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Nathan Goodyear

Mood Disorders and Obesity: Understanding Inflammation as a Pathophysiological Nexus | ... - 0 views

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    good review of the interaction between the immune system and the neuroendocrine system in obesity and mood disorders.  
Nathan Goodyear

Think Twice: How the Gut's "Second Brain" Influences Mood and Well-Being: Scientific Am... - 0 views

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    So goes your gut, so goes your brain and mood
Nathan Goodyear

Optimal Serum Selenium Concentrations Are Associated with Lower Depressive Symptoms and... - 0 views

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    Optimal Selenium levels associated with lower incidence of depressive moods--link to optimal glutathione pathways?  
Nathan Goodyear

Mild Dehydration Affects Mood in Healthy Young Women - 0 views

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    dehydration effects mood, energy and headaches in women.
Nathan Goodyear

Effect of Testosterone Replacement Therapy on Cognitive Performance and Depression in M... - 0 views

  • Azad et al [15] used single photon emission computed tomography and showed that, after 3~5 weeks of TRT, cerebral perfusion was increased in the midbrain and the superior frontal gyrus in seven men with hypogonadism
  • After 12~14 weeks, increased perfusion was still observed in the midbrain as well as in the midcingulate gyrus
  • TDS patients who received TRT showed significant improvement in cognitive function only if mild cognitive impairment was present at baseline
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  • Cherrier et al [17] evaluated a sample of 32 subjects, which included 17 men with mild cognitive impairment and 15 with Alzheimer's disease. At the 6-week follow-up, patients who received TRT showed significantly better scores regarding spatial memory, constructional abilities, and verbal memory compared to those noted in the placebo group. Taken together, these results suggest that TRT has a beneficial effect on cognitive function
  • TRT improved mood and well-being, and reduced fatigue and irritability in hypogonadal men
  • The study by Pope et al [20] involved men with depression refractory to standard anti-depressants, and found that TRT lowered the Hamilton Depression score,
  • depression tends to increase as testosterone levels decrease [21], it is highly likely that TRT improved symptoms of depression by increasing testosterone levels.
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    men with Testosterone <300 ng/dl with levels after 8 months of therapy achieving +680 ng/dl.
Nathan Goodyear

Bioavailable Testosterone and Depressed Mood in Older Men: The Rancho Bernardo Study: T... - 0 views

  • bioavailable testosterone levels decrease much more with age than does total testosterone or estradiol levels
  • The decrease in bioavailable testosterone parallels the increase in sex hormone binding globulin with age, a change that accompanies increasing body fat independent of weight change
  • a graded stepwise decrease in bioavailable testosterone with increasing level of depressed mood
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  • This association was independent of age, weight change, and physical activity, the only three significant confounding covariates of the association between sex hormone levels and BDI scores
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    bioavailable Testosterone is inversely associated with increased depressive symptoms.
Nathan Goodyear

Salivary testosterone: Associations with depression, anxiety disorders, and antidepress... - 0 views

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    large study revealed that low salivary testosterone is associated with increased depression, anxiety, and other mood disorders.
Nathan Goodyear

Nutritional therapies for mental disorders - 0 views

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    Nutritional therapies for mood disorders.
Nathan Goodyear

Testosterone and the brain. [Aging Male. 2006] - PubMed - NCBI - 0 views

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    testosterone therapy in men with "low T" will see improvement in mood i.e.. depression, energy...aggression associated with testosterone therapy is due to supra physiologic levels.
Nathan Goodyear

Neurobiological effects of the green tea constituent theanine and its potential role in... - 0 views

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    Only abstract available: l-Theanine appears to be a glutamate receptor antagonist.  The effects of l-Theanine have shown to be positive with mood disorders, psychiatric conditions, and neurodegenerative diseases.  L-Theanine increases BDNF.
Nathan Goodyear

'Maternity blues' and hormone levels in saliva. [J Affect Disord. 1984] - PubMed result - 0 views

  • This pilot study has demonstrated the potential value of using a non-invasive technique (obtaining specimens of saliva) in conjunction with determinations of a predictable mood change.
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    salivary progesterone validated in mood evaluations
Nathan Goodyear

Vitamin D3 enhances mood in healthy subjects durin... [Psychopharmacology (Berl). 1998]... - 0 views

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    Vitamin D3 enhances mood in healthy subjects during winter.
Nathan Goodyear

Omega-3 fatty acids as treatments for mental illness: which disorder and which fatty ac... - 0 views

  • The most convincing evidence for beneficial effects of omega-3 PUFA is to be found in mood disorders. A meta-analysis of trials involving patients with major depressive disorder and bipolar disorder provided evidence that omega-3 PUFA supplementation reduces symptoms of depression. Furthermore, meta-regression analysis suggests that supplementation with eicosapentaenoic acid may be more beneficial in mood disorders than with docosahexaenoic acid,
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    Omega-3 beneficial in depression and bi-polar clients
Nathan Goodyear

Effects of Self-Selected Mass Loss on Performance and Mood i... : The Journal of Streng... - 0 views

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    rapid weight loss in wrestlers pre-event causes increased mood effects and confusion
Nathan Goodyear

Kynurenine Pathway Metabolites in Humans: Disease and Healthy States - 0 views

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    review of studies looking at kyneurenine pathway and it's contribution to neurodegenerative disorders and mood disorders
Nathan Goodyear

Testosterone may improve sexual function and mood in older men with low levels | The BMJ - 0 views

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    In men older than 65 with low Testosterone, Testosterone therapy improved sexual function and mood.
Nathan Goodyear

Effect of Tongkat Ali on stress hormones and psychological mood state in moderately str... - 0 views

  • At the age of 60, testosterone levels are typically only 40-50% of youthful levels and may be lower
  • Eurycoma contains a group of small peptides referred to as “eurypeptides” that are known to have effects in improving energy status and sex drive in studies of rodents
  • The effects of tongkat ali in restoring normal testosterone levels appears to be less due to actually “stimulating” testosterone synthesis, but rather by increasing the release rate of “free” testosterone from its binding hormone, sex-hormone-binding-globulin (SHBG)
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  • The current study found that daily supplementation with tongkat ali root extract (200 mg/day) improves stress hormone profile (lower cortisol; higher testosterone) and certain mood state parameters (lower tension, anger, and confusion)
  • tongkat ali supplementation (100 mg/day) improved lean body mass, 1-RM strength, and arm circumference to a significantly greater degree compared to a placebo group.
  • In a recent 12-week trial [46] of Eurycoma longifolia supplementation (300 mg/day), men (30–55 years of age) showed significant improved compared to placebo in the Physical Functioning domain of the SF-36 quality of life survey
  • sexual libido was increased by 11%
  • In men with low testosterone levels (average age 51 years), one month of daily supplementation with tongkat ali extract (200 mg/day) resulted in a significant improvement in serum testosterone levels and quality-of-life parameters
  • rise in cortisol and drop in testosterone is an early signal of “overtraining”
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    Tongkat Ali, commonly known as long jack, is found to reduce stress and increase Testosterone.  Stress is one of the common causes of low T in men.  It appears that long Jack functions as an adaptogen.
Nathan Goodyear

Exogenous testosterone, aggression, and mood i... [Physiol Behav. 2002] - PubMed - NCBI - 0 views

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    study finds that supra physiological replacement of testosterone is not associated with aggressive behavior.
Nathan Goodyear

BMC Women's Health | Full text | Effectiveness of Compounded Bioidentical Hormone Repla... - 0 views

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    Cohort study of 6 compounding pharmacies find BHRT improves mood in those clients taking BHRT.
Nathan Goodyear

Active placebos versus antidepressants for depression - The Cochrane Library - Moncrief... - 0 views

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    cochrane review of 9 studies involving 751 patients, shows little difference between antidepressants and "active placebos".  The two groups both improved mood, but there was very little difference between the 2.  Take home: "...the effects of antidepressants my be generally overestimated..."
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