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Nathan Goodyear

Serum sex hormone-binding globulin and test... [Eur J Endocrinol. 2014] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...24670886

SHBG CVD cardiovascular disease men male hormone hormones CRP cholesterol triglycerides Testosterone

shared by Nathan Goodyear on 31 Mar 14 - No Cached
  • Nathan Goodyear on 31 Mar 14
     
    SHBG positively associated with lower CVD risk profile, CRP, blood pressure, TC, triglycerides..., in young men.  This was found independent of Testosterone.  This is similar to a lot of the research on Metabolic Syndrome as well.
Nathan Goodyear

Prevalence of low testosterone levels... [J Family Community Med. 2013] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...24672276

low T testosterone hypogonadism diabetes diabetic neuropathy BMI age men male hormone hormones

shared by Nathan Goodyear on 31 Mar 14 - No Cached
  • Nathan Goodyear on 31 Mar 14
     
    This study follows others: Diabetes associated with low Total Testosterone.  The question is whether this is a cause and effect or merely an association? This study also found age, income, BMI, and diabetic neuropathy as risk for low Testosterone.
Nathan Goodyear

The prevalence of Hypogonad... [J Diabetes Complications. 2014 Mar-Apr] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...24388552

low T Testosterone diabetes men male hormone hormones

shared by Nathan Goodyear on 31 Mar 14 - No Cached
  • Nathan Goodyear on 31 Mar 14
     
    In a study of Jordanian men, low Diabetes is clearly associated with low Testosterone.  The study found a 24.3% incidence based on lab testing and a 19.8% incidence based on symptoms.
Nathan Goodyear

Race differences in obesity and its relationship to the sex hormone milieu : Hormone Mo... - 0 views

www.degruyter.com/...34F8BE807519B51BD841611C00492B

androgens women men male female hormone hormones Testosterone bioavailable Testosterone obesity

shared by Nathan Goodyear on 24 Nov 14 - No Cached
  • increased abdominal and visceral adipose tissue (VAT) – found in women and marked by low sex hormone binding globulin (SHBG) and high bioavailable testosterone (BT) – is related to the metabolic risk profile
  • In men, increased BT is related to decreased abdominal obesity and a decrease in the metabolic risk profile
  • Nathan Goodyear on 24 Nov 14
     
    Only abstract available here.  Race (black vs white) is associated with changes in obesity effects on adrogenicity, particularly in women.  One wonders if this is a result of other variables i.e.vitamin D.
Nathan Goodyear

Testosterone deficiency and cardiovascular mortality Morgentaler A, - Asian J Androl - 0 views

www.ajandrology.com/preprintarticle.asp

testosterone low t low Testosterone CVD cardiovascular mortality therapy

shared by Nathan Goodyear on 01 Dec 14 - No Cached
  • overall mortality and CV mortality were inversely associated with serum T concentrations.
  • men with low serum T, defined as < 8.7 nmol l−1 (250 ng dl−1 ), demonstrated significantly greater all-cause mortality than men with higher serum T (hazard ratio [HR]: 2.24; 95% CI: 1.41-3.57), as well as greater CV mortality
  • lower T levels were significantly associated with the presence of any CV disease
  • ...19 more annotations...
  • more than 30 years of studies suggesting that low levels of T represent an increased risk for CV and overall mortality,
  • lower serum T concentrations also are associated with CV disease, including incident coronary artery disease [17],[18],[19] and atherosclerosis,
  • the actual rate of adverse events was only half as great in the T group (123 events in 1223 men at risk = 10.1%) as in the untreated group (1587 events in 7486 men = 21.2%)
  • The study by Vigen et al. [7] has already undergone two published corrections,
  • 29 medical societies have called for retraction of the article, asserting "gross data mismanagement and contamination," that rendered the study "no longer credible
  • Mortality in T-treated men was reduced by approximately half in treated men compared with untreated men, at 10.3% versus 20.7%, respectively
  • The mortality rate for men who received TTh was 3.4 deaths per 100 person-years, and 5.7 deaths per 100 person-years in untreated men
  • HR of 0.61 (95%CI: 0.42-0.88; P = 0.008), indicating a significant reduction in mortality with TTh
  • men in the highest prognostic MI risk quartile, treatment with TTh was associated with reduced risk
  • tripling in T prescriptions in the US over the last decade
  • a majority of observational studies have found that low endogenous serum T levels are associated with increased mortality.
  • Men who received TTh were able to exercise significantly longer without ischemia compared with men who received placebo
  • In men with congestive heart failure, those who received T demonstrated greater walking distance and other functional endpoints compared with those who received placebo
  • TTh has been shown uniformly and repeatedly to improve several known CV risk factors, including reduced fat mass, body fat percent, and waist circumference, and increased lean mass
  • improved glycemic control
  • reductions in insulin resistance.
  • the evidence strongly points to improved CV status with normal serum T or treatment with TTh in men with TD
  • analysis of health insurance claims data that reported a 36% increased rate of nonfatal MI in the 90d following receipt of a T prescription compared with the 12 prior months.
  • Comparison with men who received a prescription for a phosphodiesterase type 5 inhibitor (PDE5i) revealed no increased rate of MI following the prescription
  • Nathan Goodyear on 01 Dec 14
     
    Great review by Morgentaler of Testosterone and CVD.  He highlights the significant flaws in the JAMA and the NEJM articles of Testosterone therapy risks.  Morgentaler highlights the significant evidence that points to low T and increased risk of CVD. On contention I have, is Morgantaler seems to flip aside the massive uptick of Testosterone use in the US as compared to other countries.  The evidence definitely points to Testosterone therapy as being safe in those with low T, but there is definitely a problem of significant Testosterone doping that is taking place as well.
Nathan Goodyear

Loss of androgen receptor expression is not associated with pathological stage, grade, ... - 0 views

onlinelibrary.wiley.com/...abstract

bladder cancer bladder cancer androgen receptor androgen receptors androgen receptor

shared by Nathan Goodyear on 05 Jan 15 - No Cached
  • Nathan Goodyear on 05 Jan 15
     
    multi-center study finds no association between androgen receptor expression and invasive bladder cancer.  There was also no difference between male and female in androgen receptor expression.
Nathan Goodyear

Expression of androgen and oestrogen receptors and its prognostic significance in uroth... - 0 views

onlinelibrary.wiley.com/...abstract

AR androgen receptor androgen receptors androgen receptor ER alpha ER-alpha bladder cancer bladder cancer ER-beta ER beta hormone hormones

shared by Nathan Goodyear on 05 Jan 15 - No Cached
  • Nathan Goodyear on 05 Jan 15
     
    Study finds that loss of AR and ER-alpha is associated with high grade bladder cancer and ER-beta was positively associated. This has been contradicted by other studies.
Nathan Goodyear

A comparison of the use of urinary c... [J Clin Endocrinol Metab. 2013] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...23150688

cortisol saliva salivary Cushing's testing

shared by Nathan Goodyear on 23 Aug 14 - No Cached
  • Nathan Goodyear on 23 Aug 14
     
    night time salivary cortisol found to correlate with early morning urine samples in those with Cushing's.  This in addition to the nocturnal salivary cortisol correlation found in past studies.  The positive studies on salivary cortisol testing continues to build.
Nathan Goodyear

Associations between apolipoprotein B, apolipop... [J Intern Med. 2006] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...16629854

Apo B:Apo A1 apo B apo A1 Apolipoprotein B Apolipoprotien A1 lipoproteins cardiovascular disease risk

shared by Nathan Goodyear on 26 Aug 14 - No Cached
  • Nathan Goodyear on 26 Aug 14
     
    Meta-analysis finds "strong association" between Apo A1, Apo B and the ratio Apo B:A1 and cardiovascular risk.
Nathan Goodyear

The effects of an acute dose of Rhodiola... [J Strength Cond Res. 2013] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...23443221

rhodiola rhodiola rosea endurance exercise

shared by Nathan Goodyear on 23 Aug 14 - No Cached
  • Nathan Goodyear on 23 Aug 14
     
    rhodiola improves endurance performance.
Nathan Goodyear

Using testosterone and cortisol as bioma... [J Strength Cond Res. 2014] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...25144130

Total Testosterone cortisol testosterone:cortisol hormone hormones performance exercise stress

shared by Nathan Goodyear on 26 Aug 14 - No Cached
  • Nathan Goodyear on 26 Aug 14
     
    Study followed Total Testosterone:Cortisol ratios to monitor catabolic/anabolic states in basketball players.  The authors followed serum levels and monitored them 24-36 hours post game.  Those playing > 25 min/game had the lowest TT:C and highest cortisol indicating a catabolic state and making recovery critical.
Nathan Goodyear

Effect of intravenous ascorbic acid in hemod... [Am J Kidney Dis. 2006] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...16564942

IV vitamin C IV vitamin C antioxidant antioxidants anemia

shared by Nathan Goodyear on 25 Sep 13 - No Cached
  • Nathan Goodyear on 25 Sep 13
     
    High dose IV vitamin C shown to be well tolerated in those on hemodialysis.  Liver enzymes were followed throughout the course of the 6 month trial.  In fact, IV vitamin C was shown to improve the response of the EPO therapy.
Nathan Goodyear

Clomiphene citrate effects on testosterone/estroge... [J Sex Med. 2005] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...16422830

clomid HPA low T testosterone estrogen estradiol hypogonadism men male hormone hormones

shared by Nathan Goodyear on 24 Jul 14 - No Cached
  • Nathan Goodyear on 24 Jul 14
     
    small cohort with low serum Total Testosterone improved T:E2 ratio with clomid.  Clomid restores the HPA through inhibition of the negative feedback of Estradiol on the Hypothalamus and Pituitary in men.  This allows for an increase in gonadotropin production and thus increase in testosterone production.  Aromatase inhibition therapy would likely still prove beneficial in this situation.
Nathan Goodyear

Testicular synthesis and vitamin D a... [J Clin Endocrinol Metab. 2014] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...24937537

vitamin D Testosterone male men hormone hormones

shared by Nathan Goodyear on 29 Jul 14 - No Cached
  • Nathan Goodyear on 29 Jul 14
     
    Vitamin D regulates genes involved in Testosterone production in men.  Another reason, why evaluating Testosterone alone in men is unacceptable.
Nathan Goodyear

:: International Braz J Urol :: - 0 views

brazjurol.com.br/...DaRos_512_518.htm

climid low T Testosterone men male hormone hormones hypogonadism

shared by Nathan Goodyear on 24 Jul 14 - No Cached
  • Nathan Goodyear on 24 Jul 14
     
    small study of men with low T and symptoms of hypogonadism found to improve with clomid.  Testosterone levels were found to increase by 115% and quality of life measures improved as well.  
Nathan Goodyear

Endocrine screening for sexual dysfunction using free... [J Urol. 1996] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...8683690

free Testosterone free Total total Testosterone Testosterone low T ED men male hormone hormones

shared by Nathan Goodyear on 24 Jul 14 - No Cached
  • Nathan Goodyear on 24 Jul 14
     
    free Testosterone proves more useful than serum Total Testosterone, symptom questionnaire and testicular atrophy in the diagnosis of hypogonadism in men with ED.
Nathan Goodyear

Activation of estrogen re... [J Steroid Biochem Mol Biol. 2007 Nov-Dec] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...17692514

ER beta ER-beta siberian Rhubarb ERr 731 menopause estrogen receptors ER women health

shared by Nathan Goodyear on 01 Jul 14 - No Cached
  • Nathan Goodyear on 01 Jul 14
     
    It is always important to work out the biochemical mechanism of action.  Study finds Siberian Rhubarbs mechanism of action is through activation ER-beta receptors.  No activity/affinity for ER-alpha found in this study.  This is important as the ER-beta provides an anti-inflammatory, antigrowth signal.
Nathan Goodyear

Marked Testosterone Deficiency-Related Symptoms Ma... [J Sex Med. 2014] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...24975551

low T Testosterone low T low Testosterone CVD cardiovascular disease TDS Testosterone Deficiency Syndrome men male hormone hormones

shared by Nathan Goodyear on 07 Jul 14 - No Cached
  • Nathan Goodyear on 07 Jul 14
     
    The more severe the symptoms, the more the increased risk of CVD in men with low T.
Nathan Goodyear

International braz j urol - Age-related testosterone decline in a Brazilian cohort of h... - 0 views

www.scielo.br/scielo.php

Testosterone men male hormone hormones aging low T low Testosterone low T

shared by Nathan Goodyear on 11 Aug 14 - No Cached
  • Nathan Goodyear on 11 Aug 14
     
    Study of military men in Brazil finds a decline in Serum Total Testosterone levels with aging.
Nathan Goodyear

Associations between sex hormone binding globulin and metabolic syndrome parameters in ... - 0 views

www.indianjmedsci.org/article.asp

SHGB metabolic syndrome hormone hormones female women obesity premenopause pre-menopausal premenopausal

shared by Nathan Goodyear on 07 Aug 14 - No Cached
  • Nathan Goodyear on 07 Aug 14
     
    Low SHGB associated with increased association with metabolic syndrome components.  Low SHBG particuraliy associated with increased obesity (visceral) and glucose dysmetabolism. This study looked at premenopausal women.
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