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Nathan Goodyear

Human chorionic gonadotropin is of no value in the management of obesity. - 0 views

www.ncbi.nlm.nih.gov/...PMC1875285

human chorionic gonadotropin obesity weight loss overweight

shared by Nathan Goodyear on 21 Apr 11 - No Cached
  • Human chorionic gonadotropin is of no value in the management of obesity
  • Nathan Goodyear on 21 Apr 11
     
    Human chorionic gonadotropin is of no value in the management of obesity
Nathan Goodyear

Human chorionic gonadotropin is of no value in the... [Can Med Assoc J. 1983] - PubMed ... - 0 views

www.ncbi.nlm.nih.gov/...6340811

human chorionic gonadotropin HCG weight loss obesity overweight

shared by Nathan Goodyear on 21 Apr 11 - No Cached
  • Nathan Goodyear on 21 Apr 11
     
    Human chorionic gonadotropin is of no value in the management of obesit
Nathan Goodyear

A clinical study of the use of human chorionic gon... [J Fam Pract. 1977] - PubMed result - 0 views

www.ncbi.nlm.nih.gov/...321723

HCG human chorionic gonadotropin weight loss overweight obesity

shared by Nathan Goodyear on 21 Apr 11 - No Cached
  • reatment of obesity with human chorionic gonadotrophin was shown to be of no better value than saline in a double-blind crossover study of weight reduction in obese subjects
  • o significant difference in mood,
  • hunger, or missed injections, and no apparent difference in adherence to diet when the two agents were compare
  • Nathan Goodyear on 21 Apr 11
     
    HCG appears to be placebo effect
Nathan Goodyear

acute stimulation of aromatization in Leydig cells by human chorionic gonadotropin in v... - 0 views

www.pnas.org/...4460.full.pdf

HCG aromatase aromatization leydig cells human chorionic gonadotropin hormone hormones men male

shared by Nathan Goodyear on 11 Jun 13 - No Cached
  • Nathan Goodyear on 11 Jun 13
     
    Granted, this is a in vitro study, but this study found that HCG stimulated increased leydig cell estrogen production through stimulation of aromatase activity.
Nathan Goodyear

Ineffectiveness of human chorionic gonadotropin in... [Am J Clin Nutr. 1976] - PubMed r... - 0 views

www.ncbi.nlm.nih.gov/...786001

HCG weight loss obesity human chorionic gonadotropin

shared by Nathan Goodyear on 21 Apr 11 - No Cached
  • e sought to duplicate the Asher-Harper study (1973)
  • here was no statistically significant difference in the means of the two groups in number of injections received, weight loss, percent of weight loss, hip and waist circumference, weight loss per injections, or in hunger ratings. HCG does not appear to enhance the effectiveness of a rigidly imposed regimen for weight reduction
  • Nathan Goodyear on 21 Apr 11
     
    no improvement in weight loss with HCG injections above that in dietary changes. This isa duplication of the initial Asher-Harper study in 1973 that did show improvement in 20 women.  
Nathan Goodyear

The effect of human chorionic gonadotropin (HCG) i... [Br J Clin Pharmacol. 1995] - Pub... - 0 views

www.ncbi.nlm.nih.gov/...8527285

HCG weight loss overweight obesity human chorionic gonadotropin

shared by Nathan Goodyear on 21 Apr 11 - No Cached
  • We conclude that there is no scientific evidence that HCG is effective in the treatment of obesity; it does not bring about weight-loss of fat-redistribution, nor does it reduce hunger or induce a feeling of well-being.
  • Nathan Goodyear on 21 Apr 11
     
    review of 24 studies, some well designed and others not, lead to conclusion:  "We conclude that there is no scientific evidence that HCG is effective in the treatment of obesity; it does not bring about weight-loss of fat-redistribution, nor does it reduce hunger or induce a feeling of well-being."
Nathan Goodyear

Human chorionic gonadotropin (HCG) in the treatmen... [West J Med. 1977] - PubMed result - 0 views

www.ncbi.nlm.nih.gov/...595585

human chorionic gonadotropin HCG

shared by Nathan Goodyear on 21 Apr 11 - No Cached
  • Placebo injections, therefore, appear to be as effective as HCG in the treatment of obesity.
  • Nathan Goodyear on 21 Apr 11
     
    HCG injections no better than placebo
Nathan Goodyear

Treatment with human chorionic gonadotropin and risk of breast cancer. - 0 views

cebp.aacrjournals.org/...437.short

human chorionic gonadotropin HCG

shared by Nathan Goodyear on 21 Apr 11 - No Cached
  • these results suggest that hCG may be a means for reducing breast cancer risk.
  • Nathan Goodyear on 21 Apr 11
     
    HCG may reduce breast cancer risk; but not weight loss
Nathan Goodyear

Human Chorionic Gonadotropin (HCG) in the Treatment of Obesity - 0 views

www.ncbi.nlm.nih.gov/...PMC1237915

human chorionic obesity gonadotropin weight loss

shared by Nathan Goodyear on 21 Apr 11 - No Cached
  • Weight loss was identical between the two groups, and there was no evidence for differential effects on hunger, mood or localized body measurements. Placebo injections, therefore, appear to be as effective as HCG in the treatment of obesity.
  • Nathan Goodyear on 21 Apr 11
     
    HCG no more effective than placebo in weight loss
Nathan Goodyear

Ineffectiveness of human chorionic gonadotropin in weight reduction: a double-blind study - 0 views

www.ajcn.org/...940.short

weight loss HCG human chorionic gonadotropin obesity

shared by Nathan Goodyear on 21 Apr 11 - No Cached
  • There was no statistically significant difference in the means of the two groups in number of injections received, weight loss, percent of weight loss, hip and waist circumference, weight loss per injections, or in hunger ratings
  • HCG does not appear to enhance the effectiveness of a rigidly imposed regimen for weight reduction.
  • Nathan Goodyear on 21 Apr 11
     
    HCG ineffective in weight loss in a double-blinded study
Nathan Goodyear

Penile Growth in Response to Human Chorionic Gonadotropin (hCG) Treatment in Patients w... - 0 views

www.ncbi.nlm.nih.gov/...PMC3214853

hCG human chorionic gonadotropin idiopathic hypogonadotrophic hypogonadism hypogonadism low testosterone low T low testosterone

shared by Nathan Goodyear on 05 Feb 13 - No Cached
  • Nathan Goodyear on 05 Feb 13
     
    HCG used to stimulate endogenous testosterone production in young men with idiopathic hypogonadotrophic hypogonadism.
Nathan Goodyear

Chorionic gonadotropin in weight control. A double... [JAMA. 1976] - PubMed result - 0 views

www.ncbi.nlm.nih.gov/...792477

human chorionic gonadotropin HCG weight loss overweight obesity

shared by Nathan Goodyear on 21 Apr 11 - No Cached
  • There was no statistically significant difference between those receiving HCG vs placebo during any phase of this study
  • Nathan Goodyear on 21 Apr 11
     
    HCG provides no benefit in weight loss, over placebo
Nathan Goodyear

Chorionic Gonadotropin in Weight Control, November 29, 1976, Young et al. 236 (22): 249... - 0 views

jama.ama-assn.org/...2495.short

HCG human chorionic gonadotropin

shared by Nathan Goodyear on 21 Apr 11 - No Cached
  • There was no statistically significant difference between those receiving HCG vs placebo during any phase of this study (P>.1).
  • Nathan Goodyear on 21 Apr 11
     
    ditto: HCG no better than placebo in weight loss
Nathan Goodyear

Chorionic Gonadotropin and Obesity? - 0 views

www.ajcn.org/...681.full.pdf+html

obesity chorionic gonadotropin human HCG weight loss overweight

shared by Nathan Goodyear on 21 Apr 11 - No Cached
  • Nathan Goodyear on 21 Apr 11
     
    early letter casting doubt on HCG for weight loss
Nathan Goodyear

PLOS ONE: Probiotic Microbes Sustain Youthful Serum Testosterone Levels and Testicular ... - 0 views

journals.plos.org/...article

hormone hormones low T low Testosterone hypogonadism Testosterone probiotic L reuters probiotics Lactobacillus lactobacillus reuteri male aging

shared by Nathan Goodyear on 29 Apr 15 - No Cached
  • Studies in both humans and rodents, however, suggest that low testosterone is due to age-related lesions in testes rather than irregular luteinizing hormone metabolism
  • Various dietary factors and diet-induced obesity have been shown to increase the risk for late onset male hypogonadism and low testosterone production in both humans and mice
  • Testosterone deficiency and metabolic diseases such as obesity appear to inter-digitate in complex cause-and-effect relationships
  • ...28 more annotations...
  • dietary supplementation of aged mice with the probiotic bacterium Lactobacillus reuteri makes them appear to be younger than their matched untreated sibling mice
  • These results indicate that gut microbiota induce modulation of local gastrointestinal immunity resulting in systemic effects on the immune system which activate metabolic pathways that restore tissue homeostasis and overall health
  • all these studies we consistently observed that young and aged mice consuming purified L. reuteri organisms had particularly large testes and a dominant male behavior.
  • The testes of probiotic-fed aged mice were rescued from both seminiferous tubule atrophy and interstitial Leydig cell area reduction typical of the normal aging process. Preservation of testicular architecture despite advanced age or high-fat diet coincided with remarkably high levels of circulating testosterone. The beneficial effects of probiotic consumption were recapitulated by the depletion of the pro-inflammatory cytokine Il-17.
  • feeding of L. reuteri consistently increased the gonadal weights, consumption of a non-pathogenic strain of Escherichia coli (E. coli) K12 organisms did not affect testicular weight
  • mice with dietary L. reuteri supplements were rescued from diet-induced obesity and had normal body weight and lean physique
  • Despite the comparable numbers of ST profiles, we determined that testes from L. reuteri-treated mice had increased ST cross-sectioned profiles
  • the probiotic organism induced prominent Leydig cell accumulations in the interstitial tissue between the ST's
  • The probiotic-associated increase of interstitial Leydig cell areas was sustained with advancing age at 7 (CD vs CD+LR, P = 0.0025; CD+E.coli vs CD+LR, P = 0.0251) and 12 months
  • mice eating L. reuteri had profoundly increased levels of circulating testosterone regardless of the type of diet they consumed
  • blocking pro-inflammatory Il-17 signaling entirely recapitulates the beneficial effects of probiotics
  • previous studies we found that dietary probiotics counteract obesity [19] and age-related integumentary pathology [18] at least in part by down-regulating systemic pro-inflammatory IL-17A-dependent signaling
  • Testes histomorphometry and serum androgen concentration data were both suggestive of a probiotic-associated up-regulation of spermatogenesis in mice
  • Lactobacillus reuteri we discovered that aging male animals had larger testes compared to their age-matched controls
  • xamined testes of probiotic microbe-fed mice and found that they had less testicular atrophy coinciding with higher levels of circulating testosterone compared to their age-matched controls
  • Similar testicular health benefits were produced using systemic depletion of the pro-inflammatory cytokine Il-17 alone, implicating a chronic inflammatory pathway in hypogonadism
  • One specific aspect of this paradigm is reciprocal activities of pro-inflammatory Th-17 and anti-inflammatory Treg cells
  • Feeding of L. reuteri organisms was previously shown to up-regulate IL-10 levels and reduce levels of IL-17 [19] serving to lower systemic inflammation
  • insufficient levels of IL-10 may increase the risk for autoimmunity, obesity, and other inflammatory disease syndromes
  • Westernized diets are also low in vitamin D, a nutrient that when present normally works together with IL-10 to protect against inflammatory disorders
  • Physiological feedback loops apparently exist between microbes, host hormones, and immunity
  • The hormone testosterone has been shown to act directly through androgen receptors on CD4+ cells to increase IL-10 expression
  • studies in both humans and rodents suggest that hypogonadism is due to age-related lesions in testes rather than irregular LH metabolism
  • We postulate that probiotic gut microbes function symbiotically with their mammalian hosts to impart immune homeostasis to maintain systemic and testicular health [34]–[35] despite suboptimal dietary conditions.
  • Dietary factors and diet-induced obesity were previously shown to increase risk for age-associated male hypogonadism, reduced spermatogenesis, and low testosterone production in both humans and mice [2]–[4], [8]–[11], [14]–[17], phenotypic features that in this study were inhibited by oral probiotic therapy absent milk sugars, extra protein, or vitamin D supplied in yogurt.
  • Similar beneficial effects of probiotic microbes on testosterone levels and sperm indices were reported in male mice that had been simultaneously supplemented with selenium
  • L. reuteri-associated prevention of age- and diet-related testicular atrophy correlates with increased numbers and size of Leydig cells
  • the initial changes of testicular atrophy begin to occur in mice from the age of 6 moths onwards [7] and indicates that the trophic effect of L. reuteri on Leydig cells is a key event which precedes and prevents age-related changes in the testes of mice. This effect is reminiscent of earlier studies describing Leydig cell hyperplasia and/or hypertrophy in the mouse and the rat testis that were achievable by the administration of gonadotropins, including human chorionic gonadotropin, FSH and LH
  • Nathan Goodyear on 29 Apr 15
     
    Fascinating study on how the addition of Lactobacillus reuteri increased Testicular size, prevented testicular atrophy, increased serum Testosterone production and protected against diet-induced/obesity-induced hypogonadism.  This was a mouse model
Nathan Goodyear

Phase I Study of Human Chorionic Gonadotropin Given Subcutaneously to Patients With Acq... - 0 views

jnci.oxfordjournals.org/...1797.short

HCG human chorionic gonadotopin

shared by Nathan Goodyear on 21 Apr 11 - No Cached
  • The most common side effects were weight gain
  • Nathan Goodyear on 21 Apr 11
     
    HCG in AIDS patients actually causes weight gain as a side effect; not weight loss
Nathan Goodyear

Concomitant intramuscular human chorionic gonadotropi... [J Urol. 2013] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...23260550

HCG low t low testosterone low t Testosterone men male hormone hormones human chorionic gonadotropin hypogonadism replacement

shared by Nathan Goodyear on 03 Aug 14 - No Cached
  • Nathan Goodyear on 03 Aug 14
     
    I can't say I agree with the premise of the study design.  In this study, HCG at 500 IU every other day was used to aid Testosterone therapy.  
Nathan Goodyear

Low-Dose Human Chorionic Gonadotropin Maintains Intratesticular Testosterone in Normal ... - 0 views

digital.lib.washington.edu/...JCEM_2005_Low_Dose_Human.pdf

HCG ITT intratesticular testosterone testosterone

shared by Nathan Goodyear on 15 May 12 - No Cached
  • Nathan Goodyear on 15 May 12
     
    low dosage HCG maintains ITT.
Nathan Goodyear

Low-dose human chorionic gonadotropin maintains intratesticular testosterone in normal ... - 0 views

digital.lib.washington.edu/...4415

HCG testosterone ITT intratesticular testosterone

shared by Nathan Goodyear on 15 May 12 - No Cached
  • Nathan Goodyear on 15 May 12
     
    low dose HCG, given every other day, shown to maintain intratesticular testosterone levels (ITT) in this with testosterone induced suppression.  A high ITT:T ratio is needed for appropriate spermatogenesis.
Nathan Goodyear

Serum 17-hydroxyprogesterone strongly correlates with intratesticular testosterone in g... - 0 views

www.ncbi.nlm.nih.gov/...PMC2674872

17-hydroxyprogesterone 17-OH progesterone ITT intratesticular testosterone HCG

shared by Nathan Goodyear on 15 May 12 - No Cached
  • Nathan Goodyear on 15 May 12
     
    as the title states: 17-OH progesterone is an appropriate tool to follow ITT levels in those on HCG therapy.
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