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Nathan Goodyear

Red Versus White Wine as a Nutriti... [J Womens Health (Larchmt). 2011] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...22150098

wine red white aromatase inhibition premenopausal women breast cancer

shared by Nathan Goodyear on 06 Feb 12 - No Cached
  • Nathan Goodyear on 06 Feb 12
     
    red wine does appear to have health benefits over white wine through aromatase inhibition.  Aromatase inhibition reduces estrogen levels.  So, if the breast cancer risk is associated with elevated estrogen, then this would logically reduce the risk.  The exact amount is unknown, but aromatase inhibition is a treatment of those with breast CA.
Nathan Goodyear

The Red Wine Polyphenol Resveratrol Displays Bilevel Inhibition on Aromatase in Breast ... - 0 views

toxsci.oxfordjournals.org/...71.full

resveratrol wine red wine aromatase inhibitor inhibition cancer

shared by Nathan Goodyear on 18 Dec 12 - No Cached
  • Nathan Goodyear on 18 Dec 12
     
    resveratrol in red wine is an aromatase inhibitor.
Nathan Goodyear

Nutrition Journal | Full text | Red wine and components flavonoids inhibit UGT2B17 in v... - 0 views

www.nutritionj.com/...67

red wine wine testosterone hormone hormones male nutrition

shared by Nathan Goodyear on 08 Jan 13 - No Cached
  • Nathan Goodyear on 08 Jan 13
     
    Red wine to increase testosterone levels?  According to this study, yes.  How?  By interfering with the elimination through the UGT2B17 detoxification pathway.   Downside of this study is that this is in vitro and not in vivo.
Nathan Goodyear

JAMA Network | JAMA Internal Medicine | Resveratrol Levels and All-Cause Mortality in O... - 0 views

archinte.jamanetwork.com/article.aspx

resveratrol CVD CAD heart disease polyphenols red wine chocolate inflammation

shared by Nathan Goodyear on 13 May 14 - No Cached
  • Nathan Goodyear on 13 May 14
     
    New study finds no cardiovascular benefits from resveratrol.  It has long been claimed that reserveratrol is the polyphenol from red wine and chocolate that is the source of cardiovascular benefits such as found in the "french paradox".  However, this new study finds that resveratrol provides no benefit.  Studies still point to dark chocolate and red wine as means to reduce inflammation and reduce CVD risk, this study just points away from resveratrol as the source of the benefit.
Nathan Goodyear

Effect of wine phenolics on cytokine-induced C-reactive protein expression - KAUR - 200... - 0 views

onlinelibrary.wiley.com/...abstract

resveratrol wine inflammation

shared by Nathan Goodyear on 05 Apr 11 - No Cached
  • Wine phenolics inhibit CRP expression
  • Nathan Goodyear on 05 Apr 11
     
    Resveratrol in red wine reduces inflammation
Nathan Goodyear

Effects of Initiating Moderate Alcohol Intake on Cardiometabolic Risk in Adults With Ty... - 0 views

annals.org/article.aspx

wine CVD cardiovascular disease heart health diabetes mediterranean diet alcohol

shared by Nathan Goodyear on 10 Dec 15 - No Cached
  • Nathan Goodyear on 10 Dec 15
     
    wine, red and white, with a mediterranean diet reduced cardiometabolic risk  in individuals with diabetes.  The volume of nightly intake of wine was 5 oz.
Nathan Goodyear

Anti-Aromatase Chemicals in Red Wine - ENG - 2006 - Annals of the New York Academy of S... - 0 views

onlinelibrary.wiley.com/...24980787EDACD022AB5CA84.d04t02

resveratrol red wine aromatase inhibition inhibitor cancer

shared by Nathan Goodyear on 18 Dec 12 - No Cached
  • Nathan Goodyear on 18 Dec 12
     
    resveratrol in red wine acts as aromatase inhibitor.  
Nathan Goodyear

Nutrition Journal | Abstract | A daily glass of red wine associated with lifestyle chan... - 0 views

www.nutritionj.com/...abstract

lifestyle nutrition red wine lipids LDL HDL cholesterol

shared by Nathan Goodyear on 19 Nov 13 - No Cached
  • Nathan Goodyear on 19 Nov 13
     
    lifestyle changes, including red wine, shown to improve lipids.
Nathan Goodyear

Nutrition Journal | Full text | A daily glass of red wine associated with lifestyle cha... - 0 views

www.nutritionj.com/...147

red wine nutrition cholesterol LDL HDL arteriosclerosis CVD cardiovascular disease

shared by Nathan Goodyear on 26 Nov 13 - No Cached
  • Nathan Goodyear on 26 Nov 13
     
    tools for health are all around us.  red wine reduced the LDL/HDL ratio by 13% in patients with carotid arteriosclerosis.  This occurred  independently from dietary changes and exercise.
Nathan Goodyear

The influences of red wine in phenotypes of human cancer cells - PMC - 0 views

www.ncbi.nlm.nih.gov/...PMC6478559

cancer red wine

shared by Nathan Goodyear on 25 Mar 23 - No Cached
  • Nathan Goodyear on 25 Mar 23
     
    Red wine inhibits cancer cell growth in vivo.
Nathan Goodyear

Alcohol intake and risk of dementia. [J Am Geriatr Soc. 2004] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...15066068

wine resveratrol alcohol dementia Alzheimer's disease

shared by Nathan Goodyear on 07 Nov 13 - No Cached
  • Nathan Goodyear on 07 Nov 13
     
    Moderate wine intake daily associated with a lower risk of Alzheimer's disease in the elderly.  But, only in those without the APOE epsilon-4 allele.
Nathan Goodyear

Resveratrol, through NF-Y/p53/Sin3/HDAC1 complex phosphorylation, inhibits es... - 0 views

www.fasebj.org/3695

resveratrol estrogen cancer breast cancer ER alpha estrogen receptor

shared by Nathan Goodyear on 20 May 13 - No Cached
  • Nathan Goodyear on 20 May 13
     
    Resveratrol inhibits ER-alpha in human breast cancer cells providing potential mechanism to inhibit pro growth/pro inflammatory signaling favoring breast cancer.  So maybe, a glass of red wine keeps the breast cancer doctor away??
Nathan Goodyear

http://hyper.ahajournals.org/content/hypertensionaha/45/5/874.full.pdf - 0 views

hyper.ahajournals.org/...874.full.pdf

wine beer red wine blood pressure

shared by Nathan Goodyear on 18 Jan 17 - No Cached
  • Nathan Goodyear on 18 Jan 17
     
    study finds alcohol increases blood pressure in those without elevated blood pressure.
Nathan Goodyear

Neuroprotective Sirtuin ratio reversed by ApoE4 - 0 views

www.pnas.org/...1314145110.abstract

ApoE4 alzheimer's disease Alzheimer's disease sirtuins SIRT1 resveratrol

shared by Nathan Goodyear on 23 Oct 13 - No Cached
  • Nathan Goodyear on 23 Oct 13
     
    ApoE4 allele is known to increase Alzheimer's disease by 10 fold.  One mechanism is through a lowering of SirT1 and an increase in the SirT1:SirT2 ratio.  This SirT1 is the target of resveratrol in red wine.
Nathan Goodyear

Resveratrol, an extract of red wine, inhibits lipopolysaccharide induced airw... - 0 views

www.fasebj.org/...840.full

resveratrol inflammation anti-inflammatory NF-kappaB wine

shared by Nathan Goodyear on 03 Sep 11 - No Cached
  • Nathan Goodyear on 03 Sep 11
     
    resveratrol inhibits inflammation in in-vivo airway model, independent of NF-KB
Nathan Goodyear

American College of Cardiology Foundation | Journal of the American College of Cardiolo... - 0 views

content.onlinejacc.org/article.aspx

mitochondria oxidative stress heart failure heart

shared by Nathan Goodyear on 19 Mar 13 - No Cached
  • Although currently no drugs that specifically target mitochondrial biogenesis in HF are available, acceleration of this process through adenosine monophosphate–activated kinase (AMPK), endothelial nitric oxide synthase (eNOS), and other pathways may represent a promising therapeutic approach
  • Mitochondrial biogenesis can be enhanced therapeutically with the use of adenosine monophosphate kinase (AMPK) agonists, stimulants of nitric oxide/cyclic guanosine monophosphate (NO/cGMP) pathway (including phosphodiesteraes type 5 inhibitors), or resveratrol
  • metformin, a commonly used antidiabetic drug that activates AMPK signaling
  • ...10 more annotations...
  • Recent evidence suggests that the eNOS/NO/cGMP pathway is an important activator of mitochondrial biogenesis
  • BH4 (tetrahydrobiopterin) supplementation can prevent eNOS uncoupling and was found to reduce left ventricular hypertrophy
  • folic acid is known to replenish reduced BH4 and has been shown to protect the heart through increased eNOS activity
  • Both folate deficiency and inhibition of BH4 synthesis were associated with reduced mitochondrial number and function
  • Resveratrol, a polyphenol compound responsible for the cardioprotective properties of red wine, was recently identified as a potent stimulator of mitochondrial biogenesis
  • epidemiological studies reveal a reduced risk of cardiovascular disease in premenopausal, but not post-menopausal, women compared with men
  • post-menopausal women
    • Nathan Goodyear
      Nathan Goodyear on 19 Mar 13
       
      I would hypothesis that a change in the predominance of ER expression is one of ER beta to ER alpha: creating a more pro-inflammatory signal.
  • The majority of ROS in the heart appear to come from uncoupling of mitochondrial electron transport chain at the level of complexes I and III
  • Because the majority of ROS in HF comes from mitochondria, these organelles are the primary target of oxidative damage.
  • cardioprotective therapies such as angiotensin-converting enzyme inhibitors and ATII receptor blockers were shown to possess antioxidant properties, although it is not known whether they target mitochondrial ROS directly or indirectly
  • Nathan Goodyear on 19 Mar 13
     
    great review of mitochondrial biogenesis, oxidative stress and heart failure.  
Nathan Goodyear

Polyphenols: food sources and bioavailability - 0 views

ajcn.nutrition.org/...727.full

polyphenols nutrition

shared by Nathan Goodyear on 29 Sep 15 - No Cached
  • Fruit and beverages such as tea and red wine constitute the main sources of polyphenols
  • Nathan Goodyear on 29 Sep 15
     
    polyphenols
Nathan Goodyear

Polyphenols: antioxidants and beyond - 0 views

ajcn.nutrition.org/...215S.full

polyphenols antioxidants nutrition

shared by Nathan Goodyear on 29 Sep 15 - No Cached
  • Polyphenols are the most abundant antioxidants in the diet.
  • main dietary sources are fruits and plant-derived beverages such as fruit juices, tea, coffee, and red wine. Vegetables, cereals, chocolate, and dry legumes also contribute to the total polyphenol intake
  • Nathan Goodyear on 29 Sep 15
     
    polyphenols
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