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Nathan Goodyear

Testosterone deficiency: a key factor in the... [J Womens Health. 1998] - PubMed - NCBI - 0 views

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    Weak connection, but this study finds that Testosterone in post-menopausal women will reduce cardiovascular disease (CVD) in women.  Their conclusion is based on the rise in CVD in post-menopausal women and the decline in Testosterone levels post-hysterectomy. That is the one instant where Testosterone levels do precipitously decline.  Contrast this with natural menopause where Testosterone does not appear to decline as precipitously.
Nathan Goodyear

Ovarian estradiol production and lipid metabolism ... [Menopause. 2014] - PubMed - NCBI - 1 views

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    contrary to popular thought, the ovaries dont' shrivel up and die post menopause.  This study finds Estradiol production on going post menopause.
Nathan Goodyear

Tissue-Specific Increases in 11β-Hydroxysteroid Dehydrogenase Type 1 in Norma... - 0 views

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    11 beta HSD type 1 increases in menopause in normal weight women.  This may explain some of the metabolism changes seen in women post-menopause.
Nathan Goodyear

Peptide and steroid hormone levels in pre- and postmenopausal breast carcinoma. - PubMe... - 0 views

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    elevated Testosterone found to play role in post menopause breast cancer.  No correlation with elevated Testosterone was found in pre menopause--in fact, low estrogen/low Testosterone and elevated prolactin was found in pre menopausal breast cancer patients.
Nathan Goodyear

Cognitive effects of estradiol after menopause - 0 views

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    No benefit to memory for post menopause women with estradiol therapy.  This study looked at early and late menopause estrogen therapy.  The study also found no harm.  Only abstract available here.  These studies would do more scientific benefit if they would follow hormone levels.  This study did not touch on dementia; other studies have shown benefit from estrogen therapy  in preventing dementia in women.
Nathan Goodyear

Inflammatory and Cardiometabolic Risk on Obesity: Role of Environmental Xenoestrogens: ... - 0 views

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    Study finds heavy presence of xenoestrogens in obese Portuguese women, both pre menopause and post menopause.  This study only looked at obese women; it would be nice to have a control of thin women to contrast the plasma and adipose xenoestrogen levels.  The authors found the presence of xenoestrogens in plasma in pre menopause women to be a 10 year predictor of cardiovascular disease risk in these women.  The authors also found increased Xenoestrogen levels to be associated with metabolic dysfunction and inflammation.
Nathan Goodyear

Low Sex-Hormone Binding Globulin is Associated with the Metabolic Syndrome in Postmenop... - 0 views

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    low SHBG in post-menopausal women correlates with increased risk of metabolic syndrome.  More than that, there is an inverse correlation with SHBG in women and metabolic syndrome components.  Also, Increasing components of MetS was correlated with Testosterone and free androgen index.
Nathan Goodyear

Effects of estrogen on memory funct... [Psychoneuroendocrinology. 1992] - PubMed - NCBI - 0 views

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    estrogen therapy in surgical menopause preserves memory.  Rapid decline in estrogen levels post surgical menopause is associated with cognitive/memory decline.  Versus placebo, estrogen therapy preserved memory function.
Nathan Goodyear

Low Levels of Serum Vitamin D3 Are Associated with Autoimmune Thyroid Disease in Pre-Me... - 0 views

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    low vitamin D associated with increased autoimmune thyroid TPO antibodies in women.  This association was found in pre menopause women, but not post menopause women.
Nathan Goodyear

Estrogenic regulation of skeletal muscle proteome: a study of premenopausal women and p... - 0 views

  • Female aging is characterized by menopausal change in sex steroid hormones concomitant to increase in aging-related decrements in skeletal muscle performance that can be attenuated by HRT use
  • The major canonical pathways found to be differentially regulated included mitochondrial dysfunction, oxidative phosphorylation, glycolysis, and TCA-cycle, strong indicators for affected energy metabolism
  • E2 to exert anti-apoptotic effects in muscle progenitor cells by improving mitochondrial function
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  • E2 is a major regulator of human skeletal muscle signaling in women
  • After menopause, when ovarian E2 production is ceased, the prevalence of cardio-metabolic diseases increases. Our result that different trajectories of the energy pathways in the skeletal muscle may be regulated by E2 provides candidate molecules as key targets for future interventions to prevent or treat postmenopausal metabolic dysregulation
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    Study finds Estradiol regulates human skeletal muscle cell signaling (mitochondrial function, oxidative phosphorylation, glycolysis, and TCA cycle) in study of pre/post menopause women through proteome analysis. This study would have been complete if they had carried to search beyond that of protein to epigenetics.
Nathan Goodyear

ARS | Publication request: Sex hormone modulation of proinflammatory cytokine and CRP e... - 0 views

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    Study finds that Testosterone provided a small anti-inflammatory effect in post-menopausal women and men, whereas Estrogen increased macrophage cytokine production in post-menopausal women with elevated LDL.  Now, this study did not differentiate PCOS versus non-PCOS, nor did it look at the effects of adiposity in these hormonal effects in women.  Both of which, will effect the outcome.
Nathan Goodyear

Inclusion of Endogenous Hormone Levels in Risk ... [J Clin Oncol. 2014] - PubMed - NCBI - 0 views

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    study finds hormone evaluations in post menopause women aids in breast cancer risk assessment.
Nathan Goodyear

SHBG, Sex Hormones, and Inflammatory Markers in Older Women - 0 views

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    post menopausal estradiol in women associated with pro-inflammatory state.  SHBG was associated with a decrease in the inflammatory cytokine biomarkers.  Postmenopausal women were found to have an increased Testosterone to estradiol ratio.
Nathan Goodyear

Leg vascular and skeletal muscle mitochondrial adaptations to aerobic high-intensity ex... - 0 views

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    The early post menopause phase is critical for women. This is the phase that requires intensify strategy for exercise. The ER alpha signaling is actually increased and the ability to build muscle is intensified if exercise, particularly resistance training, is employed.
Nathan Goodyear

Efficacy and safety of testosterone in the managem... [J Sex Med. 2012] - PubMed - NCBI - 0 views

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    review of the literature finds that Testosterone therapy in women with low libido improves sexual activity without CVD and breast cancer risk in postmenopausal women.  Post menopause is a time associated with an increased risk of CVD in women.
Nathan Goodyear

Circulating 2-hydroxy and 16-α hydroxy estrone levels and risk of breast canc... - 1 views

  • 2-OH estrogens bind to the estrogen receptor (ER) with affinity equivalent to or greater than estradiol
  • previous prospective studies have not observed any significant associations with either 2-OH or 16α-OH estrone or the ratio of the two metabolites and breast cancer risk overall.
    • Nathan Goodyear
       
      whether that risk is increased or decreased
  • it has been hypothesized that metabolism favoring the 2-OH over the 16α-OH pathway may be inversely associated with breast cancer risk (28).
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  • they may act as only weak mitogens (14, 15), or as inhibitors of proliferation
  • No significant associations have been observed between 2-OH estrone and breast cancer risk
  • While 16α-OH estrone binds to the ER with lower affinity than estradiol, it binds covalently (18-20) and once bound, fails to down-regulate the receptor (21). Thus, 16α-OH estrone stimulates cell proliferation in a manner comparable to estradiol in ER+ breast cancer cell lines
  • In this large prospective study of 2-OH and 16α-OH estrone metabolites and breast cancer risk, we did not observe any significant associations overall with either individual metabolite or with the ratio of the two metabolites
  • we observed positive associations with 2-OH estrone and the 2:16α-OH estrone ratio among women with lower BMI and women with ER-/PR-tumors,
  • To date, several epidemiologic studies have examined the association between the 2-OH and 16α-OH estrogen metabolites and breast cancer risk with inconclusive results.
  • circulating estrogen levels have been associated more strongly with ER+/PR+ tumors than with ER-/PR- tumors
  • our results do not support the hypothesis that metabolism favoring the 2-OH estrone pathway is more beneficial to breast cancer risk than that favoring the 16α-OH estrone pathway
  • we observed significant positive associations of both 2-OH estrone and the 2:16α-OH estrone ratio with ER-/PR-tumors
  • Three (30, 32, 33) of four (30-33) studies observed RRs above 1 for the association between 16α-OH estrone and breast cancer risk (range of RRs=1.23-2.47); none of the point estimates was statistically significant though one trend was suggestive
  • based on animal studies, 2-OH estrone and the 2:16α-OH estrone ratio have been hypothesized to be inversely associated with breast cancer risk
  • No significant associations have been observed between 2-OH estrone, 16α-OH estrone, or the 2:16α-OH estrone ratio and breast cancer risk and the direction of the estimates is not consistent across studies.
    • Nathan Goodyear
       
      better worded is no consistent, significant associations.   There are some studies that point to the 16 catecholestrogen and increased cancer risk; limited studies show negative effects of 2 catecholestrogens on cancer risk and prospective studies available pretty much dispel the idea that the 2:16 ratio has an risk predictability.
  • we observed a suggestive inverse association with 16α-OH estrone and a significant positive association with the 2:16α-OH estrone ratio among lean women, suggesting possible associations in a low estrogen environment.
  • 16α-OH estrone increases unscheduled DNA synthesis in mouse mammary cells (27) and hence also may be genotoxic
  • Although 2-OH estrogens are capable of redox cycling, the semiquinones and quinones (i.e., the oxidized forms) form stable DNA adducts that are reversible without DNA destruction
  • In our population of PMH nonusers, we observed no associations with ER+/PR+ tumors, but significant positive associations with 2-OH estrone and the 2:16α-OH estrone ratio among women with ER-/PR- tumors
    • Nathan Goodyear
       
      one of the few studies to find this association between 2 catecholestrogens and the 2:16 ratio and ER-/PR-tumors
  • Animal and in vitro studies have shown that hydroxy estrogens can induce DNA damage either directly, through the formation of quinones and DNA adducts, or indirectly, through redox cycling and the generation of reactive oxygen species
    • Nathan Goodyear
       
      genotoxic via directe DNA adducts and indirectly via ROS; this is in addition to the proliferative effect
  • we observed a significant positive association between the 2:16α-OH estrone ratio and breast cancer risk among lean women
  • No significant associations have been observed with the 2:16α-OH estrone ratio
  • In the Danish study, no associations were observed with either ER+ or ER- tumors among PMH nonusers
  • significant positive associations with 2-OH estrone and the 2:16α-OH estrone ratio were observed among PMH users with ER+, but not ER-, tumors
  • it is possible that the genotoxicity of 2-OH estrone plays a role in hormone receptor negative tumors
  • 4-OH estrogens have a greater estrogenic potential than 2-OH estrogens, given the lower dissociation rate from estrogen receptors compared with estradiol (61), and are potentially more genotoxic since the quinones form unstable adducts, leading to depurination and mutation in vitro and in vivo
  • the balance between the catechol (i.e., 2-OH and 4-OH) and methoxy (i.e., 2-Me and 4-Me) estrogens may impact risk
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    The risks of estrogen metabolism are not clear cut.  Likely never will be due to the complexity of individual metabolism.  This study found no correlation between 2OH-Estrone and 2OH:16alpha-Estrone and breast cancer risk in ER+/PR+ breast cancer.  Translated: no benefit in breast cancer risk in 2OH-Estrone metabolism or increased 2OH:16alpha estrone metabolism.  There was a positive association between 2OH-Estrone and 2:16alpha-Estrone in women with ER-/PR- tumors and low BMI.
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Nathan Goodyear

The Journal of Nutritional Biochemistry - Record - 0 views

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    study shows that smoking cessation, physical inactivity, menopause, hysterectomy and energy intake associated with the perimenopause weight gain.  What is interesting about it is the energy imbalance is small that results in a big weight gain over time.  We need to look closely and be more frank with out clients about the risk that a hysterectomy poses for her health post surgery.
Nathan Goodyear

Program Planner | Presentation - 0 views

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    Just an abstract from the Presentation at the 2014 Scientific Session. The abstract points to a 40% reduction in CAD with the onset of BHRT (Estradiol and progesterone topical) within 6 years of menopause compared to women 10 years post-menopause.  This points to timing as a critical component of BHRT in women and CAD.
Nathan Goodyear

Relationship between endogenous testosterone and cardiovascular risk in early postmenop... - 0 views

  • Body mass index and waist circumference were significantly higher in the group with testosterone levels
  • Median CRP levels were greater in the group with higher testosterone level
  • ET-1 levels were also higher in women with greater testosterone levels
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  • An association of testosterone with CRP (r = 0.416, P = .004) and ET-1 (r = 0.323, P = .031) was observed
  • Testosterone was also associated with waist circumference and blood pressure (P = .001)
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    testosterone associated with elevated CRP, increase BMI, and increased waist circumference in early, post-menopausal women.
Nathan Goodyear

Access : Testosterone, SHBG and cardiovascular health in postmenopausal women : Interna... - 0 views

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    Review finds that low SHBG and higher Testosterone levels are associated with increased CVD risk in post menopausal women.  Exact relationship is undetermined.
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