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Nathan Goodyear

Kent Holtorf: Long Term Weight Loss - More Than Will Power? - 0 views

www.huffingtonpost.com/...-weight-loss---m_b_192933.html

leptin reverse T3 weight loss

shared by Nathan Goodyear on 09 Mar 11 - No Cached
  • which is a major reason for the regaining of lost weight with dieting as well being the mechanism behind stress induced weight gain (it is not due to increased cortisol).
  • f greater than 10, it demonstrates there is a degree of leptin resistance contributing to an inability to lose weight
  • that it is difficult to lose weight with leptin resistance. High carbohydrate diets and in particular high-fructose corn syrup is shown to significantly increase leptin resistance and is a likely mechanism that high fructose corn syrup is associated with obesity
  • ...9 more annotations...
  • inactive thyroid hormone called thyroxine
  • it is problem inside the cell that the inactive T4 is not converted to T3 but rather to a mirror image of T3 called reverse T3. The reverse T3 has the opposite effect of T3, blocking the effects of T3 and lowering rather than increasing metabolism.
  • Studies are showing that stress and dieting (especially yo-yo dieting) can set this hormone into action as well as chronic illness such as diabetes, chronic fatigue syndrome and fibromyalgia.
  • As soon as the body senses a reduction in calories, the production of reverse T3 is stimulated to lower metabolism
  • With chronic dieting or stress, the body often stays in this "starvation mode" with elevated levels of reverse T3 and decreased levels of T3, which is a major reason for the regaining of lost weight with dieting as well being the mechanism behind stress induced weight gain (it is not due to increased cortisol).
  • which is a major reason for the regaining of lost weight with dieting as well being the mechanism behind stress induced weight gain (it is not due to increased cortisol).
  • which is a major reason for the regaining of lost weight with dieting as well being the mechanism behind stress induced weight gain (it is not due to increased cortisol).
  • Studies are showing that such standard testing will miss 80% of thyroid dysfunction
  • ree T3/reverse T3 ratio
  • Nathan Goodyear on 09 Mar 11
     
    Fantastic review by Dr. Holtorf on reverse T3, leptin, and weight loss
Nathan Goodyear

Higher Free Thyroxine Levels Predict Increased Incidence of Dementia in Older Men: The ... - 0 views

jcem.endojournals.org/...E2230.abstract

thyroid free free T3 free T4 reverse T3 dementia

shared by Nathan Goodyear on 06 Dec 12 - No Cached
  • Nathan Goodyear on 06 Dec 12
     
    what a silly study!  They look at free T4, the weakest thyroid hormone and found high levels to be associated with dementia.  However, they failed to assess free T3, the most biologically active, and reverse T3, inactive.  This study was like they intentionally blinded themselves of the body's physiology to study dementia.  This is the problem with a lot of research today: they have forgotten their foundation. Many older adults struggle with poor free T4 to free T3 conversion and high reverse T3 conversion.  So, without knowing what these clients were doing in these pathways makes their conclusion obsolete.
Nathan Goodyear

The Failure of Physiologic Doses of Reverse T3 to Effect Thyroid-Pituitary Function in ... - 0 views

jcem.endojournals.org/...478

reverse T3 free

shared by Nathan Goodyear on 08 Mar 11 - No Cached
  • Nathan Goodyear on 08 Mar 11
     
    reverse T3 does not block T4 to T3 converson; but occupies T3 receptors and inhibits T3 stimulating receptors
Nathan Goodyear

Reverse T3 levels in affective disorders. [Psychiatry Res. 1983] - PubMed result - 0 views

www.ncbi.nlm.nih.gov/...6417704

reverse t3 free depression TSH T4

shared by Nathan Goodyear on 08 Mar 11 - No Cached
  • In the group of patients with acute major depressive disorder, however, a significant increase in reverse T3 levels and a significant decrease in T3 levels, but no significant difference in T4 or TSH levels
  • Nathan Goodyear on 08 Mar 11
     
    low free T3:elevated reverse T3 correlates with major depression and TSH and free T4 do not.
Nathan Goodyear

Reverse T3 as a parameter of myocardial function impairment in heart failure. - 0 views

www.pubfacts.com/...n-impairment-in-heart-failure.

Thyroid hormone hormones reverse T3 rT3 free T3) CHF congestive heart failure CVD

shared by Nathan Goodyear on 24 Nov 14 - No Cached
  • Nathan Goodyear on 24 Nov 14
     
    reverse T3 and the free T3:rT3 can be used to assess prognosis of those with CHF.
Nathan Goodyear

Free T4, Free T3, and Reverse T3 in Critically III, Thermall... : The Journal of Trauma - 0 views

journals.lww.com/...everse_T3_in_Critically.1.aspx

free reverse T3 thyroid hypothyroid hypothyroidism

shared by Nathan Goodyear on 08 Mar 11 - No Cached
  • Significant suppression of serum concentrations of 3,5,3'-triiodothyronine (T3) and elevation of serum concentrations of 3,3',5'-triiodothyronine (rT3) were seen
  • Nathan Goodyear on 08 Mar 11
     
    low free T3: elevated reverse T3 in critically ill patients
Nathan Goodyear

Reciprocal Changes in Serum Concentrations of 3,3',5'-Triiodothyronine (Reverse T3) and... - 0 views

jcem.endojournals.org/...1043

reverse T3 free hypothyroid hypothyroidism thyroid

shared by Nathan Goodyear on 08 Mar 11 - No Cached
  • The mechanism or the biological significance of such a diversion of T4, from the normally occurring conversion to highly potent T3, to the generation of poorly calorigenic rT3 in systemic illness
  • such a change in the metabolism of T4 can be reversible.
  • Nathan Goodyear on 08 Mar 11
     
    effects of systemic illness on thyroid function: elevated Reverse T3 and low free T3
Nathan Goodyear

Reverse T3 as a parameter of myocardial functi... [Int J Cardiol. 2010] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...19428128

thyroid hormone hormones reverse T3 fT3_rT3 rT3 heart failure CHF cardiovascular disease.

shared by Nathan Goodyear on 16 Aug 14 - No Cached
  • Nathan Goodyear on 16 Aug 14
     
    Another study regarding reverse T3 that many Endocrinologists need to read.  In this study, the authors find that significantly higher reverse T3 levels were associated with myocardial function impairment (MFI) class IV.  This MFI class IV was also found associated with a decreased fT3/rT3.
Nathan Goodyear

Minireview: Cracking the Metabolic Code for Thyroid Hormone Signaling - 0 views

www.ncbi.nlm.nih.gov/...PMC3159779

thyroid hormone hormones reverse T3 free T3 rT3 T4 metabolism

shared by Nathan Goodyear on 16 Aug 14 - No Cached
  • Nathan Goodyear on 16 Aug 14
     
    Here is a great review of thyroid hormone metabolism published in the very relevant journal Endocrinology.  The review describes the peripheral metabolism of the pro hormone T4 and the peripheral metabolism to free T3 and/or reverse T3 and the associated metabolic implications.  Why don't more endocrinologists read?This is an animal study.
Nathan Goodyear

The role of dietary fat in peripheral thyroid hor... [Metabolism. 1980] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...7421583

diet fat carbohydrates T3 reverse T3 metabolism HF high fat

shared by Nathan Goodyear on 16 Aug 14 - No Cached
  • Nathan Goodyear on 16 Aug 14
     
    High fat diet in this small animal study finds an increase in reverse T3 and a decrease in T3.  Higher carbohydrate diet provided no significant change.
Nathan Goodyear

Association between increased levels of reverse tr... [Am J Med. 2001] - PubMed result - 0 views

www.ncbi.nlm.nih.gov/...11747849

reverse T3 rT3 MI heart attacks thyroid hypothyroid hypothyroidism

shared by Nathan Goodyear on 01 Feb 11 - No Cached
  • CONCLUSION: Determination of reverse T3 levels may be a valuable and simple aid to improve identification of patients with myocardial infarction who are at high risk of subsequent mortality.
  • Nathan Goodyear on 01 Feb 11
     
    reverse T3 predictive of increased mortality in people with myocardial infarctions
Nathan Goodyear

A Radioimmunoassay for 3,3',5'-L-Triiodothyronine (Reverse T3): Assessment of Thyroid G... - 0 views

jcem.endojournals.org/...660

reverse T3 estrogen pregnancy hypothyroid hypothyroidism

shared by Nathan Goodyear on 08 Mar 11 - No Cached
  • Both pregnancy and estrogen administration were associated with increases in serum reverse T3 concentrations presumably because of their ability to augment thyroxine binding globulin synthesis.
  • Nathan Goodyear on 08 Mar 11
     
    oral estrogen supplementation increase reverse T3 and lowers metabolism and leads to weight gain
Nathan Goodyear

ScienceDirect - Psychiatry Research : High reverse T3 levels in manic and unipolar depr... - 0 views

www.sciencedirect.com/science

reverse psychiatry t3

shared by Nathan Goodyear on 08 Mar 11 - No Cached
  • measurement of reverse T3 levels as a potential tool in differential diagnosis of affective disorders
  • Nathan Goodyear on 08 Mar 11
     
    reverse T3 tool in affective disorders
Nathan Goodyear

Type 1 5'-deiodinase activity is inhibited by oxidative stress and restored by alpha-li... - 0 views

www.ncbi.nlm.nih.gov/...26947333

thyroid T3 oxidative stress alpha lipoic acid deiodinase rT3 reverse T3 thyroid metabolites thyroid metabolism hormones

shared by Nathan Goodyear on 28 Sep 16 - No Cached
  • Nathan Goodyear on 28 Sep 16
     
    oxidative stress decreased type 1 deiodinase activity and thus T4 to T3 conversion, resulting in increased rT3 production.  Of interesting note, Alpha lipoic acid increased type I deiodinase activity and T4 to T3 conversion.
Nathan Goodyear

Extrathyroidal Conversion of Thyroxine to 3,3',5'-Triiodothyronine (Reverse-T3)and to 3... - 0 views

jcem.endojournals.org/...733

reverse T3 free T4 hypothyroid hypothyroidism extrathyroidal conversion

shared by Nathan Goodyear on 08 Mar 11 - No Cached
  • Nathan Goodyear on 08 Mar 11
     
    reverse T3 comes from peripheral conversion from free T4
Nathan Goodyear

Adverse effects of reverse triiodothyronine on cellular metabolism as assessed by 1H an... - 0 views

www.researchgate.net/...by_1H_and_31P_NMR_spectroscopy

rT3 reverse T3 3 3' 5'-Triiodothyronine T3 thyroid hormone hormones receptor metabolism

shared by Nathan Goodyear on 12 Feb 15 - No Cached
  • Nathan Goodyear on 12 Feb 15
     
    Only abstract available here.  In vitro study finds that rT3 decreased the metabolic effect of T3.  This gives the impression that rT3 has an antagonist effect to T3 on the receptor.
Nathan Goodyear

Frontiers | Can Reverse T3 Assay Be Employed to Guide T4 vs. T4/T3 Therapy in Hypothyro... - 0 views

www.frontiersin.org/...full

cancer thyroid hormones reverse T3 thyroid metabolism rT3

shared by Nathan Goodyear on 30 Jan 21 - No Cached
  • Nathan Goodyear on 30 Jan 21
     
    This study claims no viable benefit for the follow of rT3 in patients on T4/T3 treatment; yet, rT3 increases cancer cell proliferation by up to 80%?!?! Inflammation increases rT3!?!? Context, context, context.
Nathan Goodyear

Serum concentrations of total T4, T3, reverse T3 a... [Hum Nutr Clin Nutr. 1985] - PubM... - 0 views

www.ncbi.nlm.nih.gov/...4055428

free T3 hypothyroidism hypothyroid obesity

shared by Nathan Goodyear on 08 Mar 11 - No Cached
  • Nathan Goodyear on 08 Mar 11
     
    poor nutrition leads to low free T3 in tissue which lowers cellular metabolism which leads to obesity
Nathan Goodyear

Specific 3,3′,5′-Triiodothyronine (Reverse T3) Binding Sites on Rat Liver Pla... - 0 views

informahealthcare.com/...10799898309041848

reverse T3 rT3 3 3' 5'-Triiodothyronine thyroid hormone hormones receptor

shared by Nathan Goodyear on 12 Feb 15 - No Cached
  • Nathan Goodyear on 12 Feb 15
     
    rat model finds T4 and rT3 receptors at plasma membrane.  T3 was found to bind with lower affinity than rT3 and T4 at the same receptor binding site.
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