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Nathan Goodyear

Oxidative Stress and Its Relationship With Adenosine Deaminase Activity in Various Stag... - 0 views

www.ncbi.nlm.nih.gov/...PMC3547448

Adenosine Deaminase ADA cancer breast cancer superoxide disumutase glutathione peroxidase oxidative stress inflammation

shared by Nathan Goodyear on 10 Nov 14 - No Cached
  • Reduced SOD activity might be responsible for excessive accumulation of superoxide anions leading to increased free radical mediated injury. Increased free radical production has been shown to be responsible for chromosomal damage leading to mutagenecity, cell proliferation and carcinogenesis. SOD activity showed marked improvement after mastectomy indicating the lowering of oxidative stress.
  • The increased production of reactive oxygen species causes oxidative stress leading to cell proliferation and hence increased inflammatory conditions
  • Superoxide dismutase is an important antioxidant enzyme which decomposes the harmful superoxide anions into hydrogen peroxide thus protects the body from the action of free radicals
  • ...20 more annotations...
  • Females suffering from breast cancer had significantly decreased Superoxide dismutase (SOD) and reduced glutathione (GSH) levels in comparison to normal females
  • ADA seems to be a promising marker of inflammation in breast cancer thereby suggesting that it can be used as a diagnostic tool to detect the stage of breast cancer along with cytopathological studies
  • In conclusion, our study confirmed the role of oxidative stress in the pathogenesis of breast cancer.
  • Another potent antioxidant molecule is reduced glutathione. It acts as reductant which converts hydrogen peroxide into water and reduces lipid peroxidation products into their corresponding alcohols and thus mediates protective action.
  • In the present study, significantly low SOD activity has been observed in female patients suffering from carcinoma breast both pre as well as post operative in comparison to healthy females.
  • The compromised antioxidant defence system produces the oxidative stress which in turn creates the inflammatory response shown by concomitant increased adenosine deaminase (ADA) activity in female patients.
  • Increased ADA activity in breast cancer patients has also been reported
  • We observed significantly decreased SOD activity and GSH levels in patients belonging to clinical stage 4 as compared to those having stages 1, 2 or 3 of breast cancer.
  • increased oxidative stress gives rise to inflammation which could further aggravates the disease
  • Antioxidant status was highly depressed in advanced stages of breast cancer as compared to initial stage.
  • In the present study, significantly low GSH levels were observed in female patients of carcinoma breast as compared to normal females
  • Walia et al. (1995) reported increased ADA activity in breast cancer patients as compared to age matched normal subjects.
  • These free radicals are able to cause damage to membrane, mitochondria and macromolecules including proteins, lipids and DNA and actively take part in cell proliferation. This cascade in turn generates the inflammatory response and causes the progression of the disease.
  • Experimental and epidemiological evidences implicate the involvement of oxygen derived free radical in the pathogenesis of breast cancer.
  • Breast carcinoma involves a cascade of events that are highly inflammatory.
  • Marked oxidative stress in stage 4 of breast cancer indicated advancement of the disease, hence checking oxidative stress at initial stage could be helpful for controlling the progression of the disease.
  • They concluded that ADA is a better probable parameter for detection of breast cancer
  • Adenosine deaminase enzyme (ADA) catalyzes the conversion of adenosine to inosine which finally gets converted to uric acid
  • serum ADA activity tends to increase with advancing age,
  • Prevalence of oxidative stress gives rise to inflammation.
  • Nathan Goodyear on 10 Nov 14
     
    Study finds a reduction in SuperOxide Dismutase and Glutathione Perioxidase in advancing breast cancer.  Cancer is a high oxidative stress disease that results in inflammation, mitochondrial dysfunction and proliferation.  Adenosine Deaminase (ADA) is proposed to be another biomarker to assess tumor stage.  
Nathan Goodyear

Scopus preview - Scopus - Document details - 0 views

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mercury Hg superoxide disumutase NAC N-acetylcysteine

shared by Nathan Goodyear on 10 Oct 13 - No Cached
  • Nathan Goodyear on 10 Oct 13
     
    Mercury decreases levels of superoxide dismutase in the lungs of rats exposed.  This study found NAC found to be protective.
Nathan Goodyear

Activity of glutathione peroxi... [Int Arch Occup Environ Health. 1998] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...9827878

mercury Hg glutathione peroxidase superoxide disumutase

shared by Nathan Goodyear on 10 Oct 13 - No Cached
  • Nathan Goodyear on 10 Oct 13
     
    decreased activity of glutathione peroxidase and superoxide dismutase due to mercury exposure.
Nathan Goodyear

Internet Scientific Publications - 0 views

ispub.com/8186

malondialdehyde glutathione GSH superoxide disumutase SOD saliva uric acid MDA stroke disease testing

shared by Nathan Goodyear on 21 Oct 14 - No Cached
  • Nathan Goodyear on 21 Oct 14
     
    Study of Iraqi population at elevated risk of stroke found that both serum and salivary levels of malondialdehyde, glutathione, superoxide dismutase, and uric acid proved useful as potential biomarkers of risk assessment.
Nathan Goodyear

Malondialdehyde, Bcl-2, superoxide dismutase a... [Neurochem Res. 2012] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...22143957

SOD superoxide disumutase glutathione peroxidase oxidative stress autism ASD autism spectrum disorder

shared by Nathan Goodyear on 07 Oct 13 - No Cached
  • Nathan Goodyear on 07 Oct 13
     
    decreased detoxification and increased oxidative stress in autism.
Nathan Goodyear

Susceptibility of mitochondrial superoxide dismut... [Toxicology. 2009] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...19010380

SOD superoxide disumutase aluminum AL oxidative damage

shared by Nathan Goodyear on 09 Oct 13 - No Cached
  • Nathan Goodyear on 09 Oct 13
     
    Aluminum induces oxidative damage through a reduction in SOD.
Nathan Goodyear

Mercury intolerance in relation to superoxide di... [Environ Res. 2000] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...10856185

mercury Hg SOD superoxide disumutase

shared by Nathan Goodyear on 10 Oct 13 - No Cached
  • Nathan Goodyear on 10 Oct 13
     
    mercury causes SOD dysfunction.
Nathan Goodyear

Lead-induced dysregulation of superoxide dismuta... [Environ Res. 2005] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...15721881

Pb lead SOD CAT GPX detoxification superoxide disumutase catalase glutathione glutathione peroxidase

shared by Nathan Goodyear on 16 Sep 14 - No Cached
  • Nathan Goodyear on 16 Sep 14
     
    Pb induces dysfunction of SOD, CAT, and GPX.
Nathan Goodyear

Implications of free radicals and antioxidant levels in carcinoma of the breast: A neve... - 0 views

www.indianjcancer.com/article.asp

SOD superoxide disumutase catalase antioxidants antioxidant breast cancer cancer malondialdehyde MDA lipid peroxides oxidative stress inflammation

shared by Nathan Goodyear on 10 Nov 14 - No Cached
  • Experimental investigations as well as clinical and epidemiological findings have provided evidence supporting the role of reactive oxygen metabolites or free radicals such as singlet oxygen O 2 - , superoxide anions (O 2 ), hydrogen peroxide (H­2 O2 ) and hydroxyl radical in the etiology of cancer.
  • Certain aldehydes such as Malonyldialdehyde (MDA), the end product of lipid peroxidation arising from free radical degeneration of polyunsaturated fatty acids can cause cross linking in lipids, proteins and nucleic acids leading to cellular damage.
  • In this study, patients with cancer exhibited higher levels of MDA, both in tissues and serum (p<0.001) compared to the control group [Table 1]. In tissue, the MDA level in stage IV was significantly higher as compared to stage I indicating increased free radical activity with increasing severity of cancer
  • ...6 more annotations...
  • From these observations, it can be concluded that MDA levels play an important role in assessing the outcome of cancer
  • SOD and CAT are considered primary antioxidant enzymes, since they are involved in direct elimination of reactive oxygen metabolites. [13-16] They also act as anti-carcinogens and inhibitors at initiation and promotion/transformation stage in carcinogenesis
  • In our study, SOD and CAT levels were found to be low in all cancer patients as compared to controls
  • Fridovich and Tayarani have demonstrated in their respective studies that the reduction in SOD activity increases the toxic effects of O2 - and this might lead to severe cellular damage.
  • Mehrotra et al. in their study also observed high levels of MDA and low levels of SOD and CAT in patients of cancer cervix which is in sync with our observations.
  • strong evidence regarding the definitive role of free radicals in breast malignancy.
  • Nathan Goodyear on 10 Nov 14
     
    This study finds a strong correlation between advancing breast cancer, decreased catalase and SOD with increasing MDA.  The authors of this study conclude this is a key factor in carcinogenesis and not a by-product of cancer.  This flies in the face of traditional medicines fear of antioxidant therapy in cancer.
Nathan Goodyear

Glutathione Peroxidase (GPx) and Superoxide Dismutase (SOD) in Oropharyngeal Cancer Ass... - 0 views

www.ncbi.nlm.nih.gov/...PMC7551554

glutathione peroxidase SOD superoxide disumutase cancer glutathione

shared by Nathan Goodyear on 07 Jun 23 - No Cached
  • Nathan Goodyear on 07 Jun 23
     
    Hmmm…."Both GPx and SOD activity was statistically lower in patients with EBV/HPV coinfection than in a single EBV or HPV infection. Analysis of GPx and SOD activity in relation to histological grading and tumor, node (TN) classification revealed that in poorly-differentiated tumors, the level of antioxidant enzymes was lower compared with well-differentiated lesions and in cases with greater tumor dimensions and lymph-node involvement, both GPx and SOD activity was decreased."
Nathan Goodyear

Activity of superoxide dismutase, catalase, glutathione peroxidase, and glutathione red... - 0 views

pubmed.ncbi.nlm.nih.gov/23625289

glutathione glutathione reductase SOD catalase gl cancer superoxide disumutase

shared by Nathan Goodyear on 07 Jun 23 - No Cached
  • Nathan Goodyear on 07 Jun 23
     
    "Glutathione reductase activity is lower in all colorectal carcinoma groups than in control, and a significant decrease in glutathione reductase activity was obtained between patients in tumor stage II and III compared to tumor stage IV." Same is see with SOD in study.
Nathan Goodyear

Severe oxidative damage in multiple sclerosis lesions coincides with enhanced antioxida... - 0 views

www.sciencedirect.com/...S0891584908005455

blood-brain barrier MS multiple sclerosis ROS reactive oxygen species antioxidants antioxidant SOD superoxide disumutase catalase

shared by Nathan Goodyear on 19 Mar 14 - No Cached
  • Nathan Goodyear on 19 Mar 14
     
    This article proposes that increased antioxidant enzymatic activity is an adaption to the increased ROS found in MS.  This increased ROS disrupts the blood-brain barrier.
Nathan Goodyear

Decreased Serum Cu/Zn SOD Associated with High Copper in Children with Attention Defici... - 0 views

www.ncbi.nlm.nih.gov/...PMC3661234

superoxide disumutase SOD ADD ADHD attention deficit disorder copper

shared by Nathan Goodyear on 07 Oct 13 - No Cached
  • Nathan Goodyear on 07 Oct 13
     
    low SOD found to be associated with ADD/ADHD
Nathan Goodyear

Oxidative imbalance in adult attention deficit/... [Biol Psychol. 2008] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...18644422

SOD superoxide disumutase ADD ADHD attention deficit disorder

shared by Nathan Goodyear on 07 Oct 13 - No Cached
  • Nathan Goodyear on 07 Oct 13
     
    low SOD associated with ADD/ADHD
Nathan Goodyear

Biomarkers of Adverse Response to Mercury: Histopathology versus Thioredoxin Reductase ... - 0 views

www.hindawi.com/...359879

mercury Hg detoxification catalase superoxide disumutase glutathione peroxidase glutathione selenium

shared by Nathan Goodyear on 10 Oct 13 - No Cached
  • Nathan Goodyear on 10 Oct 13
     
    Mercury and changes in detoxification biomarkers.
Nathan Goodyear

Positive effects of astaxanthin on lipid profiles and oxidative stress in overweight su... - 0 views

www.ncbi.nlm.nih.gov/...21964877

astaxanthin MDA malondialdehyde oxidative stress SOD superoxide disumutase oxidized LDL LDL LDL cholesterol CVD

shared by Nathan Goodyear on 14 Jul 15 - No Cached
  • Nathan Goodyear on 14 Jul 15
     
    Astaxanthin at 20 mg found to reduce oxidized LDL and other oxidative stress biomarkers as assessed by Malondialdehydy, SOD, Isoprostane, and TAC.  The dose was 20 mg for 12 weeks. This higher dose was associated with minimal side effects--red stools.
Nathan Goodyear

Effects of astaxanthin on oxidative stress in overweight and obese adults. - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...21480416

oxidative stress astaxanthin malondialdehyde superoxide disumutase isoprostane

shared by Nathan Goodyear on 14 Jul 15 - No Cached
  • Nathan Goodyear on 14 Jul 15
     
    short study found that astaxanthin at 5 and 20 mg was associated with a reduction in oxidative stress biomarkers.
Nathan Goodyear

Cancer-preventing attributes of probioti... [Int J Food Sci Nutr. 2010] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...20187714

protbiotics cancer SOD superoxide disumutase catalase glutathione peroxidase glutathione-S-transferase

shared by Nathan Goodyear on 05 Aug 14 - No Cached
  • Nathan Goodyear on 05 Aug 14
     
    The evidence of probiotics in cancer is limited.  The limited evidence points to an increase in anti-oxidative enzymes i.e. glutathion-S-transferase, glutathione perioxidase, catalase, SOD.
Nathan Goodyear

http://www.iasj.net/iasj?func=fulltext&aId=1538 - 0 views

www.iasj.net/iasj

oxidative stress glutathione GSH malondialdehyde testing superoxide disumutase SOD saliva uric acid

shared by Nathan Goodyear on 21 Oct 14 - No Cached
  • Nathan Goodyear on 21 Oct 14
     
    serum and salivary oxidative stress biomarkers used to follow children with autism in Iraq.
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