Activity and expression of progesterone metabolizing 5α-reductase, 20α-hydrox... - 0 views
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Exposure of human breast cell lines (MCF-7, MCF-10A, and ZR-75-1) to 5α-pregnanes results in changes associated with neoplasia, including increased proliferation and decreased attachment [1], depolymerization of F-actin [2] and decreases in adhesion plaque-associated vinculin
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Exposure to 4-pregnenes results, in general, in opposite (anti-cancer-like) effects
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5αR1 has been detected in various androgen-independent organs, such as the liver and brain
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balance of enzyme production between 5alpha-reductase and 20alpha-hydroxysteroid oxidoreductase and 3alpha(beta)-hydroxysteroid oxidoreductase play role in carcinogenesis and proliferation in the balance of production of progesterone metabolites. The 5alpha pregnenes are pro carcinogenic and the 4-pregnenes are anti carcinogenic.