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Nathan Goodyear

TESTOSTERONE AND Δ4-ANDROSTENEDIONE IN THE SALIVA OF PATIENTS WITH KLINEFELTE... - 0 views

  • measurement of salivary steroids, by reflecting their free hormone concentration in plasma, may be useful in evaluating endocrine function in both health and disease
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    salivary testing of testosterone and androstenedione reflects free hormone concentration in plasma, proving to be very useful in evaluating endocrine function and disease 
Nathan Goodyear

Stimulation of aromatase activity in bre... [Mol Cell Endocrinol. 1994] - PubMed - NCBI - 0 views

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    inflammatory cytokine, TNF-alpha, increases aromatase activity.  This article discusses the increased production of estrone from androstenedione from aromatase activity in fat tissue in the breast.
Nathan Goodyear

Measuring salivary androgens as a useful tool... [Endokrynol Pol. 2012] - PubMed - NCBI - 0 views

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    Study shows good predictive value, with very high correlation with free serum levels, of salivary androstenedione and salivary Testosterone levels in women with PCOS. This study suggests using salivary androstenedione:salivary testosterone be used in the diagnosis of PCOS.
Nathan Goodyear

Determination of salivary testosterone and an... [Clin Chim Acta. 2012] - PubMed - NCBI - 0 views

  • upper limit (the 97.5 percentile
  • reliable
  • simple to perform
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    salivary testosterone and androstenedione via mass spectroscopy shown to be valid.
Nathan Goodyear

Maternal and Cord Steroid Sex Hormones, Angiogenic Factors and Insulin-like Growth Fact... - 0 views

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    Women with elevated androgens, Testosterone and androstenedione, are at higher risk of preeclampsia.  This translates to a higher risk of CVD in women later in life, post pregnancy.  This fits with other literature that CVD is linearly associated with a rising Testosterone.  This has been found in caucasian and black women.
Nathan Goodyear

Association of Serum Bisphenol-A... [Arch Environ Contam Toxicol. 2014] - PubMed - NCBI - 0 views

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    Increasing BPA levels associated with declining androstenedione levels,but positively associated with SHBG levels in exposed men.
Nathan Goodyear

Dexamethasone in resting and exercising men. II. Effects on adrenocortical hormones - J... - 0 views

  • The consistent results obtained from the two matrices allow us to consider salivary assays as a useful tool for steroid abuse detection.
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    saliva testing for cortisol, DHEA, androstenedione
Nathan Goodyear

The android woman - a risky condition - BJÖRNTORP - 2003 - Journal of Interna... - 0 views

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    women with elevated androgens (testosterone, DHT, androstenedione, DHEA...) are shown to have more HTN, insulin resistance, overweight issues, and CVD
Nathan Goodyear

Hyperandrogenism induces a proinflam... [J Clin Endocrinol Metab. 2014] - PubMed - NCBI - 0 views

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    Very insightful study.  Study looked at hyperadrogenism and inflammation in women on the orders of PCOS.  The study subjects did not have PCOS, but hyperandrogenism via 130 mg DHEA was associated with an increase in TNF-alpha in these lean o/w healthy women.  We know this is due to hyperandrogenism as elevated Testosterone, DHEA, and androstenedione were documented with treatment. Take home:  androgens promote inflammation in women.  I believe this has serious negative implications about the massive Testosterone doping that is occurring in women today.
Nathan Goodyear

A relationship in adrenal androgen levels between mothers and their children from a dio... - 0 views

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    Endocrine Disrupting Chemicals from 1970 still disrupting hormones today.  Three fold increase in DHEA in 3 year old children via saliva and androstenedione in mothers compared to controls.
Nathan Goodyear

Postmenopausal breast cancer risk in r... [Cancer Causes Control. 2003] - PubMed - NCBI - 0 views

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    Breast cancer associated with high levels of estrone, estradiol, testosterone, and less with androstenedione and DHEAS.  Those individuals being doped by physicians (a whole lot) are increasing their risk of many health diseases, including breast cancer.
Nathan Goodyear

Serum bisphenol-A concentration and sex hormone levels in men - 0 views

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    Study finds that men exposed to BPA have lower androstenedione and free testosterone compared to those not exposed.  Also of note, SHBG is increased, which is what one would expect with xenoestrogen exposure.
Nathan Goodyear

The effect of common genetic variati... [J Clin Endocrinol Metab. 2012] - PubMed - NCBI - 0 views

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    hyperactive HPA axis associated with depression. This is becoming evident in the literature.  This study looked at SNPS in the etiology of elevated cortisol and/or androstenedione.  They followed the results with saliva and found that 3 SNPS were associated with increased 11Beta-HSD1 activity and associated increased depression.
Nathan Goodyear

Urological Research, Volume 15, Number 3 - SpringerLink - 0 views

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    aromatization of androstenedione to estrogen shown to play role in prostatitis, BPH, and prostate cancer.  In this study, they looked at aromatase inhibition to slow this process.
Nathan Goodyear

Reduced-Calorie Dietary Weight Loss, Exercise, and Sex Hormones in Postmenopausal Women... - 0 views

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    Not surprising, but nice to see in study.  Dr. McTiernan showed that weight loss as little as 5% reduces breast cancer risk.  The reason?  Decreased Testosterone production in women due to insulin resistance and decreased fat for aromatase conversion of Testosterone to Estradiol and decreased androstenedione to estrone.  This study confirms the importance of the obesity epidemic to health.
Nathan Goodyear

Serum Sex Steroids in Premenopausal Women and Breast Cancer Risk Within the European Pr... - 0 views

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    Study finds that elevated serum Testosterone and androstenedione is associated with an increase risk of breast cancer.  This EPIC study looked at serum hormones in premenopausal women.  This study also found an association with increased breast cancer and low serum progesterone in women.  This was also found in the ORDET study.  This study did not find a link with estrogen.  These are endogenous levels.  Does this translate to exogenous? This theory of elevated androgens and breast cancer was first proposed by Grattarola.
Nathan Goodyear

Effect of Dehydroepiandrosterone Replacement on Insulin Sensitivity and Lipids in Hypoa... - 0 views

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    Study finds 50 mg of DHEA improves insulin sensitivity in Hypoadrenal women.  The authors also found and increase in DHEAS, bioavailable T, androstenedione, and a reduced SHBG, insulin, and glucagon.
Nathan Goodyear

Androgen insufficiency in women: diagnostic and therapeutic implications - 0 views

  • SHBG has a differing binding affinity for sex steroids in the following order; DHT > testosterone > androstenedione > estradiol > estrone
  • SHBG also weakly binds DHEA, but not DHEAS
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    Good discuss of androgen deficiency in women.  Also, good discussion of SHBG.  
Nathan Goodyear

Endogenous estrogen, androgen, and progesterone concentrations and breast cancer risk a... - 0 views

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    estrogens and androgens found to be directly associated with breast cancer in women.  No association with progesterone and SHBG was found.
Nathan Goodyear

Intratumoral De Novo Steroid Synthesis Activates Androgen Receptor in Castration Resist... - 0 views

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    adrenal androgens contribute to ADT resistant prostate cancer as precursors to T and DHT production.
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