Skip to main content

Home/ Dr. Goodyear/ Group items tagged cocaine

Rss Feed Group items tagged

Filter: All | Bookmarks | Topics Simple Middle
Nathan Goodyear

Peripheral mechanisms of erectile dysfunction in a rat model of chronic cocaine use. - ... - 0 views

www.ncbi.nlm.nih.gov/...17420087

ED cocaine eNOS NO nitric oxide

shared by Nathan Goodyear on 11 Aug 16 - No Cached
  • Nathan Goodyear on 11 Aug 16
     
    animal study finds that cocaine binge use associated with decreased eNOS expression in the penis.  This is consistent with the other very limited studies that show that cocaine decreases eNOS protein expression and thus NO.
Nathan Goodyear

Intense sweetness surpasses cocaine reward. [PLoS One. 2007] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...17668074

artificial sweetners saccharin cocaine addiction

shared by Nathan Goodyear on 16 May 12 - No Cached
  • Nathan Goodyear on 16 May 12
     
    Rats that were sensitized to cocaine, preferred artificial sweeteners over that of cocaine. Think about that for a moment.  Does that redefine addiction?
Nathan Goodyear

Effects of Cocaine on Nitric Oxide Production in Bovine Coronary Artery Endothelial Cells - 0 views

jpet.aspetjournals.org/...980.long

NO cocaine eNOS nitric oxide

shared by Nathan Goodyear on 11 Aug 16 - No Cached
  • Nathan Goodyear on 11 Aug 16
     
    animal study finds cocaine decreased eNOS transcription and thus eNOS activity.
Nathan Goodyear

2013: Student-faculty research suggests Oreos can be compared to drugs of abuse in lab ... - 0 views

www.conncoll.edu/...drugs-of-abuse-in-lab-rats.htm

sugar drug addiction brain

shared by Nathan Goodyear on 24 Apr 14 - No Cached
  • Nathan Goodyear on 24 Apr 14
     
    Rat study suggests that sugar is just as addictive as cocaine.  So, is the food industry knowingly pushing addiction on the public?
Nathan Goodyear

ScienceDirect.com - Cell Metabolism - Estrogen Receptors and the Metabolic Network - 0 views

www.sciencedirect.com/...S1550413111003123

ER-alpha ER-beta estrogen receptor receptors metabolic syndrome MetS hormone hormones

shared by Nathan Goodyear on 11 Oct 12 - No Cached
  • The pro-opiomelanocortin (POMC) neurons have an anorexigenic action and, when activated, reduce food intake through the release of two peptides, α-melanocyte-stimulating hormone (α-MSH) and cocaine-and-amphetamine-regulated transcripts (CART). The neuropeptide Y (NPY) neurons, on the other hand, release NPY hormone and agouti gene-related protein (AgRP), which prevent the binding of α-MSH to MC3R and MC4R, increasing food intake
  • This suggests that the central anorexic effects of E2 may occur via ERβ
  • The main hypothalamic areas involved in food intake and satiety are the arcuate nucleus (ARC), the lateral hypothalamus (LH), the paraventricular nucleus (PVN), the ventromedial hypothalamus (VMH), and the dorsomedial hypothalamus (DMH)
  • ...22 more annotations...
  • Leptin is a potent anorexigenic and catabolic hormone secreted by adipose cells that reduces food intake and increases energy expenditure
  • E2 not only modulates leptin receptor mRNA in the ARC and VMH, but also increases hypothalamic sensitivity to leptin, altering peripheral fat distribution
  • ghrelin. It acts on growth hormone secretagogue receptors (GHSR1a) located in the ARC and is a potent stimulator of food intake
  • It thus appears that of the two ERs, ERα plays a predominant role in the CNS regulation of lipid and carbohydrate homeostasis.
  • Both ERs have been identified in the ARC
  • Stimulation of MCH neurons increases food intake and fat accumulation while its inhibition leads to decreased food intake and reduced fat accumulation.
  • Both ERs have been identified in the LH
  • both ERs have been identified in this nucleus
  • The PVN is the region of the hypothalamus with the highest expression of ERβ and is reported to be weakly ERα positive
  • The VMH is ERα regulated
  • Skeletal muscle is responsible for 75% of the insulin-induced glucose uptake in the body
  • GLUT4 is highly expressed in muscle and represents a rate-limiting step in the insulin-induced glucose uptake
  • data suggest that in the physiological range, E2 is beneficial for insulin sensitivity, whereas hypo- or hyperestrogenism is related to insulin resistance
  • In aging female rats, E2 treatment improves glucose homeostasis mainly through its ability to increase muscle GLUT4 content on the cell membrane
  • It is evident that ERα and ERβ have distinct actions and that much more research is needed to clearly identify the function of each receptor in muscle.
  • E2 prevents accumulation of visceral fat, increases central sensitivity to leptin, increases the expression of insulin receptors in adipocytes, and decreases the lipogenic activity of lipoprotein lipase in adipose tissue
  • In rats, ovariectomy increases body weight, intra-abdominal fat, fasting glucose and insulin levels, and insulin resistance followed by decreased phosphorylation of AMPK and its substrate acetyl-CoA carboxylase in adipose tissue
  • decreased adiponectin, PPARγ coactivator-1α (PGC-1α), and uncoupling protein 2 (UCP2) and increased resistin
  • Men with aromatase deficiency have truncal obesity, elevated blood lipids, and severe insulin resistance
  • Although not all studies are in agreement, polymorphisms of ERα in humans have been associated with risk factors for CVDs
  • Human subcutaneous and visceral adipose tissues express both ERα and ERβ, whereas only ERα mRNA has been identified in brown adipose tissue
  • suggesting that ERα is the main regulator of GLUT4 expression in adipose tissue
  • Nathan Goodyear on 11 Oct 12
     
    very nice article that looks at the balance of ER-alpha/ER-beta and their role in metabolic syndrome.  This article discusses the balance of  these receptors are tissue dependent in their effect.  I like their conclusion: "...but these mechanisms will never be completely understood if they are not considered in the context of a whole system.
Nathan Goodyear

The effects of sex, estrous cycle, and social contact on cocaine and heroin self-admini... - 0 views

link.springer.com/...10.1007%2Fs00213-016-4368-9

hormones estrogen progesterone addiction women female hormones

shared by Nathan Goodyear on 28 Sep 16 - No Cached
  • Nathan Goodyear on 28 Sep 16
     
    hormones, estrogen and/or progesterone, may provide a solution to addiction in women says animal study.
rsf123

Where to buy: codeine | weed | mdma | pills | lean | fake note bills | coke | cocaine |... - 0 views

WITHOUT WAISTING MUCH OF YOUR TIME; FULL REPORT: https://t.me/amsterdamdarkmarket

cancer Testosterone inflammation men disease obesity Male low hormone hormones weed mdma pillsforsale lean codeine psychedelic

started by rsf123 on 01 Jul 22 no follow-up yet
1 - 7 of 7
Showing 20▼ items per page