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Nathan Goodyear

New test suggests antidepressant Paxil may promote breast cancer - latimes.com - 0 views

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    article on upcoming publication of study showing Paxil has estrogenic effect. Likely through receptors from paxil itself or metabolites.
Nathan Goodyear

Selective serotonin reuptake inhibitors - PubMed Mobile - 0 views

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    SSRI's have variable inhibition of CYP.  Fluvoxamine was found to be the most potent inhibitor.  CYP3A4 and CYP2D6 were found to be the main targets of inhibition.  
Nathan Goodyear

Low environmental levels of fluoxetine induce ... [Aquat Toxicol. 2012] - PubMed - NCBI - 0 views

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    Yes, this study looked at molluscs, but water SSRI exposure shown to increase estradiol levels in the molluscs.  
Nathan Goodyear

In vivo and in vitro estrogenic activity of t... [Reprod Toxicol. 2012] - PubMed - NCBI - 0 views

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    SSRI, fluoxetine shown to increase "estrogenic response" in vitro and in vivo studies of breast cancer cell lines.
Nathan Goodyear

Pharmacological causes of hyperprolactinemia - 0 views

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    SSRI as well as other antidepressants cause hyperprolactinemia.  Antipsychotics are well known to increase prolactin production.
Nathan Goodyear

Breast enlargement during chronic antidepres... [J Affect Disord. 1997] - PubMed - NCBI - 0 views

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    SSRI therapy increases breast growth.  Both SSRI and venlafaxine increase "mammoplasia", but SSRI was more significant.
Nathan Goodyear

Effects of selective serotonin reuptake inhibitors o... [Thyroid. 2009] - PubMed - NCBI - 0 views

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    Interesting study.  They found a "significant reduction of T(3) after 15 and 30 days" with SSRI use, yet their conclusion is SSRI is safe in hypothyroid.   The take is that part of the weight gain associated with SSRI use is through dysfunction of thyroid hormone production as the effects were also found with T4.
Nathan Goodyear

A Case of Galactorrhea Associated with Excitalopram - 0 views

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    Lexapro can increase Prolactin levels which can cause libido dysfunction and galactorrhea as in this case.
Nathan Goodyear

The risks of selective serotonin reuptake inhibitor use in infertile women: a review of... - 0 views

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    There is just no reason to take SSRIs during pregnancy.  SSRIs increase risk of miscarriage, birth defects, preterm birth, newborn behavior problems, pulmonary hypertension...All women considering pregnancy should removed, yet SSRIs are prescribed as if they are candy.
Nathan Goodyear

PsychiatryOnline | American Journal of Psychiatry | S-Adenosyl Methionine (SAMe) Augmen... - 0 views

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    SAMe, in SSRI non-responders, resulted in a 46.1% response and a 35.8% remission compared to placebo.
Nathan Goodyear

Frontiers | Primum Non Nocere: An Evolutionary Analysis of Whether Antidepressants Do M... - 0 views

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    antidepressants do more harm than good, is the conclusion of this study.
Nathan Goodyear

Are antidepressants as effective as claimed... [Can J Psychiatry. 2007] - PubMed - NCBI - 0 views

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    Editorial from Dr. Moncrieff.  The title of the editorial tells you everything you need to know.  
Nathan Goodyear

J Clin Psychiatry / Document Archive - 0 views

  • This trial of urban MDD patients failed to confirm that either active treatment was better than placebo
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    study reveals that antidepressants no better than placebo. This study was sponsored by the National Institute of Mental Health.  
Nathan Goodyear

Association between patient beliefs regard... [J Clin Psychiatry. 2011] - PubMed - NCBI - 0 views

  • Patient beliefs regarding treatment may have a stronger association with clinical outcome than the actual medication received
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    study reveals that the benefit of the anti-depressant is "placebo"
Nathan Goodyear

Current Issue : Obstetrics & Gynecology - 0 views

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    analysis of 3 clinical trials found that up to 40% of 447 women that were treated with antidepressant therapy found no benefit.  Physical symptoms were provided little, if any benefit.
Nathan Goodyear

Arch Gen Psychiatry -- Abstract: Trajectories of Depression Severity in Clinical Trials... - 0 views

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    amazingly, up to 20% of patents with depression do worse on anti-depressant therapy (SSRI).  These are labeled non-responders, but when compared to placebo, the difference was significant.  Maybe, we should check their neurotransmitters first? 
Nathan Goodyear

Interferon-alpha-induced changes in tryptoph... [Biol Psychiatry. 2003] - PubMed - NCBI - 0 views

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    paroxetine, SSRI, shown to improve depressive symptoms without altering kynurenine levels.  Revealing underlying issue of depression in many individuals is disordered tryptophan metabolism due to inflammation
Nathan Goodyear

PLoS ONE: Antidepressants and Breast and Ovarian Cancer Risk: A Review of the Literatur... - 0 views

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    Antidepressants shown to increase Breast and Ovarian Cancer risk in review of 61 articles. Clear relationship found, but exact risk still needs further research.  Interestingly, the pharmaceutical industry's research, showed no risk.
Nathan Goodyear

SpringerLink - Journal of Neural Transmission, Volume 106, Numbers 7-8 - 0 views

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    inositol not effective in SSRI non-responders

Nathan Goodyear

SpringerLink - Article - 0 views

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    SSRI increase serotonin levels rapidly after initiation of therapy; to rapid to explain the therapeutic latency associated with re-uptake inhibition only
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