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Nathan Goodyear

INAUGURAL ARTICLE by a Recently Elected Academy Member:COX-2 mediates tumor-stromal pro... - 0 views

www.ncbi.nlm.nih.gov/...PMC6431196

COX-2 prolactin cancer

shared by Nathan Goodyear on 19 Aug 19 - No Cached
  • Nathan Goodyear on 19 Aug 19
     
    Cox-2 found to increase prolactin expression to increase metastatic spread of cancer cells. Cox-2 may work here more in the autocrine/paracrine prolactin signaling. This is an animal study.
Nathan Goodyear

The role of prolactin in human breast cancer | Biochemia Medica - 0 views

www.biochemia-medica.com/...-prolactin-human-breast-cancer

prolactin breast cancer cancer

shared by Nathan Goodyear on 19 Sep 18 - No Cached
  • Nathan Goodyear on 19 Sep 18
     
    prolactin and breast cancer
Nathan Goodyear

Prolactin and cancer: Has the orphan finally found a home? - 0 views

www.ncbi.nlm.nih.gov/...PMC3603025

prolactin cancer

shared by Nathan Goodyear on 19 Sep 18 - No Cached
  • Nathan Goodyear on 19 Sep 18
     
    Good review on prolactin and cancer.
Nathan Goodyear

The role of prolactin levels in the sexual activity ... [BJU Int. 2006] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...17125484

prolactin low libido ED

shared by Nathan Goodyear on 17 Jun 13 - No Cached
  • Nathan Goodyear on 17 Jun 13
     
    Elevated Prolactin level plays role in ED and reduced sexual activity in men.
Nathan Goodyear

Effect of a vegetarian diet and dexamethasone on plasma prolactin, testosterone and deh... - 0 views

www.sciencedirect.com/...S0304383579800543

diet nutrition Testosterone men male hormones hormones prolactin vegetarian

shared by Nathan Goodyear on 21 Sep 16 - No Cached
  • Nathan Goodyear on 21 Sep 16
     
    Older study finds a vegetarian diet causes a decrease in prolactin and Testosterone in men.
Nathan Goodyear

Reproducibility of Plasma Steroid Hormones, Prolactin, and Insulin-like Growth Factor L... - 0 views

cebp.aacrjournals.org/...972.long

hormone hormones androgens Testosterone DHEAS IGF-1 prolactin IGFBP-3 women female

shared by Nathan Goodyear on 21 Mar 14 - No Cached
  • Nathan Goodyear on 21 Mar 14
     
    Very interesting study finds that a single value assessment of androgens, DHEAS, prolactin, IGF-1 and IGFBP-3 can be used to assess 3 year average in pre-menopause women.  Estrogen and progesterone need to be assessed through the cycle.
Nathan Goodyear

Plasma prolactin and breast cancer risk: a meta- analysis | Scientific Reports - 0 views

www.nature.com/...srep25998

prolactin breast cancer cancer

shared by Nathan Goodyear on 19 Sep 18 - No Cached
  • Nathan Goodyear on 19 Sep 18
     
    prolactin associated wtih ER+/PR+
Nathan Goodyear

Importance of serum prolactin determinations in metastatic breast cancer patients | Ham... - 0 views

www.academia.edu/...astatic_breast_cancer_patients

cancer breast cancer liver prolactin

shared by Nathan Goodyear on 11 May 18 - No Cached
  • Nathan Goodyear on 11 May 18
     
    Prolactin is a useful marker for prognosis and metastatic potential for women with breast cancer and liver mets risk.
Nathan Goodyear

A Novel Estradiol/Estrogen Receptor α-dependent Transcriptional Mechanism Con... - 0 views

www.jbc.org/...18825.long

Estradiol ER alpha prolactin ER-alpha Breast Cancer

shared by Nathan Goodyear on 19 Aug 19 - No Cached
  • Nathan Goodyear on 19 Aug 19
     
    Estradiol increases prolactin receptor transcription through their ER-alpha receptor.
Nathan Goodyear

SERUM PROLACTIN IN MELANOMA PATIENTS WITH INTERFERON ALPHA2B TREATMENT - PubMed - 0 views

pubmed.ncbi.nlm.nih.gov/27328525

prolactin melanoma malignant melanoma

shared by Nathan Goodyear on 28 Sep 20 - No Cached
  • Nathan Goodyear on 28 Sep 20
     
    Elevated prolactin found statistically elevated in melanoma versus dysplastice nevi.
Nathan Goodyear

Malignant melanoma and prolactine imbalance | ECE2013 - 0 views

www.endocrine-abstracts.org/...ea0032p546

malignant melanoma prolactin melanoma

shared by Nathan Goodyear on 28 Sep 20 - No Cached
  • Nathan Goodyear on 28 Sep 20
     
    Elevated prolactin clearly directly associated with malignant melanoma.
Nathan Goodyear

A Case of Galactorrhea Associated with Excitalopram - 0 views

www.ncbi.nlm.nih.gov/...PMC2796073

Lexapro excitalopram SSRI Prolactin low libido galactorrhea

shared by Nathan Goodyear on 17 Jun 13 - No Cached
  • Nathan Goodyear on 17 Jun 13
     
    Lexapro can increase Prolactin levels which can cause libido dysfunction and galactorrhea as in this case.
Nathan Goodyear

Peptide and steroid hormone levels in pre- and postmenopausal breast carcinoma. - PubMe... - 0 views

www.ncbi.nlm.nih.gov/...3104809

hormones breast cancer cancer estrogen progesterone testosterone prolactin female hormones women

shared by Nathan Goodyear on 15 Sep 16 - No Cached
  • Nathan Goodyear on 15 Sep 16
     
    elevated Testosterone found to play role in post menopause breast cancer.  No correlation with elevated Testosterone was found in pre menopause--in fact, low estrogen/low Testosterone and elevated prolactin was found in pre menopausal breast cancer patients.
Nathan Goodyear

Natural Killer Cells in Pregnancy and Recurrent Pregnancy Loss: Endocrine and Immunolog... - 0 views

edrv.endojournals.org/...44.full

natural killer cells pregnancy loss recurrent immune system miscarriage NK

shared by Nathan Goodyear on 15 Apr 12 - No Cached
  • NK cells have been the cells most extensively studied, primarily because they constitute the predominant leukocyte population present in the endometrium at the time of implantation and in early pregnancy
  • parental chromosomal abnormalities, uterine anatomic anomalies, endometrial infections, endocrine etiologies (luteal phase defect, thyroid dysfunction, uncontrolled diabetes mellitus), antiphospholipid syndrome, inherited thrombophilias, and alloimmune causes
  • estrogen
  • ...28 more annotations...
  • progesterone
  • prolactin
  • In summary, in vivo animal experiments have shown an inhibitory role of estrogen on peripheral NK cell lytic activity, which is partly due to suppression of NK cell output by the bone marrow and partly due to suppression of individual NK cell cytotoxicity. However, in vitro studies so far have failed to show conclusively a direct effect of estrogen on NK cells.
  • At the progesterone concentrations believed to be present in the uterus [up to 10−5 m at the maternal-fetal interface (35)], studies consistently show inhibition of lymphocyte proliferation (33) and inhibition of NK cytolytic activity in vitro
  • The exact role of prolactin in NK cell regulation is unknown.
  • The overall effects of estrogen on NK cells are likely multifactorial, therefore, and depend on the type of cell affected as well as the kind of ER expressed by that cell.
  • It is known that progesterone can directly affect T cell differentiation in vitro, suppressing development of the Th1 pathway and enhancing differentiation along the Th2 pathway (44)
  • Th1 cells predominantly produce interferon-γ (IFN-γ), IL-2, and TNF-β and are involved in cell-mediated immunity. Th2 cells produce IL-4, IL-5, IL-6, IL-10, and IL-13 and stimulate humoral immunity
  • Furthermore, in response to progesterone, γδ T cells produce progesterone-induced blocking factor (PIBF) (54
  • A defining characteristic of NK cells is their ability to lyse target cells without prior sensitization and without restriction by HLA antigens.
  • NK cell function is mainly regulated by IL-2 and IFN-γ
  • IL-2 causes both NK cell proliferation and enhanced cytotoxicity. IFN-γ augments NK cytolytic activity, but does not cause NK proliferation. The two cytokines act synergistically to augment NK cytotoxicity (6).
  • The largest leukocyte population in the endometrium consists of NK cells named large granulated lymphocytes
  • there is a significant increase in the number of uNK cells throughout the secretory phase, which peaks in early pregnancy when uNK cells comprise about 75% of uterine leukocytes (62)
  • Second, uNK cell phenotype changes during the normal menstrual cycle and early pregnancy (68)
  • general proinflammatory effect of estrogen, causing an influx of macrophages and neutrophils, which is antagonized by progesterone through its receptor (70, 71).
  • The mechanism of such a progesterone-induced local immunosuppression is unclear.
  • progesterone plays an important role in proliferation and differentiation of uNK cells (32).
  • Through promotion of a uterine Th2 environment, progesterone could indirectly affect uNK cell function
  • The mechanism of this increase in uNK cell numbers has been addressed in both human and mouse models, and is likely the result of: 1) recruitment of peripheral NK cells to the uterus, and 2) proliferation of existing uNK cells
  • prolactin system plays an important role in implantation and the maintenance of pregnancy
  • the exact pathways of hormonal regulation of NK cells remain to be delineated.
  • The exact function of uNK cells has not yet been unequivocally determined
  • uNK cells express a different cytokine profile, compared with resting peripheral NK cells. mRNAs for granulocyte CSF, M-CSF, GM-CSF, TNF-α, IFN-γ, TGF-β, and leukemia inhibitory factor (LIF) have been found in decidual CD56+ cells
  • Their increased numbers in early pregnancy, their hormonal dependence, and their close proximity to the infiltrating trophoblast all suggest that they play an important role in the regulation of the maternal immune response to the fetal allograft and the control of trophoblast growth and invasion during human pregnancy
  • role of uNK cell-derived cytokines on trophoblast growth and differentiation (114, 115, 116, 117).
  • Th1 immunity to trophoblast is associated with RPL, whereas Th2 immunity is associated with a successful pregnancy
  • RPL is associated with Th1 immunity, for which NK cells are partly responsible.
  • Nathan Goodyear on 15 Apr 12
     
    dysregulated immune system plays role in recurrent miscarriage.  Specifically, this article discusses natural killer cells (NK).
Nathan Goodyear

Brazilian Journal of Medical and Biological Research - Is the infertility in hypothyroi... - 0 views

www.scielo.br/scielo.php

functional hypothyroidism prolactin elevated gonadotropins infertility LH FSH

shared by Nathan Goodyear on 17 Nov 11 - No Cached
  • Nathan Goodyear on 17 Nov 11
     
    functional hypothyroidism associated with elevated prolactin levels and thus gonadotropin dysfunction and infertility
Nathan Goodyear

Pharmacological causes of hyperprolactinemia - 0 views

www.ncbi.nlm.nih.gov/...PMC2376090

SSRI prolactin hyperprolactinemia antidepressants

shared by Nathan Goodyear on 01 Nov 13 - No Cached
  • Nathan Goodyear on 01 Nov 13
     
    SSRI as well as other antidepressants cause hyperprolactinemia.  Antipsychotics are well known to increase prolactin production.
Nathan Goodyear

Hyperprolactinemia in polycystIc ovary syndrome - 0 views

www.endocrine-abstracts.org/...ea0020p653.htm

prolactin polycystic ovarian syndrome polycystic ovary syndrome female hormones hormone women

shared by Nathan Goodyear on 10 Sep 14 - No Cached
  • Nathan Goodyear on 10 Sep 14
     
    Study finds Prolactin not associated with PCOS.
Nathan Goodyear

Polycystic ovarian syndrome (PCOS) (Nov. 2004) - 0 views

www.townsendletter.com/...phyto1104.htm

PCOS polycystic ovarian syndrome polycystic ovary syndrome Prolactin hormone hormones women female

shared by Nathan Goodyear on 10 Sep 14 - No Cached
  • Nathan Goodyear on 10 Sep 14
     
    PCOS review.  Therapy focus' on the natural treatments.  25% of women with PCOS have elevated prolactin levels. 
Nathan Goodyear

Inhibition of sex hormone-binding globulin production in the human ... - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...2842359

SHBG insulin Prolactin Testosterone Estradiol E2 T4 hormone hormones

shared by Nathan Goodyear on 28 Oct 14 - No Cached
  • Nathan Goodyear on 28 Oct 14
     
    Insulin and Prolactin inhibit liver SHBG production.  Testosterone, Estradiol and T4 stimulate SHBG in in vitro study.
Nathan Goodyear

Breast carcinoma associated with prolactinoma: A case report - 0 views

www.ncbi.nlm.nih.gov/...PMC5389425

prolactin cancer breast cancer

shared by Nathan Goodyear on 19 Sep 18 - No Cached
  • Nathan Goodyear on 19 Sep 18
     
    prolactin and breast cancer
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