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Nathan Goodyear

Severe sensory motor polyneuropathy at the onset of diabetes mellit... - PubMed - NCBI - 0 views

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    only abstract available.  Testosterone therapy involved in the resolution of polyneuropathy in new onset Diabetes.
Nathan Goodyear

MedLink - 0 views

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    Mercury exposure associated with polyneuropathy. Sensory is more recent exposure with long term exposure associated with motor.
Nathan Goodyear

Chronic inorganic mercury induced peripheral neuropathy. - PubMed - NCBI - 0 views

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    Only abstract available: chronic inorganic Hg associated with demyelinating sensorimotor polyneuropathy.  The exposure in this case study was through herbal supplements.
Nathan Goodyear

Vitamin B6 supplementation can improve peripheral polyneuropathy in patients ... - 0 views

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    vitamin B6 was shown to improve peripheral neuropathy in renal failure patients.  
Nathan Goodyear

Oral Treatment With α-Lipoic Acid Improves Symptomatic Diabetic Polyneuropathy - 0 views

  • Oral treatment with ALA for 5 weeks improved neuropathic symptoms and deficits in patients with DSP
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    alpha Lipoic Acid improves Diabetic Neuropathy
Nathan Goodyear

Therapeutic Testosterone Administration Preserves Excitatory Synaptic Transmission in t... - 0 views

  • direct androgen receptor activation is not a mutually exclusive requirement of testosterone-mediated neuroprotection.
  • Testosterone treatment after EAE induction restores synaptic transmission and corresponding synaptic protein levels within the hippocampus during EAE
  • A growing body of evidence suggests that testosterone enhances hippocampal synaptogenesis
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  • This study demonstrates that testosterone treatment either before or after EAE disease induction partially restores deficits in synaptic transmission, preserves presynaptic and postsynaptic integrity, and prevents hippocampal pathology.
  • treatment with a pregnancy estrogen, estriol, can prevent deficits in excitatory synaptic transmission in the hippocampus during EAE
  • testosterone is important to the maintenance of normal synaptic spine density in the hippocampus
  • estriol treatment was also capable of preserving levels of synaptic proteins that are known to orchestrate functional synaptic transmission within the hippocampus.
  • Estriol is a therapeutic candidate in MS because it has widespread effects on the immune system and the CNS
  • MS patients have significantly decreased relapse rates during the third trimester of pregnancy, when estriol levels are most elevated, and relapse rates rebound during the postpartum period coinciding with an abrupt decline in serum estriol levels
  • In nonpregnant MS patients, estriol treatment has been shown to significantly reduce gadolinium-enhancing lesion number and volumes measured by MRI
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    Testosterone restores/preserves nerve synapsis within the hippocampus in autoimmune demyelinating disease.  Testosterone appears to have neuroprotection.  The authors conclude that the majority of the protective effect was through aromatase activity.
Nathan Goodyear

Peripheral neuropathy: an underdiagnosed cause of erectile dysfunction - Vall... - 1 views

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    Peripheral neuropathy involved in/associated with the pathogenesis of ED proposed by this study.
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