Women Receiving Chemotherap... - 0 views

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    Chemotherapy is associated with a decline in lean body mass.  This could play a role in increase weight, especially in pre menopause women.
Nathan Goodyear

Muscles, exercise and obesity: skeletal muscle as a secretory organ : Abstract : Nature... - 0 views

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    Skeletal muscles are much more than just about contraction.  There produce inflammatory cytokines and other signals that have endocrine-like effects.  This article calls them myokines.  A decrease in physical activity would leave an altered myokine response effecting the liver, adipose tissue, immune system and pancreatic function.
Nathan Goodyear

Age-related hormonal adaptations, muscle circumference and strength development with 8w... - 0 views

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    Moderate resistance training program over 8 weeks associated with increased Testosterone production in young and middle age lean men.  Growth hormone was also increased in both groups.  ACTH and cortisol decreased in this lean men.  
Nathan Goodyear

Effect of resistance exercise on muscle steroidogenesis | Journal of Applied Physiology - 0 views

  • skeletal muscle cell cultures incubated with DHEA produced testosterone in a DHEA dose-dependent manner
  • Muscle joins a growing list of tissues found to be capable of steroidogenesis
  • testosterone appears to have a role in the maintenance of muscle mass in women, although the importance of this role has not yet been fully established.
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  • Circulating testosterone concentrations are generally elevated following a bout of resistance exercise in men (24, 31, 46, 52), whereas findings for the effect of resistance exercise on circulating testosterone in women are equivocal, with increases (10, 42) and no changes observed (22, 31)
  • swimming (51) and treadmill running (2) can significantly increase muscle testosterone concentrations in male and female rats
  • This upregulation of muscle testosterone in rats appears, at least in part, to be due to an increase in 3β-HSD and 17β-HSD type 1 expression
  • The primary finding in this study was that muscle steroidogenesis (i.e., testosterone production) in highly resistance-trained humans was not affected by an acute bout of heavy resistance exercise
  • A secondary finding was that the apparent molecular mass of 17β-HSD type 3 was increased following a single bout of heavy resistance exercise.
  • No differences were found for muscle testosterone or steroidogenic enzyme (17β-HSD type 3 and 3β-HSD types 1 and 2) concentrations between sexes or in response to resistance exercise
  • In conclusion, heavy resistance exercise did not induce changes in muscle steroidogenesis as measured by muscle concentrations of testosterone, 3β-HSD types 1 and 2, and 17β-HSD type 3 in highly resistance-trained young men and women.
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    Resistance exercise did not increase muscle concentrations of Testosterone in men or women.  The individuals in this study were actively training.  These were not sedentary individuals.
Nathan Goodyear

Cardiovascular risk associated with tes... [Expert Opin Drug Saf. 2014] - PubMed - NCBI - 0 views

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    Testosterone therapy in men with low Testosterone, over 34 weeks, found to improve metabolism, reduce fat and increase muscle mass and not associated with any increase cardiovascular risk.
Nathan Goodyear

Low free testosterone is associated with loss of appendicular muscle mass in Japanese c... - 0 views

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    low Free testosterone found to be associated with muscle mass loss in women when compared to high free Testosterone levels.
Nathan Goodyear

Relationship between Low Free Testosterone Levels and Loss of Muscle Mass : Scientific ... - 0 views

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    Study finds low free Testosterone and low calculated free Testosterone was associated with sarcopenia in Japanese men.  This association was not found with Total Testosterone.
Nathan Goodyear

https://endo.confex.com/endo/2014endo/webprogram/Paper11377.html - 0 views

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    from CHAMP study: low serum Testosterone, free Testosterone, Estradiol and Estrone associated with functional decline in elderly men via muscle weakness.
Nathan Goodyear

Muscle Mass Index As a Predictor of Longevity in Older Adults - The American Journal of... - 0 views

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    Higher muscle mass associated with lower mortality in older adults.  so many focus on cardio and forget about resistance training.
Nathan Goodyear

Citrulline stimulates muscle protein synthesis in ... [Clin Nutr. 2014] - PubMed - NCBI - 0 views

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    Not really a surprise, but citrulline shown to stimulate anabolic muscle growth.
Nathan Goodyear

11Beta hydroxysteroid dehydrogenase ty... [Clin Endocrinol (Oxf). 2006] - PubMed - NCBI - 0 views

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    11beta-HSD type I dominantly expressed in muscle.
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