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Data review finds NAC improves pregnancy rates and ovulation rates in women with PCOS against placebo.  Meta-analysis revealed limited studies on the topic.  When compared to metformin, there was no difference found.  Though, one wonders if attacking insulin resistance through proper diet and additional neutraceutical approach would negate that.  The reason?  NAC and metformin are working in different biochemical pathways.  The authors here seem to not realize this. It appears that they think NAC and metormin are both working in the same manner, but they don't.  The fact that there is still benefit found compared to placebo, despited the authors lack of understanding of what NAC is and does is a positive.

N-acetylcysteine, also known as NAC, a precursor to glutathione, is shown to significantly reduce the incidence of flu symptoms.  NAC should be taken through out the winter months as a flu prevention?  Well, this study does not support that, but if one gets the flu, NAC will significantly reduce the flu symptoms.

NAC shown to improve secondary measures of cognitive function in small study in those with Alzheimer's disease. NAC proves to be a reliable means to reduce free radical induced advanced glycation end productions and resultant inflammation. Also was shown to be well tolerated.

Good discussion of NAC and neurodegenerative diseases.

IV NAC therapy treatment for tylenol toxicity.  NAC is the precursor to glutathione

900 mg of NAC over short 4 week course provided significant improvement in behavior of children with autism.  No pre treatment evaluation was performed.  One wonders if therapeutic therapy was actually undertaken if the results would have been better.  NAC is a precursor to Glutathione production and detoxification compromise is common place in autism.

NAC reduced COPD exacerbation and hospitalization versus placebo.  The dosing and the duration of this study was low and short respectively. 

NAC lowers evidence of liver toxicity.

pilot study finds that NAC protects the dopaminergic neurons in the brains in cell line stud.  Clinical found increased dopamine binding in the brain compared to placebo in individuals with Parkinson's disease.

IV glutathione and NAC shown to reduce oxidative stress markers associated with septic shock

antioxidant support in early pregnancy, including NAC, shown to reduce the incidence in pre-eclampsia

use of NAC provides many health benefits above and beyond tylenol overdose.

IV vitamin C therapy shown to improved the response of blood pressure to acetylcholine and nitroprusside in those patients with essential hypertension.  This effect was not found in NAC.  Vitamin C acts as a superoxide scavenger and glutathione recycler.

A small pilot study, but the antioxidant NAC finds benefit in those with autism.

Mercury decreases levels of superoxide dismutase in the lungs of rats exposed.  This study found NAC found to be protective.

reduced glutathione, via increased oxidative stress, levels lost in HIV.  NAC and liposomal Glutathione increased innate immune function--macrophages.

Oral NAC useful for elevated liver enzymes in NAFLD

NAC benefits short-term survival in alcoholic hepatitis, including a drop in bilirubin.

NAC more beneficial in lowering Total bilirubin compared to glutathione in patients with chronic hepatitis B.

NAC for treatment of hepatocellular cancer.