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Nathan Goodyear

Associations between sex hormone binding globulin and metabolic syndrome parameters in ... - 0 views

www.indianjmedsci.org/article.asp

SHGB metabolic syndrome hormone hormones female women obesity premenopause pre-menopausal premenopausal

shared by Nathan Goodyear on 07 Aug 14 - No Cached
  • Nathan Goodyear on 07 Aug 14
     
    Low SHGB associated with increased association with metabolic syndrome components.  Low SHBG particuraliy associated with increased obesity (visceral) and glucose dysmetabolism. This study looked at premenopausal women.
Nathan Goodyear

Urinary Estrogens and Estrogen Metabolites and Subsequent Risk of Breast Cancer among P... - 0 views

cancerres.aacrjournals.org/...696.full

estrogen metabolites estrogen metabolism ER estrogen receptors ROS hormones cancer breast cancer

shared by Nathan Goodyear on 07 Oct 15 - No Cached
  • both 2- and 4-catechol estrogen metabolites bind to the ER with affinities comparable with estradiol, 4-catechol estrogen metabolites have lower dissociation rates than estradiol and an enhanced ability to upregulate ER-dependent processes
  • 2-catechol estrogen metabolites act as either weak mitogens (39) or weak inhibitors of cell proliferation
  • While 16α-hydroxyestrone binds to the ER with lower affinity than estradiol, it binds covalently (41) and leads to a constitutively activated ER
  • ...15 more annotations...
  • 4-hydroxyestradiol and 16α-hydroxyestrone increasing proliferation and decreasing apoptosis in a manner similar to estradiol; however, these effects were achieved only at concentrations 10-fold higher than estradiol (39). In contrast, 2-hydroxyestradiol did not have substantial proliferative or antiapoptotic effects
  • In our study, the associations with both 2-hydroxyestrone and 16α-hydroxyestrone were nonsignificantly inverse and we did not observe a consistent trend or significant associations between the 2-hydroxyestrone:16α-hydroxyestrone ratio and breast cancer risk
  • Ratios of the 3 hydroxylation pathways were not significantly associated with risk although the 2:16-pathway and 4:16-pathway ratios were suggestively inversely associated
  • a significant inverse association with the ratio of parent estrogens to estrogen metabolites
  • several potentially estrogenic and genotoxic mechanisms
  • Estrogen metabolites also can be genotoxic
  • Catechol estrogens can be oxidized into quinones and induce DNA damage directly through the formation of DNA adducts, or indirectly via redox cycling and generation of reactive oxygen species
  • the oxidized forms of the catechol estrogens differ in their ability to damage DNA through adducts, with oxidized 2-catechols forming stable and reversible DNA adducts and oxidized 4-catechols forming unstable adducts, which lead to depurination and mutations
  • 2- and 4-catechols have been shown to produce reactive oxygen species and induce oxidative DNA damage
  • act independently from the ER
  • 16α-Hydroxyestrone also may be genotoxic
  • While the catechol estrogens have estrogenic and genotoxic potential, the methylated catechol estrogens, which are catechol estrogens with one hydroxyl group methylated, have been hypothesized to lower the risk of breast cancer
  • The suggested mechanisms are indirect, by decreasing circulating levels of catechol estrogens and thereby the opportunity for catechols to exert genotoxic or proliferative effects, or direct, by inhibiting tumor growth and inducing apoptosis
  • the balance between phase I (oxidation) and phase II (methylation) metabolism of estrogen may be important in hormonally related cancer development.
  • Despite the estrogenic and genotoxic potential of many of the estrogen metabolites, we only observed a significantly increased breast cancer risk with one estrogen metabolite, 17-epiestriol, which has particularly strong estrogenic activity and binds to both ERα and ERβ with an affinity comparable with estradiol
  • Nathan Goodyear on 07 Oct 15
     
    review of estrogen metabolites and breast cancer risk in premenopausal women.
Nathan Goodyear

Saliva as a Medium for Investigating Intra- and Interindividual Differences in Sex Horm... - 0 views

cebp.aacrjournals.org/...59.full

hormone testing saliva salivary Estrogen progesterone

shared by Nathan Goodyear on 03 Nov 10 - No Cached
  • These results indicate that daily saliva samples can be combined to clarify the interindividual differences in E2 and PG levels in premenopausal women, and that these interindividual differences may be greater than previously imagined.
  • Nathan Goodyear on 03 Nov 10
     
    Saliva as a Medium for Investigating Intra- and Interindividual Differences in Sex Hormone Levels in Premenopausal Women1
Nathan Goodyear

Ovarian hormones and reproductive risk factors for breast cancer in premenopausal women... - 0 views

humrep.oxfordjournals.org/...1519.full

estradiol progesterone estrogen hormone hormones saliva salivary testing breast Cancer Norwegian EBBA-I study Norwegian

shared by Nathan Goodyear on 14 Nov 12 - No Cached
  • Nathan Goodyear on 14 Nov 12
     
    this study looked at ovarian sex hormones as it relates to premenopausal women and breast cancer risk.  They used saliva as the test medium to evaluate estradiol and progesterone.
Nathan Goodyear

High Testosterone and Low Progesterone Circulating Levels in Premenopausal Patients wit... - 0 views

cancerres.aacrjournals.org/...841.long

Testosterone progesterone hormones cancer women female hormones breast pre-menopause

shared by Nathan Goodyear on 15 Sep 16 - No Cached
  • Nathan Goodyear on 15 Sep 16
     
    higher Testosterone levels, in conjunction with lower progesterone levels, found in premenopausal women with breast hyperplasia and breast cancer.  The authors point to elevated androgens in breast cancer induction and development.  This same hormone patter, low progesterone/elevated Testosterone, is associated with PCOS in women.
Nathan Goodyear

Adiponectin: A Risk Biomarker and Attractive Target for Chemoprevention - 0 views

jco.ascopubs.org/...124.full

adiponectin breast cancer premenopausal women tumor marker

shared by Nathan Goodyear on 17 Mar 12 - No Cached
  • Nathan Goodyear on 17 Mar 12
     
    adiponectin suggested to be a breast cancer tumor marker in premenopausal women.
Nathan Goodyear

Serum Sex Steroids in Premenopausal Women and Breast Cancer Risk Within the European Pr... - 0 views

jnci.oxfordjournals.org/...755.long

serum hormone hormones Testosterone progesterone estrogen estradiol breast cancer women female

shared by Nathan Goodyear on 21 Mar 14 - No Cached
  • Nathan Goodyear on 21 Mar 14
     
    Study finds that elevated serum Testosterone and androstenedione is associated with an increase risk of breast cancer.  This EPIC study looked at serum hormones in premenopausal women.  This study also found an association with increased breast cancer and low serum progesterone in women.  This was also found in the ORDET study.  This study did not find a link with estrogen.  These are endogenous levels.  Does this translate to exogenous? This theory of elevated androgens and breast cancer was first proposed by Grattarola.
Nathan Goodyear

http://care.diabetesjournals.org/content/early/2013/02/07/dc12-1912.full.pdf - 0 views

care.diabetesjournals.org/...dc12-1912.full.pdf

protein carbohydrates macronutrients insulin resistance obesity obese inflammation inflammatory cytokines premenopause women

shared by Nathan Goodyear on 17 Mar 14 - No Cached
  • Nathan Goodyear on 17 Mar 14
     
    Study finds that higher protein to carbohydrate intake has a positive effect on inflammatory cytokines, oxidative stress, improves insulin sensitivity and improves Beta cell function in premenopausal, non diabetic obese women.
Nathan Goodyear

Steroid Hormone Levels during Pregnancy and Incidence of Maternal Breast Cancer - 0 views

cebp.aacrjournals.org/...361.long

breast cancer hormone hormones breast cancer progesterone pregnancy premenopausal

shared by Nathan Goodyear on 14 Oct 13 - No Cached
  • Nathan Goodyear on 14 Oct 13
     
    Women with the highest progesterone levels during pregnancy have an inverse low breast cancer risk.  This association was found with premenopausal breast cancer.  The reduction was upwards of 70%.  One fault of this study is the use of serum hormone levels.  
Nathan Goodyear

Changes in Weight, Body Composition, and Factors Influencing Energy Balance Among Preme... - 0 views

jco.ascopubs.org/...2381.short

chemotherapy breast cancer muscle weight gain obesity cancer

shared by Nathan Goodyear on 26 Aug 15 - No Cached
  • Nathan Goodyear on 26 Aug 15
     
    study finds weight gain in premenopausal breast cancer survivors on adjuvant chemo is due to sarcopenia.
Nathan Goodyear

Characteristics of salivary profiles of oestradiol and progesterone in premenopausal wo... - 0 views

joe.endocrinology-journals.org/...77

saliva testing salivary hormone progesterone estradiol estrogen

shared by Nathan Goodyear on 02 Nov 10 - No Cached
  • Nathan Goodyear on 02 Nov 10
     
    Characteristics of salivary profiles of oestradiol and progesterone in premenopausal women
Nathan Goodyear

Endogenous sex hormones and subsequent breast canc... [Int J Cancer. 2004] - PubMed result - 0 views

www.ncbi.nlm.nih.gov/...15352045

progesterone breast cancer hormones

shared by Nathan Goodyear on 19 Jan 11 - No Cached
  • These findings support the hypothesis that ovarian hyperandrogenism associated with luteal insufficiency increases the risk of BC in premenopausal women.
  • Nathan Goodyear on 19 Jan 11
     
    Progesterone deficiency and elevated male hormones in women increase premenopausal breast cancer
Nathan Goodyear

Dietary glycemic index, glycemic load, and the risk of breast cancer in an Italian pros... - 0 views

ajcn.nutrition.org/...1160.full

nutrition diet glycemic index glycemic load cancer breast cancer carbohydrates sugar menopause women premenopause

shared by Nathan Goodyear on 09 Dec 14 - No Cached
  • GI is a measure of carbohydrate quality in relation to glucose availability and is independent of quantity, whereas GL is a measure of the total glycemic effect and hence is anindicator of the insulin demand of the diet. High-glycemic diets are in fact generally associated with greater insulin secretion
  • the consumption of large quantities of high-GI foods rather than the consumption of high quantities of carbohydrates is linked to the development of breast cancer.
  • Nathan Goodyear on 09 Dec 14
     
    High glycemic load and glycemic index associated with increased breast cancer risk in premenopausal women.
Nathan Goodyear

Influence of Endogenous Reproductive Hormones on F2-Isoprostane Levels in Premenopausal... - 0 views

www.ncbi.nlm.nih.gov/...PMC2950793

F2 Isoprostane estrogen estradiol hormones oxidative stress cardiovascular disease

shared by Nathan Goodyear on 16 Jul 17 - No Cached
  • Nathan Goodyear on 16 Jul 17
     
    Endogenous estradiol levels correlate with F2 Isoprostane levels in premenopausal women.
Nathan Goodyear

Insulin-like growth factor-I, its binding proteins (IGFBP-1 and IGFBP-3), and growth ho... - 0 views

erc.endocrinology-journals.org/...583.long

HGH GH IGF-1 IGFBP-1 IGFBP-3 breast cancer premenopause premenopausal women Nurses Health Study Nurses Health Study II

shared by Nathan Goodyear on 06 Jul 12 - No Cached
  • Nathan Goodyear on 06 Jul 12
     
    GH, IGF-1, IGFBP-1, and IGFBP-3 were not found to be associated with increased risk of breast cancer in premenopuasal women.
Nathan Goodyear

Vitamin D and breast cancer recurrence in the Women's Healthy Eating and Living (WHEL) ... - 0 views

www.ajcn.org/...108.abstract

vitamin D breast cancer recurrence

shared by Nathan Goodyear on 01 Feb 12 - No Cached
  • Nathan Goodyear on 01 Feb 12
     
    Vitamin D shown to reduce breast cancer recurrence in premenopausal women.  Same association not found in postmenopausal women.
Nathan Goodyear

BREAST CANCER INCIDENCE IN WOMEN WITH A HISTORY OF PROGESTERONE DEFICIENCY - 0 views

aje.oxfordjournals.org/...209

progesterone deficiency breast cancer breast cancer women hormone hormones

shared by Nathan Goodyear on 14 Oct 13 - No Cached
  • Nathan Goodyear on 14 Oct 13
     
    Women with low progesterone have 5.4 x elevated risk of premenopausal breast cancer.  This was a study done on women seeking fertility.  This study followed women for 33 years.
Nathan Goodyear

Why women gain weight with adjuvant chemotherapy for breast cancer. - 0 views

jco.ascopubs.org/...1418.short

pre-menopause postmenopause chemotherapy cancer women hormone hormones

shared by Nathan Goodyear on 08 Oct 14 - No Cached
  • Nathan Goodyear on 08 Oct 14
     
    weight gain in cancer treatment seems to be directed at adjuvant therapy (chemo) and premenopausal status.
Nathan Goodyear

Weight gain after primary surgery fo... [Breast Cancer Res Treat. 1992] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...1391977

tamoxifen weight weight gain women hormones hormone cancer breast breast cancer pre-menopause Postmenopause

shared by Nathan Goodyear on 08 Oct 14 - No Cached
  • Nathan Goodyear on 08 Oct 14
     
    The increased weight with tamoxifen is seen premenopausal women, but less with postmenopausal women.
Nathan Goodyear

Estrogen Metabolism and Breast Cancer : Epidemiology - 0 views

journals.lww.com/...lism_and_Breast_Cancer.15.aspx

estrogen metabolism estrogen metabolism estrogen metabolite metabolite metabolites breast cancer 2-OH-estrone 16alpha-OH-estrone 2:16alpha-OHE1

shared by Nathan Goodyear on 21 Aug 14 - No Cached
  • Nathan Goodyear on 21 Aug 14
     
    Maybe the risks of estrogen metabolism is age dependent?  This Long Island Breast Cancer Study Project found that an increased 2:16alphOH-estrone ratio was associated with a reduced premenopausal, invasive breast cancer risk.  This association declined when looked at in postmenopausal women.
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