Intratumoral androgen biosynthesis in prostate cancer pathogenesis and response to therapy - 0 views
-
Additional studies have similarly found that prostate tissue levels of DHT in PCa patients treated with ADT therapy before prostatectomy declined by only ∼75% versus declines of ∼95% in serum levels
-
In a recent study in healthy men, treatment for 1 month with a GnRH antagonist to suppress testicular androgen synthesis caused a 94% decline in serum testosterone, but only a 70–80% decline in prostate tissue testosterone and DHT
-
progression to CRPC was associated with increased intratumoral accumulation or synthesis of testosterone.
- ...9 more annotations...