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Nathan Goodyear

Is docosahexaenoic acid, an n-3 long-chain polyunsaturated fatty acid, required for development of normal brain function? An overview of evidence from cognitive and behavioral tests in humans and animals - 0 views

www.ajcn.org/...281.abstract

long-chain fatty acid brain development function behavioral DHA Omega-3

shared by Nathan Goodyear on 06 Sep 11 - No Cached
  • Nathan Goodyear on 06 Sep 11
     
    changes in brain concentrations of DHA (omega-3) are positively associated with changes in cognitive or behavioral performance
Nathan Goodyear

Normal gut microbiota modulates brain development and behavior - 0 views

www.pnas.org/...3047.abstract

gut brain development behavior balance gastrointestinal dysbiosis

shared by Nathan Goodyear on 29 Jun 11 - No Cached
  • Nathan Goodyear on 29 Jun 11
     
    mice model study that shows how gut bacterial balance can alter neurochemistry and cause behavior/developmental changes
finchloe121

How To Diagnose And Defeat Insomnia In An Easy Manner! - 0 views

www.pharmahealthonline.com/...eat-insomnia-in-an-easy-manner

Health Pharmacy Medicine

shared by finchloe121 on 24 Sep 22 - No Cached
  • finchloe121 on 24 Sep 22
     
    Insomnia is a condition that prevents a person from getting peaceful and sound sleep for hours. It is a symptom that occurs due to various symptoms and causes. This sleep disorder affects people in different ways. If you suffer from insomnia, you may not be able to fall asleep or stay asleep. Cognitive behavioral therapy or CBT is a type of psychotherapy used to treat insomnia, anxiety disorders, depression, eating disorders, marital disorders, and quality of life. Cognitive-behavioral therapy focuses on changing individuals' negative thoughts because thoughts can primarily contribute to the construction of anxiety, depression, and emotional difficulties. Many people typically need at least 3-4 hours of sleep a night, but the average sleep time is 6-9 hours. This means that sleep duration and sleep cycles vary from person to person. The most important thing is to get enough sleep, no matter how long it takes. The best remedy to treat the symptoms of this disorder is to use OTC Zolpidem 5mg Tablets Online.
Nathan Goodyear

Neuropsychopharmacology - Oxytocin Infusion Reduces Repetitive Behaviors in Adults with Autistic and Asperger's Disorders - 0 views

www.nature.com/...1300021a.html

autism autism spectrum disorder ASD oxytocin

shared by Nathan Goodyear on 14 Aug 13 - No Cached
  • Nathan Goodyear on 14 Aug 13
     
    oxytocin improves repetitive behavior in autism
Nathan Goodyear

Neuropeptidergic regulation of affiliative behavior and social bonding in animals - 0 views

www.sciencedirect.com/...S0018506X06001802

autism ASD autism spectrum disorder oxytocin vasopressin

shared by Nathan Goodyear on 14 Aug 13 - No Cached
  • Nathan Goodyear on 14 Aug 13
     
    The dogma on oxytocin and vasopressin, both posterior pituitary hormones, is being challenged by the literature.  Both hormones are proposed to be involved in improving social behavior in those with autism and other psychiatric disorders.
Nathan Goodyear

Promoting social behavior with oxytocin in high-functioning autism spectrum disorders - 0 views

www.pnas.org/...4389.full

oxytocin ASD autism autism spectrum disorder

shared by Nathan Goodyear on 14 Aug 13 - No Cached
  • Nathan Goodyear on 14 Aug 13
     
    Small study, but intranasal oxytocin was used to improve social behavior in high functioning ASD.
Nathan Goodyear

Evaluation, Diagnosis, and Treatment of Gastrointestinal Disorders in Individuals With ASDs: A Consensus Report - 0 views

pediatrics.aappublications.org/...S1.full

ASDs autism gastrointestinal disorder ASD

shared by Nathan Goodyear on 28 Jun 11 - No Cached
  • The consensus expert opinion of the panel was that individuals with ASDs deserve the same thoroughness and standard of care in the diagnostic workup and treatment of gastrointestinal concerns as should occur for patients without ASDs. Care providers should be aware that problem behavior in patients with ASDs may be the primary or sole symptom of the underlying medical condition, including some gastrointestinal disorders
  • Nathan Goodyear on 28 Jun 11
     
    ASD behavior problems may have underlying gastrointestinal disorders as the cause
Nathan Goodyear

Low-dose penicillin in early life induces long-term changes in murine gut microbiota, brain cytokines and behavior | Nature Communications - 0 views

www.nature.com/...ncomms15062

brain brain health probiotics antibiotics gut-brain gut bacteria gut flora gut health gut microbiome gut microbiota gut

shared by Nathan Goodyear on 26 Oct 17 - No Cached
  • Nathan Goodyear on 26 Oct 17
     
    Gut bacteria brain connection: animal study finds antibiotics early in life alter gut flora which effects young brain and alters behavior; probiotics with Lactobacillus rhamnosus JB-1 appears to blunt the altered Gut bacteria brain connection.
Nathan Goodyear

The risks of selective serotonin reuptake inhibitor use in infertile women: a review of the impact on fertility, pregnancy, neonatal health and beyond - 0 views

humrep.oxfordjournals.org/...humrep.des383.short

SSRI serotonin reuptake inhibitor anti-depressants pregnancy health fertility

shared by Nathan Goodyear on 02 Nov 12 - No Cached
  • Nathan Goodyear on 02 Nov 12
     
    There is just no reason to take SSRIs during pregnancy.  SSRIs increase risk of miscarriage, birth defects, preterm birth, newborn behavior problems, pulmonary hypertension...All women considering pregnancy should removed, yet SSRIs are prescribed as if they are candy.
Nathan Goodyear

Salivary testosterone diurnal variation and psychopathology in adolescent males and females: individual differences and developmental effects. | ResearchGate - 0 views

www.researchgate.net/...nces_and_developmental_effects

saliva salivary testosterone hormones hormone

shared by Nathan Goodyear on 30 Oct 12 - No Cached
  • Nathan Goodyear on 30 Oct 12
     
    low testosterone in boys associated with anxiety/depression and attention problems.  Disruptive behavior found in girls with low testosterone.  All determined by salivary testing.
Nathan Goodyear

Access : The neurobiology of appetite: hunger as addiction : International Journal of Obesity - 0 views

www.nature.com/...ijo200969a.html

overweight obesity over-eating hunger addiction

shared by Nathan Goodyear on 19 Mar 12 - No Cached
  • Nathan Goodyear on 19 Mar 12
     
    complex interplay between behavior, genetics, and CNS play role in over-eating.  Add in environment as well.
Nathan Goodyear

Exogenous testosterone, aggression, and mood i... [Physiol Behav. 2002] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...12062320

testosterone therapy treatment low T low testosterone mood brain men male hormone hormones aggression

shared by Nathan Goodyear on 06 Jul 12 - No Cached
  • Nathan Goodyear on 06 Jul 12
     
    study finds that supra physiological replacement of testosterone is not associated with aggressive behavior.
Nathan Goodyear

Validation of a cortisol enzyme immunoassay and characterization of salivary cortisol circadian rhythm in chimpanzees (Pan troglodytes) - Heintz - 2011 - American Journal of Primatology - Wiley Online Library - 0 views

onlinelibrary.wiley.com/...full

saliva testing salivary hormone BHRT evaluation cortisol adrenal circadian rhythm

shared by Nathan Goodyear on 26 Nov 11 - No Cached
  • Nathan Goodyear on 26 Nov 11
     
    granted, this comes from the American Journal of Primatology; but their conclusion says it all: "we recommend that saliva collection may be the moste effective method of measuring stress reactivity and as the potential to complement behavioral, cognitive, physiologic, and welfare studies".
Nathan Goodyear

A Randomized Controlled Pilot Trial of Oral N-Acetylcysteine in Children with Autism - 0 views

www.biologicalpsychiatryjournal.com/...fulltext

autism ASD glutathione NAC N-acetylcysteine children

shared by Nathan Goodyear on 04 Mar 14 - No Cached
  • Nathan Goodyear on 04 Mar 14
     
    900 mg of NAC over short 4 week course provided significant improvement in behavior of children with autism.  No pre treatment evaluation was performed.  One wonders if therapeutic therapy was actually undertaken if the results would have been better.  NAC is a precursor to Glutathione production and detoxification compromise is common place in autism.
Nathan Goodyear

Prosocial effects of oxytocin in two mouse models of autism spectrum disorders - 0 views

www.sciencedirect.com/...S0028390813001846

autism autism spectrum disorder ASD oxytocin

shared by Nathan Goodyear on 14 Aug 13 - No Cached
  • Nathan Goodyear on 14 Aug 13
     
    Mouse model of autism, but oxytocin found to improve social interactions and repetitive behaviors.  
Nathan Goodyear

Oxytocin Increases Retention of Social Cognition in Autism - 0 views

www.biologicalpsychiatryjournal.com/...abstract

autism autism spectrum disorder ASD oxytocin

shared by Nathan Goodyear on 14 Aug 13 - No Cached
  • Nathan Goodyear on 14 Aug 13
     
    This could be a repeat post, but oxytocin shown to improve social behavior, especially recognition.
Nathan Goodyear

Efficacy of tablet huperzine-A on me... [Zhongguo Yao Li Xue Bao. 1995] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...8701750

Huperzine A Huperzine-A alzheimer's disease Alzheimer's disease memory cognition brain

shared by Nathan Goodyear on 06 Nov 13 - No Cached
  • Nathan Goodyear on 06 Nov 13
     
    8 week study finds Huperzine A improved memory, cognition, and behavior in those with Alzheimer's disease at 400 mcg.
Nathan Goodyear

[Clinical efficacy and safety of hupe... [Zhonghua Yi Xue Za Zhi. 2002] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...12181083

Huperzine A Huperzine-A cognition Alzheimer's disease

shared by Nathan Goodyear on 06 Nov 13 - No Cached
  • Nathan Goodyear on 06 Nov 13
     
    Huperzine A improved cognition and behavior in Alzheimer's disease
Nathan Goodyear

The Intestinal Microbiota Affect Central Levels of Brain-Derived Neurotropic Factor and Behavior in Mice - 0 views

www.gastrojournal.org/...abstract

behavior Gut intestinal microbiota anxiety mood depression

shared by Nathan Goodyear on 25 May 11 - No Cached
  • Nathan Goodyear on 25 May 11
     
    Gut and Brain linked together
Nathan Goodyear

Stuck at the bench: Potential natural neuroprotective compounds for concussion - 0 views

www.ncbi.nlm.nih.gov/...PMC3205506

concussions concussion natural therapies brain curcumin omega 3 resveratrol green tea EGCG EPA DHA vitamin E vitamin c vitamin D

shared by Nathan Goodyear on 20 Feb 16 - No Cached
  • Long-chain polyunsaturated fatty acids, including eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), are highly enriched in neuronal synaptosomal plasma membranes and vesicles
  • The predominant CNS polyunsaturated fatty acid is DHA
  • effective supplementation and/or increased ingestion of dietary sources rich in EPA and DHA, such as cold-water fish species and fish oil, may help improve a multitude of neuronal functions, including long-term potentiation and cognition.
  • ...45 more annotations...
  • multiple preclinical studies have suggested that DHA and/or EPA supplementation may have potential benefit through a multitude of diverse, but complementary mechanisms
  • pre-injury dietary supplementation with fish oil effectively reduces post-traumatic elevations in protein oxidation
  • The benefits of pre-traumatic DHA supplementation have not only been independently confirmed,[150] but DHA supplementation has been shown to significantly reduce the number of swollen, disconnected and injured axons when administered following traumatic brain injury.
  • DHA has provided neuroprotection in experimental models of both focal and diffuse traumatic brain injury
  • potential mechanisms of neuroprotection, in addition to DHA and EPA's well-established anti-oxidant and anti-inflammatory properties
  • Despite abundant laboratory evidence supporting its neuroprotective effects in experimental models, the role of dietary DHA and/or EPA supplementation in human neurological diseases remains uncertain
  • Several population-based, observational studies have suggested that increased dietary fish and/or omega-3 polyunsaturated fatty acid consumption may reduce risk for ischemic stroke in several populations
  • Randomized control trials have also demonstrated significant reductions in ischemic stroke recurrence,[217] relative risk for ischemic stroke,[2] and reduced incidence of both symptomatic vasospasm and mortality following subarachnoid hemorrhage
  • Clinical trials in Alzheimer's disease have also been largely ineffective
  • The clinical evidence thus far appears equivocal
  • curcumin has gained much attention from Western researchers for its potential therapeutic benefits in large part due to its potent anti-oxidant[128,194,236] and anti-inflammatory properties
  • Curcumin is highly lipophilic and crosses the blood-brain barrier enabling it to exert a multitude of different established neuroprotective effects
  • in the context of TBI, a series of preclinical studies have suggested that pre-traumatic and post-traumatic curcumin supplementation may bolster the brain's resilience to injury and serve as a valuable therapeutic option
  • Curcumin may confer significant neuroprotection because of its ability to act on multiple deleterious post-traumatic, molecular cascades
  • studies demonstrated that both pre- and post-traumatic curcumin administration resulted in a significant reduction of neuroinflammation via inhibition of the pro-inflammatory molecules interleukin 1β and nuclear factor kappa B (NFκB)
  • no human studies have been conducted with respect to the effects of curcumin administration on the treatment of TBI, subarachnoid or intracranial hemorrhage, epilepsy or stroke
  • studies have demonstrated that resveratrol treatment reduces brain edema and lesion volume, as well as improves neurobehavioral functional performance following TBI
  • green tea consumption or supplementation with its derivatives may bolster cognitive function acutely and may slow cognitive decline
  • At least one population based study, though, did demonstrate that increased green tea consumption was associated with a reduced risk for Parkinson's disease independent of total caffeine intake
  • a randomized, placebo-controlled trial demonstrated that administration of green tea extract and L-theanine, over 16 weeks of treatment, improved indices of memory and brain theta wave activity on electroencephalography, suggesting greater cognitive alertness
  • Other animal studies have also demonstrated that theanine, another important component of green tea extract, exerts a multitude of neuroprotective benefits in experimental models of ischemic stroke,[63,97] Alzheimer's disease,[109] and Parkinson's disease
  • Theanine, like EGCG, contains multiple mechanisms of neuroprotective action including protection from excitotoxic injury[97] and inhibition of inflammation
  • potent anti-oxidant EGCG which is capable of crossing the blood-nerve and blood-brain barrier,
  • Epigallocatechin-3-gallate also displays neuroprotective properties
  • More recent research has suggested that vitamin D supplementation and the prevention of vitamin D deficiency may serve valuable roles in the treatment of TBI and may represents an important and necessary neuroprotective adjuvant for post-TBI progesterone therapy
  • Progesterone is one of the few agents to demonstrate significant reductions in mortality following TBI in human patients in preliminary trials
  • in vitro and in vivo studies have suggested that vitamin D supplementation with progesterone administration may significantly enhance neuroprotection
  • Vitamin D deficiency may increase inflammatory damage and behavioral impairment following experimental injury and attenuate the protective effects of post-traumatic progesterone treatment.[37]
  • emerging evidence has suggested that daily intravenous administration of vitamin E following TBI significantly decreases mortality and improves patient outcomes
  • high dose vitamin C administration following injury stabilized or reduced peri-lesional edema and infarction in the majority of patients receiving post-injury treatment
  • it has been speculated that combined vitamin C and E therapy may potentiate CNS anti-oxidation and act synergistically with regards to neuroprotection
  • one prospective human study has found that combined intake of vitamin C and E displays significant treatment interaction and reduces the risk of stroke
  • Pycnogenol has demonstrated the ability to slow or reduce the pathological processes associated with Alzheimer's disease
  • Pcynogenol administration, in a clinical study of elderly patients, led to improved cognition and reductions in markers of lipid peroxidase
  • One other point of consideration is that in neurodegenerative disease states like Alzheimer's disease and Parkinson's disease, where there are high levels of reactive oxygen species generation, vitamin E can tend to become oxidized itself. For maximal effectiveness and to maintain its anti-oxidant capacity, vitamin E must be given in conjunction with other anti-oxidants like vitamin C or flavonoids
  • These various factors might account for the null effects of alpha-tocopherol supplementation in patients with MCI and Alzheimer's disease
  • preliminary results obtained in a pediatric population have suggested that post-traumatic oral creatine administration (0.4 g/kg) given within four hours of traumatic brain injury and then daily thereafter, may improve both acute and long-term outcomes
  • Acutely, post-traumatic creatine administration seemed to reduce duration of post-traumatic amnesia, length of time spent in the intensive care unit, and duration of intubation
  • At three and six months post-injury, subjects in the creatine treatment group demonstrated improvement on indices of self care, communication abilities, locomotion, sociability, personality or behavior and cognitive function when compared to untreated controls
  • patients in the creatine-treatment group were less likely to experience headaches, dizziness and fatigue over six months of follow-up
  • CNS creatine is derived from both its local biosynthesis from the essential amino acids methionine, glycine and arginine
  • Studies of patients with CNS creatine deficiency and/or murine models with genetic ablation of creatine kinase have consistently demonstrated significant neurological impairment in the absence of proper creatine, phosphocreatine, or creatine kinase function; thus highlighting its functional importance
  • chronic dosing may partially reverse neurological impairments in human CNS creatine deficiency syndromes
  • Several studies have suggested that creatine supplementation may also reduce oxidative DNA damage and brain glutamate levels in Huntington disease patients
  • Another study highlighted that creatine supplementation marginally improved indices of mood and reduced the need for increased dopaminergic therapy in patients with Parkinson's disease
  • Nathan Goodyear on 20 Feb 16
     
    great review of natural therapies in the treatment of concussions
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