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Nathan Goodyear

Testosterone replacement therapy improves i... [Eur J Endocrinol. 2006] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...16728551

low T low Testosterone low T men male hormone hormones Testosterone diabetes hypogonadism visceral fat cholesterol replacement therapy

shared by Nathan Goodyear on 07 Aug 14 - No Cached
  • Nathan Goodyear on 07 Aug 14
     
    In obese men with low T and type 2 diabetes, Testosterone replacement improves insulin sensitivity.  Glycated hemoglobin was also improved.  In this study group, a decrease in visceral adiposity and TC was seen.
Nathan Goodyear

Inclusion of Endogenous Hormone Levels in Risk ... [J Clin Oncol. 2014] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...25135988

post-menopause post menopause women female hormones hormone estradiol estrone testosterone DHEA prolactin SHBG dehydroepiandrosterone breast cancer

shared by Nathan Goodyear on 21 Aug 14 - No Cached
  • Nathan Goodyear on 21 Aug 14
     
    study finds hormone evaluations in post menopause women aids in breast cancer risk assessment.
Nathan Goodyear

Relationship between non-alcoholic fatty liver ... [World J Urol. 2014] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...25189458

NAFLD BPH LUTS men male fatty liver liver metabolic syndrome

shared by Nathan Goodyear on 09 Sep 14 - No Cached
  • Nathan Goodyear on 09 Sep 14
     
    Men with NAFLD have higher incidence of lower urinary tract symptoms including BPH.
Nathan Goodyear

A preliminary investigation of the enzym... [J Herb Pharmacother. 2005] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...16093232

Saw Palmetto Astaxanthin 5alpha reductase prostate cancer prostate cancer herb

shared by Nathan Goodyear on 08 Jul 13 - No Cached
  • Nathan Goodyear on 08 Jul 13
     
    Saw Palmetto show to inhibit 5alpha reductase activity in prostate cancer cells.
Nathan Goodyear

Prolactin levels in the polycystic ovary syndrome. [J Reprod Med. 1984] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...6233421

Prolactin PCOS polycystic ovarian syndrome polycystic ovary syndrome hormone hormones female women LH

shared by Nathan Goodyear on 10 Sep 14 - No Cached
  • Nathan Goodyear on 10 Sep 14
     
    hyperprolactinemia found in some with PCOS.
Nathan Goodyear

Recovery after heavy resistance exercise... [J Strength Cond Res. 2011] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...21311349

recovery resistance exercise training resistance training Testosterone Total free men male hormone hormones

shared by Nathan Goodyear on 03 Sep 14 - No Cached
  • Nathan Goodyear on 03 Sep 14
     
    "Heavy resistance exercise" associated with acute increase in TT and fT in men.  No changes were see in basal T and fT in recovery or AR.  The recovery phase was estimated to take 6 days.
Nathan Goodyear

Regulation of abdominal adiposity by probiot... [Eur J Clin Nutr. 2010] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...20216555

probiotic probiotics metabolism obesity

shared by Nathan Goodyear on 11 Sep 14 - No Cached
  • Nathan Goodyear on 11 Sep 14
     
    Probiotics for metabolic dysfunction.  In this case, the Lactobacillus gasser species.
Nathan Goodyear

Testosterone and metabolic syndrome Cunningham GR - Asian J Androl - 0 views

www.ajandrology.com/article.asp

Testosterone metabolic syndrome MetS TT total Testosterone SHBG men male hormone hormones Estradiol insulin resistance

shared by Nathan Goodyear on 02 Mar 15 - No Cached
  • The relationship of low testosterone to MetS often is considered to be bidirectional; however, the relationships probably are not direct
  • Many of the components of the MetS are recognized risk factors for the development of cardiovascular disease (CVD)
  • Multiple cross-sectional studies have found low TT and low sex hormone binding globulin (SHBG) levels in Caucasian and African-American men with the MetS, irrespective of age
  • ...20 more annotations...
  • Low TT and SHBG levels also are prevalent in Chinese [7],[8] and Korean [9] men with the MetS
  • Normally 40%-50% of TT is bound to SHBG, so reducing SHBG levels will decrease TT.
  • Hyperinsulinism suppresses SHBG synthesis and secretion by the liver
  • significant increase in SHBG levels occurred after acutely lowering insulin levels in obese men
  • Estradiol levels are increased in men with the MetS, and they are positively correlated with the number of abnormal components of the MetS.
  • Although it is known that estrogen will increase SHBG levels, apparently the hyperinsulinism associated with obesity has a greater effect on SHBG levels
  • Estradiol also can inhibit luteinizing hormone (LH) secretion
  • Inflammatory cytokines are thought to have a direct effect on the pituitary to reduce LH secretion [15] and also a direct effect on Leydig cell secretion of testosterone
  • Low TT Levels have been shown to predict development of the MetS in men with normal BMI
  • Men in the lowest quartiles of serum TT, calculated free testosterone (cFT) and SHBG at baseline had the highest odds ratios for developing the MetS or DM during the 11 years follow-up
  • More recently, investigators conducting population-based studies have reported that only SHBG is associated with future development of the MetS
  • Additional evidence that low TT increases the risk of MetS comes from androgen deprivation treatment of prostate cancer
  • Low TT and low bioavailable testosterone (bT) were each significantly associated with elevated 20 years risk of CVD mortality in an older population in which cause-specific mortality was age, adiposity, and lifestyle-adjusted.
  • combination of low bT and ATP III-defined MetS is associated with increased cardiovascular mortality in men aged 40 years and above
  • in elderly men, testosterone may weakly protect against CVD. Alternatively, low TT may indicate poor general health
  • Muraleedharan and Jones [27] concluded that there is convincing evidence that low T is a biomarker for disease severity and mortality.
  • The evidence that TRT improves insulin sensitivity and glucose control is conflicted
  • It is widely recognized that testosterone treatment can reduce fat mass and increase lean body mass; however, until recently most reports have not been associated with much weight loss
  • Changes in body composition and weight loss are considered potential mechanisms by which testosterone treatment improves insulin sensitivity and glucose control in patients with diabetes. Effects on inflammatory cytokines [38] and changes in oxidative metabolism [39] also have been reported to improve glucose metabolism.
  • Testosterone replacement therapy has been reported to improve some or all of the components of the MetS.
  • Nathan Goodyear on 02 Mar 15
     
    To be read article on Testosterone and Metabolic Syndrome.
Nathan Goodyear

Testosterone therapy in men with prostate cancer: literature review, clinical experienc... - 0 views

www.ajandrology.com/article.asp

Testosterone prostate cancer men male hormone hormones

shared by Nathan Goodyear on 02 Mar 15 - No Cached
  • Nathan Goodyear on 02 Mar 15
     
    To be read article on Testosterone and prostate cancer.
Nathan Goodyear

Peripheral neuropathy: an underdiagnosed cause of erectile dysfunction - Vall... - 1 views

onlinelibrary.wiley.com/...abstract

ED erectile dysfunction polyneuropathy neuropathy men men's health male health

shared by Nathan Goodyear on 16 Mar 15 - No Cached
  • Nathan Goodyear on 16 Mar 15
     
    Peripheral neuropathy involved in/associated with the pathogenesis of ED proposed by this study.
Nathan Goodyear

Reverse T3 as a parameter of myocardial functi... [Int J Cardiol. 2010] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...19428128

thyroid hormone hormones reverse T3 fT3_rT3 rT3 heart failure CHF cardiovascular disease.

shared by Nathan Goodyear on 16 Aug 14 - No Cached
  • Nathan Goodyear on 16 Aug 14
     
    Another study regarding reverse T3 that many Endocrinologists need to read.  In this study, the authors find that significantly higher reverse T3 levels were associated with myocardial function impairment (MFI) class IV.  This MFI class IV was also found associated with a decreased fT3/rT3.
Nathan Goodyear

Lack of association between pe... [J Clin Res Pediatr Endocrinol. 2014] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...24932603

TSH thyroid hormone hormones obese children obesity

shared by Nathan Goodyear on 16 Aug 14 - No Cached
  • Nathan Goodyear on 16 Aug 14
     
    no correlation found between TSH and peripheral thyroid hormones in obese children.
Nathan Goodyear

Growth hormone treatment of abdomina... [J Clin Endocrinol Metab. 1997] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...9062473

GH growth hormone hormone hormones men male obesity metabolic syndrome metabolic syndrome insulin resistance cholesterol triglycerides blood pressure fat

shared by Nathan Goodyear on 03 Aug 14 - No Cached
  • Nathan Goodyear on 03 Aug 14
     
    Growth hormone treatment of abdominally obese men reduces abdominal fat mass, improves glucose and lipoprotein metabolism, and reduces diastolic blood pressure.
Nathan Goodyear

Lipoprotein(a) as a cardiovascular risk factor: ... [Eur Heart J. 2010] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...20965889

Lp(a) lipoprotein a cardiovascular risk disease CVD

shared by Nathan Goodyear on 06 Aug 14 - No Cached
  • Nathan Goodyear on 06 Aug 14
     
    Lp(a) is a useful biomarker in the overall assessment of those at moderate to high risk of CVD.
Nathan Goodyear

The reversibility of anabolic steroid-induced azoospe... [J Urol. 1995] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...7714991

HCG human chorionic gonadotropin low T low Testosterone infertility azoospermia men male hormone hormones

shared by Nathan Goodyear on 03 Aug 14 - No Cached
  • Nathan Goodyear on 03 Aug 14
     
    Case study of 1 of a man with remote history of anabolic steroid use and current azoospermia.  HCG therapy for 3 months led to resolution of infertility.
Nathan Goodyear

Testosterone deficiency and quality of life in ... [Intern Med J. 2014] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...25081047

Testosterone quality of life QOL Testicular cancer low T men male hormone hormones

shared by Nathan Goodyear on 04 Aug 14 - No Cached
  • Nathan Goodyear on 04 Aug 14
     
    Small study in men s/p Testicular cancer found no association between Testosterone levels and quality of life measures.
Nathan Goodyear

Concomitant intramuscular human chorionic gonadotropi... [J Urol. 2013] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...23260550

HCG low t low testosterone low t Testosterone men male hormone hormones human chorionic gonadotropin hypogonadism replacement

shared by Nathan Goodyear on 03 Aug 14 - No Cached
  • Nathan Goodyear on 03 Aug 14
     
    I can't say I agree with the premise of the study design.  In this study, HCG at 500 IU every other day was used to aid Testosterone therapy.  
Nathan Goodyear

Cancer-preventing attributes of probioti... [Int J Food Sci Nutr. 2010] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...20187714

protbiotics cancer SOD superoxide disumutase catalase glutathione peroxidase glutathione-S-transferase

shared by Nathan Goodyear on 05 Aug 14 - No Cached
  • Nathan Goodyear on 05 Aug 14
     
    The evidence of probiotics in cancer is limited.  The limited evidence points to an increase in anti-oxidative enzymes i.e. glutathion-S-transferase, glutathione perioxidase, catalase, SOD.
Nathan Goodyear

Testosterone in Men with Advanced Li... [J Gastroenterol Hepatol. 2014] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...25087838

Testosterone men male hormone hormones cirrhosis liver disease

shared by Nathan Goodyear on 05 Aug 14 - No Cached
  • Nathan Goodyear on 05 Aug 14
     
    published ahead of print.  The authors conclude that the Testosterone therapy in hypogonadal men with cirrhosis requires further study.  They, the authors, state that the risk of Testosterone and hepatocellular carcinoma is overstated.  This risk is associated with oral Testosterone replacement and thus in that light is not overstated.  The majority of treatment strategies today employ none oral routes of administration which would support their statement.
Nathan Goodyear

Hyperandrogenism induces a proinflam... [J Clin Endocrinol Metab. 2014] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...24512496

androgens polycystic ovarian syndrome Testosterone DHEA androstenedione women inflammation TNF-alpha PCOS

shared by Nathan Goodyear on 05 Aug 14 - No Cached
  • Nathan Goodyear on 05 Aug 14
     
    Very insightful study.  Study looked at hyperadrogenism and inflammation in women on the orders of PCOS.  The study subjects did not have PCOS, but hyperandrogenism via 130 mg DHEA was associated with an increase in TNF-alpha in these lean o/w healthy women.  We know this is due to hyperandrogenism as elevated Testosterone, DHEA, and androstenedione were documented with treatment. Take home:  androgens promote inflammation in women.  I believe this has serious negative implications about the massive Testosterone doping that is occurring in women today.
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