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Nathan Goodyear

International Journal of Impotence Research - Obesity, low testosterone levels and erec... - 0 views

www.nature.com/...ijir200842a.html

low T low Testosterone men male hormone hormones ED erectile dysfunction Testosterone diabetes metabolic syndrome obesity

shared by Nathan Goodyear on 27 Jan 15 - No Cached
  • Studies have shown that ED may be an early biomarker of general endothelial dysfunction, atherosclerosis and CVD
  • testosterone treatment of hypogonadal young and older men improves sexual function, increases lean mass and decreases fat mass
  • In men with low serum testosterone (for example, <8 or 230 nmol l−1) with obesity, metabolic syndrome and diabetes mellitus, treatment with testosterone is warranted
  • ...12 more annotations...
  • In obese middle-aged men, testosterone treatment reduced visceral adipocity, insulin resistance, serum cholesterol and glucose levels
  • testosterone replacement has a favorable impact on body mass, insulin secretion and sensitivity, lipid profile and blood pressure in hypogonadal men with the metabolic syndrome as well as type 2 diabetes mellitus
  • Testosterone significantly inhibits lipoprotein lipase activity, which reduces triglycerides uptake into adipocytes in the abdominal adipose tissue
  • testosterone treatment decreased endogenous inflammatory cytokines (tumor necrosis factor-α and IL-1β) and lipids (total cholesterol) and increased IL-10 in hypogonadal men
  • Testosterone treatment reduced leptin and adiponectin levels in hypogonadal type 2 diabetic men after 3 months of testosterone replacement
  • available data clearly show a relationship between obesity, low testosterone levels and ED
  • Obesity adversely affects endothelial function and lowers serum testosterone levels through the development of insulin resistance and metabolic syndrome
  • Metabolic disturbances as well as production of cytokines and adipokines by inflamed fat cells may be causal factors in the development of ED
  • The onset of ED and the associated risk of CVD may be delayed through lifestyle modifications that affect obesity, such as diet and exercise
  • Very low testosterone levels contribute to the development of ED in obesity, metabolic syndrome and type 2 diabetes mellitus
  • Obesity is associated with low total testosterone levels that can be explained at least partially by lower sex hormone-binding globulin (SHBG) in obese men
  • epidemiological studies have shown a negative correlation between BMI and total testosterone and to a lesser extent with free and bioavailable (biologically active) testosterone levels
  • Nathan Goodyear on 27 Jan 15
     
    Obesity is associated with low Testosterone and ED in men.
Nathan Goodyear

Erectile dysfunction is a prognostic indicator of comorbidities in men with late onset ... - 1 views

www.ncbi.nlm.nih.gov/...26030350

erectile dysfunction ED low T men male hormone hormones Testosterone CVD hypogonadism low Testosterone LOH late onset hypogonadism metabolic syndrome

shared by Nathan Goodyear on 04 Jun 15 - No Cached
  • Nathan Goodyear on 04 Jun 15
     
    Study finds that increasing severity of ED is associated with increasing components of Metabolic Syndrome in men with late onset hypogonadism.   The link is really just an increased severity of CVD in men with severe ED and low T.  ED is CVD in men.
Nathan Goodyear

Hormonal Modulation in Aging Patients with Erectile Dysfunction and Metabolic Syndrome - 0 views

www.ncbi.nlm.nih.gov/...PMC3888699

low T Testosterone hypogonadism MetS metabolic syndrome men male hormone hormones

shared by Nathan Goodyear on 05 Feb 14 - No Cached
  • Hypogonadism and MetS are strongly associated [12, 13, 16], having even been demonstrated that with the increasing number of MetS parameters there is a proportional raise in the incidence of hypogonadism
  • increasing number of MetS components is inversely associated with T levels
  • the presence of MetS did not prove to be a significant determinant of hypogonadism, as it did not lead to a decline in T levels, in MetS patients with already established hypogonadism, the increasing number of MetS features was associated with further decline in T
  • ...15 more annotations...
  • In the setting of MetS, hypertriglyceridemia and increased WC have been reported as the most important determinants of hypogonadism
  • recent literature consistently associates obesity not only with higher risk of hypogonadism [4, 6, 27] but also with lower T levels
  • Visceral adiposity has been particularly related with reduction of T and SHBG levels (independent of other metabolic disorders)
  • WC was one of the MetS parameters with the greatest influence in T levels decrease, presenting itself as a strong risk factor for hypogonadism development
  • MetS-related T decline was not accompanied by an increase in pituitary LH levels, suggesting impairment in gonadotropin secretion
  • The molecules behind this smoothing compensatory effect of GnRH/LH are still unknown, but estrogens and insulin, as well as leptin, TNF-α, and other adipokines, were proposed candidates
  • fat stores undertake an increase aromatization of androgens, therefore raising estrogen levels [9, 15], which in turn decrease LH secretion
  • our data contradicts the concept that estradiol exerts a negative feedback on hypothalamic GnRH secretion
  • taking into account that high estradiol levels have already been described as the only abnormality in a subset of patients with ED, the hypothesis that the later might not only be caused by androgen deficiency is becoming increasingly evident
  • it has been reported that the chronic exposure to phosphodiesterase type 5 inhibitors (PDE5i), widely used for the treatment of ED, may influence serum estradiol levels
  • thyroid disorders (specially hyperthyroidism) have been related to ED and hypogonadism, and so must be considered in a sexual-dysfunction setting
  • It is clear from the current literature that collecting a more thorough hormonal panel might be a wise approach to further uncover hormonal relations
    • Nathan Goodyear
      Nathan Goodyear on 05 Feb 14
       
      outstanding point.  This hits to the point that Low T is the effect not the cause.
  • We concluded that in ED patients with hypogonadism and MetS, the attenuated response of HPG axis (normal or low LH levels) might not always be due to an underlying adiposity-dependent estrogen-raising effect.
  • our findings indicate that ED, aging, and estradiol might have a stronger connection than what is currently described in the literature.
  • this study underlines the importance of the collection of a full hormonal panel in ED men
  • Nathan Goodyear on 05 Feb 14
     
    low T strongly associated with metabolic syndrome in men.
Nathan Goodyear

Metabolic syndrome and risk for ED: a meta-a... [Int J Impot Res. 2014] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...24599048

metabolic syndrome metabolic syndrome ED men male hormone hormones

shared by Nathan Goodyear on 10 Mar 14 - No Cached
  • Nathan Goodyear on 10 Mar 14
     
    Metabolic syndrome associated with increased risk of ED in men in meta-analysis.  This points to ED as a metabolic condition.
snfilms

Ed sheeran Music Video - 0 views

www.sdtunes.com/...ran-huge-hit-music-video-songs

sdtunes edsheeran musicvideo edsheeransongs

shared by snfilms on 06 Nov 20 - No Cached
  • snfilms on 06 Nov 20
     
    Ed Sheeran #MusicVideo #LyricalVideo http://www.sdtunes.com/.../ed-sheeran-huge-hit-music... #sdtunes #edsheeran #musicvideos #edsheeransongs
Nathan Goodyear

Dehydroepiandrosterone in the treatment of erectile... [Urol Res. 2001] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...11585284

DHEA ED low libido

shared by Nathan Goodyear on 12 Jun 13 - No Cached
  • Nathan Goodyear on 12 Jun 13
     
    DHEA may be beneficial in those with ED + hypertension and those with organic ED cause.  "Organic" causes like diabetes and neurological problems DHEA provided no benefit.
Nathan Goodyear

PLOS Medicine: Erectile Dysfunction Severity as a Risk Marker for Cardiovascular Diseas... - 0 views

www.plosmedicine.org/...journal.pmed.1001372

erectile dysfunction ED CVD cardiovascular disease

shared by Nathan Goodyear on 02 Feb 13 - No Cached
  • Nathan Goodyear on 02 Feb 13
     
    As ED is a cardiovascular problem, it is no surprise that those with ED have an increase in CVD.
Nathan Goodyear

Study finds impotence risk higher in men taking several drugs: MedlinePlus - 0 views

www.nlm.nih.gov/...fullstory_119543.html

ED impotence prescription drugs erectile dysfunction

shared by Nathan Goodyear on 10 Dec 11 - No Cached
  • Nathan Goodyear on 10 Dec 11
     
    Study reveals that the more medications a man takes, the more symptoms of ED he has.  This was found to be independent from variables such as hypertension, diabetes...  ED symptoms started at 1 medication
Nathan Goodyear

The Dark Side of Testosterone Deficiency: I. Metabolic Syndrome and Erectile Dysfunctio... - 0 views

onlinelibrary.wiley.com/...full

low T Testosterone metabolic syndrome ED metabolic syndrome obesity men male hormone hormones

shared by Nathan Goodyear on 30 Jan 14 - No Cached
  • Nathan Goodyear on 30 Jan 14
     
    Article reviews the link between obesity, low T, metabolic syndrome and ED.  ED has been shown to be predictive of CVD by 3-5 years.  
Nathan Goodyear

Endocrine milieu and erectile dysfunction: is oestradiol-testosterone imbalance, a risk... - 0 views

www.ncbi.nlm.nih.gov/...PMC3739617

erectile dysfunction ED low T Testosterone T:E2 Estradiol men male hormone hormones

shared by Nathan Goodyear on 05 Feb 14 - No Cached
  • Nathan Goodyear on 05 Feb 14
     
    This article points to the impact of T:E2 on ED in men.  A declining T:E2 increases ED in older men.  
Nathan Goodyear

Metabolic syndrome in men with low testosterone le... [J Sex Med. 2013] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...23898860

metabolic syndrome low testosterone T MetS men male hormone hormones ED obesity alcohol peripheral vascular disease

shared by Nathan Goodyear on 06 Feb 14 - No Cached
  • Nathan Goodyear on 06 Feb 14
     
    Metabolic syndrome and Low T definitely run together.  Whether one causes the other or merely associations, they reflect the risk of the other.  It is known that increasing MetS parameters drives the Testosterone lower.  In this study, they found ED, obesity, PVD, and Etoh intake associated with increased incidence of MetS.  ED and obesity are both associated with low T.
Nathan Goodyear

Total Testosterone Levels and the Effect of Sildenafil on Type 2 Diabetics with Erectil... - 0 views

www.ncbi.nlm.nih.gov/...PMC3910416

low T Testosterone Diabetes sildenafil erectile dysfunction ED

shared by Nathan Goodyear on 17 Feb 14 - No Cached
  • Nathan Goodyear on 17 Feb 14
     
    Interesting study. In this study group, 36% of type II diabetes with ED had low Testosterone.  This fits with the estimated 40% of those with Diabetes have low T. What is really interesting about this study is that the degree of improvement with ED by Sildenfafil was dependent on the Testosterone level in the low T group.  Meanining that Testosterone therapy in these men would probably be more of a therapy directed at the cause and not Sildenafil.  Of course, the Testosterone therapy would benefit glucose regulation as well documented in the literature.
Nathan Goodyear

The effect of rosuvastatin and atorvastatin on e... [Kardiol Pol. 2013] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...24142756

statins ED men

shared by Nathan Goodyear on 30 Oct 13 - No Cached
  • Nathan Goodyear on 30 Oct 13
     
    Increased ED found with atorvastatin, but not with Rosuvastatin.  Statin therapy has been suggested to be the cause of ED in some men.  This study points to the fact that the effects may vary between statins.
Nathan Goodyear

Erectile dysfunction is associated with low total serum testosteron... - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...25562576

ED erectile dysfunction low Testosterone low T Testosterone men male hormone hormones

shared by Nathan Goodyear on 27 Jan 15 - No Cached
  • Nathan Goodyear on 27 Jan 15
     
    low Testosterone correlated with moderate to severe ED, but not mild ED in men 40-80.
Nathan Goodyear

Erectile Dysfunction and Mortality in a National Prospective Cohort Study. - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...26559652

ED erectile dysfunction men CVD cardiovascular death mortality

shared by Nathan Goodyear on 06 Jan 16 - No Cached
  • Nathan Goodyear on 06 Jan 16
     
    ED equals CVD in men.  This cohort found a 70% increase in early mortality in men with ED.
Nathan Goodyear

Chronic kidney disease and erectile dysfunction - 0 views

www.ncbi.nlm.nih.gov/...PMC4220354

ED erectile dysfunction Zinc Zn sexual dysfunction

shared by Nathan Goodyear on 09 Mar 17 - No Cached
hoangkimchi liked it
  • Nathan Goodyear on 09 Mar 17
     
    Zinc deficiency implicated in ED in men.  In addition, zinc supplementation improves ED in men.
Nathan Goodyear

Chronic lead exposure may be associated with erect... [J Sex Med. 2007] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...17727353

lead Pb exposure ED CVD men male infertility erectile dysfunction

shared by Nathan Goodyear on 10 Jun 13 - No Cached
  • Nathan Goodyear on 10 Jun 13
     
    chronic lead exposure associated with ED in men.  As lead is a contributor to CVD, logically, this is not a surprise.
Nathan Goodyear

Erectile Function and Risk of Parkinson's Disease - 0 views

aje.oxfordjournals.org/...1446.short

ED erectile dysfunction Parkinson's parkinson's disease inflammation

shared by Nathan Goodyear on 21 May 13 - No Cached
  • Nathan Goodyear on 21 May 13
     
    ED associated with a 3.8 x increase in Parkinson's disease.
Nathan Goodyear

Erectile dysfunction and coronary disease: Evaluating the link - 0 views

www.maturitas.org/...abstract

ED erectile dysfunction erectile dysfunction cardiovascular disease CVD heart disease

shared by Nathan Goodyear on 01 Jun 13 - No Cached
  • Nathan Goodyear on 01 Jun 13
     
    ED in men precedes cardiovascular disease by 3-5 years.
Nathan Goodyear

Erectile dysfunction and depression in patients with chronic lead poisoning - Gonulalan... - 0 views

onlinelibrary.wiley.com/...abstract

erectile dysfunction ED lead Pb

shared by Nathan Goodyear on 10 Jun 13 - No Cached
  • Nathan Goodyear on 10 Jun 13
     
    chronic lead toxicity linked with increased ED in men.
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