Only abstract available: chronic inorganic Hg associated with demyelinating sensorimotor polyneuropathy. The exposure in this case study was through herbal supplements.
This study demonstrates that testosterone treatment either before or after EAE disease induction partially restores deficits
in synaptic transmission, preserves presynaptic and postsynaptic integrity, and prevents hippocampal pathology.
treatment with a pregnancy estrogen, estriol, can prevent deficits in excitatory
synaptic transmission in the hippocampus during EAE
testosterone is important to the maintenance of normal synaptic spine density in the hippocampus
estriol treatment was also capable of preserving levels of synaptic proteins that are known to orchestrate
functional synaptic transmission within the hippocampus.
Estriol is a therapeutic candidate in MS because it has widespread effects on the immune system and the CNS
MS patients have significantly decreased relapse rates during the third trimester of pregnancy, when estriol levels are
most elevated, and relapse rates rebound during the postpartum period coinciding with an abrupt decline in serum estriol levels
In nonpregnant MS patients, estriol treatment has been shown to significantly reduce gadolinium-enhancing lesion number
and volumes measured by MRI
Testosterone restores/preserves nerve synapsis within the hippocampus in autoimmune demyelinating disease. Testosterone appears to have neuroprotection. The authors conclude that the majority of the protective effect was through aromatase activity.