Chiro-inositol increases the action of insulin in patients with the polycystic ovary syndrome, thereby improving ovulatory function and decreasing serum androgen concentrations, blood pressure, and plasma triglyceride concentrations.
Statin therapy worsens insulin sensitivity and thus glucose regulation in women with PCOS. Women with PCOS are at increased risk for type II Diabetes. Statins interfere with glucose metabolism and thus will increase the effective risk for these women. This study was a randomized, prospective study.
The medical field continues to be amazed that people are different. More, that different people groups are different. This study found that black women with PCOS have an elevated risk of metabolic syndrome when compared to white women with PCOS. Body weight was a variable that was controlled for. This was a retrospective study.
In women with PCOS, inflammation DIRECTLY stimulates androgen production from the ovaries. Inflammation is the driving force behind the high androgen levels in women with PCOS.
Quercetin found to increase adiponectin levels within women with PCOS with insulin resistance. Adiponectin has been shown to be inversly associated with insulin and insulin resistance.
Study found that PCOS was associated with increased glycolysis, reduced kreb's cycle activity, and decreased gluconeogenesis. Also found a decrease in the BCAA/AAA ratio.
insulin, in women with PCOS, promotes increased 5-alpha reductase activity. This results in a dysregulated HPA axis, promoting increased cortisol and androgen levels.