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Nathan Goodyear

Glutathione Redox Regulates Airway Hyperresponsiveness and Airway Inflammation in Mice ... - 0 views

www.atsjournals.org/...rcmb.2006-0423OC

glutathione asthma inflammation

shared by Nathan Goodyear on 07 Jul 16 - No Cached
  • γ-GCE reduced levels of IL-4, IL-5, IL-10, and the chemokines eotaxin and RANTES (regulated on activation, normal T cell expressed and secreted) in bronchoalveolar lavage fluid, whereas it enhanced the production of IL-12 and IFN-γ.
  • γ-GCE suppressed eosinophils infiltration
  • γ-GCE directly inhibited chemokine-induced eosinophil chemotaxis
  • ...10 more annotations...
  • these findings suggest that changing glutathione redox balance, increase in GSH level, and the GSH/GSSG ratio by γ-GCE, ameliorate bronchial asthma by altering the Th1/Th2 imbalance through IL-12 production from APC and suppressing chemokine production and eosinophil migration itself.
  • Bronchial asthma is a typical helper T cell type 2 (Th2) disease
  • Through the release of Th2 cytokines, such as IL-4, IL-5, and IL-13, orchestrate the recruitment and activation of the primary effector cells of the allergic response: the mast cells and the eosinophils
  • Glutathione is the most abundant nonprotein sulfhydryl compound in almost all cells. This tripeptide plays a significant role in many biological processes. It also constitutes the first line of the cellular defense mechanism against oxidative injury along with SOD, ascorbate, vitamin E, and catalase, and is the major intracellular redox buffer in ubiquitous cell types
  • We have shown that glutathione redox status, namely the balance between intracellular reduced (GSH) and oxidized (GSSG) glutathione, in murine antigen-presenting cells (APC) plays a central role in determining which of the reductive and oxidative APC predominate during immune status, and the balance between reductive and oxidative APC regulates Th1/Th2 balance through production of IL-12
  • we have also shown that exposure of human alveolar macrophages to the Th1 cytokine IFN-γ or the Th2 cytokine IL-4 either increases or decreases the GSH/GSSG ratio, respectively, which regulates Th1/Th2 balance through IL-12 production
  • the ability to generate a Th1 or Th2 type response has turned out to depend not only on T cells but also on the intracellular glutathione redox status of APC
  • Th1 cytokine IFN-γ and Th2 cytokine IL-4 increases and decreases the GSH/GSSG ratio, respectively, and that this ratio influences LPS-induced IL-12 production from alveolar macrophages
  • the ability to generate a Th1 or Th2 response is dependent on glutathione redox status of APC
  • administration of γ-GCE elevates GSH level and GSH/GSSG ratio in the lung, and ameliorates AHR and eosinophilic airway inflammation by altering the Th1/Th2 balance and suppressing chemokine production and eosinophil migration in a mouse asthma model
  • Nathan Goodyear on 07 Jul 16
     
    glutathione redox reaction plays an important role in the ability to balance Th1 and Th2 and thus disease potential i.e. asthma as this study example.  
wheelchairindia9

J6 Power Wheelchair - 0 views

www.wheelchairindia.com/...J6-Power-Wheelchair

J6 Power Wheelchair Quantum Wheelchair Quantum Power Chairs J6 Power Chair Pride J6 Wheelchair Quantum Motorized Wheelchairs J6 Power Wheelchair Price J6 Wheelchair

shared by wheelchairindia9 on 02 Mar 16 - No Cached
  • wheelchairindia9 on 02 Mar 16
     
    J6 Power Wheelchair The compact J6 is the ultimate choice for users who demand the superb stability of Mid-Wheel 6 design and tight-quarter maneuverability. Highly adaptable, the J6 accepts a wide range of seating and electronics options while its powerful drive train delivers high-performance torque. J6 Power Wheelchair Features: Mid-Wheel 6 allows six wheels on the ground for maximum stability. Compatible with TRU-Balance Tilt. OMNI-Casters (nylon, spherical-shaped casters) on front and rear prevent wheel hang-ups. Side-mounted, easily accessible freewheel levers. ATX Suspension (Active-Trac with extra stability) incorporates front OMNI-Casters for enhanced. Performance over more varied terrain. Easy front access to batteries. J6 Power Wheelchair Specifications: Drive Wheels: 10" Solid Optional: 10" Pneumatic Caster Wheels Front: 5" Solid Rear: 6" Solid Anti-Tip Wheels N/A Maximum Speed^4/^: Up to 4 mph Ground Clearance: 2.5" (frame) Turning Radius^5/^: 22" Overall Length: 34.74" without foot riggings Base Width: 23.19" Seating Sizes: TRU-Balance® 2 Synergy/Static: W: 10-20" D: 10-20" Power Tilt: W: 14-20" D: 14-20" Lift & Tilt: N/A Seat-to-Floor Heights: TRU-Balance® 2 Synergy/Static8: 16.5" - 17.5" Power Tilt8: 16.875" Lift & Tilt8: N/A Manual Tilt/Recline^10/^: Yes Battery Size^6/^: U-1 Battery Weight^14/^: 23.4 lbs. Available Electronics^12/^: 70A Q-Logic 2 NE 70A Q-Logic 2 NE+ 70A Q-Logic 2 EX Battery Charger 5A Off-board Motor Packages 2-Pole 4 mph Weight Capacity^7/^: 300 lbs.9 Base Weight: 100.2 lbs
Nathan Goodyear

An obesity-associated gut microbiome with increased capacity for energy harvest : Abstr... - 0 views

www.nature.com/...nature05414.html

gut bacteria dysbiosis microbiota balance obesity overweight metabolic endotoxemia

shared by Nathan Goodyear on 15 Jan 13 - No Cached
  • Nathan Goodyear on 15 Jan 13
     
    gut bacteria balance associated with obesity.  The balance of ones gut bacteria plays a significant role in whether a high fat,western diet leads to obesity or not.
Nathan Goodyear

http://download.journals.elsevierhealth.com/pdfs/journals/0168-8278/PIIS016882781300887... - 0 views

download.journals.elsevierhealth.com/...PIIS0168827813008878.pdf

dysbiosis liver disease gut microbiota bacterial balance

shared by Nathan Goodyear on 10 Feb 14 - No Cached
  • Nathan Goodyear on 10 Feb 14
     
    gut bacterial balance plays role in progression of liver disease.  Dysbiosis worsens cirrhosis, liver failure...where as a health gut bacterial balance seems to slow progression
Nathan Goodyear

Changes in gut microbiota control metabolic endotoxemia-induced inflammation in high-fa... - 0 views

diabetes.diabetesjournals.org/...1470.full.pdf

dysbiosis obesity endotoxemia diabetes gut metabolic endotoxemia

shared by Nathan Goodyear on 15 Jan 13 - No Cached
  • Nathan Goodyear on 15 Jan 13
     
    This article discusses how an imbalance gut bacteria balance leads to endotoxemia and resultant obesity and diabetes. So, the balance of gut bacteria plays a role in obesity. Really changes ones view of how the body interacts and how disease develops through dysfunction.
Nathan Goodyear

ScienceDirect.com - Cell Metabolism - Estrogen Receptors and the Metabolic Network - 0 views

www.sciencedirect.com/...S1550413111003123

ER-alpha ER-beta estrogen receptor receptors metabolic syndrome MetS hormone hormones

shared by Nathan Goodyear on 11 Oct 12 - No Cached
  • The pro-opiomelanocortin (POMC) neurons have an anorexigenic action and, when activated, reduce food intake through the release of two peptides, α-melanocyte-stimulating hormone (α-MSH) and cocaine-and-amphetamine-regulated transcripts (CART). The neuropeptide Y (NPY) neurons, on the other hand, release NPY hormone and agouti gene-related protein (AgRP), which prevent the binding of α-MSH to MC3R and MC4R, increasing food intake
  • This suggests that the central anorexic effects of E2 may occur via ERβ
  • The main hypothalamic areas involved in food intake and satiety are the arcuate nucleus (ARC), the lateral hypothalamus (LH), the paraventricular nucleus (PVN), the ventromedial hypothalamus (VMH), and the dorsomedial hypothalamus (DMH)
  • ...22 more annotations...
  • Leptin is a potent anorexigenic and catabolic hormone secreted by adipose cells that reduces food intake and increases energy expenditure
  • E2 not only modulates leptin receptor mRNA in the ARC and VMH, but also increases hypothalamic sensitivity to leptin, altering peripheral fat distribution
  • ghrelin. It acts on growth hormone secretagogue receptors (GHSR1a) located in the ARC and is a potent stimulator of food intake
  • It thus appears that of the two ERs, ERα plays a predominant role in the CNS regulation of lipid and carbohydrate homeostasis.
  • Both ERs have been identified in the ARC
  • Stimulation of MCH neurons increases food intake and fat accumulation while its inhibition leads to decreased food intake and reduced fat accumulation.
  • Both ERs have been identified in the LH
  • both ERs have been identified in this nucleus
  • The PVN is the region of the hypothalamus with the highest expression of ERβ and is reported to be weakly ERα positive
  • The VMH is ERα regulated
  • Skeletal muscle is responsible for 75% of the insulin-induced glucose uptake in the body
  • GLUT4 is highly expressed in muscle and represents a rate-limiting step in the insulin-induced glucose uptake
  • data suggest that in the physiological range, E2 is beneficial for insulin sensitivity, whereas hypo- or hyperestrogenism is related to insulin resistance
  • In aging female rats, E2 treatment improves glucose homeostasis mainly through its ability to increase muscle GLUT4 content on the cell membrane
  • It is evident that ERα and ERβ have distinct actions and that much more research is needed to clearly identify the function of each receptor in muscle.
  • E2 prevents accumulation of visceral fat, increases central sensitivity to leptin, increases the expression of insulin receptors in adipocytes, and decreases the lipogenic activity of lipoprotein lipase in adipose tissue
  • In rats, ovariectomy increases body weight, intra-abdominal fat, fasting glucose and insulin levels, and insulin resistance followed by decreased phosphorylation of AMPK and its substrate acetyl-CoA carboxylase in adipose tissue
  • decreased adiponectin, PPARγ coactivator-1α (PGC-1α), and uncoupling protein 2 (UCP2) and increased resistin
  • Men with aromatase deficiency have truncal obesity, elevated blood lipids, and severe insulin resistance
  • Although not all studies are in agreement, polymorphisms of ERα in humans have been associated with risk factors for CVDs
  • Human subcutaneous and visceral adipose tissues express both ERα and ERβ, whereas only ERα mRNA has been identified in brown adipose tissue
  • suggesting that ERα is the main regulator of GLUT4 expression in adipose tissue
  • Nathan Goodyear on 11 Oct 12
     
    very nice article that looks at the balance of ER-alpha/ER-beta and their role in metabolic syndrome.  This article discusses the balance of  these receptors are tissue dependent in their effect.  I like their conclusion: "...but these mechanisms will never be completely understood if they are not considered in the context of a whole system.
Nathan Goodyear

Effects of Polyunsaturated Fatty Acids in Growth Medium on Lipid Composition and on Phy... - 0 views

www.ncbi.nlm.nih.gov/...PMC321255

PUFA poly unsaturated fatty acids GI dysbiosis bacteria microbiota

shared by Nathan Goodyear on 01 May 12 - No Cached
  • Nathan Goodyear on 01 May 12
     
    PUFA shown to effect GI bacterial balance.  Altering adhesion of lactobacillus to intestinal surface.  Also, lactobacilli species shown to alter PUFA metabolism in GI.  This article reveals the effect that diet can have on GI bacterial balance.
Nathan Goodyear

Social Support and Salivary Cortisol in Women With Metastatic Breast Cancer - 0 views

www.psychosomaticmedicine.org/...337.abstract

saliva salivary cortisol HPA axis breast cancer metastatic hormone hormones test testing evaluation

shared by Nathan Goodyear on 28 Nov 11 - No Cached
  • Nathan Goodyear on 28 Nov 11
     
    better cortisol pattern seen in women with good social support.  This is indicative of a better balanced HPA axis and thus immune system balance.  Significant implications in women with metastatic breast cancer.  Cortisol evaluated by saliva
Nathan Goodyear

Activity and expression of progesterone metabolizing 5α-reductase, 20α-hydrox... - 0 views

www.ncbi.nlm.nih.gov/...PMC154104

progesterone metabolites breast cancer 5alpha-reductase 5-alpha pregnene 5-alpha pregnenes 4-pregnene 4-pregnenes

shared by Nathan Goodyear on 30 Jan 14 - No Cached
  • Exposure of human breast cell lines (MCF-7, MCF-10A, and ZR-75-1) to 5α-pregnanes results in changes associated with neoplasia, including increased proliferation and decreased attachment [1], depolymerization of F-actin [2] and decreases in adhesion plaque-associated vinculin
  • Exposure to 4-pregnenes results, in general, in opposite (anti-cancer-like) effects
  • 5αR1 has been detected in various androgen-independent organs, such as the liver and brain
  • ...10 more annotations...
  • 5αR2 has been found predominantly in androgen-dependent organs, such as epididymis and prostate
  • The 5α-pregnanes:4-pregnenes ratio was about 8-fold higher in tumorous than in nontumorous breast tissue after an 8-hour incubation with [14C]progesterone
  • Studies with breast cell lines, showing that 5α-pregnanes stimulate proliferation and decrease attachment of cells
  • both tissue and breast cell line studies suggest that an elevated level of progesterone 5α-reductase activity may be an indicator of breast tumorigenesis, regardless of presence or absence of ER and/or PR
  • 5αR1 is the main isoform expressed in human breast carcinomas [29] and that 5αR2 may not be associated with risk of breast cancer
  • the differences in 5α-pregnane production between the cells is due primarily to a difference in 5αR1 expression
  • As in the case of 5α-reductase activity, the presence or absence of ER and PR do not appear to be related to 5α-reductase expression.
  • the conversion of progesterone to the cancer promoting 5α-pregnanes is significantly higher in the human tumorigenic breast cell lines
  • lthough both 5αR1 and 5αR2 are expressed by these cells, the elevated 5α-reductase activity appears to be the result of significantly greater expression of 5αR1
  • Changes in progesterone metabolizing enzyme expression (resulting in enzyme activity changes) may be responsible for promoting breast cancer progression due to increased production of tumor-promoting 5α-pregnanes and decreased production of anti-cancer 20α – and 3α-4-pregnenes
  • Nathan Goodyear on 30 Jan 14
     
    balance of enzyme production between 5alpha-reductase and 20alpha-hydroxysteroid oxidoreductase and 3alpha(beta)-hydroxysteroid oxidoreductase play role in carcinogenesis and proliferation in the balance of production of progesterone metabolites. The 5alpha pregnenes are pro carcinogenic  and the 4-pregnenes are anti carcinogenic.
Nathan Goodyear

Progesterone metabolites in breast cancer - 0 views

erc.endocrinology-journals.org/...717.long

progesterone metabolism metabolites breast cancer hormones progesterone metabolites

shared by Nathan Goodyear on 12 Jun 14 - No Cached
  • In breast tumor tissue and tumorigenic cell lines, 5α-reductase activity and mRNA expression are significantly higher, whereas 3α- and 20α-HSO activities and mRNA expression are significantly lower than in normal breast tissue and nontumorigenic cells
  • Studies using various breast cell lines have shown that 5αP and 3αHP have opposing actions in terms of cell proliferation and adhesion; 5αP stimulates cell proliferation (through increased mitosis and decreased apoptosis) and cell detachment, whereas 3αHP suppresses cell proliferation (through decreased mitosis and increased apoptosis) and detachment
  • the paracrine/ autocrine functions of 5αP are cancer-promoting and those of 3αHP are cancer-inhibiting
  • Nathan Goodyear on 12 Jun 14
     
    Awesome article on progesterone metabolism in breast cancer.  The author, weibe, describes 2 categories of progesterone metabolites in breast tissue: 5alpha-pregnanes and 4-pregnenes.  The author describes 3 primary enzymes that control the balance between these 2 metabolites--5alpha reductase, 3alpha-HSO, and 20alpha-HSO.  The resultant balance of 5alpha-dihydroprogesterone and 3alpha-dihydroprogesterone helps to determine the cancer potential of breast tissue.
wheelchairindia9

Handicapped Two Wheeler - 0 views

www.wheelchairindia.com/...SIDE-WHEEL-ATTACHMENT

Innovative Scooter For The Benefit Of Disabled Scooter For Handicapped Person 2 Piece Tyre Size Handicapped Two Wheeler power-operated vehicle delta-style steering arrangement

shared by wheelchairindia9 on 24 Apr 15 - No Cached
  • wheelchairindia9 on 24 Apr 15
     
    Heavy duty mobility scooters are strong enough to accommodate almost any user. When compared with lighter units, mobility scooters models tend to feature bigger motors, wider bases, and larger tires. While a lighter model may be difficult to maneuver through rougher landscapes, mobility scooter is designed to tackle even the most challenging terrain.An excellent selection of scooters for sale. An extensive scooter accessories section, where find plenty of customization options to help ensure that the model select is a perfect fit. Side Wheels For Hero Pleasure: Side Wheel Attachment for Hero Pleasure or Side Wheels For Hero Pleasure or Three wheeler Hero Pleasure for handicapped is product, designed for use with bikes meant for the open road. Instead of shifting with a foot, a rider can drive easily their bike on road using his or her hand. This piece of equipment has been tested at well-known motorcycle tracks. This provides assembly and installation for all products at all facilities. Side Wheel Attachment For Hero Pleasure to fit the widest array of motorcycles and all-terrain vehicles possible. Side Wheel Attachment For Hero Pleasure Measurements: Frame : 38 mm 16 Gauge CR Pipe With Powder Coated Wheel Hub : Alloys Molded 2 Piece Tyre Size : 3.50 x 10 Inches 2 Piece Tube Size : 3.50 x 10 inches 2 Piece Shocks Up Heavy Duty 4 Piece ball baring 2 Piece pin bush 2 Piece mudguard chrome plated 2 Piece Disk with 4 Hole Wheel Type: Alloy Wheel Width: 40" to 48" inch Carrying Capacity: 100 -150 kg Side Wheels For Hero Pleasure Features: Independent Mobility Minimal Cost Heavy Duty International quality standards Comfort High level of performance Carrying Capacity: 100 -150 kg Sturdy design Provides excellent balance Provides excellent support High durability Side Wheels For CD Deluxe: Side Wheel Attachment for CD Deluxe or Side Wheels For CD Deluxe or Three wheeler CD Deluxe for handicapped is product, designed for u
Nathan Goodyear

Dietary intervention impact on gut microbial gene richness : Nature : Nature Publishing... - 0 views

www.nature.com/...nature12480.html

gut bacteria dysbiosis obesity overweight diet nutrition metabolism metabolic endotoxemia

shared by Nathan Goodyear on 29 Aug 13 - No Cached
  • Nathan Goodyear on 29 Aug 13
     
    Nutrition is a language.  Poor gut balance and as what the authors call "richness" contributes to metabolic dysfunction and obesity.  This study found that Nutrition can improve gut bacterial balance and "richness" that then will improve the metabolic impact of the nutrition. Complex and beautiful nutrition--gut--metabolism connection.
Nathan Goodyear

Distinct composition of gut microbiota during pregnancy in overweight and normal-weight... - 0 views

www.ajcn.org/...894.abstract

obesity gut pregnancy microbiota bacteroidetes clostridium staphylococcus

shared by Nathan Goodyear on 02 Sep 11 - No Cached
  • Nathan Goodyear on 02 Sep 11
     
    the gut bacterial balance in overweight women is distinctly different than normal weight women during pregnancy.  We know that bacterial balance in the infants plays a pivotal role in obesity risk.  Maybe, probiotic and gut health in the pregnant mother is the starting point to preventing obesity risk in children
Nathan Goodyear

Coming Full Circle: Contributions of Central and Peripheral Oxytocin Actions to Energy ... - 0 views

endo.endojournals.org/...589.abstract

oxytocin anorexin appetite weight loss

shared by Nathan Goodyear on 13 Feb 13 - No Cached
  • Nathan Goodyear on 13 Feb 13
     
    oxytocin shown to inhibit appetite as an anorexigen.  As a hormone, prolactin, regulates energy balance
Nathan Goodyear

Biological functions and clinical implications of oestrogen receptors alfa and beta in ... - 0 views

onlinelibrary.wiley.com/...full

ER estrogen receptors ER-alpha ER alpha ER-beta ER beta hormones hormone

shared by Nathan Goodyear on 21 Jan 14 - No Cached
  • ERα-positive cells respond to E2 with increased proliferation
  • ERβ was artificially introduced into these cells, E2-induced proliferation was inhibited
  • The proliferative response to E2 seems to be determined by the ratio of ERα/ERβ. The functions of ERβ in the breast are probably related to its antiproliferative as well as its prodifferentiative functions
  • ...7 more annotations...
  • The risk of developing PC seems to be related to the diet
  • In the human prostate, ERβ is expressed in the basal epithelial cells and AR in the luminal epithelium.
  • For many years, DHT was considered to be the main hormone guiding prostate development and function. However, the idea was challenged when in 2001 Mahendroo et al. showed that mice in which both forms of 5α-reductase had been inactivated, have a normal functional prostate [50]. The question was then raised as to what is the real function of DHT in the prostate. In 1989 we hypothesized that DHT is a precursor of an oestrogen, 5α-androstane-3β,17β-diol (3β-Adiol) and that physiological levels of an oestrogen could be produced in the total absence of aromatase [51]. We later demonstrated that 3β-Adiol is abundant in the prostate and is a good natural ligand for ERβ
  • The overall effect of oestrogens in the immune system is determined by a balance between ERα and ERβ signalling
  • The hypothesis of our group is that ERβ plays an important role in regulating the differentiation of pluripotent haematopoietic progenitor cells whereas ERα induces proliferation
  • In tissues and cell lines of mammary epithelium for example, it has been noticed that E2 in the presence of ERα elicits proliferation, but in the presence of ERβ it inhibits proliferation
  • ERα and ERβ have distinctive tissue distributions and to the great surprise of endocrinologists [7] many tissues previously thought to be ‘oestrogen-insensitive tissues’ were found to be ERβ positive and oestrogen sensitive. The most notable of the ERα-negative ERβ-abundant tissues were the epithelium of the rodent ventral prostate [8], the granulosa cells of the ovaries [9] and the parenchyma of the lungs
  • Nathan Goodyear on 21 Jan 14
     
    Awesome article discusses the different balance of ER alpha and ER beta and the effects on tissue as it relates to proliferation versus differentiation.  This has clear implications in disease.  Physicians prescribing hormones without a knowledge and understanding of this are only causing potential harm to their clients.
Nathan Goodyear

Restoration of regulatory and effector T cell balance and B cell homeostasis in systemi... - 0 views

www.ncbi.nlm.nih.gov/...PMC3580532

vitamin d vitamin D T reg Th17 inflammation autoimmune disease lupus SLE

shared by Nathan Goodyear on 31 Jul 13 - No Cached
  • Nathan Goodyear on 31 Jul 13
     
    Vitamin D support provides benefit in those with Lupus.  The proposed mechanism is through the balance of Treg cells and Th17 cells.  This imbalance plays a role in the etiology of autoimmune disease and those with autoimmune disease, such as in Lupus, frequently have low vitamin D levels.
tapforfreedom

EFT Emotional Freedom Techniques Practitioner - Kalleen Henderson: Tapforfreedom.com : ... - 0 views

tapforfreedom.blogspot.in/...com-eft-emotional-freedom.html

EFT Emotional Freedom Technique EFT Matrix Reimprinting EFT Practitioners

shared by tapforfreedom on 10 May 14 - No Cached
  • tapforfreedom on 10 May 14
     
    Kalleen Henderson specialized in EFT (Emotional Freedom Technique) and Matrix Reimprinting tapping to release stress and create physical and/or emotional balance. http://tapforfreedom.com
  • tapforfreedom on 10 May 14
     
    Kalleen Henderson specialized in EFT (Emotional Freedom Technique) and Matrix Reimprinting tapping to release stress and create physical and/or emotional balance. http://tapforfreedom.com
Nathan Goodyear

Reevaluation of the protein requirement in young men with the indicator amino acid oxid... - 0 views

ajcn.nutrition.org/...995.long

protein macronutrients nutrition diet men

shared by Nathan Goodyear on 21 Jul 15 - No Cached
  • the mean and population-safe protein requirements were estimated to be 0.93 and 1.2 g · kg−1 · d
  • diet containing 0.90 g · kg−1 · d−1 was at or above physiologic protein requirements for sedentary men
  • The current EAR recommendation and RDA for protein are 0.66 and 0.80 g · kg−1 · d−1, respectively. We believe that these recommendations are tentative because no long-term studies have suggested that these values would maintain nitrogen balance along with lean body mass, muscle mass, serum protein concentrations, immunity, functional capacity etc
  • ...2 more annotations...
  • a series of long-term balance studies (67-69) showed that intake of the proposed safe allowance of 0.57 g (70) egg protein resulted in negative nitrogen balance, loss of lean body mass, and deteriorating serum protein and transferase values unless additional energy or nonessential nitrogen was supplied
  • The results of the present study suggest that the current EAR recommendations (0.66 g · kg−1 · d−1) and RDA (0.80 g · kg−1 · d−1) for protein are underestimated at 29% and 33%, respectively
  • Nathan Goodyear on 21 Jul 15
     
    study looked at protein requirements in 8 "healthy" men.  This study pointed to 1.2 g/kg/day as an appropriate daily dietary protein intake for healthy men.  This far exceeds levels per RDA.
Nathan Goodyear

The Effect of Testosterone Replacement on Endogenous Inflammatory Cytokines and Lipid P... - 0 views

jcem.endojournals.org/...3313

testosterone effect lipids cholesterol inflammation

shared by Nathan Goodyear on 02 Mar 11 - No Cached
  • In conclusion, testosterone replacement shifts the cytokine balance to a state of reduced inflammation and lowers total cholesterol.
  • Nathan Goodyear on 02 Mar 11
     
    Testosterone helped to balance inflammation and lower total cholesterol
Nathan Goodyear

Insulin action in the brain can lead to obesity: How insulin in hypothalamus controls b... - 0 views

www.sciencedaily.com/...110606121839.htm

insulin obesity

shared by Nathan Goodyear on 07 Jun 11 - No Cached
  • Nathan Goodyear on 07 Jun 11
     
    Insulin effects the hypothalamus and it's control of balance between energy storage: energy production = obesity
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