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Nathan Goodyear

Evaluation, Diagnosis, and Treatment of Gastrointestinal Disorders in Individuals With ... - 0 views

pediatrics.aappublications.org/...S1.full

ASDs autism gastrointestinal disorder ASD

shared by Nathan Goodyear on 28 Jun 11 - No Cached
  • The consensus expert opinion of the panel was that individuals with ASDs deserve the same thoroughness and standard of care in the diagnostic workup and treatment of gastrointestinal concerns as should occur for patients without ASDs. Care providers should be aware that problem behavior in patients with ASDs may be the primary or sole symptom of the underlying medical condition, including some gastrointestinal disorders
  • Nathan Goodyear on 28 Jun 11
     
    ASD behavior problems may have underlying gastrointestinal disorders as the cause
Nathan Goodyear

Autistic enterocolitis: Fact or fiction? - 0 views

mercola.fileburst.com/...0ot%20Fiction%20Fed%202009.pdf

autism ASD inflammation gastrointestinal

shared by Nathan Goodyear on 29 Jan 12 - No Cached
  • Nathan Goodyear on 29 Jan 12
     
    report of 2 cases studies that find link between autism and gastrointestinal inflammation. Again, suggestion some immune system dysfunction in the gastrointestinal system in some children with autism
Nathan Goodyear

Dysregulated Innate Immune Responses in Young Children with Autism Spectrum Disorders: ... - 0 views

mercola.fileburst.com/...europsych%20--%20Jyonouchi.pdf

autism ASD LPS inflammation innate immune system gut gastrointestinal

shared by Nathan Goodyear on 29 Jan 12 - No Cached
  • Nathan Goodyear on 29 Jan 12
     
    Dysfunctions of the innate immune system, in the gastrointestinal system, in children with autism found. LPS found to be involved. Again, revealing a gut-brain connection in autism.
Nathan Goodyear

Celiac Disease Presenting as Autism - 0 views

mercola.fileburst.com/...celaic%20and%20autism.pdf

inflammation autism ASD gut gastrointestinal brain

shared by Nathan Goodyear on 30 Jan 12 - No Cached
  • Nathan Goodyear on 30 Jan 12
     
    This case study shows the link between gastrointestinal inflammation and the brain. This case is of a child diagnosed with autism that recovered once a gluten free diet was instituted.
Nathan Goodyear

Gastrointestinal abnormalities in children with autistic disorder - 0 views

mercola.fileburst.com/...4.Horvath%201.pdf

autism ASD

shared by Nathan Goodyear on 29 Jan 12 - No Cached
  • Nathan Goodyear on 29 Jan 12
     
    study shows that gastrointestinal dysfunction, reflux esophagitis and disaccharide malabsorption, found in children with autism. This confirms the gut-brain link component of autism
Nathan Goodyear

Colonic CD8 and gamma delta T-cell infiltration with epithelial damage in children with... - 0 views

www.ncbi.nlm.nih.gov/...11241044

ASD autism inflammation children Lymphoid nodular hyperplasia LNH regressive

shared by Nathan Goodyear on 30 Jan 12 - No Cached
  • Nathan Goodyear on 30 Jan 12
     
    Study shows that gastrointestinal epithelial dysfunction is found in autism. This would play a critical role in systemic inflammation and would contribute to ASD symptoms through the gut-brain connection.
Nathan Goodyear

Gastrointestinal Symptoms in a sample of children with Pervasive Developmental Disorders - 0 views

mercola.fileburst.com/...symptoms%20in%20PDD%20Yale.pdf

ASD autism PDD GI gastrointestinal symptoms inflammation anxiety children

shared by Nathan Goodyear on 30 Jan 12 - No Cached
  • Nathan Goodyear on 30 Jan 12
     
    This study didn't find major differences between children with/without GI symptoms in those with PDD. But some differences were identified: more anxiety, more listlessness, and more refractory to medical therapy in children with PDD and GI symptoms.
Nathan Goodyear

Therapy in the Early Stage: Incretins - 0 views

care.diabetesjournals.org/...S264.full

incretins glucose diabetes

shared by Nathan Goodyear on 11 Dec 13 - No Cached
  • Increased resistance to insulin action in the skeletal muscle and liver associated with enhanced hepatic glucose output and impaired insulin secretion due to a progressive decline of β-cell function are long-recognized core defects
  • in addition, other mechanisms/organs are involved, augmenting the pathological pathways: adipocytes (altered fat metabolism due to insulin resistance), gastrointestinal tract (incretin deficiency and/or resistance), pancreatic α-cells (hyperglucagonemia and increased hepatic sensitivity to glucagon), kidneys (enhanced glucose reabsorption), and central nervous system (insulin resistance)
  • β-cell failure
    • Nathan Goodyear
      Nathan Goodyear on 11 Dec 13
       
      and studies have shown that a reduction in insulin function will decrease LH production and thus lead to a decrease in Testosterone production in men.
  • ...2 more annotations...
  • Incretins are gut-derived hormones, members of the glucagon superfamily, released in response to nutrient ingestion (mainly glucose and fat)
  • They exert a wide range of effects, including stimulation of pancreatic insulin secretion in a glucose-dependent manner and play an important role in the local gastrointestinal and whole-body physiology
  • Nathan Goodyear on 11 Dec 13
     
    good discussion on incretins and their role in glucose homeostasis. 
Nathan Goodyear

Gastrointestinal Microflora Studies in Late-Onset Autism - 0 views

cid.oxfordjournals.org/...S6.abstract

autism gut gastrointestinal balance children

shared by Nathan Goodyear on 29 Jun 11 - No Cached
  • Nathan Goodyear on 29 Jun 11
     
    Gut bacterial balance different in children with autism when compared to children without autism
fnfdoc

How Lupus Affects The Health? - 0 views

www.fnfdoc.com/...lupus-affects-health

Lupus SLE

shared by fnfdoc on 29 Apr 18 - No Cached
  • fnfdoc on 29 Apr 18
     
    SLE or Lupus is an autoimmune disease that causes inflammation of the organs and swelling of the joints. It has vast effects on the renal, skeletal, gastrointestinal and blood systems. It affects mostly people of Chinese and African origin and presents in a capricious and unpredictable manner.
  • fnfdoc on 09 May 18
     
    10 May Is Lupus Day We Must Know About Lupus
Nathan Goodyear

Update on Serologic Testing in Celiac Disease - 0 views

usagiedu.com/...cdtest.pdf

gluten sensitivity gluten celiac disease celiac gastrointestinal

shared by Nathan Goodyear on 02 Mar 13 - No Cached
  • Nathan Goodyear on 02 Mar 13
     
    New clarification of celiac disease and the new gluten sensitivity. It has been many years that gluten sensitivity was frowned upon, but now clarification and validation comes.
Nathan Goodyear

Resolution of cryptosporidiosis with probiotic treatment - 0 views

pmj.bmj.com/...112.full.pdf

probiotic GI gastrointestinal probiotics

shared by Nathan Goodyear on 01 May 12 - No Cached
  • Nathan Goodyear on 01 May 12
     
    probiotic treatment has efficacy against active GI infection with cryptosporidium.
Nathan Goodyear

Malabsorption and cerebral dysfunction: A multivariate and comparative study of autisti... - 0 views

www.springerlink.com/...l1501v2578535741

autism ASD gut brain gastrointestinal gluten inflammation children

shared by Nathan Goodyear on 30 Jan 12 - No Cached
  • Nathan Goodyear on 30 Jan 12
     
    Study all the way back from 1971 suggesting link between the gut and brain in children with autism. They suggested a malabsorptive and inflammatory response to gluten.
Nathan Goodyear

short-term benefit from oral vancomycin treatment of regressive-onset autism - 0 views

www.ncbi.nlm.nih.gov/pubmed

autism ASD dysbiosis inflammation gut GI gastrointestinal children

shared by Nathan Goodyear on 30 Jan 12 - No Cached
  • Nathan Goodyear on 30 Jan 12
     
    disruption of gut bacteria balance, dysbiosis, proposed to play role in regression autism. This study treated these children with vancomycin. Short interval improvement was found. The take home from this study is the gut-brain connection in children with regression autism
Nathan Goodyear

Immune activation of peripheral blood and mucosal CD3+ lymphocyte cytokine profiles in ... - 0 views

mercola.fileburst.com/...Ileal%20cytokines.pdf

ASD autism inflammation

shared by Nathan Goodyear on 29 Jan 12 - No Cached
  • Nathan Goodyear on 29 Jan 12
     
    immune dysfunction found in children with autism. This again, suggests a gut-brain link in autism.
Nathan Goodyear

clinical presentation and Histologic Findings at Ileocolonoscopy in children with Autis... - 0 views

mercola.fileburst.com/...Krigsman%20proof.pdf

autism ASD inflammation GI

shared by Nathan Goodyear on 29 Jan 12 - No Cached
  • Nathan Goodyear on 29 Jan 12
     
    Ileal and colonic inflammation found in children with autism. Prominent GI symptoms were found in this chart review of 143 children with autism and developmental disorders.
Nathan Goodyear

EVALUATION OF AN ASSOCIATION BETWEEN GASTROINTESTINAL SYMPTOMS AND CYTOKINE PRODUCTION ... - 0 views

mercola.fileburst.com/...Jyonouchi%202005.pdf

autism ASD food sensitivies food allergies sensitivity TNF-alpha IL-12 inflammation

shared by Nathan Goodyear on 29 Jan 12 - No Cached
  • Nathan Goodyear on 29 Jan 12
     
    Food sensitivities found to play a role in elevated TNF-alpha and IL-12 in children with autism.
Nathan Goodyear

Branched-chain amino acids increase arterial blood ammonia in spite of enhanced intrins... - 0 views

ajpgi.physiology.org/...G269

BCAA branched chain amino acids NH3 ammonia liver disease cirrhosis alpha-ketoglutarate

shared by Nathan Goodyear on 10 Feb 14 - No Cached
  • Nathan Goodyear on 10 Feb 14
     
    Good review of the effects of BCAA on ammonia metabolism.  BCAA increase intramuscular NH3 production through the production of alpha-ketoglutarate.
Nathan Goodyear

BMC Microbiology | Full text | The Firmicutes / Bacteroidetes ratio of the human microb... - 0 views

www.biomedcentral.com/...123

gut flora gut microbiome gut microbiota firmicutes bacteroidetes firmicutes_bacteroidetes health gut microbiome

shared by Nathan Goodyear on 06 May 15 - No Cached
  • The microbiota of the large intestine plays an important role in host metabolism and maintenance of host health
  • Our results defining a standard adult profile, together with previous reports, showed that C. leptum, C. coccoides, Bacteroides and Bifidobacterium represent the four dominant groups of the adult fecal microbiota
  • Sub-dominant groups are Lactobacilli Enterobacteriaceae, Desulfovibrio, Sporomusa, Atopobium as well as other bacterial groups including Clostridium clusters XI, XIVb, and XVIII
  • ...12 more annotations...
  • In infant fecal microbiota, we observed Bifidobacterium as the dominant group
  • this observation is strongly related to diet, being enhanced by breast feeding
  • Significant higher numbers of Bifidobacterium were observed in infants versus adults and seniors
  • the gastrointestinal tract is first colonized by facultative anaerobes, such as E. coli
  • Strict anaerobes, such as Clostridium, colonize at later stages, as can be seen by the relatively low levels of C. leptum and C. coccoides in infants
  • diet change must be considered among the primary causes for such a shift of microbiota between infants and adults.
  • In the case of elderly subjects, our qPCR results indicated a significant increase in the counts of E. coli when compared to adults. This data is consistent with other publications indicating that elderly subjects harbor a different E. coli microbiota profile compared to younger adults
  • a number of authors reported a reduction in the numbers and diversity of many protective commensal anaerobes, such as Bacteroides and Bifidobacteria
  • The Firmicutes to Bacteroidetes ratio was already shown to be of significant relevance in signaling human gut microbiota status
  • Our measurements of the Firmicutes/Bacteroidetes ratio in adults obtained by our species-specific qPCR are in agreement with those obtained by Ley et al
  • Compared with young adults, the elderly have a different digestive physiology, characterized at a physiological level by a reduction in transit and of digestive secretions
  • The Firmicutes/Bacteroidetes ratio undergoes an increase from birth to adulthood and is further altered with advanced age
  • Nathan Goodyear on 06 May 15
     
    Good discussion of the gut microbiome.  Age effects the gut bacteria balance.  The Firmicutes/Bacteroidetes ratio increases from young, to young adult, to the elderly in this study.  Is this simply a reflection of aging or is the a biomarker that can be changed through diet and targeted probiotics?
Nathan Goodyear

Clostridium scindens: a human gut microbe with a high potential to convert glucocortico... - 0 views

www.jlr.org/...2437.full

gut microbiota gut microbiome gut bacteria androgens hormones clostridium scindens

shared by Nathan Goodyear on 29 Apr 15 - No Cached
  • During the enterohepatic circulation (EC), bile salts are synthesized in the liver, concentrated in the gallbladder, and function in the lumen of the small intestine to absorb dietary lipids and limit microbial growth at the site of nutrient uptake
  • Bile acid 7α/β-dehydroxylating bacteria are organisms capable of converting primary bile acids made by the host to harmful secondary bile acids, deoxycholic acid, and lithocholic acid
  • These bacteria normally comprise a small proportion of the gut microbiota (∼103–104/g wet weight) and consist of species within the genus Clostridium
  • ...3 more annotations...
  • C. scindens and a small number of species belonging to the genus Clostridium are responsible for significant alterations in the human bile acid pool composition through bile acid 7α/β dehydroxylation
  • bile acids play an important role in maintaining intestinal barrier function as antimicrobial agents in the small bowel (37, 38) and inducers of antimicrobial peptides
  • Perturbations in the biliary bile acid pool composition can be indicative of hepatogastrointestinal diseases such as fat malabsorption (40), gallstones (3), gastrointestinal cancers (41), and possibly type II diabetes
  • Nathan Goodyear on 29 Apr 15
     
    Gut microbiota appears to be source of androgen production that originates from the gut.  Who would have thought that the Gut as an androgen producing endocrine gland.
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